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12 results on '"Fang, Shun Li"'

2. Association of susceptibility to septic shock with platelet endothelial cell adhesion molecule-1 gene Leu125Val polymorphism and serum sPECAM-1 levels in sepsis patients

Author

Wei, Sun, Fang-Shun, Li, Yuan-Huai, Zhang, Xiao-Ping, Wang, and Chao-Rong, Wang

Subjects
Original Article
Abstract

Sepsis is a systemic inflammatory response to infection and includes severe sepsis, septic shock and death. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is one cell adhesion molecule expressed on platelets and leukocytes. It regulates platelet activation and mediates transendothelial migration of leukocytes, thus maintaining the integrity of the vasculature. There are some animal experiments associated with the protective role of PECAM-1 against septic shock. However few host genetic risk factors have been identified for sepsis severity and susceptibility to septic shock. A case-control study was conducted, which included 217 patients with sepsis and 90 control subjects recruited from our hospital. One single nucleotide polymorphisms (SNP) of PECAM-1 gene Leu125Val (C373G) was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Serum soluble PECAM-1 (sPECAM-1) levels were determined by enzyme-linked immunosorbent assay (ELISA). Our results showed that the CG and GG genotypes of SNP in Leu125Val of PECAM-1 (rs668: C>G) was significantly associated with increased susceptibility to septic shock compared with CC genotype in sepsis patients (CG genotype, OR: 2.493, 95% CI: 1.175~5.287, P = 0.016; GG genotype: OR: 3.328, 95% CI: 1.445~7.666, P = 0.004). The serum levels of sPECAM-1 in the sepsis patients (47.1 ± 17.5 ng/ml) were significantly higher than those in the healthy controls (61.3 ± 20.9 ng/ml, P

Published
2015

12. [Detection of Mycoplasma hominis in Trichomonas vaginalis by PCR].

Author

Fang SL, Xiao JC, and Lun ZR

Subjects
Animals, China, DNA Primers, DNA, Bacterial genetics, Female, Humans, Mycoplasma hominis genetics, Trichomonas Vaginitis parasitology, Trichomonas vaginalis isolation & purification, Mycoplasma hominis isolation & purification, Polymerase Chain Reaction methods, Trichomonas vaginalis microbiology
Abstract

Twelve of 28 isolates of Trichomonas vaginalis collected from patients in hospitals in Guangzhou were found naturally infected with Mycoplasma hominis by PCR using specific primers. It suggests that the symbiosis of M. hominis in T. vaginalis also commonly occurs in China.

Published
2006

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