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High glucose (HG)-induced mammalian target of rapamycin (mTOR) overactivation acts as a signaling hub for the formation of tau hyperphosphorylation, which contributes to the development of diabetes-associated cognitive deficit. How HG induces the sustained activation of mTOR in neurons is not clearly understood. ErbB4, a member of the receptor tyrosine kinase family, plays critical roles in development and function of neural circuitry, relevant to behavioral deficits. Here, we showed HG-induced ErbB4 overexpression in differentiated SH-SY5Y cells and primary hippocampal neurons and hippocampal pyramidal neurons of streptozotocin-induced diabetic rats. Inhibition of ErbB4 signaling prevented the HG-induced activation of mTOR/S6K signaling to suppress tau hyperphosphorylation. In contrast, ErbB4 overexpression increased the activation of mTOR/S6K signaling, resulting in tau hyperphosphorylation similar to HG treatment. We also demonstrated that HG upregulated the expression of ErbB4 at a mTOR-dependent posttranscriptional level. Together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of mTOR involving overexpressed ErbB4, leading to the formation of tau hyperphosphorylation under HG condition. Therefore, ErbB4 is a potential therapeutic target for diabetes-associated neurodegeneration.

In china, with the development of GPS, GIS, RS, 3S technology is gradually used in the agriculture in recent years. This paper introduced the concepts of GPS, GIS, RS. Considering the fact of the Chinese agriculture, we developed the farmland information support system based on the integration of GPS, GIS, RS. With the application of this system in some counties of Yunnan province, the work mode of the department of the agriculture has started to be changed.

Considering the hidden danger in the finished stopes in underground metal mines in China, a new cavity data acquisition method based on 3D laser scanning technology is proposed in Dahongshan mine district. This technology uses contactless measurement mode, by which not only the geometric parameter of cavity such as length, area, volume, deformation of roof and wall rock can be gained accurately, but also the security and efficiency of cavity data acquisition are greatly raised. It provides relatively reliable datum for the safety evaluation and the control of emptied stopes as well as the design of ore column stopping. There is certain particularity in application method of 3D laser scanning technology for the finished stopes in mine. For the sake of enhancing the precision and reliability of obtained datum, in this paper, based on systematic analysis of measurement errors of CMS, the key systematic errors of side rolling, pitching and orientation were discussed in detail, and the corresponding calibration method was put forward.

With the development of the project of Formula Fertilization by Soil Testing in china,in order to investigate the soil condition,fertility level,nutrients status,soil degeneration status and the farmland integrated productivity of china,the government decided to start up the project of the Evaluation of the farmland productivity with the field investigation data and the analysis assay data, which were got in the project of Formula Fertilization by Soil Testing. Based on the spatial analysis function of the geographic information system(GIS), such as overlay analysis and spatial interpolation,using soil image,Present land use map and administrative map of the poroject area?this research decided evaluation unit and connected the field investigation data and the analysis assay data. Considering the actual conditions of the poroject area, the experts selected Sixteen affected factors from four aspects as land management?land growing situation?profile situation and soil nutrient content?and the evaluation system of farmland fertility of was built up?Aimed at the affected factors,It adopts the Delphi method to identify the membership function of severa1 affected factors and introduces Analytica1 Hierarch process (AHP) to calculate the weight of evaluating factors.On the basis of these datas,this research used the Additive Model to calculate the Integrated Fertility Index(IFI) and also analyses its space distribution?Because The results are in 1ine with the local situation of the city,This result can be applied to agricultural production.

Parallel editing of spatial data is one of the concern focuses in GIS research. The paper firstly discusses current status of research and analyzes mechanism and implement method of ArcSDE version management. With ArcObjects component as exploitation platform and Visual Basic as tools, a version management component is designed and developed and integrated into application software which implements multi-users parallel editing and version management of spatial data.