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10 results on '"Fang, Zhang-fu"'

4. Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease

Author

Peng, Yang, primary, Wang, Zhao-Ni, additional, Chen, Shi-Ying, additional, Xu, Ai-Ru, additional, Fang, Zhang-Fu, additional, Sun, Jing, additional, Zhou, Zi-Qing, additional, Hou, Xiao-Tao, additional, Cen, Lai-Jian, additional, Ma, Jian-Juan, additional, Zhao, Jin-Cun, additional, Guan, Wei-Jie, additional, Wang, De-Yun, additional, and Zhong, Nan-Shan, additional

Published
2022
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5. Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis

Author

Peng, Yang, primary, Wang, Zhao-Ni, additional, Xu, Ai-Ru, additional, Fang, Zhang-Fu, additional, Chen, Shi-Ying, additional, Hou, Xiao-Tao, additional, Zhou, Zi-Qing, additional, Lin, Hui-Min, additional, Xie, Jia-Xing, additional, Tang, Xiao Xiao, additional, Wang, De-Yun, additional, and Zhong, Nan-Shan, additional

Published
2022
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6. Serum levels of the IgA isotype switch factor TGF‐β1 are elevated in patients with COVID‐19

Author

Wang, Er‐yi, primary, Chen, Hao, additional, Sun, Bao‐qing, additional, Wang, Hui, additional, Qu, Hui‐Qi, additional, Liu, Yichuan, additional, Sun, Xi‐zhuo, additional, Qu, Jingchun, additional, Fang, Zhang‐fu, additional, Tian, Lifeng, additional, Zeng, Yi‐feng, additional, Huang, Shau‐Ku, additional, Hakonarson, Hakon, additional, and Liu, Zhi‐gang, additional

Published
2021
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8. Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Author

Yu, Hai-qiong, primary, Sun, Bao-qing, additional, Fang, Zhang-fu, additional, Zhao, Jin-cun, additional, Liu, Xiao-yu, additional, Li, Yi-min, additional, Sun, Xi-zhuo, additional, Liang, Hong-feng, additional, Zhong, Bei, additional, Huang, Zhi-feng, additional, Zheng, Pei-yan, additional, Tian, Li-feng, additional, Qu, Hui-Qi, additional, Liu, De-chen, additional, Wang, Er-yi, additional, Xiao, Xiao-jun, additional, Li, Shi-yue, additional, Ye, Feng, additional, Guan, Li, additional, Hu, Dong-sheng, additional, Hakonarson, Hakon, additional, Liu, Zhi-gang, additional, and Zhong, Nan-shan, additional

Published
2020
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10. Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease.

Author

Peng Y, Wang ZN, Chen SY, Xu AR, Fang ZF, Sun J, Zhou ZQ, Hou XT, Cen LJ, Ma JJ, Zhao JC, Guan WJ, Wang DY, and Zhong NS

Subjects
Angiotensin-Converting Enzyme 2, Epithelial Cells, Humans, Lung, Peptidyl-Dipeptidase A, SARS-CoV-2, COVID-19, Pulmonary Disease, Chronic Obstructive
Abstract

Accumulating evidence has confirmed that chronic obstructive pulmonary disease (COPD) is a risk factor for development of severe pathological changes in the peripheral lungs of patients with COVID-19. However, the underlying molecular mechanisms remain unclear. Because bronchiolar club cells are crucial for maintaining small airway homeostasis, we sought to explore whether the altered susceptibility to SARS-CoV-2 infection of the club cells might have contributed to the severe COVID-19 pneumonia in COPD patients. Our investigation on the quantity and distribution patterns of angiotensin-converting enzyme 2 (ACE2) in airway epithelium via immunofluorescence staining revealed that the mean fluorescence intensity of the ACE2-positive epithelial cells was significantly higher in club cells than those in other epithelial cells (including ciliated cells, basal cells, goblet cells, neuroendocrine cells, and alveolar type 2 cells). Compared with nonsmokers, the median percentage of club cells in bronchiolar epithelium and ACE2-positive club cells was significantly higher in COPD patients. In vitro, SARS-CoV-2 infection (at a multiplicity of infection of 1.0) of primary small airway epithelial cells, cultured on air-liquid interface, confirmed a higher percentage of infected ACE2-positive club cells in COPD patients than in nonsmokers. Our findings have indicated the role of club cells in modulating the pathogenesis of SARS-CoV-2-related severe pneumonia and the poor clinical outcomes, which may help physicians to formulate a novel therapeutic strategy for COVID-19 patients with coexisting COPD.

Published
2022
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