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11 results on '"Fankhauser, Beat"'

1. Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group

Author

Jaeger, Veronika K, Distler, Oliver, Maurer, Britta, Czirják, László, Lóránd, Veronika, Valentini, Gabriele, Vettori, Serena, Del Galdo, Francesco, Abignano, Giuseppina, Denton, Christopher P, Nihtyanova, Svetlana, Allanore, Yannick, Avouac, Jérôme, Riemekasten, Gabriele, Siegert, Elise, Huscher, Dörte, Matucci-Cerinic, Marco, Guiducci, Serena, Frerix, Marc, Tarner, Ingo H, Garay Toth, Beata, Fankhauser, Beat, Umbricht, Jörg, Zakharova, Anastasia, Mihai, Carina, Cozzi, Franco, Yavuz, Sule, Hunzelmann, Nicolas, Rednic, Simona, Vacca, Alessandra, et al, and University of Zurich

Subjects
2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2736 Pharmacology (medical), 610 Medicine & health
Published
2018
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2. Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group

Author

Jaeger, Veronika K., Distler, Oliver, Maurer, Britta, Czirjak, Laszlo, Lorand, Veronika, Valentini, Gabriele, Vettori, Serena, Del Galdo, Francesco, Abignano, Giuseppina, Denton, Christopher, Nihtyanova, Svetlana, Allanore, Yannick, Avouac, Jerome, Riemekasten, Gabriele, Siegert, Elise, Huscher, Doerte, Matucci-Cerinic, Marco, Guiducci, Serena, Frerix, Marc, Tarner, Ingo H., Toth, Beata Garay, Fankhauser, Beat, Umbricht, Jorg, Zakharova, Anastasia, Mihai, Carina, Cozzi, Franco, Yavuz, Sule, Hunzelmann, Nicolas, Rednic, Simona, Vacca, Alessandra, Schmeiser, Tim, Riccieri, Valeria, de la Pena Lefebvre, Paloma Garciae, Gabrielli, Armando, Krummel-Lorenz, Brigitte, Martinovic, Duska, Ancuta, Codrina, Smith, Vanessa, Mueller-Ladner, Ulf, Walker, Ulrich A., Jaeger, Veronika K., Distler, Oliver, Maurer, Britta, Czirjak, Laszlo, Lorand, Veronika, Valentini, Gabriele, Vettori, Serena, Del Galdo, Francesco, Abignano, Giuseppina, Denton, Christopher, Nihtyanova, Svetlana, Allanore, Yannick, Avouac, Jerome, Riemekasten, Gabriele, Siegert, Elise, Huscher, Doerte, Matucci-Cerinic, Marco, Guiducci, Serena, Frerix, Marc, Tarner, Ingo H., Toth, Beata Garay, Fankhauser, Beat, Umbricht, Jorg, Zakharova, Anastasia, Mihai, Carina, Cozzi, Franco, Yavuz, Sule, Hunzelmann, Nicolas, Rednic, Simona, Vacca, Alessandra, Schmeiser, Tim, Riccieri, Valeria, de la Pena Lefebvre, Paloma Garciae, Gabrielli, Armando, Krummel-Lorenz, Brigitte, Martinovic, Duska, Ancuta, Codrina, Smith, Vanessa, Mueller-Ladner, Ulf, and Walker, Ulrich A.

Abstract

The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc. SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions. The mean SHAQ and HAQ scores of the 944 patients included were 0.87 (s.d. = 0.66) and 0.92 (s.d. = 0.78); 59% of the patients were in the mild to moderate difficulty SHAQ category (0 a (c) 1/2 SHAQ < 1), 34% in the moderate to severe disability category (1 a (c) 1/2 SHAQ < 2) and 7% in the severe to very severe disability category (2 a (c) 1/2 SHAQ a (c) 1/2 3). The means of the visual analogue scales scores were in order of magnitude: overall disease severity (37 mm), RP (31 mm), pulmonary symptoms (24 mm), gastrointestinal symptoms (20 mm) and digital ulcers (19 mm). In multiple regression, the main factors associated with high SHAQ scores were the presence of dyspnoea [modified New York Heart Association (NYHA) class IV (regression coefficient B = 0.62), modified NYHA class III (B = 0.53) and modified NYHA class II (B = 0.21; all modified NYHA class I)], FM (B = 0.37), muscle weakness (B = 0.27), digital ulcers (B = 0.20) and gastrointestinal symptoms (oesophageal symptoms, B = 0.16; stomach symptoms, B = 0.15; intestinal symptoms, B = 0.15). SSc patients perceive dyspnoea, pain, digital ulcers, muscle weakness and gastrointestinal symptoms as the main factors driving their level of disability, unlike physicians who emphasize objective measures of disability.

Published
2018

3. Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group

Author

Jaeger, Veronika K, primary, Distler, Oliver, additional, Maurer, Britta, additional, Czirják, Laszlo, additional, Lóránd, Veronika, additional, Valentini, Gabriele, additional, Vettori, Serena, additional, Del Galdo, Francesco, additional, Abignano, Giuseppina, additional, Denton, Christopher, additional, Nihtyanova, Svetlana, additional, Allanore, Yannick, additional, Avouac, Jerome, additional, Riemekasten, Gabriele, additional, Siegert, Elise, additional, Huscher, Dörte, additional, Matucci-Cerinic, Marco, additional, Guiducci, Serena, additional, Frerix, Marc, additional, Tarner, Ingo H, additional, Garay Toth, Beata, additional, Fankhauser, Beat, additional, Umbricht, Jörg, additional, Zakharova, Anastasia, additional, Mihai, Carina, additional, Cozzi, Franco, additional, Yavuz, Sule, additional, Hunzelmann, Nicolas, additional, Rednic, Simona, additional, Vacca, Alessandra, additional, Schmeiser, Tim, additional, Riccieri, Valeria, additional, García de la Peña Lefebvre, Paloma, additional, Gabrielli, Armando, additional, Krummel-Lorenz, Brigitte, additional, Martinovic, Duska, additional, Ancuta, Codrina, additional, Smith, Vanessa, additional, Müller-Ladner, Ulf, additional, and Walker, Ulrich A, additional

Published
2017
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10. Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group

Author

Ulf Müller-Ladner, Beat Fankhauser, Valeria Riccieri, Marco Matucci-Cerinic, Christopher P. Denton, Jörg Umbricht, Brigitte Krummel-Lorenz, Franco Cozzi, László Czirják, Jérôme Avouac, Ulrich A Walker, Alessandra Vacca, Armando Gabrielli, Serena Vettori, Yannick Allanore, Marc Frerix, Francesco Del Galdo, Giuseppina Abignano, Paloma García de la Peña Lefebvre, Dörte Huscher, Veronika Lóránd, Carina Mihai, Ingo H. Tarner, Britta Maurer, Gabriele Valentini, Elise Siegert, T. Schmeiser, Nicolas Hunzelmann, Simona Rednic, G. Riemekasten, Beata Garay Toth, Serena Guiducci, Svetlana I. Nihtyanova, Codrina Ancuta, Sule Yavuz, Oliver Distler, Vanessa Smith, Anastasia Zakharova, Veronika K. Jaeger, Duska Martinovic, Jaeger, Veronika K, Distler, Oliver, Maurer, Britta, Czirják, Laszlo, Lóránd, Veronika, Valentini, Gabriele, Vettori, Serena, Del Galdo, Francesco, Abignano, Giuseppina, Denton, Christopher, Nihtyanova, Svetlana, Allanore, Yannick, Avouac, Jerome, Riemekasten, Gabriele, Siegert, Elise, Huscher, Dörte, Matucci Cerinic, Marco, Guiducci, Serena, Frerix, Marc, Tarner, Ingo H, Garay Toth, Beata, Fankhauser, Beat, Umbricht, Jörg, Zakharova, Anastasia, Mihai, Carina, Cozzi, Franco, Yavuz, Sule, Hunzelmann, Nicola, Rednic, Simona, Vacca, Alessandra, Schmeiser, Tim, Riccieri, Valeria, García de la Peña Lefebvre, Paloma, Gabrielli, Armando, Krummel Lorenz, Brigitte, Martinovic, Duska, Ancuta, Codrina, Smith, Vanessa, Müller Ladner, Ulf, and Walker, Ulrich A.

Subjects
medicine.medical_specialty, functional disability, systemic sclerosis, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Quality of life, Internal medicine, Severity of illness, medicine, Functional disability, Predictors of disability, Scleroderma health assessment questionnaire, Systemic sclerosis, Europe, Gastrointestinal Diseases, Humans, Hypertension, Pulmonary, Longitudinal Studies, Muscle Weakness, Pain Measurement, Prospective Studies, Regression Analysis, Risk Factors, Scleroderma, Systemic, Severity of Illness Index, Skin Ulcer, Activities of Daily Living, Disability Evaluation, Quality of Life, Sickness Impact Profile, Pharmacology (medical), 030212 general & internal medicine, Prospective cohort study, 030203 arthritis & rheumatology, business.industry, predictors of disability, scleroderma health assessment questionnaire, Muscle weakness, sistemska skleroza, funkcionalna invalidnost, zdravstveni upitnik, prediktori invaliditeta, Skin ulcer, medicine.disease, Pulmonary hypertension, Rheumatoid arthritis, Cohort, Physical therapy, Functional disability, systemic sclerosis, medicine.symptom, business
Abstract

Objectives: The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc. Methods: SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions. Results: The mean SHAQ and HAQ scores of the 944 patients included were 0.87 ( s . d . = 0.66) and 0.92 ( s . d . = 0.78); 59% of the patients were in the mild to moderate difficulty SHAQ category (0 ⩽ SHAQ < 1), 34% in the moderate to severe disability category (1 ⩽ SHAQ < 2) and 7% in the severe to very severe disability category (2 ⩽ SHAQ ⩽ 3). The means of the visual analogue scales scores were in order of magnitude: overall disease severity (37 mm), RP (31 mm), pulmonary symptoms (24 mm), gastrointestinal symptoms (20 mm) and digital ulcers (19 mm). In multiple regression, the main factors associated with high SHAQ scores were the presence of dyspnoea [modified New York Heart Association (NYHA) class IV (regression coefficient B = 0.62), modified NYHA class III (B = 0.53) and modified NYHA class II (B = 0.21; all vs modified NYHA class I)], FM (B = 0.37), muscle weakness (B = 0.27), digital ulcers (B = 0.20) and gastrointestinal symptoms (oesophageal symptoms, B = 0.16; stomach symptoms, B = 0.15; intestinal symptoms, B = 0.15). Conclusion: SSc patients perceive dyspnoea, pain, digital ulcers, muscle weakness and gastrointestinal symptoms as the main factors driving their level of disability, unlike physicians who emphasize objective measures of disability.

Published
2017

11. Functional disability and its predictors in systemic sclerosis: a study from the DeSScipher project within the EUSTAR group.

Author

Jaeger VK, Distler O, Maurer B, Czirják L, Lóránd V, Valentini G, Vettori S, Del Galdo F, Abignano G, Denton C, Nihtyanova S, Allanore Y, Avouac J, Riemekasten G, Siegert E, Huscher D, Matucci-Cerinic M, Guiducci S, Frerix M, Tarner IH, Garay Toth B, Fankhauser B, Umbricht J, Zakharova A, Mihai C, Cozzi F, Yavuz S, Hunzelmann N, Rednic S, Vacca A, Schmeiser T, Riccieri V, García de la Peña Lefebvre P, Gabrielli A, Krummel-Lorenz B, Martinovic D, Ancuta C, Smith V, Müller-Ladner U, and Walker UA

Subjects
Europe, Gastrointestinal Diseases etiology, Gastrointestinal Diseases physiopathology, Humans, Hypertension, Pulmonary etiology, Hypertension, Pulmonary physiopathology, Longitudinal Studies, Muscle Weakness etiology, Muscle Weakness physiopathology, Pain Measurement, Prospective Studies, Regression Analysis, Risk Factors, Scleroderma, Systemic complications, Scleroderma, Systemic psychology, Severity of Illness Index, Skin Ulcer etiology, Skin Ulcer physiopathology, Activities of Daily Living, Disability Evaluation, Quality of Life, Scleroderma, Systemic physiopathology, Sickness Impact Profile
Abstract

Objectives: The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc., Methods: SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions., Results: The mean SHAQ and HAQ scores of the 944 patients included were 0.87 (s.d. = 0.66) and 0.92 (s.d. = 0.78); 59% of the patients were in the mild to moderate difficulty SHAQ category (0 ⩽ SHAQ < 1), 34% in the moderate to severe disability category (1 ⩽ SHAQ < 2) and 7% in the severe to very severe disability category (2 ⩽ SHAQ ⩽ 3). The means of the visual analogue scales scores were in order of magnitude: overall disease severity (37 mm), RP (31 mm), pulmonary symptoms (24 mm), gastrointestinal symptoms (20 mm) and digital ulcers (19 mm). In multiple regression, the main factors associated with high SHAQ scores were the presence of dyspnoea [modified New York Heart Association (NYHA) class IV (regression coefficient B = 0.62), modified NYHA class III (B = 0.53) and modified NYHA class II (B = 0.21; all vs modified NYHA class I)], FM (B = 0.37), muscle weakness (B = 0.27), digital ulcers (B = 0.20) and gastrointestinal symptoms (oesophageal symptoms, B = 0.16; stomach symptoms, B = 0.15; intestinal symptoms, B = 0.15)., Conclusion: SSc patients perceive dyspnoea, pain, digital ulcers, muscle weakness and gastrointestinal symptoms as the main factors driving their level of disability, unlike physicians who emphasize objective measures of disability., (© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com)

Published
2018
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