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379 results on '"Fang, Vicky J."'

5. Influenza A(H3N2) Antibody Responses to Standard-Dose Versus Enhanced Influenza Vaccine Immunogenicity in Older Adults and Prior Season's Vaccine Status.

Author

Zhong, Shuyi, Ng, Tiffany W Y, Skowronski, Danuta M, Iuliano, A Danielle, Leung, Nancy H L, Perera, Ranawaka A P M, Ho, Faith, Fang, Vicky J, Tam, Yat Hung, Ip, Dennis K M, Havers, Fiona G, Fry, Alicia M, Aziz-Baumgartner, Eduardo, Barr, Ian G, Peiris, Malik, Thompson, Mark G, and Cowling, Benjamin J

Subjects
VACCINATION status, VACCINE immunogenicity, OLDER people, INFLUENZA vaccines, ANTIBODY formation
Abstract

Background Annual influenza vaccination is recommended for older adults but repeated vaccination with standard-dose influenza vaccine has been linked to reduced immunogenicity and effectiveness, especially against A(H3N2) viruses. Methods Community-dwelling Hong Kong adults aged 65–82 years were randomly allocated to receive 2017–2018 standard-dose quadrivalent, MF59-adjuvanted trivalent, high-dose trivalent, and recombinant-HA quadrivalent vaccination. Antibody response to unchanged A(H3N2) vaccine antigen was compared among participants with and without self-reported prior year (2016–2017) standard-dose vaccination. Results Mean fold rise (MFR) in antibody titers from day 0 to day 30 by hemagglutination inhibition and virus microneutralization assays were lower among 2017–2018 standard-dose and enhanced vaccine recipients with (range, 1.7–3.0) versus without (range, 4.3–14.3) prior 2016–2017 vaccination. MFR was significantly reduced by about one-half to four-fifths for previously vaccinated recipients of standard-dose and all 3 enhanced vaccines (β range,.21–.48). Among prior-year vaccinated older adults, enhanced vaccines induced higher 1.43 to 2.39-fold geometric mean titers and 1.28 to 1.74-fold MFR versus standard-dose vaccine by microneutralization assay. Conclusions In the context of unchanged A(H3N2) vaccine strain, prior-year vaccination was associated with reduced antibody response among both standard-dose and enhanced influenza vaccine recipients. Enhanced vaccines improved antibody response among older adults with prior-year standard-dose vaccination. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Standard-dose versus MF59-adjuvanted, high-dose or recombinant-hemagglutinin influenza vaccine immunogenicity in older adults: comparison of A(H3N2) antibody response by prior season’s vaccine status

Author

Zhong, Shuyi, primary, Ng, Tiffany W Y, additional, Skowronski, Danuta M, additional, Iuliano, A Danielle, additional, Leung, Nancy H L, additional, Perera, Ranawaka A P M, additional, Ho, Faith, additional, Fang, Vicky J, additional, Tam, Yat Hung, additional, Ip, Dennis K M, additional, Havers, Fiona G, additional, Fry, Alicia M, additional, Aziz-Baumgartner, Eduardo, additional, Barr, Ian G, additional, Peiris, Malik, additional, Thompson, Mark G, additional, and Cowling, Benjamin J, additional

Published
2023
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8. Influenza-associated excess respiratory mortality in China, 2010–15: a population-based study

Author

Li, Li, Liu, Yunning, Wu, Peng, Peng, Zhibin, Wang, Xiling, Chen, Tao, Wong, Jessica Y T, Yang, Juan, Bond, Helen S, Wang, Lijun, Lau, Yiu Chung, Zheng, Jiandong, Feng, Shuo, Qin, Ying, Fang, Vicky J, Jiang, Hui, Lau, Eric H Y, Liu, Shiwei, Qi, Jinlei, Zhang, Juanjuan, Yang, Jing, He, Yangni, Zhou, Maigeng, Cowling, Benjamin J, Feng, Luzhao, and Yu, Hongjie

Published
2019
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14. Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013–17: an epidemiological study of laboratory-confirmed case series

Author

Wang, Xiling, Jiang, Hui, Wu, Peng, Uyeki, Timothy M, Feng, Luzhao, Lai, Shengjie, Wang, Lili, Huo, Xiang, Xu, Ke, Chen, Enfu, Wang, Xiaoxiao, He, Jianfeng, Kang, Min, Zhang, Renli, Zhang, Jin, Wu, Jiabing, Hu, Shixiong, Zhang, Hengjiao, Liu, Xiaoqing, Fu, Weijie, Ou, Jianming, Wu, Shenggen, Qin, Ying, Zhang, Zhijie, Shi, Yujing, Zhang, Juanjuan, Artois, Jean, Fang, Vicky J, Zhu, Huachen, Guan, Yi, Gilbert, Marius, Horby, Peter W, Leung, Gabriel M, Gao, George F, Cowling, Benjamin J, and Yu, Hongjie

Published
2017
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17. Variation in Influenza B Virus Epidemiology by Lineage, China

Author

Yang, Juan, Lau, Yiu Chung, Wu, Peng, Feng, Luzhao, Wang, Xiling, Chen, Tao, Ali, Sheikh T., Peng, Zhibin, Fang, Vicky J., Zhang, Juanjuan, He, Yangni, Lau, Eric H.Y., Qin, Ying, Yang, Jing, Zheng, Jiandong, Jiang, Hui, Yu, Hongjie, and Cowling, Benjamin J.

Subjects
Influenza viruses -- Research, Sentinel surveillance -- Research, Epidemiology -- Analysis, Health
Abstract

Influenza B virus, first identified in 1940 (7), is associated with considerable hospital admissions and deaths worldwide every year (2). During the early 1980s, influenza B viruses split into 2 [...]

Published
2018
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25. Reconstructing household transmission dynamics to estimate the infectiousness of asymptomatic influenza virus infections.

Author

Tim K. Tsang, Can Wang, Fang, Vicky J., Perera, Ranawaka A. P. M., Hau Chi So, Ip, Dennis K. M., Leung, Gabriel M., Peiris, J. S. Malik, Cauchemez, Simon, and Cowling, Benjamin J.

Subjects
VIRUS diseases, INFECTIOUS disease transmission, INFLUENZA viruses, HOUSEHOLDS, INFLUENZA
Abstract

There has long been controversy over the potential for asymptomatic cases of the influenza virus to have the capacity for onward transmission, but recognition of asymptomatic transmission of COVID-19 stimulates further research into this topic. Here, we develop a Bayesian methodology to analyze detailed data from a large cohort of 727 households and 2515 individuals in the 2009 pandemic influenza A(H1N1) outbreak in Hong Kong to characterize household transmission dynamics and to estimate the relative infectiousness of asymptomatic versus symptomatic influenza cases. The posterior probability that asymptomatic cases [36% of cases; 95% credible interval (CrI): 32%, 40%] are less infectious than symptomatic cases is 0.82, with estimated relative infectiousness 0.57 (95% CrI: 0.11, 1.54). More data are required to strengthen our understanding of the contribution of asymptomatic cases to the spread of influenza. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Human infection with influenza A(H7N9) virus during 3 major epidemic waves, China, 2013-2015

Author

Wu, Peng, Peng, Zhibin, Fang, Vicky J., Feng, Luzhao, Tsang, Tim K., Jiang, Hui, Lau, Eric H.Y., Yang, Juan, Zheng, Jiandong, Qin, Ying, Li, Zhongjie, Leung, Gabriel M., Yu, Hongjie, and Cowling, Benjamin J.

Subjects
China -- Diseases, Avian influenza -- Demographic aspects -- Patient outcomes, Epidemics -- Research -- China, Health
Abstract

Medscape ACTIVITY Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit. This activity has been planned [...]

Published
2016

36. Additional file 1 of Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study

Author

Tsang, Tim K., Lam, Kwok-Tai, Liu, Yinping, Fang, Vicky J., Mu, Xiaofeng, Leung, Nancy H. L., Peiris, J. S. Malik, Leung, Gabriel M., Cowling, Benjamin J., and Tu, Wenwei

Abstract

Additional file 1: Figure S1. Gating strategy and representative data of FACS analysis for influenza virus-specific CD4 and CD8 T cells. Figure S2. Flowchart of the cohort studies and the collection of serum samples and whole blood samples. Figure S3. The HAI titer distribution before and after the first pandemic wave of pH1N1 and the five epidemics of pH1N1 and H3N2 in 2010-2013. Figure S4. The odds ratios for influenza virus infection for every fold increase in standardized influenza subtype-specific CD4 and CD8 T cell response for sH1N1, pH1N1 and H3N2 estimated by logistic regression. Figure S5. The odds ratios for influenza virus infection for every fold increase in standardized influenza subtype-specific CD4 and CD8 T cell response for sH1N1, pH1N1 and H3N2 estimated by logistic regression. Figure S6. The odds ratios for influenza virus infection for every fold increase in standardized influenza subtype-specific CD4 and CD8 T cell response for sH1N1, pH1N1 and H3N2 estimated by logistic regression for children (age

Published
2022
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40. Poultry market closures and human infection with influenza A(H7N9) virus, China, 2013-14

Author

Wu, Peng, Jiang, Hui, Wu, Joseph T., Chen, Enfu, He, Jianfeng, Zhou, Hang, Wei, Lan, Yang, Juan, Yang, Bingyi, Qin, Ying, Fang, Vicky J., Li, Ming, Tsang, Tim K., Zheng, Jiandong, Lau, Eric H.Y., Cao, Yu, Chai, Chengliang, Zhong, Haojie, Li, Zhongjie, Leung, Gabriel M., Feng, Luzhao, Gao, George F., Cowling, Benjamin J., and Yu, Hongjie

Subjects
Avian influenza -- Health aspects, Poultry industry -- Health aspects, Infection -- Health aspects, Health
Abstract

A novel avian influenza A(H7N9) virus was first identified in China during March 2013, and by March 25, 2014, it had caused 390 laboratory-confirmed human cases in mainland China. The [...]

Published
2014
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47. Responses to threat of influenza A(H7N9) and support for live poultry markets, Hong Kong, 2013

Author

Wu, Peng, Fang, Vicky J., Liao, Qiuyan, Ng, Diane M.W., Wu, Joseph T., Leung, Gabriel M., Fielding, Richard, and Cowling, Benjamin J.

Subjects
Influenza -- Health aspects, Poultry industry -- International economic relations -- Health aspects, Health
Abstract

A novel influenza A(H7N9) virus was detected in China in March 2013, and an epidemic of infections in poultry and humans occurred during April and May of that year (1,2). [...]

Published
2014
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50. Comparative epidemiology of pandemic and seasonal influenza A in households

Author

Cowling, Benjamin J., Kwok Hung Chan, Fang, Vicky J., Lau, Lincoln L.H., Hau Chi So, Fung, Rita O.P., Ma, Edward S.K., Kwong, Alfred S.K., Chi-Wan Chan, Tsui, Wendy W.S., Ho-Yin Ngai, Chu, Daniel W.S., Lee, Paco W.Y., Ming-Chee Chiu, Leung, Gabriel M., and Peiris, Joseph S.M.

Subjects
Influenza viruses -- Diagnosis, Influenza viruses -- Care and treatment, Influenza viruses -- Patient outcomes
Abstract

A study was conducted to evaluate and compare the epidemiology of pandemic 2009 influenza A (H1N1) virus and seasonal influenza A in households. Results indicated that both types of viruses have similar characteristics in terms of rates of viral shedding, clinical illness and transmissibility in household settings.

Published
2010

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