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Fig. S4. The Kaplan-Meier curves. (a) OS among patients in training cohort stratified by IRGPI and tumor stage. (b) Relapse-free survival among patients in validation cohort of GSE13898. (c) OS among patients in meta-validation cohort stratified by IRGPI and tumor stage.

Fig. S2. Flow chart of IRGPI construction.

Table. S4. The expression levels of six genes in training and validation dataset.

Fig. S1. Overview of the construction and validation of immune-related gene pairs signature (IRGPI). Four datasets were included in this study. TCGA dataset was used for training cohort, and GSE13898, GSE19417, GSE53625 were merged to the meta-validation cohort. The training cohort was used to build an IRGPI. The IRGPI was verified on the meta-validation cohort and independent validation cohorts.

Fig. S5. Kaplan-Meier curves in different subgroups’ cases of meta-validation dataset. (a) OS of cases in early stage. (b) OS of male cases. (c) OS of cases ≤ 60 years old. (d) OS of cases in late stage. (e) OS of female cases. (f) OS of cases > 60 years old.

Table S3. The significant biological processes enriched by genes consisted in the IRGPI.

Table S2. Model information about the IRGPI

Fig. S3. Kaplan-Meier curves in different subgroups’ cases of training set. (a) OS of cases with early stage. (b) OS of male cases. (c) OS of cases ≤ 60 years old. (d) OS of cases with late stage. (e) OS of female cases. (f) OS of cases > 60 years old

A deep space multi-file delivery protocol (DSMDP) based on LT codes is proposed to reduce the influence of long delay and a high bit error rate (BER) in deep space communication. The protocol increases sending redundancy by LT codes to improve the success rate of file delivery, and adopts different protective strategies for different situations of packet loss. At the same time, the multi-file united delivery strategy is adopted to make full use of the retransmission time to reduce the end-to- end transmission delay. Furthermore, the protocol determines the quantity of encoded packets according to the feedback for controlling redundancy. The simulation results show that the proposed protocol can significantly reduce the transmission delay of files, which would be effectively suitable for deep space communication environment of high BER and long delay.