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310 results on '"Fan, Xiangshan"'

1. Neoadjuvant sintilimab in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction adenocarcinoma: a single-arm phase 2 trial

Author

Wei, Jia, Lu, Xiaofeng, Liu, Qin, Fu, Yao, Liu, Song, Zhao, Yang, Zhou, Jiawei, Chen, Hui, Wang, Meng, Li, Lin, Yang, Ju, Liu, Fangcen, Zheng, Liming, Yin, Haitao, Yang, Yang, Zhou, Chong, Zeng, Ping, Zhou, Xiaoyu, Ding, Naiqing, Chen, Shiqing, Zhao, Xiaochen, Yan, Jing, Fan, Xiangshan, Guan, Wenxian, and Liu, Baorui

Published
2023
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4. Parallel Classification of Cells in Thinprep Cytology Test Image for Cervical Cancer Screening

Author

Cao, Maosong, Zhang, Xin, Fan, Xiangshan, Zhang, Lichi, Wang, Qian, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Ali, Sharib, editor, van der Sommen, Fons, editor, Papież, Bartłomiej Władysław, editor, van Eijnatten, Maureen, editor, Jin, Yueming, editor, and Kolenbrander, Iris, editor

Published
2022
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5. Whole Slide Cervical Cancer Screening Using Graph Attention Network and Supervised Contrastive Learning

Author

Zhang, Xin, Cao, Maosong, Wang, Sheng, Sun, Jiayin, Fan, Xiangshan, Wang, Qian, Zhang, Lichi, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wang, Linwei, editor, Dou, Qi, editor, Fletcher, P. Thomas, editor, Speidel, Stefanie, editor, and Li, Shuo, editor

Published
2022
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6. Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis

Author

Wang, Pin, Wang, Yunshan, Langley, Sasha A, Zhou, Yan-Xia, Jen, Kuang-Yu, Sun, Qi, Brislawn, Colin, Rojas, Carolina M, Wahl, Kimberly L, Wang, Ting, Fan, Xiangshan, Jansson, Janet K, Celniker, Susan E, Zou, Xiaoping, Threadgill, David W, Snijders, Antoine M, and Mao, Jian-Hua

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Human Genome, Genetics, Biotechnology, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Cancer, Animals, Carcinogenesis, Collaborative Cross Mice, Disease Models, Animal, Female, Genetic Predisposition to Disease, Male, Mice, Stomach Neoplasms, collaborative cross, gastric cancer, mouse model, tumor susceptibility, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

ObjectiveThe Collaborative Cross (CC) is a mouse population model with diverse and reproducible genetic backgrounds used to identify novel disease models and genes that contribute to human disease. Since spontaneous tumour susceptibility in CC mice remains unexplored, we assessed tumour incidence and spectrum.DesignWe monitored 293 mice from 18 CC strains for tumour development. Genetic association analysis and RNA sequencing were used to identify susceptibility loci and candidate genes. We analysed genomes of patients with gastric cancer to evaluate the relevance of genes identified in the CC mouse model and measured the expression levels of ISG15 by immunohistochemical staining using a gastric adenocarcinoma tissue microarray. Association of gene expression with overall survival (OS) was assessed by Kaplan-Meier analysis.ResultsCC mice displayed a wide range in the incidence and types of spontaneous tumours. More than 40% of CC036 mice developed gastric tumours within 1 year. Genetic association analysis identified Nfκb1 as a candidate susceptibility gene, while RNA sequencing analysis of non-tumour gastric tissues from CC036 mice showed significantly higher expression of inflammatory response genes. In human gastric cancers, the majority of human orthologues of the 166 mouse genes were preferentially altered by amplification or deletion and were significantly associated with OS. Higher expression of the CC036 inflammatory response gene signature is associated with poor OS. Finally, ISG15 protein is elevated in gastric adenocarcinomas and correlated with shortened patient OS.ConclusionsCC strains exhibit tremendous variation in tumour susceptibility, and we present CC036 as a spontaneous laboratory mouse model for studying human gastric tumourigenesis.

Published
2019

16. Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in DLBCL

Author

Xu-Monette, Zijun Y., primary, Li, Yong, additional, Snyder, Thomas, additional, Yu, Tiantian, additional, Lu, Tingxun, additional, Tzankov, Alexandar, additional, Visco, Carlo, additional, Bhagat, Govind, additional, Qian, Wenbin, additional, Dybkaer, Karen, additional, Chiu, April, additional, Tam, Wayne, additional, Zu, Youli, additional, Hsi, Eric D., additional, Hagemeister, Fredrick B., additional, Wang, Yingjun, additional, Go, Heounjeong, additional, Ponzoni, Maurilio, additional, Ferreri, Andrés J.M., additional, Moller, Michael B., additional, Parsons, Benjamin M., additional, Fan, Xiangshan, additional, van Krieken, J.Han, additional, Piris, Miguel A., additional, Winter, Jane N., additional, Au, Qingyan, additional, Kirsch, Ilan, additional, Zhang, Mingzhi, additional, Shaughnessy, John, additional, Xu, Bing, additional, and Young, Ken H., additional

Published
2023
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28. Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression

Author

Zhang, Heng, primary, Chen, Gang, additional, Feng, Xing, additional, Song, Huiwen, additional, Meng, Lingbing, additional, Fu, Yao, additional, Yang, Jun, additional, Fan, Zhiwen, additional, Ding, Youxiang, additional, Du, Zhijie, additional, Wang, Jianchao, additional, Yang, Li, additional, Zhang, Jun, additional, Sun, Lixia, additional, Liu, Zhigang, additional, Zhang, Zhiyong, additional, Li, Quanhai, additional, and Fan, Xiangshan, additional

Published
2023
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31. Efficacy and Safety of Sintilimab in Combination with Concurrent Chemoradiotherapy for Locally Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (SHARED): Study Protocol of a Prospective, Multi-Center, Single-Arm Phase 2 Trial

Author

Wei,Jia, Lu,Xiaofeng, Liu,Qin, Fu,Yao, Liu,Song, Li,Lin, Liu,Fangcen, Fan,Xiangshan, Yang,Ju, Yang,Yang, Zhao,Yang, Guan,Wenxian, and Liu,Baorui

Subjects
Oncology, Cancer Management and Research
Abstract

Jia Wei,1 Xiaofeng Lu,2 Qin Liu,1 Yao Fu,3 Song Liu,4 Lin Li,3 Fangcen Liu,3 Xiangshan Fan,3 Ju Yang,1 Yang Yang,1 Yang Zhao,5 Wenxian Guan,2 Baorui Liu1 1The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, 210008, People’s Republic of China; 2Department of General Surgery, Drum Tower Hospital, Nanjing, 210008, People’s Republic of China; 3Department of Pathology, Drum Tower Hospital, Nanjing, 210008, People’s Republic of China; 4Department of Radiology, Drum Tower Hospital, Nanjing, 210008, People’s Republic of China; 5Department of Biostatistics, Nanjing Medical University, Nanjing, 210029, People’s Republic of ChinaCorrespondence: Baorui Liu, The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, 210008, People’s Republic of China, Tel +86 2583107081, Email baoruiliu@nju.edu.cnPurpose: Concurrent chemoradiotherapy (cCRT) is the mainstay therapy of locally advanced gastric (G) and gastroesophageal junction (GEJ) cancers with a poor prognosis. Programmed cell death receptor-1 (PD-1) inhibitor has been approved and recommended to treat ≥ 3 line G/GEJ patients. A significant clinical benefit of PD-1 inhibitors in addition to cCRT has been observed in locally advanced lung cancer. Sintilimab, a humanized IgG4 monoclonal antibody with high affinity and specificity for PD-1, has shown promising efficacy with an overall response rate of 85% in combination with chemotherapy in gastric cancer in a phase Ib study (NCT02937116).Patients and Methods: SHARED is a prospective, multicentre, single-arm Phase II trial in China, exploring the efficacy of sintilimab in combination with cCRT in locally advanced G/GEJ adenocarcinoma. According to a Simon optimal two-stage clinical design, 34 patients will be enrolled. All the eligible patients will receive one cycle of induction chemotherapy (S-1 plus nab-PTX) combined with sintilimab, followed by cCRT (radiotherapy plus nab-PTX) combined with sintilimab. Prior to the surgery, patients will receive another cycle of chemotherapy (S-1 plus nab-PTX) combined with sintilimab. In the adjuvant setting, all participants will be treated with 3 cycles of chemotherapy (S-1 plus nab-PTX) combined with sintilimab. The primary endpoint is the rate of pathological complete response (pCR). The secondary endpoints include disease-free survival (DFS), major pathological response (MPR), R0 resection rate, surgical AEs, overall survival (OS), event-free survival (EFS), and safety profile. Moreover, the prognostic value of tumor biomarkers and immune biomarkers will be explored.Conclusion: SHARED is designed to primally evaluate the efficacy and safety of sintilimab in combination with cCRT in locally advanced G/GEJ cancers and to prospectively validate the prognostic value of tumor biomarkers and immune biomarkers.Keywords: anti-PD-1, induction chemotherapy, chemoradiotherapy, immunotherapy

Published
2022

41. The efficacy of additional surgical resection after endoscopic resection in pT1b esophageal squamous cell carcinoma: A multi-institutional retrospective study in China

Author

Xue, Xuemin, primary, Sun, Qi, additional, Jiang, Dongxian, additional, Wang, Xinran, additional, Liu, Yong, additional, Guo, Changyuan, additional, Liu, Linxiu, additional, Cheng, Na, additional, Wang, Guiqi, additional, Liu, Yueping, additional, Hou, Yingyong, additional, Fan, Xiangshan, additional, and Xue, Liyan, additional

Published
2022
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42. A Retrospective Cohort Study of Factors Influencing Lymph Node Metastasis in Patients With Early Gastric Papillary Adenocarcinoma

Author

Zheng, Chang, primary, Xu, Guifang, additional, Tang, Dehua, additional, Ni, Muhan, additional, Cheng, Yuqing, additional, Du, Mingzhan, additional, Wang, Yaohui, additional, Xu, Yuejie, additional, Jiang, Jingwei, additional, Xiang, Ying, additional, Sun, Qi, additional, Chen, Ling, additional, Fan, Xiangshan, additional, Huang, Qin, additional, Zhou, Yihua, additional, Zou, Xiaoping, additional, and Wang, Lei, additional

Published
2022
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45. MIST: multiple instance learning network based on Swin Transformer for whole slide image classification of colorectal adenomas.

Author

Cai, Hongbin, Feng, Xiaobing, Yin, Ruomeng, Zhao, Youcai, Guo, Lingchuan, Fan, Xiangshan, and Liao, Jun

Subjects
AEROSOLS, ADENOMA, COLORECTAL cancer, PRECANCEROUS conditions, DEEP learning, OBJECT recognition (Computer vision), SIGNAL convolution
Abstract

Colorectal adenoma is a recognized precancerous lesion of colorectal cancer (CRC), and at least 80% of colorectal cancers are malignantly transformed from it. Therefore, it is essential to distinguish benign from malignant adenomas in the early screening of colorectal cancer. Many deep learning computational pathology studies based on whole slide images (WSIs) have been proposed. Most approaches require manual annotation of lesion regions on WSIs, which is time‐consuming and labor‐intensive. This study proposes a new approach, MIST – Multiple Instance learning network based on the Swin Transformer, which can accurately classify colorectal adenoma WSIs only with slide‐level labels. MIST uses the Swin Transformer as the backbone to extract features of images through self‐supervised contrastive learning and uses a dual‐stream multiple instance learning network to predict the class of slides. We trained and validated MIST on 666 WSIs collected from 480 colorectal adenoma patients in the Department of Pathology, The Affiliated Drum Tower Hospital of Nanjing University Medical School. These slides contained six common types of colorectal adenomas. The accuracy of external validation on 273 newly collected WSIs from Nanjing First Hospital was 0.784, which was superior to the existing methods and reached a level comparable to that of the local pathologist's accuracy of 0.806. Finally, we analyzed the interpretability of MIST and observed that the lesion areas of interest in MIST were generally consistent with those of interest to local pathologists. In conclusion, MIST is a low‐burden, interpretable, and effective approach that can be used in colorectal cancer screening and may lead to a potential reduction in the mortality of CRC patients by assisting clinicians in the decision‐making process. © 2022 The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2023
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