677 results on '"Fargue, A."'
Search Results
2. 4-hydroxy-2-oxoglutarate metabolism in a mouse model of Primary Hyperoxaluria Type 3
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Xingsheng Li, Owen P. Cunneely, Sonia Fargue, Kyle D. Wood, Dean G. Assimos, and John Knight
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Primary hyperoxaluria type 3 ,Hydroxyproline ,4-Hydroxy-2-oxoglutarate ,4-Hydroxy-2-oxoglutarate aldolase ,Kidney stones ,Oxalate ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Primary Hyperoxaluria Type 3 (PH3) results from 4-hydroxy-2-oxoglutarate (HOG) aldolase (HOGA) deficiency, which causes an increase in endogenous oxalate synthesis leading to calcium oxalate kidney stone disease. The mechanisms underlying HOG metabolism and increased oxalate synthesis in PH3 are not well understood. We used a Hoga1 knock-out mouse model of PH3 to investigate two aspects of HOG metabolism: reduction to dihydroxyglutarate (DHG), a pathway that may limit oxalate synthesis in PH3, and metabolism to glyoxylate, which is a direct precursor to oxalate. The metabolism of HOG to DHG was highest in liver and kidney cortical tissue, enhanced in the cytosolic compartment of the liver, and preferred NADPH as a cofactor. In the absence of HOGA, HOG to glyoxylate aldolase activity was highest in liver mitoplasts, with no activity present in brain tissue lysates. These findings will assist in the identification of enzymes responsible for the metabolism of HOG to DHG and glyoxylate, which may lead to novel therapeutic approaches to limit oxalate synthesis in those afflicted with PH3.
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- 2024
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3. Author Correction: Comparing the carbon footprints of urban and conventional agriculture
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Hawes, Jason K., Goldstein, Benjamin P., Newell, Joshua P., Dorr, Erica, Caputo, Silvio, Fox-Kämper, Runrid, Grard, Baptiste, Ilieva, Rositsa T., Fargue-Lelièvre, Agnès, Poniży, Lidia, Schoen, Victoria, Specht, Kathrin, and Cohen, Nevin
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- 2024
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4. What do we really know about urban agriculture's impact on people, places, and the planet?
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Fargue-Lelièvre, Agnès, Hawes, Jason K., Goldstein, Benjamin, Poniży, Lidia, and Dorr, Erica
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URBAN agriculture , *CARBON emissions , *CLIMATE change - Abstract
Urban agriculture has myriad benefits for those who participate in it, but it's not guaranteed to be more climate-friendly than conventional agriculture. That said, there are some very specific steps urban farmers can take to slash carbon emissions. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Publisher Correction: Comparing the carbon footprints of urban and conventional agriculture
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Hawes, Jason K., Goldstein, Benjamin P., Newell, Joshua P., Dorr, Erica, Caputo, Silvio, Fox-Kämper, Runrid, Grard, Baptiste, Ilieva, Rositsa T., Fargue-Lelièvre, Agnès, Poniży, Lidia, Schoen, Victoria, Specht, Kathrin, and Cohen, Nevin
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- 2024
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6. Castle by a River.
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Fargue, Karel la and Fargue, Karel la
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- Drawing, Dutch 18th century., Rivers., Trees., Castles., Boats and boating., Birds., Numerals., Trees, Birds, Arbres., Oiseaux., Nombres., Canotiers (Coiffures), numerals., boaters., trees (woody plants), Numerals, Birds, Boats and boating, Castles, Drawing, Dutch, Rivers, Trees
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- 2024
7. A sustainability scoring system to assess food initiatives in city regions
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Cirone, Francesco, Petruzzelli, Mara, De Menna, Fabio, Samoggia, Antonella, Buscaroli, Enrico, Durante, Emanuele, Orsini, Francesco, Rufí-Salís, Martí, Tonini, Pietro, Durany, Xavier Gabarrell, Graamans, Luuk, Fargue-Lelièvre, Agnès, Saint-Ges, Vèronique, Fox-Kämper, Runrid, Specht, Kathrin, Pascual-Fernández, José J., and Vittuari, Matteo
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- 2023
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8. Endogenous oxalate synthesis and urinary oxalate excretion
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Fargue, Sonia, Wood, Kyle D, Crivelli, Joseph J, Assimos, Dean G, Oster, Robert A, and Knight, John
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- 2023
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9. Food production and resource use of urban farms and gardens: a five-country study
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Dorr, Erica, Hawes, Jason K., Goldstein, Benjamin, Fargue-Lelièvre, Agnès, Fox-Kämper, Runrid, Specht, Kathrin, Fedeńczak, Konstancja, Caputo, Silvio, Cohen, Nevin, Poniży, Lidia, Schoen, Victoria, Górecki, Tomasz, Newell, Joshua P., Jean-Soro, Liliane, and Grard, Baptiste
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- 2023
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10. Stakeholder’s practices for the sustainability assessment of professional urban agriculture reveal numerous original criteria and indicators
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Clerino, Paola, Fargue-Lelièvre, Agnès, and Meynard, Jean-Marc
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- 2023
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11. Effect of alanine supplementation on oxalate synthesis
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Wood, Kyle D., Freeman, Brian L., Killian, Mary E., Lai, Win Shun, Assimos, Dean, Knight, John, and Fargue, Sonia
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- 2021
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12. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria
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Buchalski, Brianna, Wood, Kyle D., Challa, Anil, Fargue, Sonia, Holmes, Ross P., Lowther, W. Todd, and Knight, John
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- 2020
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13. Generation of a GLO-2 deficient mouse reveals its effects on liver carbonyl and glutathione levels
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Xingsheng Li, Sonia Fargue, Anil Kumar Challa, William Poore, John Knight, and Kyle D. Wood
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Glyoxalase ,Oxalate ,Glutathione ,Methylglyoxal ,Glyoxal ,d-lactate ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Objective: Hydroxyacylglutathione hydrolase (aka as GLO-2) is a component of the glyoxalase pathway involved in the detoxification of the reactive oxoaldehydes, glyoxal and methylglyoxal. These reactive metabolites have been linked to a variety of pathological conditions, including diabetes, cancer and heart disease and may be involved in the aging process. The objective of this study was to generate a mouse model deficient in GLO-2 to provide insight into the function of GLO-2 and to determine if it is potentially linked to endogenous oxalate synthesis which could influence urinary oxalate excretion. Methods: A GLO-2 knock out mouse was generated using CRISPR/Cas 9 techniques. Tissue and 24-h urine samples were collected under baseline conditions from adult male and female animals for biochemical analyses, including chromatographic measurement of glycolate, oxalate, glyoxal, methylglyoxal, D-lactate, ascorbic acid and glutathione levels. Results: The GLO-2 KO animals developed normally and there were no changes in 24-h urinary oxalate excretion, liver levels of methylglyoxal, glyoxal, ascorbic acid and glutathione, or plasma d-lactate levels. GLO-2 deficient males had lower plasma glycolate levels than wild type males while this relationship was not observed in females. Conclusions: The lack of a unique phenotype in a GLO-2 KO mouse model under baseline conditions is consistent with recent evidence, suggesting a functional glyoxalase pathway is not required for optimal health. A lower plasma glycolate in male GLO-2 KO animals suggests glyoxal production may be a significant contributor to circulating glycolate levels, but not to endogenous oxalate synthesis.
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- 2021
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14. 'We Have Been Part of the Response': The Effects of COVID-19 on Community and Allotment Gardens in the Global North
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Victoria Schoen, Chris Blythe, Silvio Caputo, Runrid Fox-Kämper, Kathrin Specht, Agnès Fargue-Lelièvre, Nevin Cohen, Lidia Poniży, and Konstancja Fedeńczak
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community garden ,allotment garden ,COVID-19 ,resilience ,response ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Throughout history, urban agriculture practitioners have adapted to various challenges by continuing to provide food and social benefits. Urban gardens and farms have also responded to sudden political, economic, ecological, and social crises: wartime food shortages; urban disinvestment and property abandonment; earthquakes and floods; climate-change induced weather events; and global economic disruptions. This paper examines the effects on, and responses by, urban farms and gardens to the COVID-19 pandemic. The paper is based on data collected in the summer of 2020 at the onset of the pandemic when cities were struggling with appropriate responses to curb its spread. It builds on an international research project (FEW-meter) that developed a methodology to measure material and social benefits of urban agriculture (UA) in five countries (France, Germany, Poland, UK and USA) over two growing seasons, from a Food-Energy-Water nexus perspective. We surveyed project partners to ascertain the effects of COVID-19 on those gardens and farms and we interviewed policy stakeholders in each country to investigate the wider impacts of the pandemic on UA. We report the results with respect to five key areas: (1) garden accessibility and service provision during the pandemic; (2) adjustments to operational arrangements; (3) effects on production; (4) support for urban farms and gardens through the pandemic; and (5) thoughts about the future of urban agriculture in the recovery period and beyond. The paper shows that the pandemic resulted in multiple challenges to gardens and farms including the loss of ability to provide support services, lost income, and reductions in output because of reduced labor supply. But COVID-19 also created several opportunities: new markets to sell food locally; more time available to gardeners to work in their allotments; and increased community cohesion as neighboring gardeners looked out for one another. By illustrating the range of challenges faced by the pandemic, and strategies to address challenges used by different farms and gardens, the paper illustrates how gardens in this pandemic have adapted to become more resilient and suggests lessons for pandemic recovery and longer-term planning to enable UA to respond to future public health and other crises.
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- 2021
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15. Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity
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Wood, Kyle D., Holmes, Ross P., Erbe, David, Liebow, Abigail, Fargue, Sonia, and Knight, John
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- 2019
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16. Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1
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Miyata, Non, Steffen, Janos, Johnson, Meghan E, Fargue, Sonia, Danpure, Christopher J, and Koehler, Carla M
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Rare Diseases ,Genetics ,Urologic Diseases ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Animals ,Anti-Infective Agents ,Local ,CHO Cells ,Cricetinae ,Cricetulus ,Dequalinium ,Drug Evaluation ,Preclinical ,Embryo ,Nonmammalian ,Humans ,Hyperoxaluria ,Primary ,Immunoblotting ,Microscopy ,Fluorescence ,Mitochondria ,Mutation ,Oxalates ,Peroxisomes ,Protein Transport ,Pyridoxine ,Transaminases ,Zebrafish - Abstract
Primary hyperoxaluria 1 (PH1; Online Mendelian Inheritance in Man no. 259900), a typically lethal biochemical disorder, may be caused by the AGT(P11LG170R) allele in which the alanine:glyoxylate aminotransferase (AGT) enzyme is mistargeted from peroxisomes to mitochondria. AGT contains a C-terminal peroxisomal targeting sequence, but mutations generate an N-terminal mitochondrial targeting sequence that directs AGT from peroxisomes to mitochondria. Although AGT(P11LG170R) is functional, the enzyme must be in the peroxisome to detoxify glyoxylate by conversion to alanine; in disease, amassed glyoxylate in the peroxisome is transported to the cytosol and converted to oxalate by lactate dehydrogenase, leading to kidney failure. From a chemical genetic screen, we have identified small molecules that inhibit mitochondrial protein import. We tested whether one promising candidate, Food and Drug Administration (FDA)-approved dequalinium chloride (DECA), could restore proper peroxisomal trafficking of AGT(P11LG170R). Indeed, treatment with DECA inhibited AGT(P11LG170R) translocation into mitochondria and subsequently restored trafficking to peroxisomes. Previous studies have suggested that a mitochondrial uncoupler might work in a similar manner. Although the uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhibited AGT(P11LG170R) import into mitochondria, AGT(P11LG170R) aggregated in the cytosol, and cells subsequently died. In a cellular model system that recapitulated oxalate accumulation, exposure to DECA reduced oxalate accumulation, similar to pyridoxine treatment that works in a small subset of PH1 patients. Moreover, treatment with both DECA and pyridoxine was additive in reducing oxalate levels. Thus, repurposing the FDA-approved DECA may be a pharmacologic strategy to treat PH1 patients with mutations in AGT because an additional 75 missense mutations in AGT may also result in mistrafficking.
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- 2014
17. Hereditary disorders of oxalate metabolism: The primary hyperoxalurias
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Fargue, Sonia, additional, Milliner, Dawn S., additional, and Danpure, Christopher J., additional
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- 2020
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18. 4-hydroxy-2-oxoglutarate metabolism in a mouse model of Primary Hyperoxaluria Type 3
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Li, Xingsheng, Cunneely, Owen P., Fargue, Sonia, Wood, Kyle D., Assimos, Dean G., and Knight, John
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- 2024
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19. From folding to function through compartmentalisation : influence of amino acid changes and pyridoxal-5'-phosphate on the cell biology of alanine:glyoxylate aminotransferase
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Fargue, S., Danpure, C. J., and Rumsby, G.
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572 - Abstract
From folding to function through compartmentalisation - influence of aminoacid changes and roles of pyridoxal-5'-phosphate on alanine:glyoxylate aminotransferase. Primary hyperoxaluria type 1 (PH1), is a rare inherited disease caused by a deficiency in the liver-specific, pyridoxal-5’-phosphate (PLP)-dependent enzyme alanine:glyoxylate aminotransferase (AGT). AGT is normally localized to the peroxisomes where it catalyses the conversion of the intermediary metabolite glyoxylate to glycine. In a subset of patients with PH1, linked with the Gly170Arg mutation, AGT is mistargeted to mitochondria and patients may respond to pharmacological doses of pyridoxine, a precursor of PLP. Using a model system of stably transformed CHO cells expressing different AGT variants, we have studied four mutations – Gly170Arg, Phe152Ile, Ile244Thr, Gly41Arg - on the background of a common polymorphism, Pro11Leu, characteristic of a minor AGXT allele. All four mutations unexpectedly result in the peroxisome-to-mitochondrion mistargeting of AGT. However, significant differences were found on AGT quaternary status and catalytic activity. These results emphasize the synergistic effect of the Pro11Leu polymorphism and disease-causing mutations and its potential to act as a mitochondrial targeting signal. Varying the concentration of pyridoxine in cells had a biphasic effect on AGT expression, activity and compartmentalization that differed between constructs. Where some mutants had improved function with additional pyridoxine, normal AGT was inhibited at higher levels. The results provide an explanation for the therapeutic effect of pyridoxine in some patients. Overall, PLP was shown to have both chaperone and prosthetic group effects on mutant AGTs. Using a specially developed cell-based assay of indirect glycolate toxicity, we have shown the lower ability of mutant AGTs to detoxify glyoxylate. This is the basis for a functional assay of AGT in mammalian cells which could be used to screen drugs targeted at AGT.
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- 2012
20. The Socio-Cultural Benefits of Urban Agriculture: A Review of the Literature
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Rositsa T. Ilieva, Nevin Cohen, Maggie Israel, Kathrin Specht, Runrid Fox-Kämper, Agnès Fargue-Lelièvre, Lidia Poniży, Victoria Schoen, Silvio Caputo, Caitlin K. Kirby, Benjamin Goldstein, Joshua P. Newell, and Chris Blythe
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urban agriculture ,socio-cultural benefits ,social services ,metrics ,indicators ,assessment ,Agriculture - Abstract
Despite extensive literature on the socio-cultural services of urban open spaces, the role of food-producing spaces has not received sufficient attention. This hampers advocacy for preserving and growing urban agricultural activities, often dismissed on justifications that their contributions to overall food supply are negligible. To understand how the social benefits of urban agriculture have been measured, we conducted a systematic review of 272 peer-reviewed publications, which drew on insights from urban agriculture sites in 57 different countries. Through content analysis, we investigated socio-cultural benefits in four spheres: engaged and cohesive communities, health and well-being, economic opportunities, and education. The analysis revealed growth in research on the social impacts of gardens and farms, with most studies measuring the effects on community cohesion and engagement, followed by increased availability and consumption of fruits and vegetables associated with reduced food insecurity and better health. Fewer studies assessed the impact of urban farming on educational and economic outcomes. Quantifying the multiple ways in which urban agriculture provides benefits to people will empower planners and the private sector to justify future investments. These findings are also informative for research theorizing cities as socio-ecological systems and broader efforts to measure the benefits of urban agriculture, in its many forms.
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- 2022
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21. Future treatments for hyperoxaluria
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Burns, Zachary, Knight, John, Fargue, Sonia, Holmes, Ross, Assimos, Dean, and Wood, Kyle
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- 2020
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22. A sustainability scoring system to assess food initiatives in city regions
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Francesco Cirone, Mara Petruzzelli, Fabio De Menna, Antonella Samoggia, Enrico Buscaroli, Emanuele Durante, Francesco Orsini, Martí Rufí-Salís, Pietro Tonini, Xavier Gabarrell Durany, Luuk Graamans, Agnès Fargue-Lelièvre, Vèronique Saint-Ges, Runrid Fox-Kämper, Kathrin Specht, José J. Pascual-Fernández, Matteo Vittuari, University of Bologna/Università di Bologna, Institut de Ciencia i Tecnologia Ambientals (ICTA), Universitat Autònoma de Barcelona (UAB), Wageningen University and Research [Wageningen] (WUR), Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ILS - Research Institute for Regional and Urban Development, Universidad de La Laguna [Tenerife - SP] (ULL), This work was supported by the funding from the European Union's Horizon 2020 research and innovation programme [grant agreement No 862663), Elsevier, European Project: 862663,FoodE, Cirone, Francesco, Petruzzelli, Mara, De Menna, Fabio, Samoggia, Antonella, Buscaroli, Enrico, Durante, Emanuele, Orsini, Francesco, Rufí-Salís, Martí, Tonini, Pietro, Durany, Xavier Gabarrell, Graamans, Luuk, Fargue-Lelièvre, Agnè, Saint-Ges, Vèronique, Fox-Kämper, Runrid, Specht, Kathrin, Pascual-Fernández, José J, and Vittuari, Matteo
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City Region Food Systems ,Environmental Engineering ,Scoring mechanism ,Renewable Energy, Sustainability and the Environment ,food system resilience ,City region food system initiative ,Sustainability performance ,Industrial and Manufacturing Engineering ,City region food system initiatives ,GTB Tuinbouw Technologie ,nutrition security ,Multi-stakeholder approach ,Environmental Chemistry ,Life cycle thinking ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; The City Region Food Systems approach has been proposed to achieve food system resilience and nutrition security while promoting the urgent ecological transition within urban and peri-urban areas, especially after the COVID-19 pandemic. However, the great diversity of the initiatives composing City Region Food Systems in Europe poses barriers to the assessment of their integrated sustainability. Hence, the present work is developed within the EU-H2020 project Food System in European Cities (FoodE), to build a consistentsustainability scoring system that allows comparative evaluation of City Region Food System Initiatives. Adopting a Life Cycle Thinking approach, it advances on existing knowledge and past projects, taking advantage of a participatory process, with stakeholders from multidisciplinary expertise. As a result, the research designs, and tests on 100 case studies a simplified and ready-to-use scoring mechanism based on a quali-quantitative appraisal survey tool, delivering a final sustainability score on a 1-5 points scale, to get insights on the social, economic, and environmental impacts. As in line with the needs of the UN Sustainable Development Goals, the outcome represents a step forward for the sustainable development and social innovation of food communities in cities and regions, providing a practical and empirical lens for improvedplanning and governance.
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- 2023
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23. Déjeuners de soleil
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. Publié en 1942, "Déjeuners de soleil" est un recueil nostalgique d'essais et de chroniques poétiques sur un Paris d'avant-guerre disparu: celui des artisans d'art, des omnibus, du tout jeune métro, de l'ancien Trocadéro, de la Loterie Nationale, du bottin du téléphone, etc., mais aussi celui plus récent des bouleversements que traversent la capitale et les parisiens sous l'Occupation. Fargue évoque aussi divers autres thèmes plus intemporels: le silence, la neige, le printemps, l'automne,... "Et, dans ce Paris silencieux, nostalgique, suspendu comme un mirage et qui se respire lui-même comme devait faire le palais de la Belle au Bois Dormant, tous ces bruits qu'on n'entendait plus sortent du temps, de leurs gîtes, de l'ombre d'un tournant de rue, d'une porte, se divisent et se rejoignent, comme des bêtes qui émergent de leur antre, l'une après l'autre, après l'orage. Cris des marchands et des bricoleurs, rires roulant comme les billes des enfants qui jouent et se poursuivent sur les chaussées libres, longuement dorées, où les voitures ne menacent plus, qu'on peut traverser en lisant son journal ; traînes des cloches qui pleurent doucement, chansons des musiciens ambulants et des racleurs, qui cheminent plus lentement au milieu de la rue en prenant le temps de lever les yeux vers chaque fenêtre." — Léon-Paul Fargue
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- 2022
24. Méandres
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. En 1943, marié depuis peu avec la peintre Chériane, Léon-Paul Fargue est frappé d'hémiplégie alors qu'il dîne avec Pablo Picasso à la terrasse d'un café. Dès lors, "inscrit dans son écorce", coincé entre l'inerte et la poésie, lui qui affirmait écrire pour mettre de l'ordre dans sa sensualité, est condamné à regarder en face la "douleur aux yeux de corbeau". Depuis son appartement du boulevard Montparnasse, soigné avec un infini dévouement par sa femme, il reste à l'affût du passé et du miracle, auquel il ne cessera de croire, d'une possible guérison. Le lit devient écritoire d'où sortira notamment ce recueil de chroniques littéraires intitulé "Méandres" qui, entre divers textes sur la Paix, la Guerre et Paris de la Belle époque à la Libération, contient aussi un émouvant témoignage sur son état ("En rampant au chevet de ma vie").
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- 2022
25. Refuges
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. Dans ce volume de chroniques littéraires publié en 1942, l'auteur du "Piéton de Paris" évoque de nouveau à travers ses souvenirs et ses réflexions le Paris de sa jeunesse: Montparnasse 1910-1935, le vieux Montmartre, les chambres, cafés et guinguettes de la vie de bohême, ses amis Paul Claudel, Maurice Ravel, Paul Valéry, Claude Debussy, Stéphane Mallarmé, Erik Satie, Pierre Louys, Alfred Jarry, etc.. Le recueil se termine par une longue méditation sur la France à ce moment très sombre de son histoire.
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- 2022
26. Etc…
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. Consacré à la période 1943-1947, ce recueil de chroniques s'attache à décrire une époque aussi étrange qu'intemporelle. De l'exposition de New-York 1939 à la saison théâtrale 1946, du quartier parisien du Marais aux Phares de France, de Paul Valéry à Stéphane Mallarmé, de la Musique à la Bombe atomique, ces chroniques aussi poétiques que politiques du "Piéton de Paris" forment un document littéraire essentiel sur la vie parisienne à la fin de la Seconde Guerre mondiale.
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- 2022
27. Dîners de lune
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. Faisant suite à "Déjeuners de soleil", "Dîners de lune", publié en 1952, est un autre recueil de chroniques nostalgiques et poétiques sur Paris et la vie parisienne des années 1930-1940. L'auteur du "Piéton de Paris" y traite du Musée Grévin, des Maisons Tellier, du Bal des Petits Lits Blancs, de la Haute couture, etc., mais aussi de divers sujets variés parfois graves, parfois légers: la féminité occidentale, l'argent, le stylographe ("Il y a dans le stylo un côté insecte domestique, cheval de course, des feux éteints, une forme réussie et un contact enfin qui séduisent les hommes de plume les plus attachés aux traditions"), le camping, le rapport entre les sexes fort et faible, le mal du siècle,... "Jadis, dans ma prose d'avant-guerre, j'écrivais que tout a pour but la solitude. Je suis sûr aujourd'hui de ne pas m'être trompé...", constate le poète.
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- 2022
28. Lanterne magique
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
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Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. Publié en 1944 à Marseille, ces chroniques littéraires, véritable recueil de poèmes en prose, s'attache à décrire Paris sous l'Occupation (1941-1943). L'auteur du "Piéton de Paris" y mêle souvenirs d'enfance, essais littéraires et portraits d'artistes (le Symbolisme, Stéphane Mallarmé, Victor Hugo, Réjane, Ernst Meissonier, Marcel Prévost,...), choses vues et scènes de la vie quotidienne (les fiacres des boulevards, les soirées de printemps,...), réflexions érudites (sur la poésie, la musique, la peinture,...) et commentaires intemporels sur l'actualité de son temps (la politique, l'art, la mode,...). "Donc, je me promène, et, naturellement, je rêve en me promenant. Si Paris, le soir, s'enroule de deuil, il rayonne le jour comme si l'enfantement de l'Histoire ne lui travaillait pas, à lui aussi, les tripes. Il y a dans les pas, le guet des yeux, l'ondulation des hanches, la grâce des cous, le choix des cravates et des écharpes, une allégresse quand même et le voeu de revivre" — Léon-Paul Fargue
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- 2022
29. What is Sustainability and How Do We Measure It?
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Fargue-Lelièvre, Agnès, primary and Clerino, Paola, additional
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- 2023
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30. The Pedestrian of Paris
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Fargue, Léon-Paul, primary
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- 2018
- Full Text
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31. Food production and resource use of urban farms and gardens: a five-country study
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Erica Dorr, Jason K. Hawes, Benjamin Goldstein, Agnès Fargue-Lelièvre, Runrid Fox-Kämper, Kathrin Specht, Konstancja Fedeńczak, Silvio Caputo, Nevin Cohen, Lidia Poniży, Victoria Schoen, Tomasz Górecki, Joshua P. Newell, Liliane Jean-Soro, and Baptiste Grard
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Environmental Engineering ,Agronomy and Crop Science - Abstract
There is a lack of data on resources used and food produced at urban farms. This hampers attempts to quantify the environmental impacts of urban agriculture or craft policies for sustainable food production in cities. To address this gap, we used a citizen science approach to collect data from 72 urban agriculture sites, representing three types of spaces (urban farms, collective gardens, individual gardens), in five countries (France, Germany, Poland, United Kingdom, and United States). We answered three key questions about urban agriculture with this unprecedented dataset: (1) What are its land, water, nutrient, and energy demands? (2) How productive is it relative to conventional agriculture and across types of farms? and (3) What are its contributions to local biodiversity? We found that participant farms used dozens of inputs, most of which were organic (e.g., manure for fertilizers). Farms required on average 71.6 L of irrigation water, 5.5 L of compost, and 0.53 m2 of land per kilogram of harvested food. Irrigation was lower in individual gardens and higher in sites using drip irrigation. While extremely variable, yields at well-managed urban farms can exceed those of conventional counterparts. Although farm type did not predict yield, our cluster analysis demonstrated that individually managed leisure gardens had lower yields than other farms and gardens. Farms in our sample contributed significantly to local biodiversity, with an average of 20 different crops per farm not including ornamental plants. Aside from clarifying important trends in resource use at urban farms using a robust and open dataset, this study also raises numerous questions about how crop selection and growing practices influence the environmental impacts of growing food in cities. We conclude with a research agenda to tackle these and other pressing questions on resource use at urban farms.
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- 2023
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32. Stakeholder’s practices for the sustainability assessment of professional urban agriculture reveal numerous original criteria and indicators
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Paola Clerino, Agnès Fargue-Lelièvre, Jean-Marc Meynard, Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AgroParisTech, This work was supported by the Urban Agriculture Chair of AgroParisTech and has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 862663., and European Project: 862663,FoodE
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Qualitative indicators ,Urban farming ,Environmental Engineering ,Internal sustainability ,Credibility ,[SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy ,External sustainability ,Evaluation ,Innovation ,Agronomy and Crop Science ,[SHS]Humanities and Social Sciences - Abstract
With the rapid growth of professional intra-urban agriculture (PIUA) projects in the Global North, sponsors, projects leaders, and experts developing these projects are seeking to evaluate their sustainability. As existing assessment tools are not adapted to PIUA projects, they establish their own assessment practices. Our study examines these practices to identify their original features, criteria, and indicators used. To this end, we analysed 19 case studies of different PIUA projects. We identified four dimensions underpinning sustainability assessment, namely, internal sustainability, external sustainability, the project leader’s credibility, and the innovative nature of the project. We also shed light on the wide diversity of the 67 assessment criteria identified, as well as the qualitative nature of 78% of indicators used. In addition, our study highlights that assessment practices evolve over time as the project progresses from ideation to implementation, according to the variety of assessment situations. Our study is the first to provide an in-depth exploration of PIUA stakeholders’ sustainability assessment practices and to shed light on their specific features. Our results afford a better understanding of the way the sustainability of PIUA projects is assessed and contribute to reflection on the design of a flexible assessment tool, considering the diverse criteria and practices used by stakeholders to assess the sustainability of PIUA.
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- 2023
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33. Les services écosystémiques rendus par les agricultures urbaines
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Stella, Patrick, Grard, Baptiste, Fargue-Lelièvre, Agnès, Clerino, Paola, Redlingshofer, Barbara, Saint-Ges, Veronique, Consalès, Jean-Noël, Giacchè, Giulia, Lemaire, Bruno J., Joimel, Sophie, Vieublé-Gonod, L., Chenu, Claire, Castell, Jean-François, Saint-Jean, Sébastien, Personne, Erwan, Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), Agroécologie et Environnement (AGE), Isara, AgroParisTech, Aix Marseille Université (AMU), Hydrosystèmes continentaux anthropisés : ressources, risques, restauration (UR HYCAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Quae
- Subjects
agriculture urbaine ,[SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy ,[SDE.ES]Environmental Sciences/Environmental and Society ,services écosystémiques - Abstract
chapitre de l'ouvrage de notice https://hal.archives-ouvertes.fr/hal-03829916; International audience
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- 2022
34. Do we still need to develop new tools to assess the sustainability of urban agriculture?
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Fargue-Lelièvre, A., primary and Clerino, P., additional
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- 2022
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35. Primary Hyperoxaluria
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Cochat, Pierre, Fargue, Sonia, Harambat, Jérôme, Avner, Ellis, editor, Harmon, William, editor, Niaudet, Patrick, editor, and Yoshikawa, Norishige, editor
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- 2009
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36. Haute solitude
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Fargue, Léon-Paul, Fargue, Léon-Paul, Fargue, Léon-Paul, and Fargue, Léon-Paul
- Abstract
Texte intégral révisé suivi d'une biographie de Léon-Paul Fargue. "Haute solitude" est l'oeuvre la plus accomplie et la plus déchirante de Fargue. Reprenant les chemins de rêves et de cauchemars déjà parcourus dans "Vulturne", l'auteur poursuit cette fois son investigation jusqu'au point critique où le poète, se séparant de lui-même, s'installe dans la "Haute solitude", lieu étrange dont il nous dit les peurs et les prestiges. Par elle, il atteint la nuit des temps préhistoriques comme celle de la fin du monde dont il nous dit être l'un des six témoins. C'est entre ces deux nuits de la terre et du ciel, de la naissance et de la mort, que s'inscrit ce recueil de proses. Visionnaire stupéfait "d'avoir vu d'un coup Dieu dans le monde, comme on s'aperçoit dans une glace à l'autre bout de la chambre", Fargue possède cette puissance verbale propre à entraîner le lecteur dans la randonnée préhistorique qui ouvre le livre. Nous y assistons à la formation des mondes, à la succession des époques, à l'apparition d'un "monstre bizarre", l'Homme. Puis, délaissant ces mondes chaotiques, un autre univers non moins fantastique est exploré: ce Paris tant aimé, parcouru et arpenté par l'auteur du "Piéton de Paris". Le voici déambulant à travers les rues, accompagné par les fantômes et les visages de ceux qu'il a aimé. Il dit les gares, les banlieues, les cafés, les nuits blanches, les rumeurs de la ville et la vie dans son désordre cosmique. Mais aucune rue qui ne conduise inexorablement vers ce haut lieu où souffle l'esprit: la solitude. "Je travaille à ma solitude, cherchant à la diriger dans la mer d'insomnie où nous a jetés la longue file des morts..."
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- 2021
37. Introduction
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Lochak, Georges, Karatchentzeff, Michel, Fargue, Daniel, Araki, H., editor, Brézin, E., editor, Ehlers, J., editor, Frisch, U., editor, Hepp, K., editor, Jaffe, R. L., editor, Kippenhahn, R., editor, Weidenmüller, H. A., editor, Wess, J., editor, Zittartz, J., editor, Beiglböck, W., editor, de Broglie, Louis, Lochak, Georges, editor, Karatchentzeff, Michel, editor, and Fargue, Daniel, editor
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- 1995
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38. Thermodiffusion in Porous Media and Its Consequences
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Costesèque, Pierre, Fargue, Daniel, Jamet, Philippe, Beig, R., editor, Englert, B. -G., editor, Frisch, U., editor, Hänggi, P., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Lipowsky, R., editor, v. Löhneysen, H., editor, Ojima, I., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Wess, J., editor, Zittartz, J., editor, Köhler, Werner, editor, and Wiegand, Simone, editor
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- 2002
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39. MP05-15 THE GULO(-/-) MOUSE: A USEFUL MODEL FOR STUDYING ENDOGENOUS OXALATE PRODUCTION FROM ASCORBIC ACID TURNOVER
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Joseph Crivelli, Xingsheng Li, Sonia Fargue, Kyle Wood, Dean Assimos, Ross Holmes, and John Knight
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Urology - Published
- 2022
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40. MP05-15 THE GULO(-/-) MOUSE: A USEFUL MODEL FOR STUDYING ENDOGENOUS OXALATE PRODUCTION FROM ASCORBIC ACID TURNOVER
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Crivelli, Joseph, primary, Li, Xingsheng, additional, Fargue, Sonia, additional, Wood, Kyle, additional, Assimos, Dean, additional, Holmes, Ross, additional, and Knight, John, additional
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- 2022
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41. Primary hyperoxaluria type 1: pathophysiology and genetics
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Fargue, Sonia, primary and Acquaviva Bourdain, Cécile, additional
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- 2022
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42. The Socio-Cultural Benefits of Urban Agriculture: A Review of the Literature
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Ilieva, Rositsa T., primary, Cohen, Nevin, additional, Israel, Maggie, additional, Specht, Kathrin, additional, Fox-Kämper, Runrid, additional, Fargue-Lelièvre, Agnès, additional, Poniży, Lidia, additional, Schoen, Victoria, additional, Caputo, Silvio, additional, Kirby, Caitlin K., additional, Goldstein, Benjamin, additional, Newell, Joshua P., additional, and Blythe, Chris, additional
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- 2022
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43. Future treatments for hyperoxaluria
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John Knight, Zachary R. Burns, Sonia Fargue, Dean G. Assimos, Kyle Wood, and Ross P. Holmes
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Adult ,medicine.medical_specialty ,Urology ,Urinary system ,030232 urology & nephrology ,Gastroenterology ,Article ,Oxalate ,Kidney Calculi ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Humans ,Renal Insufficiency, Chronic ,Hyperoxaluria ,Oxalates ,Extramural ,business.industry ,medicine.disease ,Diet ,Rats ,Clinical trial ,chemistry ,030220 oncology & carcinogenesis ,Kidney stones ,Dietary oxalate ,business ,Kidney disease - Abstract
Purpose of review The review of potential therapies in the treatment of hyperoxaluria is timely, given the current excitement with clinical trials and the mounting evidence of the importance of oxalate in both kidney stone and chronic kidney disease. Recent findings Given the significant contribution of both endogenous and dietary oxalate to urinary oxalate excretions, it is not surprising therapeutic targets are being studied in both pathways. This article covers the existing data on endogenous and dietary oxalate and the current targets in these pathways. Summary In the near future, there will likely be therapies targeting both endogenous and dietary oxalate, especially in subsets of kidney stone formers.
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- 2020
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44. Terrix City: A la découverte de l'univers caché de votre assiette
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Vidotto, Margaux, Saint-Ges, Veronique, Fargue-Lelièvre, Agnès, Painchaud, Claire, Centre National de la Recherche Scientifique (CNRS), THALIM - Théorie et histoire des arts et des littératures de la modernité - UMR 7172 (THALIM), Université Sorbonne Nouvelle - Paris 3-Centre National de la Recherche Scientifique (CNRS)-Département Arts - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecole Estienne, and European Project: 862663,FoodE
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alimentation ,interactivité ,[SDE]Environmental Sciences ,durabilité ,environnement ,vulgarisation ,agriculture - Abstract
Ecrit par des chercheuses d’AgroParisTech, de l’INRAE et du CNRS et illustré/mis en forme par Claire Painchaud, cet ouvrage interactif est un outil pédagogique pensé pour les enfants de 8 à 12 ans pour introduire les notions autour du système alimentaire durable passant par 5 étapes (production, transformation, distribution, consommation et gestion des déchets) présentant à chaque fois différents modes ou systèmes associant une présentation, une définition de terme et une activité à faire avec les enfants (quizz, recettes, lien vidéo…). Le parcours se fait en suivant 2 personnages, Marah et Arti, dans la ville de Terrix City afin de comprendre tout ce que cache notre assiette.
- Published
- 2022
45. Reviewing chemical and biological risks in urban agriculture : A comprehensive framework for a food safety assessment of city region food systems
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Chiara Cirillo, Francesco Orsini, Ilaria Braschi, A. Fargue-Lelièvre, Enrico Buscaroli, Giuseppina Pennisi, Kathrin Specht, Isabella Righini, G.C. Modarelli, E.Buscaroli, I.Braschi, C.Cirillo, A.Fargue-Lelièvre, G.C.Modarelli, G.Pennisi, I.Righini, K.Specht, F.Orsini, University of Bologna, CNR-SPIN Salerno and Dipartimento di Fisica 'E. R. CAianiello', Università degli Studi di Salerno (UNISA), Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Greenhouse Horticulture & Flower Bulbs [Wageningen], Wageningen University and Research [Wageningen] (WUR), ILS - Research Institute for Regional and Urban Development (ILS - Research Institute for Regional and Urban Development), ILS - Research Institute for Regional and Urban Development, The research leading to this publication has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 862663. The publication reflects the authors' views. The Research Executive Agency (REA) is not liable for any use that may be made of the information contained therein. Giuseppe Calore, Giampaolo Nitti and Youssef Rouphael are gratefully acknowledged for their contribution to literature search., Elsevier, Buscaroli, E., Braschi, I., Cirillo, C., Fargue-Lelièvre, A., Modarelli, G. C., Pennisi, G., Righini, I., Specht, K., and Orsini, F.
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Resource (biology) ,Food policy ,[SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy ,Review ,01 natural sciences ,12. Responsible consumption ,CRFS framework Assessment ,0404 agricultural biotechnology ,11. Sustainability ,Urban agriculture ,Environmental planning ,Risk assessment ,2. Zero hunger ,Food security ,business.industry ,010401 analytical chemistry ,04 agricultural and veterinary sciences ,Food safety ,040401 food science ,language.human_language ,0104 chemical sciences ,City region ,13. Climate action ,Agriculture ,Food safety indicator ,GTB Tuinbouw Technologie ,language ,Food systems ,business ,Food safety indicators ,Food safety indicators, CRFS framework assessment, Risk assessment, Food policy ,Food Science ,Biotechnology - Abstract
Attention to urban agriculture (UA) has recently grown among practitioners, scientists, and the public, resulting in several initiatives worldwide. Despite the positive perception of modern UA and locally grown, fresh produce, the potential food safety risks connected to these practices may be underestimated, leading to regulatory gaps. Thus, there is a need for assessment tools to evaluate the food safety risks connected to specific UA initiatives, to assist practitioners in self-evaluation and control, and to provide policy makers and scholars a means to pursue and assess food safety in city regions, avoiding either a lack or an excess of regulation that could ultimately hinder the sector. To address this aim, this paper reviews the most recent and relevant literature on UA food safety assessments. Food safety indicators were identified first. Then, a food safety assessment framework for UA initiatives was developed. The framework uses business surveys and food analyses (if available) as a data source for calculating a food safety index for single UA businesses and the whole UA landscape of a given city region. The proposed framework was designed to allow its integration into the CRFS (City Region Food System) toolkit developed by FAO (Food and Agriculture Organization of the United Nations), RUAF foundation (Resource Centres on Urban Agriculture and Food Security) and Wilfrid Laurier University., Highlights • Connection of several biological and chemical food safety risks to UA techniques. • Identifiable food safety risk factors for diverse UA practices. • Framework for the assessment of food safety levels of UA initiatives. • Development of a risk-based assessment that can be integrated into the FAO CRFS framework.
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- 2021
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46. Hyperoxalurie primitive
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Cochat, Pierre, Fargue, Sonia, Bacchetta, Justine, Bertholet-Thomas, Aurélia, Sabot, Jean-François, and Harambat, Jérôme
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- 2011
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47. 'We Have Been Part of the Response': The Effects of COVID-19 on Community and Allotment Gardens in the Global North
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Runrid Fox-Kämper, Lidia Poniży, Chris Blythe, Agnès Fargue-Lelièvre, Nevin Cohen, Kathrin Specht, Konstancja Fedeńczak, Victoria Schoen, Silvio Caputo, University of Kent [Canterbury], Social Farms & Gardens, ILS - Research Institute for Regional and Urban Development (ILS - Research Institute for Regional and Urban Development), ILS - Research Institute for Regional and Urban Development, Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), City University of New York [New York] (CUNY), Adam Mickiewicz University in Poznań (UAM), JPI Urban Europe's call SUGI—FWE Nexus, ANR-17-SUGI-0001,FEW-meter,The FEW-meter : an integrative model to measure and improve urban agriculture, shifting it towards circular urban metabolism(2017), European Project: ES/S002170/2,FEW-meter project, European Project: 01LF1801A, European Project: 18929627, European Project: 2017/25/Z/HS4/03048, and European Project: 730254
- Subjects
Community cohesion ,Economic growth ,media_common.quotation_subject ,[SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy ,010501 environmental sciences ,Horticulture ,Management, Monitoring, Policy and Law ,01 natural sciences ,Food processing and manufacture ,03 medical and health sciences ,0302 clinical medicine ,11. Sustainability ,Pandemic ,allotment garden ,Disinvestment ,TX341-641 ,030212 general & internal medicine ,Urban agriculture ,resilience ,0105 earth and related environmental sciences ,media_common ,2. Zero hunger ,Global and Planetary Change ,response ,Ecology ,community garden ,Nutrition. Foods and food supply ,COVID-19 ,TP368-456 ,Allotment ,Geography ,Work (electrical) ,13. Climate action ,Psychological resilience ,Agronomy and Crop Science ,Nexus (standard) ,Food Science - Abstract
Throughout history, urban agriculture practitioners have adapted to various challenges by continuing to provide food and social benefits. Urban gardens and farms have also responded to sudden political, economic, ecological, and social crises: wartime food shortages;urban disinvestment and property abandonment;earthquakes and floods;climate-change induced weather events;and global economic disruptions. This paper examines the effects on, and responses by, urban farms and gardens to the COVID-19 pandemic. The paper is based on data collected in the summer of 2020 at the onset of the pandemic when cities were struggling with appropriate responses to curb its spread. It builds on an international research project (FEW-meter) that developed a methodology to measure material and social benefits of urban agriculture (UA) in five countries (France, Germany, Poland, UK and USA) over two growing seasons, from a Food-Energy-Water nexus perspective. We surveyed project partners to ascertain the effects of COVID-19 on those gardens and farms and we interviewed policy stakeholders in each country to investigate the wider impacts of the pandemic on UA. We report the results with respect to five key areas: (1) garden accessibility and service provision during the pandemic;(2) adjustments to operational arrangements;(3) effects on production;(4) support for urban farms and gardens through the pandemic;and (5) thoughts about the future of urban agriculture in the recovery period and beyond. The paper shows that the pandemic resulted in multiple challenges to gardens and farms including the loss of ability to provide support services, lost income, and reductions in output because of reduced labor supply. But COVID-19 also created several opportunities: new markets to sell food locally;more time available to gardeners to work in their allotments;and increased community cohesion as neighboring gardeners looked out for one another. By illustrating the range of challenges faced by the pandemic, and strategies to address challenges used by different farms and gardens, the paper illustrates how gardens in this pandemic have adapted to become more resilient and suggests lessons for pandemic recovery and longer-term planning to enable UA to respond to future public health and other crises. © Copyright © 2021 Schoen, Blythe, Caputo, Fox-Kamper, Specht, Fargue-Lelievre, Cohen, Ponizy and Fedenczak.
- Published
- 2021
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48. THE EFFECT OF ALANINE ON CELL VIABILITY AND AGT ACTIVITY IN TRANSFORMED CHINESE HAMSTER OVARY CELLS: MP67-02
- Author
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Lai, Win Shun, Killian, Mary Elaine, Fargue, Sonia, Knight, John, Holmes, Ross, and Assimos, Dean
- Published
- 2016
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49. MITOCHONDRIAL IMPLICATIONS OF GLYCOLATE METABOLISM IN PRIMARY HYPEROXALURIA: MP67-03
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Fargue, Sonia, Mitchell, Tanecia, Knight, John, and Holmes, Ross
- Published
- 2016
- Full Text
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50. Generation of a GLO-2 deficient mouse reveals its effects on liver carbonyl and glutathione levels
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Li, Xingsheng, Fargue, Sonia, Challa, Anil Kumar, Poore, William, Knight, John, and Wood, Kyle D.
- Published
- 2021
- Full Text
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