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1. Osteosarcoma

Author

Farfalli, German Luis, Albergo, Jose Ignacio, Slullitel, Pablo, editor, Rossi, Luciano, editor, and Camino-Willhuber, Gastón, editor

Published
2024
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2. Staging, Preoperative, and Surgical Planning

Author

Ritacco, Lucas Eduardo, Milano, Federico Edgardo, Farfalli, Germán Luis, Ayerza, Miguel Angel, Muscolo, D. L., Aponte-Tinao, Luis Alberto, Guo, Wei, editor, Hornicek, Francis J., editor, and Sim, Franklin H., editor

Published
2020
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4. Ewing sarcoma of the bone. Multidisciplinary approach and oncological results in 88 patients

Author

Sanchez Saba, Javier E., Abrego, Mariano O., Albergo, José I., Farfalli, Germán Luis, Aponte Tinao, Luis A., Ayerza, Miguel A., Cayol, Federico, Streitenberger, Patricia, Risk, Marcelo, and Roitman, Pablo Daniel

Subjects
CIRUGÍA DE CONSERVACIÓN DE MIEMBRO, CIENCIAS MÉDICAS Y DE LA SALUD, MULTIDISCIPLINA, purl.org/becyt/ford/3.2 [https], purl.org/becyt/ford/3 [https], Medicina Clínica, SARCOMA DE EWING, Oncología
Abstract

El sarcoma de Ewing óseo es un tumor poco frecuente, agresivo, que afecta principalmente a niñosy adultos jóvenes. Existe ausencia de registros en nuestro país respecto de la prevalencia de estaenfermedad, los esquemas de tratamiento utilizados y sus resultados. El objetivo fue analizar, en un grupode pacientes con sarcoma de Ewing óseo tratados con quimioterapia y cirugía de conservación de miembro,las tasas de supervivencia global, de recurrencia local y los factores de riesgo oncológicos. Se incluyó a 88pacientes. La edad media de la serie fue de 14.5 años y el seguimiento promedio de 8.8 años. La tasa de supervivencia global fue de 79.5% a los 2 años, de 69% a 5 años y de 64% a 10 años. Los factores pronósticosnegativos asociados a menor supervivencia fueron: mala respuesta a la quimioterapia, edad ≥ de 16 años,localización central, y recurrencia local. En el análisis multivariable únicamente la respuesta a la quimioterapiatuvo significancia estadística. La tasa libre de recurrencia local a 2 y 5 años fue del 87%. La mala respuesta ala quimioterapia fue el único factor significativo para la recurrencia local. Consideramos que la cirugía de conservación de miembro asociada a quimioterapia pre y postoperatoria debe ser el tratamiento para el sarcomade Ewing óseo, alcanzando de esta manera una supervivencia global a 5 años del 69%. En nuestra serie, larespuesta a la quimioterapia ha sido el factor pronóstico más relevante para supervivencia y recurrencia local. Ewing sarcoma of the bone is a rare, highly aggressive tumor that typically affects children and young adults. In Argentina, the lack of Ewing’s sarcoma registries reflects in the absence of information regarding prevalence, treatment protocols and patient´s outcome. The purpose of this study was to analyze, in a group of patients diagnosed with Ewing sarcoma of the bone, treated with chemotherapy and limb-conserving surgery, their overall survival rate, local recurrence rate, and oncological risk factors. A retrospective research was conducted between 1990 and 2017. Eighty-eight patients with Ewing sarcoma of the bone matched the inclusion criteria. Median age was 14.5 years and median follow-up was 8.8 years. Overall survival rate was 79.5%, 69% and 64% at 2, 5 and 10 years respectively. Negative prognostic factors, associated with less survival rate after univariate analysis, were: bad response to chemotherapy (tumoral necrosis 0-89%), age > 16 years-old, central tumor localization and local recurrence. Gender and tumor size were not significant prognostic factors. After multivariate analysis, response to chemotherapy remained statistical significant. Local recurrence-free survival rate at 2 and 5 years was 87%. Tumor response to chemotherapy (0-89%) was the only significant factor for local recurrence. We consider that limb-salvage surgery, with neoadjuvant and adjuvant chemotherapy, are the mainstays of treatment for Ewing’s sarcoma, with an overall survival rate, at 5 years, of 69%. In this population, response to chemotherapy is the most relevant prognostic factor, being associated with both local recurrence and overall survival. Fil: Sanchez Saba, Javier E.. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Abrego, Mariano O.. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Albergo, José I.. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Farfalli, Germán Luis. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Aponte Tinao, Luis A.. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Ayerza, Miguel A.. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Cayol, Federico. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Streitenberger, Patricia. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina Fil: Risk, Marcelo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina Fil: Roitman, Pablo Daniel. Instituto Universidad Escuela de Medicina del Hospital Italiano; Argentina

Published
2020

5. Transfer accuracy and precision scoring in planar bone cutting validated with ex vivo data

Author

Milano, Federico Edgardo, Ritacco, Lucas, Farfalli, Germán Luis, Bahamonde, Luis Alberto, Aponte Tinao, Luis Alberto, and Risk, Marcelo

Subjects
PRECISION, CIENCIAS MÉDICAS Y DE LA SALUD, OSTEOTOMY, ACCURACY, purl.org/becyt/ford/3.2 [https], purl.org/becyt/ford/3 [https], CLINICAL SCORE, Medicina Critica y de Emergencia, Medicina Clínica
Abstract

The use of interactive surgical scenarios for virtual preoperative planning of osteotomies has increased in the last 5 years.As it has been reported by several authors, this technology has been used in tumor resection osteotomies, knee osteotomies, and spine surgery with good results. A digital three-dimensional preoperative plan makes possible to quantitatively evaluate the transfer processfrom the virtual plan to the anatomy of the patient. We introduce an exact definition of accuracy and precision of this transfer process for planar bone cutting. We present a method to compute these properties from ex vivo data. We also propose a clinical score to assess the goodness of a cut. A computer simulation is used to characterize the definitions and the data generated by the measurement method. The definitions and method are evaluated in 17 ex vivo planar cuts of tumor resection osteotomies. The results show that the proposed method and definitions are highly correlated with a previous definition of accuracy based in ISO 1101. The score is also evaluated by showing that it distinguishes among different transfer techniques based in its distribution location and shape. The introduced definitions produce acceptable results in cases where the ISO-based definition produce counter intuitive results. Fil: Milano, Federico Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; Argentina Fil: Ritacco, Lucas. Hospital Italiano; Argentina Fil: Farfalli, Germán Luis. Hospital Italiano; Argentina Fil: Bahamonde, Luis Alberto. Universidad de Chile; Chile Fil: Aponte Tinao, Luis Alberto. Hospital Italiano; Argentina Fil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Tecnológico de Buenos Aires; Argentina

Published
2015
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6. Face to Face Appointment vs. Telemedicine in First Time Appointment Orthopedic Oncology Patients: A Cost Analysis.

Author

Alberto Aponte-Tinao, Luis, Farfalli, Germán Luis, Ignaciov Albergo, José, Plazzotta, Fernando, Sommer, Janine, Luna, Daniel, and de Quirós, Fernán González Bernaldo

Subjects
TELEMEDICINE, MEDICAL appointments, MEDICAL care costs, INFORMATION & communication technologies, MEDICAL consultation
Abstract

Medicine has evolved considerably in recent decades in part thanks to information and communication technologies in health (ICTs). However, face-to-face consultations continue to be the predominant model, since alternatives such as telemedicine are still the subject of debate. On the other hand, in some very specific specialties, centralization is relevant, mainly due to the low frequency and prevalence of diseases, as well as the need to have highly specialized professionals, causing problems in terms of accessibility and costs for the health system. In this study we have analyzed the first consultations to an orthopedics oncology service at a tertiary institution and performed an analysis of economic costs was carried out between 2 possible scenarios: face-to-face consultations versus telemedicine. Analyzing the 2 scenarios, there would be a cost-benefit in the use of telemedicine leading to a decrease in healthcare cost between 12.2% and 72%. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Face to Face Appointment vs. Telemedicine in First Time Appointment Orthopedic Oncology Patients: A Cost Analysis.

Author

Aponte-Tinao, Luis Alberto, Farfalli, Germán Luis, Albergo, José Ignacio, Plazzotta, Fernando, Sommer, Janine, Luna, Daniel, and de Quirós, Fernán González Bernaldo

Abstract

Medicine has evolved considerably in recent decades in part thanks to information and communication technologies in health (ICTs). However, face-to-face consultations continue to be the predominant model, since alternatives such as telemedicine are still the subject of debate. On the other hand, in some very specific specialties, centralization is relevant, mainly due to the low frequency and prevalence of diseases, as well as the need to have highly specialized professionals, causing problems in terms of accessibility and costs for the health system. In this study we have analyzed the first consultations to an orthopedics oncology service at a tertiary institution and performed an analysis of economic costs was carried out between 2 possible scenarios: face-to-face consultations versus telemedicine. Analyzing the 2 scenarios, there would be a cost-benefit in the use of telemedicine leading to a decrease in healthcare cost between 12.2% and 72%. [ABSTRACT FROM AUTHOR]

Published
2019
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9. VALIDACIÓN POSOPERATORIA EN LA SELECCIÓN ASISTIDA POR COMPUTADORA DE ALOINJERTOS DE FÉMUR DISTAL.

Author

Milano, Federico Edgardo, Albergo, José Ignacio, Farfalli, Germán Luis, Aponte-Tinao, Luis Alberto, Ayerza, Miguel Ángel, Muscolo, Domingo Luis, and Ritacco, Lucas Eduardo

Abstract

Copyright of Actualizaciones en Osteología is the property of Asociacion Argentina de Osteologia y Metabolismo Mineral and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016

10. [Pediatric soft tissue sarcomas: analysis of non rhabdomyosarcoma group].

Author

Farfalli GL, Iriberry A, Albergó JI, Ayerza MÁ, Muscolo DL, and Aponte-Tinao LA

Subjects
Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Retrospective Studies, Survival Rate, Sarcoma mortality, Sarcoma surgery, Soft Tissue Neoplasms mortality, Soft Tissue Neoplasms surgery
Abstract

We evaluated 29 patients with non rhabdomyosarcoma soft tissue sarcomas treated with surgery between 2000 and 2010; we analyzed overall survival and which factors affect the prognosis. The mean age was 11.6 years (range 3 months-17 years); 16 patients were males and the median follow-up was 56 months (8 to 132 months). Eight different histological malignant tumors were identified, being synovial sarcoma the most prevalent one (14 patients). Twenty-eight patients were treated with limb salvage surgery and in 26 cases, adjuvant therapy was used. Five years overall survival was 72%. Nine of the 29 patients presented a local recurrence. The presence of metastases (p <0.0001) and local recurrence (p <0.007) were negative prognostic factors for overall survival.

Published
2014
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