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189 results on '"Fang, Yisheng"'

1. PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

Author

Lin, Chang-Ching, Chang, Tsung-Cheng, Wang, Yunguan, Guo, Lei, Gao, Yunpeng, Bikorimana, Emmanuel, Lemoff, Andrew, Fang, Yisheng V., Zhang, He, Zhang, Yanfeng, Ye, Dan, Soria-Bretones, Isabel, Servetto, Alberto, Lee, Kyung-min, Luo, Xuemei, Otto, Joseph J., Akamatsu, Hiroaki, Napolitano, Fabiana, Mani, Ram, Cescon, David W., Xu, Lin, Xie, Yang, Mendell, Joshua T., Hanker, Ariella B., and Arteaga, Carlos L.

Published
2024
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3. Antiferromagnetic spatial photonic Ising machine through optoelectronic correlation computing

Author

Huang, Junyi, Fang, Yisheng, and Ruan, Zhichao

Subjects
Computer Science - Emerging Technologies, Condensed Matter - Disordered Systems and Neural Networks, Physics - Applied Physics, Physics - Optics
Abstract

Recently, spatial photonic Ising machines (SPIM) have been demonstrated to compute the minima of Hamiltonians for large-scale spin systems. Here we propose to implement an antiferromagnetic model through optoelectronic correlation computing with SPIM. Also we exploit the gauge transformation which enables encoding the spins and the interaction strengths in a single phase-only spatial light modulator. With a simple setup, we experimentally show the ground state search of an antiferromagnetic model with $40000$ spins in number-partitioning problem. Thus such an optoelectronic computing exhibits great programmability and scalability for the practical applications of studying statistical systems and combinatorial optimization problems., Comment: 7 pages, 4 figures

Published
2021
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6. Experimental Observation of Phase Transitions in Spatial Photonic Ising Machine

Author

Fang, Yisheng, Huang, Junyi, and Ruan, Zhichao

Subjects
Condensed Matter - Disordered Systems and Neural Networks, Nonlinear Sciences - Adaptation and Self-Organizing Systems, Physics - Applied Physics, Physics - Data Analysis, Statistics and Probability, Physics - Optics
Abstract

Statistical spin dynamics plays a key role to understand the working principle for novel optical Ising machines. Here we propose the gauge transformations for spatial photonic Ising machine, where a single spatial phase modulator simultaneously encodes spin configurations and programs interaction strengths. Thanks to gauge transformation, we experimentally evaluate the phase diagram of high-dimensional spin-glass equilibrium system with $100$ fully-connected spins. We observe the presence of paramagnetic, ferromagnetic as well as spin-glass phases and determine the critical temperature $T_c$ and the critical probability ${{p}_{c}}$ of phase transitions, which agree well with the mean-field theory predictions. Thus the approximation of the mean-field model is experimentally validated in the spatial photonic Ising machine. Furthermore, we discuss the phase transition in parallel with solving combinatorial optimization problems during the cooling process and identify that the spatial photonic Ising machine is robust with sufficient many-spin interactions, even when the system is associated with the optical aberrations and the measurement uncertainty.

Published
2020
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7. Optical computation of divergence operation for vector field

Author

Lou, Yijie, Fang, Yisheng, and Ruan, Zhichao

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Topological physics desires stable methods to measure the polarization singularities in optical vector fields. Here a periodic plasmonic metasurface is proposed to perform divergence computation of vectorial paraxial beams. We design such an optical device to compute spatial differentiation along two directions, parallel and perpendicular to the incident plane, simultaneously. The divergence operation is achieved by creating the constructive interference between two derivative results. We demonstrate that such optical computations provide a new direct pathway to elucidate specific polarization singularities of vector fields., Comment: 6 pages, 4 figures

Published
2020
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9. On-grating graphene surface plasmons enabling spatial differentiation in terahertz region

Author

Fang, Yisheng, Lou, Yijie, and Ruan, Zhichao

Subjects
Physics - Optics
Abstract

We propose a graphene-on-grating nanostructure to enable second-order spatial differentiation computation in terahertz (THz) region. The differentiation operation is based on the interference between the direct reflected field and the leakage of two excited surface plasmon polaritons counter-propagating along the graphene sheet. With the spatial coupled-mode theory, we derive out that the requirement for the second-order spatial differentiation is the critical coupling condition. We numerically demonstrate such an analog computation with Gaussian beams. It shows that the spatial bandwidth of the proposed differentiator is large enough such that even when the waist radius of the Gaussian beam is as narrow as ${{w}_{0}}=0.68\lambda $ ($\lambda $ is the free-space wavelength), the accuracy of the differentiator is higher than 95\%. The proposed differentiator is ultra-compact, with a thickness less than $0.1\lambda $, and useful for real-time imaging applications in THz security detections.

Published
2017
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11. A Calibration Method for 6-UPS Stewart Platform

Author

Jing, Xuedong, Fang, Yisheng, Wang, Ziteng, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Du, Junping, editor, and Zhang, Weicun, editor

Published
2020
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13. Temporal Coupled-Mode Theory for Light Scattering and Absorption by Nanostructures

Author

Fang, Yisheng, Ruan, Zhichao, Adibi, Ali, Series Editor, Asakura, Toshimitsu, Series Editor, Hänsch, Theodor W., Series Editor, Krausz, Ferenc, Series Editor, Masters, Barry R., Series Editor, Monemar, Bo A.J., Series Editor, Venghaus, Herbert, Series Editor, Weber, Horst, Series Editor, Weinfurter, Harald, Series Editor, Midorikawa, Katsumi, Series Editor, Rhodes, William T., Editor-in-Chief, Kamenetskii, Eugene, editor, Sadreev, Almas, editor, and Miroshnichenko, Andrey, editor

Published
2018
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17. Abstract 3934: PRMT5 is an actionable target in CDK4/6 inhibitor-resistant ER+/Rb-deficient breast cancer

Author

Lin, Chang-Ching, primary, Chang, Tsung-Cheng, additional, Wang, Yunguan, additional, Zhang, Yanfeng, additional, Lemoff, Andrew, additional, Fang, Yisheng V., additional, Zhang, He, additional, Ye, Dan, additional, Soria-Bretones, Isabel, additional, Servetto, Alberto, additional, Lee, Kyung-min, additional, Luo, Xuemei, additional, Otto, Joseph J., additional, Akamatsu, Hiroaki, additional, Cescon, David W., additional, Xu, Lin, additional, Xie, Yang, additional, Mendell, Joshua T., additional, Hanker, Ariella B., additional, and Arteaga, Carlos L., additional

Published
2023
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18. Abstract 3445: Immune cells infiltration and activation are higher in breast cancers resistant to antiestrogen therapy

Author

Napolitano, Fabiana, primary, Sudhan, Dhivya R., additional, Wang, Yunguan, additional, González-Ericsson, Paula I., additional, Formisano, Luigi, additional, Lee, Kyung-Min, additional, Lin, Chang-Ching, additional, Chica-Parrado, María Rosario, additional, Ma, Hongli, additional, Evans, Nathaniel, additional, Servetto, Alberto, additional, Mendiratta, Saurabh, additional, Barnes, Spencer, additional, Fang, Yisheng V., additional, Balko, Justin M., additional, Mills, Gordon B., additional, Labrie, Marilyne, additional, Hanker, Ariella B., additional, and Arteaga, Carlos L., additional

Published
2023
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22. Abstract OT2-17-01: Phase 1 trial of anthracycline chemotherapy in combination with CD40 agonist and Flt3 ligand in metastatic triple-negative breast cancer

Author

Reddy, Sangeetha, primary, Carter, Meredith, additional, Chan, Isaac, additional, Unni, Nisha, additional, Peswani, Namrata, additional, Klemow, Dawn, additional, Syed, Samira, additional, Shakeel, Shahbano, additional, Fattah, Farjana, additional, Ahn, Chul, additional, Fang, Yisheng, additional, McArthur, Heather, additional, Sinclair, Nicole, additional, Yellin, Michael, additional, Yardley, Denise, additional, Chen, Nan, additional, O’Shaughnessy, Joyce, additional, Nanda, Rita, additional, Conzen, Suzanne D., additional, and Arteaga, Carlos, additional

Published
2023
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23. Pleiotrophin drives a prometastatic immune niche in breast cancer

Author

Ganguly, Debolina, primary, Schmidt, Marcel O., additional, Coleman, Morgan, additional, Ngo, Tuong-Vi Cindy, additional, Sorrelle, Noah, additional, Dominguez, Adrian T.A., additional, Murimwa, Gilbert Z., additional, Toombs, Jason E., additional, Lewis, Cheryl, additional, Fang, Yisheng V., additional, Valdes-Mora, Fatima, additional, Gallego-Ortega, David, additional, Wellstein, Anton, additional, and Brekken, Rolf A., additional

Published
2023
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24. Clinicopathologic Predictors of Clinical Outcomes in Mammary Adenoid Cystic Carcinoma: A Multi-institutional Study

Author

Khoury, Thaer, primary, Rosa, Marilin, additional, Nayak, Anupma, additional, Karabakhtsian, Rouzan, additional, Fadare, Oluwole, additional, Li, Zaibo, additional, Turner, Bradley, additional, Fang, Yisheng, additional, Kumarapeli, Asangi, additional, Li, Xiaoxian, additional, Numbere, Numbereye, additional, Villatoro, Tatiana, additional, Wang, Ji-Gang, additional, Sadeghi, Saed, additional, Attwood, Kristopher, additional, George, Anthony, additional, and Bhargava, Rohit, additional

Published
2023
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25. Abstract B016: Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

Author

Ganguly, Debolina, primary, Schmidt, Marcel, additional, Coleman, Morgan, additional, Ngo, Tuong-Vi, additional, Sorrelle, Noah, additional, Dominguez, Adrian, additional, Toombs, Jason, additional, Lewis, Cheryl, additional, Fang, Yisheng, additional, Mora, Fatima, additional, Ortega, David, additional, Wellstein, Anton, additional, and Brekken, Rolf, additional

Published
2023
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28. Case report: Two novel intergenic region-ALK fusions in non-small-cell lung cancer resistant to alectinib: A report of two cases

Author

Liao, Shan, Sun, Huiying, Wu, Jianhua, Lu, Hao, Fang, Yisheng, Wang, Yuanyuan, and Liao, Wangjun

Subjects
Cancer Research, Oncology
Abstract

BackgroundThe anaplastic lymphoma kinase (ALK) mutation, also known as the diamond mutation in non–small-cell lung cancer (NSCLC), has been treated with tremendous success since it was first reported in 2007. Alectinib, a second generation ALK-Tyrosine kinase inhibitor (TKI), has been reported to have significantly longer progression- free survival (PFS) than first generation ALK inhibitors in untreated ALK positive NSCLC. However, the clinical efficacy of ALK-TKIs on rare ALK fusions remains unclear. In recent years, with the popularity of next-generation sequencing (NGS) technology, an increasing number of novel ALK fusion partners have been reported, but the responses are heterogeneous among different ALK fusions. Considering the inconsistent reactions, the clinical efficacy of ALK-TKIs in rare ALK gene fusions remains to be evaluated in more cases.MethodsTo seek for individualized therapy, the tumor tissues acquired during biopsy were sent for genomic testing by NGS based on a 139-gene panel and a 425-gene panel in a centralized clinical testing center (GENESEEQ Technology Inc, Nanjing, China). See Supplementary Material for more details about the methods for DNA-based NGS, RNA-based NGS.ResultsWe present two cases of patients with lung adenocarcinoma harboring two novel Intergenic Region (IGR)-ALK rearrangements detected by DNA sequencing, which had limited clinical response to ALK-TKIs but showed sensitivity to chemotherapy combined with bevacizumab therapy in patient 2, with a PFS of over 1 year up till the last follow‐up assessment.ConclusionsIn summary, our cases emphasize the need for comprehensive molecular analysis of different ALK fusion partners at the DNA level to formulate accurate treatment strategies and provide a certain therapeutic reference for these two types of novel IGR-ALK fusions.

Published
2022
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29. ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells

Author

Luo, Maowu, primary, Bao, Lei, additional, Chen, Yan, additional, Xue, Yuanyuan, additional, Wang, Yong, additional, Zhang, Bo, additional, Wang, Chenliang, additional, Corley, Chase D., additional, McDonald, Jeffrey G., additional, Kumar, Ashwani, additional, Xing, Chao, additional, Fang, Yisheng, additional, Nelson, Erik R., additional, Wang, Jennifer E., additional, Wang, Yingfei, additional, and Luo, Weibo, additional

Published
2022
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30. Phase 1 pilot study with dose expansion of chemotherapy in combination with CD40 agonist and Flt3 ligand in metastatic triple-negative breast cancer.

Author

Reddy, Sangeetha M., primary, Carter, Meredith, additional, Chan, Isaac, additional, Hullings, Melanie, additional, Unni, Nisha, additional, Medina, Jessica, additional, Shakeel, Shahbano, additional, Armstrong, Susan, additional, Cade, Lakeisha, additional, Fattah, Farjana J., additional, Ahn, Chul, additional, Fang, Yisheng V., additional, Chen, Nan, additional, McArthur, Heather L., additional, Sinclair, Nicole, additional, Yellin, Michael Jay, additional, O'Shaughnessy, Joyce, additional, Nanda, Rita, additional, Conzen, Suzanne D., additional, and Arteaga, Carlos L., additional

Published
2022
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31. Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

Author

Ganguly, Debolina, primary, Schmidt, Marcel O, additional, Coleman, Morgan, additional, Ngo, Tuong-Vi, additional, Sorrelle, Noah, additional, Dominguez, Adrian TA., additional, Toombs, Jason, additional, Lewis, Cheryl, additional, Fang, Yisheng, additional, Mora, Fa Valdes, additional, Gallego-Ortega, David, additional, Wellstein, Anton, additional, and Brekken, Rolf A, additional

Published
2022
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33. Overexpression of GmMYB14 improves high‐density yield and drought tolerance of soybean through regulating plant architecture mediated by the brassinosteroid pathway

Author

Qiu Dezhen, Dong Cao, Xinan Zhou, Wei Guo, Chen Limiao, Dai Wenjun, Zhihui Shan, Yi Huang, Haifeng Chen, Zhonglu Yang, Zhang Xiaojuan, Chen Shuilian, Qingnan Hao, Xiaorong Liu, Chanjuan Zhang, Fang Yisheng, Hongli Yang, Lam-Son Phan Tran, and Songli Yuan

Subjects
0106 biological sciences, 0301 basic medicine, plant architecture, Osmotic shock, Transgene, Drought tolerance, drought tolerance, Plant Science, Genetically modified crops, Biology, 01 natural sciences, Petiole (botany), 03 medical and health sciences, chemistry.chemical_compound, Gene Expression Regulation, Plant, Stress, Physiological, Brassinosteroid, MYB, soybean, Research Articles, MYB transcription factor, Plant Proteins, Brassinolide, fungi, food and beverages, yield, Plants, Genetically Modified, Droughts, Cell biology, brassinosteroids, 030104 developmental biology, chemistry, Soybeans, Agronomy and Crop Science, Research Article, 010606 plant biology & botany, Biotechnology
Abstract

Summary MYB transcription factors (TFs) have been reported to regulate the biosynthesis of secondary metabolites, as well as to mediate plant adaption to abiotic stresses, including drought. However, the roles of MYB TFs in regulating plant architecture and yield potential remain poorly understood. Here, we studied the roles of the dehydration‐inducible GmMYB14 gene in regulating plant architecture, high‐density yield and drought tolerance through the brassinosteroid (BR) pathway in soybean. GmMYB14 was shown to localize to nucleus and has a transactivation activity. Stable GmMYB14‐overexpressing (GmMYB14‐OX) transgenic soybean plants displayed a semi‐dwarfism and compact plant architecture associated with decreased cell size, resulting in a decrease in plant height, internode length, leaf area, leaf petiole length and leaf petiole angle, and improved yield in high density under field conditions. Results of the transcriptome sequencing suggested the involvement of BRs in regulating GmMYB14‐OX plant architecture. Indeed, GmMYB14‐OX plants showed reduced endogenous BR contents, while exogenous application of brassinolide could partly rescue the phenotype of GmMYB14‐OX plants. Furthermore, GmMYB14 was shown to directly bind to the promoter of GmBEN1 and up‐regulate its expression, leading to reduced BR content in GmMYB14‐OX plants. GmMYB14‐OX plants also displayed improved drought tolerance under field conditions. GmBEN1 expression was also up‐regulated in the leaves of GmMYB14‐OX plants under polyethylene glycol treatment, indicating that the GmBEN1‐mediated reduction in BR level under stress also contributed to drought/osmotic stress tolerance of the transgenic plants. Our findings provided a strategy for stably increasing high‐density yield and drought tolerance in soybean using a single TF‐encoding gene.

Published
2020
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34. CRISPR/Cas9-Mediated Targeted Mutagenesis of GmUGT Enhanced Soybean Resistance Against Leaf-Chewing Insects Through Flavonoids Biosynthesis

Author

Zhang, Yongxing, primary, Guo, Wei, additional, Chen, Limiao, additional, Shen, Xinjie, additional, Yang, Hongli, additional, Fang, Yisheng, additional, Ouyang, Wenqi, additional, Mai, Sihua, additional, Chen, Haifeng, additional, Chen, Shuilian, additional, Hao, Qingnan, additional, Yuan, Songli, additional, Zhang, Chanjuan, additional, Huang, Yi, additional, Shan, Zhihui, additional, Yang, Zhonglu, additional, Qiu, Dezhen, additional, Zhou, Xinan, additional, Cao, Dong, additional, Li, Xia, additional, and Jiao, Yongqing, additional

Published
2022
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35. Abstract P1-02-14: A comparative analysis of clinical and pathologic characteristics of patients with HER2 positive breast cancer treated with neoadjuvant versus adjuvant anti-HER2 therapy: Analysis of 397 cases

Author

Sarode, Venetia, primary, Rood, Tricia, additional, Liu, Yulun, additional, Fang, Yisheng, additional, Sahoo, Sunati, additional, Peng, Yan, additional, Hwang, Helena, additional, Leitch, Marilyn, additional, and Haley, Barbara, additional

Published
2022
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41. Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β 2 ‐AR/MACC1 axis

Author

Pan, Changqie, primary, Wu, Jianhua, additional, Zheng, Siting, additional, Sun, Huiying, additional, Fang, Yisheng, additional, Huang, Zhenhua, additional, Shi, Min, additional, Liang, Li, additional, Bin, Jianping, additional, Liao, Yulin, additional, Chen, Jinzhang, additional, and Liao, Wangjun, additional

Published
2021
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44. Comprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancer

Author

Fang, Yisheng, primary, Wang, Yuanyuan, additional, Zeng, Dongqiang, additional, Zhi, Shimeng, additional, Shu, Tingting, additional, Huang, Na, additional, Zheng, Siting, additional, Wu, Jianhua, additional, Liu, Yantan, additional, Huang, Genjie, additional, Xue, Yichen, additional, Bin, Jianping, additional, Liao, Yulin, additional, Shi, Min, additional, and Liao, Wangjun, additional

Published
2021
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45. Overexpression of GmMYB14 improves high‐density yield and drought tolerance of soybean through regulating plant architecture mediated by the brassinosteroid pathway

Author

Chen, Limiao, primary, Yang, Hongli, additional, Fang, Yisheng, additional, Guo, Wei, additional, Chen, Haifeng, additional, Zhang, Xiaojuan, additional, Dai, Wenjun, additional, Chen, Shuilian, additional, Hao, Qingnan, additional, Yuan, Songli, additional, Zhang, Chanjuan, additional, Huang, Yi, additional, Shan, Zhihui, additional, Yang, Zhonglu, additional, Qiu, Dezhen, additional, Liu, Xiaorong, additional, Tran, Lam‐Son Phan, additional, Zhou, Xinan, additional, and Cao, Dong, additional

Published
2020
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