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1. Long-term Outcomes with Spinal versus General Anesthesia for Hip Fracture Surgery: A Randomized Trial

Author

Vail, Emily A., Feng, Rui, Sieber, Frederick, Carson, Jeffrey L., Ellenberg, Susan S., Magaziner, Jay, Dillane, Derek, Marcantonio, Edward R., Sessler, Daniel I., Ayad, Sabry, Stone, Trevor, Papp, Steven, Donegan, Derek, Mehta, Samir, Schwenk, Eric S., Marshall, Mitchell, Jaffe, J. Douglas, Luke, Charles, Sharma, Balram, Azim, Syed, Hymes, Robert, Chin, Ki-Jinn, Sheppard, Richard, Perlman, Barry, Sappenfield, Joshua, Hauck, Ellen, Tierney, Ann, Horan, Annamarie D., Neuman, Mark D., Looke, Thomas, Bent, Sandra, Franco-Mora, Ariana, Hedrick, Pamela, Newbern, Matthew, Tadros, Rafik, Pealer, Karen, Vlassakov, Kamen, Buckley, Carolyn, Gavin, Lauren, Gorbatov, Svetlana, Gosnell, James, Steen, Talora, Vafai, Avery, Zeballos, Jose, Hruslinski, Jennifer, Cardenas, Louis, Berry, Ashley, Getchell, John, Quercetti, Nicholas, Hassan, Manal, Bajracharya, Gauasan, Billow, Damien, Bloomfield, Michael, Cuko, Evis, Elyaderani, Mehrun K., Hampton, Robert, Honar, Hooman, Khoshknabi, Dilara, Kim, Daniel, Krahe, David, Lew, Michael M., Maheshwer, Conjeevram B., Niazi, Azfar, Saha, Partha, Salih, Ahmed, de Swart, Robert J., Volio, Andrew, Bolkus, Kelly, DeAngelis, Matthew, Dodson, Gregory, Gerritsen, Jeffrey, McEniry, Brian, Mitrev, Ludmil, Kwofie, M. Kwesi, Belliveau, Anne, Bonazza, Flynn, Lloyd, Vera, Panek, Izabela, Dabiri, Jared, Chavez, Chris, Craig, Jason, Davidson, Todd, Dietrichs, Chad, Fleetwood, Cheryl, Foley, Mike, Getto, Chris, Hailes, Susie, Hermes, Sarah, Hooper, Andy, Koener, Greg, Kohls, Kate, Law, Leslie, Lipp, Adam, Losey, Allison, Nelson, William, Nieto, Mario, Rogers, Pam, Rutman, Steve, Scales, Garrett, Sebastian, Barbara, Stanciu, Tom, Lobel, Gregg, Giampiccolo, Michelle, Herman, Dara, Kaufman, Margit, Murphy, Bryan, Pau, Clara, Puzio, Thomas, Veselsky, Marlene, Apostle, Kelly, Boyer, Dory, Chen Fan, Brenda, Lee, Susan, Lemke, Mike, Merchant, Richard, Moola, Farhad, Payne, Kyrsten, Perey, Bertrand, Viskontas, Darius, Poler, Mark, D’Antonio, Patricia, O’Neill, Greg, Abdullah, Amer, Fish-Fuhrmann, Jamie, Giska, Mark, Fidkowski, Christina, Guthrie, Stuart Trent, Hakeos, William, Hayes, Lillian, Hoegler, Joseph, Nowak, Katherine, Beck, Jeffery, Cuff, Jaslynn, Gaski, Greg, Haaser, Sharon, Holzman, Michael, Malekzadeh, A. Stephen, Ramsey, Lolita, Schulman, Jeff, Schwartzbach, Cary, Azefor, Tangwan, Davani, Arman, Jaberi, Mahmood, Masear, Courtney, Haider, Syed Basit, Chungu, Carolyn, Ebrahimi, Ali, Fikry, Karim, Marcantonio, Andrew, Shelvan, Anitha, Sanders, David, Clarke, Collin, Lawendy, Abdel, Schwartz, Gary, Garg, Mohit, Kim, Joseph, Caruci, Juan, Commeh, Ekow, Cuevas, Randy, Cuff, Germaine, Franco, Lola, Furgiuele, David, Giuca, Matthew, Allman, Melissa, Barzideh, Omid, Cossaro, James, D’Arduini, Armando, Farhi, Anita, Gould, Jason, Kafel, John, Patel, Anuj, Peller, Abraham, Reshef, Hadas, Safur, Mohammed, Toscano, Fiore, Tedore, Tiffany, Akerman, Michael, Brumberger, Eric, Clark, Sunday, Friedlander, Rachel, Jegarl, Anita, Lane, Joseph, Lyden, John P., Mehta, Nili, Murrell, Matthew T., Painter, Nathan, Ricci, William, Sbrollini, Kaitlyn, Sharma, Rahul, Steel, Peter A.D., Steinkamp, Michele, Weinberg, Roniel, Stephenson Wellman, David, Nader, Antoun, Fitzgerald, Paul, Ritz, Michaela, Bryson, Greg, Craig, Alexandra, Farhat, Cassandra, Gammon, Braden, Gofton, Wade, Harris, Nicole, Lalonde, Karl, Liew, Allan, Meulenkamp, Bradley, Sonnenburg, Kendra, Wai, Eugene, Wilkin, Geoffrey, Troxell, Karen, Alderfer, Mary Ellen, Brannen, Jason, Cupitt, Christopher, Gerhart, Stacy, McLin, Renee, Sheidy, Julie, Yurick, Katherine, Chen, Fei, Dragert, Karen, Kiss, Geza, Malveaux, Halina, McCloskey, Deborah, Mellender, Scott, Mungekar, Sagar S., Noveck, Helaine, Sagebien, Carlos, Biby, Luat, McKelvy, Gail, Richards, Anna, Abola, Ramon, Ayala, Brittney, Halper, Darcy, Mavarez, Ana, Rizwan, Sabeen, Choi, Stephen, Awad, Imad, Flynn, Brendan, Henry, Patrick, Jenkinson, Richard, Kaustov, Lilia, Lappin, Elizabeth, McHardy, Paul, Singh, Amara, Donnelly, Joanne, Gonzalez, Meera, Haydel, Christopher, Livelsberger, Jon, Pazionis, Theresa, Slattery, Bridget, Vazquez-Trejo, Maritza, Baratta, Jaime, Cirullo, Michael, Deiling, Brittany, Deschamps, Laura, Glick, Michael, Katz, Daniel, Krieg, James, Lessin, Jennifer, Mojica, Jeffrey, Torjman, Marc, Jin, Rongyu, Salpeter, Mary Jane, Powell, Mark, Simmons, Jeffrey, Lawson, Prentiss, Kukreja, Promil, Graves, Shanna, Sturdivant, Adam, Bryant, Ayesha, Crump, Sandra Joyce, Verrier, Michelle, Green, James, Menon, Matthew, Applegate, Richard, Arias, Ana, Pineiro, Natasha, Uppington, Jeffrey, Wolinsky, Phillip, Gunnett, Amy, Hagen, Jennifer, Harris, Sara, Hollen, Kevin, Holloway, Brian, Horodyski, Mary Beth, Pogue, Trevor, Ramani, Ramachandran, Smith, Cameron, Woods, Anna, Warrick, Matthew, Flynn, Kelly, Mongan, Paul, Ranganath, Yatish, Fernholz, Sean, Ingersoll-Weng, Esperanza, Marian, Anil, Seering, Melinda, Sibenaller, Zita, Stout, Lori, Wagner, Allison, Walter, Alicia, Wong, Cynthia, Orwig, Denise, Goud, Maithri, Helker, Chris, Mezenghie, Lydia, Montgomery, Brittany, Preston, Peter, Schwartz, J. Sanford, Weber, Ramona, Fleisher, Lee A., Mehta, Samir, Stephens-Shields, Alisa J., Dinh, Cassandra, Schwartz, Aron, Chelly, Jacques E., Goel, Shiv, Goncz, Wende, Kawabe, Touichi, Khetarpal, Sharad, Monroe, Amy, Shick, Vladislav, Breidenstein, Max, Dominick, Timothy, Friend, Alexander, Mathews, Donald, Lennertz, Richard, Sanders, Robert, Akere, Helen, Balweg, Tyler, Bo, Amber, Doro, Christopher, Goodspeed, David, Lang, Gerald, Parker, Maggie, Rettammel, Amy, Roth, Mary, White, Marissa, Whiting, Paul, Allen, Brian F.S., Baker, Tracie, Craven, Debra, McEvoy, Matt, Turnbo, Teresa, Kates, Stephen, Morgan, Melanie, Willoughby, Teresa, Weigel, Wade, Auyong, David, Fox, Ellie, Welsh, Tina, Cusson, Bruce, Dobson, Sean, Edwards, Christopher, Harris, Lynette, Henshaw, Daryl, Johnson, Kathleen, McKinney, Glen, Miller, Scott, Reynolds, Jon, Segal, B. Scott, Turner, Jimmy, VanEenenaam, David, Weller, Robert, Lei, Jineli, Treggiari, Miriam, Akhtar, Shamsuddin, Blessing, Marcelle, Johnson, Chanel, Kampp, Michael, Kunze, Kimberly, OʼConnor, Mary, Gaskins, Lakisha J., Looke, Thomas, Tadros, Rafik, Vlassakov, Kamen, Cardenas, Louis, Hassan, Manal, Bolkus, Kelly, Mitrev, Ludmil, Kwofie, M. Kwesi, Dabiri, Jared, Lobel, Gregg, Poler, Mark, Giska, Mark, Sanders, David, Schwartz, Gary, Giuca, Matthew, Tedore, Tiffany, Nader, Antoun, Papp, Stephen, Bryson, Greg, Troxell, Karen, Kiss, Geza, Choi, Stephen, Powell, Mark, Applegate, Richard, Warrick, Matthew, Ranganath, Yatish, Elkassabany, Nabil, Chelly, Jacques E., Hoeft, Mark A., Lennertz, Richard, Sanders, Robert, Allen, Brian F.S., Kates, Stephen, Weigel, Wade, Li, Jinlei, Wijeysundera, Duminda N., Kheterpal, Sachin, Moore, Reneé H., Smith, Alexander K., Tosi, Laura L., Elkassabany, Nabil, Looke, Thomas, Menio, Diane, Mehta, Samir, Fleisher, Lee, Menio, Diane, Hruslinski, Jennifer, Ramsey, Lolita, Gaskins, Lakisha J., Langlois, Christine, Gaskins, Lakisha J., Mezenghie, Lydia, Montgomery, Brittany, Oduwole, Samuel, and Rose, Thomas

Published
2024
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2. Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults

Author

Looke, Thomas, Bent, Sandra, Franco-Mora, Ariana, Hedrick, Pamela, Newbern, Matthew, Tadros, Rafik, Pealer, Karen, Marcantonio, Edward, Vlassakov, Kamen, Buckley, Carolyn, Gorbatov, Svetlana, Gosnell, James, Steen, Talora, Vafai, Avery, Zeballos, Jose, Cardenas, Louis, Berry, Ashley, Getchell, John, Quercetti, Nicholas, Sessler, Daniel I., Ayad, Sabry, Hassan, Manal, Ali, Assad, Bajracharya, Gauasan, Billow, Damien, Bloomfield, Michael, Elliott, Kavita, Hampton, Robert, He, Linda, Honar, Hooman, Khoshknabi, Dilara, Kim, Daniel, Minko, Paul, Morris, Adam, Niazi, Azfar, Nutcharoen, Tara, Roberts, Jeffrey, Saha, Partha, Salih, Ahmed, Skolaris, Alexis, Stang, Taylor, Strimbu, Victor, Templeton, Jesse, Volio, Andrew, Wang, Jiayi, Bolkus, Kelly, DeAngelis, Matthew, Dodson, Gregory, Gerritsen, Jeffrey, McEniry, Brian, Mitrev, Ludmil, Kwofie, Kwesi, Bonazza, Flynn, Lloyd, Vera, Panek, Izabela, Dabiri, Jared, Chavez, Chris, Craig, Jason, Davidson, Todd, Dietrichs, Chad, Fleetwood, Cheryl, Foley, Mike, Getto, Chris, Hailes, Susie, Hermes, Sarah, Hooper, Andy, Koener, Greg, Kohls, Kate, Law, Leslie, Lipp, Adam, Losey, Allison, Nelson, William, Nieto, Mario, Rogers, Pam, Rutman, Steve, Scales, Garrett, Sebastian, Barbara, Stanciu, Tom, Lobel, Gregg, Giampiccolo, Michelle, Herman, Dara, Kaufman, Margit, Murphy, Bryan, Pau, Clara, Puzio, Thomas, Veselsky, Marlene, Stone, Trevor, Apostle, Kelly, Boyer, Dory, Fan, Brenda Chen, Lee, Susan, Lemke, Mike, Merchant, Richard, Moola, Farhad, Payne, Kyrsten, Perey, Bertrand, Viskontas, Darius, Poler, Mark, D'Antonio, Patricia, Sheppard, Richard, Abdullah, Amer, Fish-Fuhrmann, Jamie, Giska, Mark, Fidkowski, Christina, Guthrie, Trent, Hakeos, William, Hayes, Lillian, Hoegler, Joseph, Nowak, Katherine, Hymes, Robert, Beck, Jeffery, Cuff, Jaslynn, Gaski, Greg, Haaser, Sharon, Holzman, Michael, Malekzadeh, A. Stephen, Ramsey, Lolita, Schulman, Jeff, Schwartzbach, Cary, Sieber, Frederick, Azefor, Tangwan, Brown, Charles, Davani, Arman, Jaberi, Mahmood, Masear, Courtney, Sharma, Balram, Haider, Syed Basit, Chungu, Carolyn, Ebrahimi, Ali, Fikry, Karim, Gannon, Kerri, Marcantonio, Andrew, Pace, Meredith, Sanders, David, Clarke, Collin, Lawendy, Abdel, Schwartz, Gary, Garg, Mohit, Kim, Joseph, Marshall, Mitchell, Caurci, Juan, Commeh, Ekow, Cuevas, Randy, Cuff, Germaine, Franco, Lola, Furguiele, David, Giuca, Matthew, Allman, Melissa, Barzideh, Omid, Cossaro, James, D'Arduini, Armando, Farhi, Anita, Gould, Jason, Kafel, John, Patel, Anuj, Peller, Abraham, Reshef, Hadas, Safur, Mohammed, Toscano, Fiore, Tedore, Tiffany, Akerman, Michael, Brumberger, Eric, Clark, Sunday, Friedlander, Rachel, Jegarl, Anita, Lane, Joseph, Lyden, John P., Mehta, Nili, Murrell, Matthew T., Painter, Nathan, Ricci, William, Sbrollini, Kaitlyn, Sharma, Rahul, Steel, Peter A.D., Steinkamp, Michele, Weinberg, Roniel, Wellman, David Stephenson, Nader, Antoun, Fitzgerald, Paul, Ritz, Michaela, Papp, Steven, Bryson, Greg, Craig, Alexandra, Farhat, Cassandra, Gammon, Braden, Gofton, Wade, Harris, Nicole, Lalonde, Karl, Liew, Allan, Meulenkamp, Bradley, Sonnenburg, Kendra, Wai, Eugene, Wilkin, Geoffrey, Donegan, Derek, Dinh, Cassandra, Elkassabany, Nabil, Horan, Annamarie, Mehta, Samir, Troxell, Karen, Alderfer, Mary Ellen, Brannen, Jason, Cupitt, Christopher, Gerhart, Stacy, McLin, Renee, Sheidy, Julie, Yurick, Katherine, Carson, Jeffrey, Chen, Fei, Dragert, Karen, Kiss, Geza, Malveaux, Halina, McCloskey, Deborah, Mellender, Scott, Mungekar, Sagar S., Noveck, Helaine, Sagebien, Carlos, Perlman, Barry, Biby, Luat, McKelvy, Gail, Richards, Anna, Azim, Syed, Abola, Ramon, Ayala, Brittney, Halper, Darcy, Mavarez, Ana, Choi, Stephen, Awad, Imad, Flynn, Brendan, Henry, Patrick, Jenkinson, Richard, Kaustov, Lilia, Lappin, Elizabeth, McHardy, Paul, Singh, Amara, Hauck, Ellen, Donnelly, Joanne, Gonzalez, Meera, Haydel, Christopher, Livelsberger, Jon, Pazionis, Theresa, Slattery, Bridget, Vazquez-Trejo, Maritza, Schwenk, Eric, Baratta, Jaime, Deiling, Brittany, Deschamps, Laura, Glick, Michael, Katz, Daniel, Krieg, James, Lessin, Jennifer, Torjman, Marc, Chin, Ki Jinn, Jin, Rongyu, Salpeter, Mary Jane, Powell, Mark, Simmons, Jeffrey, Lawson, Prentiss, Kukreja, Promil, Graves, Shanna, Sturdivant, Adam, Bryant, Ayesha, Crump, Sandra Joyce, Dillane, Derek, Taylor, Michael, Verrier, Michelle, Applegate, Richard, Arias, Ana, Pineiro, Natasha, Uppington, Jeffrey, Wolinsky, Phillip, Sappenfield, Joshua, Gunnett, Amy, Hagen, Jennifer, Harris, Sara, Hollen, Kevin, Holloway, Brian, Horodyski, Mary Beth, Pogue, Trevor, Ramani, Ramachandran, Smith, Cameron, Woods, Anna, Warrick, Matthew, Flynn, Kelly, Mongan, Paul, Ranganath, Yatish, Fernholz, Sean, Ingersoll-Weng, Esperanza, Marian, Anil, Seering, Melinda, Sibenaller, Zita, Stout, Lori, Wagner, Allison, Walter, Alicia, Wong, Cynthia, Magaziner, Jay, Orwig, Denise, Brown, Trina, Dattilo, Jim, Ellenberg, Susan, Feng, Rui, Fleisher, Lee, Gaskins, Lakisha, Goud, Maithri, Helker, Chris, Mezenghie, Lydia, Montgomery, Brittany, Preston, Peter, Stephens, Alisa, Schwartz, J. Sanford, Tierney, Ann, Weber, Ramona, Chelly, Jacques, Goel, Shiv, Goncz, Wende, Kawabe, Touichi, Khetarpal, Sharad, King, Kevin, Kunkel, Frank, Luke, Charles, Monroe, Amy, Shick, Vladislav, Silipo, Anthony, Stehle, Caroline, Szabo, Katherine, Yennam, Sudhakar, Hoeft, Mark, Breidenstein, Max, Dominick, Timothy, Friend, Alexander, Mathews, Donald, Lennertz, Richard, Akere, Helen, Balweg, Tyler, Bo, Amber, Doro, Christopher, Goodspeed, David, Lang, Gerald, Parker, Maggie, Rettammel, Amy, Roth, Mary, Sanders, Robert, White, Marissa, Whiting, Paul, Allen, Brian, Baker, Tracie, Craven, Debra, McEvoy, Matt, Turnbo, Teresa, Kates, Stephen, Morgan, Melanie, Willoughby, Teresa, Weigel, Wade, Auyong, David, Fox, Ellie, Welsh, Tina, Jaffe, J. Douglas, Cusson, Bruce, Dobson, Sean, Edwards, Christopher, Harris, Lynette, Henshaw, Daryl, Johnson, Kathleen, McKinney, Glen, Miller, Scott, Reynolds, Jon, Turner, Jimmy, VanEenenaam, David, Weller, Robert, Akhtar, Shamsuddin, Blessing, Marcelle, Johnson, Chanel, Kampp, Michael, Kunze, Kimberly, Li, Jinlei, O'Connor, Mary, Treggiari, Miriam, Hruslinski, Jennifer, Menio, Diane A., Hymes, Robert A., Langlois, Christine, Gaskins, Lakisha J., and Neuman, Mark D.

Published
2021
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3. Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti

Author

Choate, Keith A, Lu, Yin, Zhou, Jing, Elias, Peter M, Zaidi, Samir, Paller, Amy S, Farhi, Anita, Nelson-Williams, Carol, Crumrine, Debra, Milstone, Leonard M, and Lifton, Richard P

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Pediatric, Skin, Adult, Age of Onset, Amino Acid Sequence, Cell Line, Tumor, Cell Nucleus, Child, Child, Preschool, Chromosomes, Human, Pair 12, Cytoskeleton, Frameshift Mutation, Humans, Ichthyosis, Intermediate Filaments, Keratin-1, Keratinocytes, Loss of Heterozygosity, Male, Molecular Sequence Data, Mosaicism, Phenotype, Polymorphism, Single Nucleotide, Protein Transport, Transfection, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Widespread reversion of genetic disease is rare; however, such events are particularly evident in some skin disorders in which normal clones develop on a background of affected skin. We previously demonstrated that mutations in keratin 10 (KRT10) cause ichthyosis with confetti (IWC), a severe dominant disorder that is characterized by progressive development of hundreds of normal skin spots via revertant mosaicism. Here, we report on a clinical and histological IWC subtype in which affected subjects have red, scaly skin at birth, experience worsening palmoplantar keratoderma in childhood, and develop hundreds of normal skin spots, beginning at around 20 years of age, that increase in size and number over time. We identified a causal de novo mutation in keratin 1 (KRT1). Similar to IWC-causing KRT10 mutations, this mutation in KRT1 resulted in a C-terminal frameshift, replacing 22 C-terminal amino acids with an alternate 30-residue peptide. Mutant KRT1 caused partial collapse of the cytoplasmic intermediate filament network and mislocalized to the nucleus. As with KRT10 mutations causing IWC, reversion of KRT1 mutations occurred via mitotic recombination. Because reversion is not observed with other disease-causing keratin mutations, the results of this study implicate KRT1 and KRT10 C-terminal frameshift mutations in the high frequency of revertant mosaicism in IWC.

Published
2015

4. Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome

Author

Abelson, Jesse F., Kwan, Kenneth Y., O'Roak, Brian J., Baek, Danielle Y., Stillman, Althea A., Morgan, Thomas M., Mathews, Carol A., Pauls, David L., Rašin, Mladen-Roko, Gunel, Murat, Davis, Nicole R., Ercan-Sencicek, A. Gulhan, Guez, Danielle H., Spertus, John A., Leckman, James F., Dure, Leon S., Kurlan, Roger, Singer, Harvey S., Gilbert, Donald L., Farhi, Anita, Louvi, Angeliki, Lifton, Richard P., Šestan, Nenad, and State, Matthew W.

Published
2005

13. Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults

Author

Hruslinski, Jennifer, primary, Menio, Diane A., additional, Hymes, Robert A., additional, Jaffe, J. Douglas, additional, Langlois, Christine, additional, Ramsey, Lolita, additional, Gaskins, Lakisha J., additional, Neuman, Mark D., additional, Looke, Thomas, additional, Bent, Sandra, additional, Franco-Mora, Ariana, additional, Hedrick, Pamela, additional, Newbern, Matthew, additional, Tadros, Rafik, additional, Pealer, Karen, additional, Marcantonio, Edward, additional, Vlassakov, Kamen, additional, Buckley, Carolyn, additional, Gorbatov, Svetlana, additional, Gosnell, James, additional, Steen, Talora, additional, Vafai, Avery, additional, Zeballos, Jose, additional, Cardenas, Louis, additional, Berry, Ashley, additional, Getchell, John, additional, Quercetti, Nicholas, additional, Sessler, Daniel I., additional, Ayad, Sabry, additional, Hassan, Manal, additional, Ali, Assad, additional, Bajracharya, Gauasan, additional, Billow, Damien, additional, Bloomfield, Michael, additional, Elliott, Kavita, additional, Hampton, Robert, additional, He, Linda, additional, Honar, Hooman, additional, Khoshknabi, Dilara, additional, Kim, Daniel, additional, Minko, Paul, additional, Morris, Adam, additional, Niazi, Azfar, additional, Nutcharoen, Tara, additional, Roberts, Jeffrey, additional, Saha, Partha, additional, Salih, Ahmed, additional, Skolaris, Alexis, additional, Stang, Taylor, additional, Strimbu, Victor, additional, Templeton, Jesse, additional, Volio, Andrew, additional, Wang, Jiayi, additional, Bolkus, Kelly, additional, DeAngelis, Matthew, additional, Dodson, Gregory, additional, Gerritsen, Jeffrey, additional, McEniry, Brian, additional, Mitrev, Ludmil, additional, Kwofie, Kwesi, additional, Bonazza, Flynn, additional, Lloyd, Vera, additional, Panek, Izabela, additional, Dabiri, Jared, additional, Chavez, Chris, additional, Craig, Jason, additional, Davidson, Todd, additional, Dietrichs, Chad, additional, Fleetwood, Cheryl, additional, Foley, Mike, additional, Getto, Chris, additional, Hailes, Susie, additional, Hermes, Sarah, additional, Hooper, Andy, additional, Koener, Greg, additional, Kohls, Kate, additional, Law, Leslie, additional, Lipp, Adam, additional, Losey, Allison, additional, Nelson, William, additional, Nieto, Mario, additional, Rogers, Pam, additional, Rutman, Steve, additional, Scales, Garrett, additional, Sebastian, Barbara, additional, Stanciu, Tom, additional, Lobel, Gregg, additional, Giampiccolo, Michelle, additional, Herman, Dara, additional, Kaufman, Margit, additional, Murphy, Bryan, additional, Pau, Clara, additional, Puzio, Thomas, additional, Veselsky, Marlene, additional, Stone, Trevor, additional, Apostle, Kelly, additional, Boyer, Dory, additional, Fan, Brenda Chen, additional, Lee, Susan, additional, Lemke, Mike, additional, Merchant, Richard, additional, Moola, Farhad, additional, Payne, Kyrsten, additional, Perey, Bertrand, additional, Viskontas, Darius, additional, Poler, Mark, additional, D'Antonio, Patricia, additional, Sheppard, Richard, additional, Abdullah, Amer, additional, Fish-Fuhrmann, Jamie, additional, Giska, Mark, additional, Fidkowski, Christina, additional, Guthrie, Trent, additional, Hakeos, William, additional, Hayes, Lillian, additional, Hoegler, Joseph, additional, Nowak, Katherine, additional, Hymes, Robert, additional, Beck, Jeffery, additional, Cuff, Jaslynn, additional, Gaski, Greg, additional, Haaser, Sharon, additional, Holzman, Michael, additional, Malekzadeh, A. Stephen, additional, Schulman, Jeff, additional, Schwartzbach, Cary, additional, Sieber, Frederick, additional, Azefor, Tangwan, additional, Brown, Charles, additional, Davani, Arman, additional, Jaberi, Mahmood, additional, Masear, Courtney, additional, Sharma, Balram, additional, Haider, Syed Basit, additional, Chungu, Carolyn, additional, Ebrahimi, Ali, additional, Fikry, Karim, additional, Gannon, Kerri, additional, Marcantonio, Andrew, additional, Pace, Meredith, additional, Sanders, David, additional, Clarke, Collin, additional, Lawendy, Abdel, additional, Schwartz, Gary, additional, Garg, Mohit, additional, Kim, Joseph, additional, Marshall, Mitchell, additional, Caurci, Juan, additional, Commeh, Ekow, additional, Cuevas, Randy, additional, Cuff, Germaine, additional, Franco, Lola, additional, Furguiele, David, additional, Giuca, Matthew, additional, Allman, Melissa, additional, Barzideh, Omid, additional, Cossaro, James, additional, D'Arduini, Armando, additional, Farhi, Anita, additional, Gould, Jason, additional, Kafel, John, additional, Patel, Anuj, additional, Peller, Abraham, additional, Reshef, Hadas, additional, Safur, Mohammed, additional, Toscano, Fiore, additional, Tedore, Tiffany, additional, Akerman, Michael, additional, Brumberger, Eric, additional, Clark, Sunday, additional, Friedlander, Rachel, additional, Jegarl, Anita, additional, Lane, Joseph, additional, Lyden, John P., additional, Mehta, Nili, additional, Murrell, Matthew T., additional, Painter, Nathan, additional, Ricci, William, additional, Sbrollini, Kaitlyn, additional, Sharma, Rahul, additional, Steel, Peter A.D., additional, Steinkamp, Michele, additional, Weinberg, Roniel, additional, Wellman, David Stephenson, additional, Nader, Antoun, additional, Fitzgerald, Paul, additional, Ritz, Michaela, additional, Papp, Steven, additional, Bryson, Greg, additional, Craig, Alexandra, additional, Farhat, Cassandra, additional, Gammon, Braden, additional, Gofton, Wade, additional, Harris, Nicole, additional, Lalonde, Karl, additional, Liew, Allan, additional, Meulenkamp, Bradley, additional, Sonnenburg, Kendra, additional, Wai, Eugene, additional, Wilkin, Geoffrey, additional, Donegan, Derek, additional, Dinh, Cassandra, additional, Elkassabany, Nabil, additional, Horan, Annamarie, additional, Mehta, Samir, additional, Troxell, Karen, additional, Alderfer, Mary Ellen, additional, Brannen, Jason, additional, Cupitt, Christopher, additional, Gerhart, Stacy, additional, McLin, Renee, additional, Sheidy, Julie, additional, Yurick, Katherine, additional, Carson, Jeffrey, additional, Chen, Fei, additional, Dragert, Karen, additional, Kiss, Geza, additional, Malveaux, Halina, additional, McCloskey, Deborah, additional, Mellender, Scott, additional, Mungekar, Sagar S., additional, Noveck, Helaine, additional, Sagebien, Carlos, additional, Perlman, Barry, additional, Biby, Luat, additional, McKelvy, Gail, additional, Richards, Anna, additional, Azim, Syed, additional, Abola, Ramon, additional, Ayala, Brittney, additional, Halper, Darcy, additional, Mavarez, Ana, additional, Choi, Stephen, additional, Awad, Imad, additional, Flynn, Brendan, additional, Henry, Patrick, additional, Jenkinson, Richard, additional, Kaustov, Lilia, additional, Lappin, Elizabeth, additional, McHardy, Paul, additional, Singh, Amara, additional, Hauck, Ellen, additional, Donnelly, Joanne, additional, Gonzalez, Meera, additional, Haydel, Christopher, additional, Livelsberger, Jon, additional, Pazionis, Theresa, additional, Slattery, Bridget, additional, Vazquez-Trejo, Maritza, additional, Schwenk, Eric, additional, Baratta, Jaime, additional, Deiling, Brittany, additional, Deschamps, Laura, additional, Glick, Michael, additional, Katz, Daniel, additional, Krieg, James, additional, Lessin, Jennifer, additional, Torjman, Marc, additional, Chin, Ki Jinn, additional, Jin, Rongyu, additional, Salpeter, Mary Jane, additional, Powell, Mark, additional, Simmons, Jeffrey, additional, Lawson, Prentiss, additional, Kukreja, Promil, additional, Graves, Shanna, additional, Sturdivant, Adam, additional, Bryant, Ayesha, additional, Crump, Sandra Joyce, additional, Dillane, Derek, additional, Taylor, Michael, additional, Verrier, Michelle, additional, Applegate, Richard, additional, Arias, Ana, additional, Pineiro, Natasha, additional, Uppington, Jeffrey, additional, Wolinsky, Phillip, additional, Sappenfield, Joshua, additional, Gunnett, Amy, additional, Hagen, Jennifer, additional, Harris, Sara, additional, Hollen, Kevin, additional, Holloway, Brian, additional, Horodyski, Mary Beth, additional, Pogue, Trevor, additional, Ramani, Ramachandran, additional, Smith, Cameron, additional, Woods, Anna, additional, Warrick, Matthew, additional, Flynn, Kelly, additional, Mongan, Paul, additional, Ranganath, Yatish, additional, Fernholz, Sean, additional, Ingersoll-Weng, Esperanza, additional, Marian, Anil, additional, Seering, Melinda, additional, Sibenaller, Zita, additional, Stout, Lori, additional, Wagner, Allison, additional, Walter, Alicia, additional, Wong, Cynthia, additional, Magaziner, Jay, additional, Orwig, Denise, additional, Brown, Trina, additional, Dattilo, Jim, additional, Ellenberg, Susan, additional, Feng, Rui, additional, Fleisher, Lee, additional, Gaskins, Lakisha, additional, Goud, Maithri, additional, Helker, Chris, additional, Mezenghie, Lydia, additional, Montgomery, Brittany, additional, Preston, Peter, additional, Stephens, Alisa, additional, Schwartz, J. Sanford, additional, Tierney, Ann, additional, Weber, Ramona, additional, Chelly, Jacques, additional, Goel, Shiv, additional, Goncz, Wende, additional, Kawabe, Touichi, additional, Khetarpal, Sharad, additional, King, Kevin, additional, Kunkel, Frank, additional, Luke, Charles, additional, Monroe, Amy, additional, Shick, Vladislav, additional, Silipo, Anthony, additional, Stehle, Caroline, additional, Szabo, Katherine, additional, Yennam, Sudhakar, additional, Hoeft, Mark, additional, Breidenstein, Max, additional, Dominick, Timothy, additional, Friend, Alexander, additional, Mathews, Donald, additional, Lennertz, Richard, additional, Akere, Helen, additional, Balweg, Tyler, additional, Bo, Amber, additional, Doro, Christopher, additional, Goodspeed, David, additional, Lang, Gerald, additional, Parker, Maggie, additional, Rettammel, Amy, additional, Roth, Mary, additional, Sanders, Robert, additional, White, Marissa, additional, Whiting, Paul, additional, Allen, Brian, additional, Baker, Tracie, additional, Craven, Debra, additional, McEvoy, Matt, additional, Turnbo, Teresa, additional, Kates, Stephen, additional, Morgan, Melanie, additional, Willoughby, Teresa, additional, Weigel, Wade, additional, Auyong, David, additional, Fox, Ellie, additional, Welsh, Tina, additional, Cusson, Bruce, additional, Dobson, Sean, additional, Edwards, Christopher, additional, Harris, Lynette, additional, Henshaw, Daryl, additional, Johnson, Kathleen, additional, McKinney, Glen, additional, Miller, Scott, additional, Reynolds, Jon, additional, Turner, Jimmy, additional, VanEenenaam, David, additional, Weller, Robert, additional, Akhtar, Shamsuddin, additional, Blessing, Marcelle, additional, Johnson, Chanel, additional, Kampp, Michael, additional, Kunze, Kimberly, additional, Li, Jinlei, additional, O'Connor, Mary, additional, and Treggiari, Miriam, additional

Published
2021
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14. High bone density due to a mutation in LDL-receptor-related protein 5

Author

Boyden, Lynn M., Mao, Junhao, Belsky, Joseph, Mitzner, Lyle, Farhi, Anita, Mitnick, Mary A., Wu, Dianquing, Insogna, Karl, and Lifton, Richard P.

Subjects
Bones -- Density, Osteoporosis -- Genetic aspects
Abstract

Researchers describe a family with a gene mutation that causes increased bone density. It occurs in the gene for low-density lipoprotein receptor-related protein 5, which is on chromosome 11q12-13. This gene could play a role in osteoporosis.

Published
2002

16. Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

Author

Boyden, Lynn M., Choi, Murim, Choate, Keith A., Nelson-Williams, Carol J., Farhi, Anita, Toka, Hakan R., Tikhonova, Irina R., Bjornson, Robert, Mane, Shrikant M., Colussi, Giacomo, Lebel, Marcel, Gordon, Richard D., Semmekrot, Ben A., Poujol, Alain, Välimäki, Matti J., De Ferrari, Maria E., Sanjad, Sami A., Gutkin, Michael, Karet, Fiona E., Tucci, Joseph R., Stockigt, Jim R., Keppler-Noreuil, Kim M., Porter, Craig C., Anand, Sudhir K., Whiteford, Margo L., Davis, Ira D., Dewar, Stephanie B., Bettinelli, Alberto, Fadrowski, Jeffrey J., Belsha, Craig W., Hunley, Tracy E., Nelson, Raoul D., Trachtman, Howard, Cole, Trevor R. P., Pinsk, Maury, Bockenhauer, Detlef, Shenoy, Mohan, Vaidyanathan, Priya, Foreman, John W., Rasoulpour, Majid, Thameem, Farook, Al-Shahrouri, Hania Z., Radhakrishnan, Jai, Gharavi, Ali G., Goilav, Beatrice, and Lifton, Richard P.

Published
2012
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22. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22–23

Author

Gharavi, Ali G., primary, Yan, Yan, additional, Scolari, Francesco, additional, Schena, F. Paolo, additional, Frasca, Giovanni M., additional, Ghiggeri, Gian Marco, additional, Cooper, Kerry, additional, Amoroso, Antonio, additional, Viola, Battista Fabio, additional, Battini, Graziana, additional, Caridi, Gianluca, additional, Canova, Cristina, additional, Farhi, Anita, additional, Subramanian, Vairavan, additional, Nelson-Williams, Carol, additional, Woodford, Sue, additional, Julian, Bruce A., additional, Wyatt, Robert J., additional, and Lifton, Richard P., additional

Published
2000
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23. Psychiatric status after human fetal mesencephalic tissue transplantation in Parkinson's disease

Author

Price, Lawrence H., primary, Spencer, Dennis D., additional, Marek, Kenneth L., additional, Robbins, Richard J., additional, Leranth, Csaba, additional, Farhi, Anita, additional, Naftolin, Frederick, additional, Roth, Robert H., additional, Bunney, Benjamin S., additional, Hoffer, Paul B., additional, Makuch, Robert, additional, and Eugene Redmond, D., additional

Published
1995
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24. Genetic diagnosis by whole exome capture and massively parallel DNA sequencing.

Author

Murim Choi, Scholl, Ute I., Weizhen Ji, Tiewen Liu, Tikhonova, Irina R., Zumbo, Paul, Nayir, Ahmet, Bakkaloglu, Aysin, Özen, Seza, Sanjad, Sami, Nelson-Williams, Carol, Farhi, Anita, Mane, Shrikant, and Lifton, Richard P.

Subjects
GENETIC disorder diagnosis, HUMAN genome, NUCLEOTIDE sequence, BARTTER syndrome, GENETIC mutation, MOLECULAR biology
Abstract

Protein coding genes constitute only approximately 1% of the human genome but harbor 85% of the mutations with large effects on disease-related traits. Therefore, efficient strategies for selectively sequencing complete coding regions (i.e., "whole exome") have the potential to contribute to the understanding of rare and common human diseases. Here we report a method for whole-exome sequencing coupling Roche/NimbleGen whole exome arrays to the Illumina DNA sequencing platform. We demonstrate the ability to capture approximately 95% of the targeted coding sequences with high sensitivity and specificity for detection of homozygous and heterozygous variants. We illustrate the utility of this approach by making an unanticipated genetic diagnosis of congenital chloride diarrhea in a patient referred with a suspected diagnosis of Bartter syndrome, a renal salt-wasting disease. The molecular diagnosis was based on the finding of a homozygous missense D652N mutation at a position in 5LC26A3 (the known congenital chloride diarrhea locus) that is virtually completely conserved in orthologues and paralogues from invertebrates to humans, and clinical follow-up confirmed the diagnosis. To our knowledge, whole-exome (or genome) sequencing has not previously been used to make a genetic diagnosis. Five additional patients suspected to have Bartter syndrome but who did not have mutations in known genes for this disease had homozygous deleterious mutations in SLC26A3. These results demonstrate the clinical utility of whole-exome sequencing and have implications for disease gene discovery and clinical diagnosis. [ABSTRACT FROM AUTHOR]

Published
2009
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25. High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5.

Author

Boyden, Lynn M., Mao, Junhao, Belsky, Joseph, Mitzner, Lyle, Farhi, Anita, Mitnick, Mary A., Wu, Dianqing, Insogna, Karl, and Lifton, Richard P.

Subjects
*OSTEOPOROSIS, *GENETIC mutation, *LOW density lipoproteins, *WNT proteins, *GROWTH factors, *GLYCOPROTEINS, *PSEUDOGLIOMA, *PUBLIC health, *GENETICS
Abstract

Background: Osteoporosis is a major public health problem of largely unknown cause. Loss-of-function mutations in the gene for low-density lipoprotein receptor–related protein 5 (LRP5), which acts in the Wnt signaling pathway, have been shown to cause osteoporosis–pseudoglioma. Methods: We performed genetic and biochemical analyses of a kindred with an autosomal dominant syndrome characterized by high bone density, a wide and deep mandible, and torus palatinus. Results: Genetic analysis revealed linkage of the syndrome to chromosome 11q12–13 (odds of linkage, >1 million to 1), an interval that contains LRP5. Affected members of the kindred had a mutation in this gene, with valine substituted for glycine at codon 171 (LRP5). This mutation segregated with the trait in the family and was absent in control subjects. The normal glycine lies in a so-called propeller motif that is highly conserved from fruit flies to humans. Markers of bone resorption were normal in the affected subjects, whereas markers of bone formation such as osteocalcin were markedly elevated. Levels of fibronectin, a known target of signaling by Wnt, a developmental protein, were also elevated. In vitro studies showed that the normal inhibition of Wnt signaling by another protein, Dickkopf-1 (Dkk-1), was defective in the presence of LRP5V171 and that this resulted in increased signaling due to unopposed Wnt activity. Conclusions: The LRP5 mutation causes high bone density, with a thickened mandible and torus palatinus, by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling. These findings demonstrate the role of altered LRP5 function in high bone mass and point to Dkk as a potential target for the prevention or treatment of osteoporosis. (N Engl J Med 2002;346:1513-21.) [ABSTRACT FROM AUTHOR]

Published
2002
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26. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial.

Author

Neuman MD, Feng R, Ellenberg SS, Sieber F, Sessler DI, Magaziner J, Elkassabany N, Schwenk ES, Dillane D, Marcantonio ER, Menio D, Ayad S, Hassan M, Stone T, Papp S, Donegan D, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Tierney A, Gaskins LJ, Horan AD, Brown T, Dattilo J, Carson JL, Looke T, Bent S, Franco-Mora A, Hedrick P, Newbern M, Tadros R, Pealer K, Vlassakov K, Buckley C, Gavin L, Gorbatov S, Gosnell J, Steen T, Vafai A, Zeballos J, Hruslinski J, Cardenas L, Berry A, Getchell J, Quercetti N, Bajracharya G, Billow D, Bloomfield M, Cuko E, Elyaderani MK, Hampton R, Honar H, Khoshknabi D, Kim D, Krahe D, Lew MM, Maheshwer CB, Niazi A, Saha P, Salih A, de Swart RJ, Volio A, Bolkus K, DeAngelis M, Dodson G, Gerritsen J, McEniry B, Mitrev L, Kwofie MK, Belliveau A, Bonazza F, Lloyd V, Panek I, Dabiri J, Chavez C, Craig J, Davidson T, Dietrichs C, Fleetwood C, Foley M, Getto C, Hailes S, Hermes S, Hooper A, Koener G, Kohls K, Law L, Lipp A, Losey A, Nelson W, Nieto M, Rogers P, Rutman S, Scales G, Sebastian B, Stanciu T, Lobel G, Giampiccolo M, Herman D, Kaufman M, Murphy B, Pau C, Puzio T, Veselsky M, Apostle K, Boyer D, Fan BC, Lee S, Lemke M, Merchant R, Moola F, Payne K, Perey B, Viskontas D, Poler M, D'Antonio P, O'Neill G, Abdullah A, Fish-Fuhrmann J, Giska M, Fidkowski C, Guthrie ST, Hakeos W, Hayes L, Hoegler J, Nowak K, Beck J, Cuff J, Gaski G, Haaser S, Holzman M, Malekzadeh AS, Ramsey L, Schulman J, Schwartzbach C, Azefor T, Davani A, Jaberi M, Masear C, Haider SB, Chungu C, Ebrahimi A, Fikry K, Marcantonio A, Shelvan A, Sanders D, Clarke C, Lawendy A, Schwartz G, Garg M, Kim J, Caruci J, Commeh E, Cuevas R, Cuff G, Franco L, Furgiuele D, Giuca M, Allman M, Barzideh O, Cossaro J, D'Arduini A, Farhi A, Gould J, Kafel J, Patel A, Peller A, Reshef H, Safur M, Toscano F, Tedore T, Akerman M, Brumberger E, Clark S, Friedlander R, Jegarl A, Lane J, Lyden JP, Mehta N, Murrell MT, Painter N, Ricci W, Sbrollini K, Sharma R, Steel PAD, Steinkamp M, Weinberg R, Wellman DS, Nader A, Fitzgerald P, Ritz M, Bryson G, Craig A, Farhat C, Gammon B, Gofton W, Harris N, Lalonde K, Liew A, Meulenkamp B, Sonnenburg K, Wai E, Wilkin G, Troxell K, Alderfer ME, Brannen J, Cupitt C, Gerhart S, McLin R, Sheidy J, Yurick K, Chen F, Dragert K, Kiss G, Malveaux H, McCloskey D, Mellender S, Mungekar SS, Noveck H, Sagebien C, Biby L, McKelvy G, Richards A, Abola R, Ayala B, Halper D, Mavarez A, Rizwan S, Choi S, Awad I, Flynn B, Henry P, Jenkinson R, Kaustov L, Lappin E, McHardy P, Singh A, Donnelly J, Gonzalez M, Haydel C, Livelsberger J, Pazionis T, Slattery B, Vazquez-Trejo M, Baratta J, Cirullo M, Deiling B, Deschamps L, Glick M, Katz D, Krieg J, Lessin J, Mojica J, Torjman M, Jin R, Salpeter MJ, Powell M, Simmons J, Lawson P, Kukreja P, Graves S, Sturdivant A, Bryant A, Crump SJ, Verrier M, Green J, Menon M, Applegate R, Arias A, Pineiro N, Uppington J, Wolinsky P, Gunnett A, Hagen J, Harris S, Hollen K, Holloway B, Horodyski MB, Pogue T, Ramani R, Smith C, Woods A, Warrick M, Flynn K, Mongan P, Ranganath Y, Fernholz S, Ingersoll-Weng E, Marian A, Seering M, Sibenaller Z, Stout L, Wagner A, Walter A, Wong C, Orwig D, Goud M, Helker C, Mezenghie L, Montgomery B, Preston P, Schwartz JS, Weber R, Fleisher LA, Mehta S, Stephens-Shields AJ, Dinh C, Chelly JE, Goel S, Goncz W, Kawabe T, Khetarpal S, Monroe A, Shick V, Breidenstein M, Dominick T, Friend A, Mathews D, Lennertz R, Sanders R, Akere H, Balweg T, Bo A, Doro C, Goodspeed D, Lang G, Parker M, Rettammel A, Roth M, White M, Whiting P, Allen BFS, Baker T, Craven D, McEvoy M, Turnbo T, Kates S, Morgan M, Willoughby T, Weigel W, Auyong D, Fox E, Welsh T, Cusson B, Dobson S, Edwards C, Harris L, Henshaw D, Johnson K, McKinney G, Miller S, Reynolds J, Segal BS, Turner J, VanEenenaam D, Weller R, Lei J, Treggiari M, Akhtar S, Blessing M, Johnson C, Kampp M, Kunze K, O'Connor M, Looke T, Tadros R, Vlassakov K, Cardenas L, Bolkus K, Mitrev L, Kwofie MK, Dabiri J, Lobel G, Poler M, Giska M, Sanders D, Schwartz G, Giuca M, Tedore T, Nader A, Bryson G, Troxell K, Kiss G, Choi S, Powell M, Applegate R, Warrick M, Ranganath Y, Chelly JE, Lennertz R, Sanders R, Allen BFS, Kates S, Weigel W, Li J, Wijeysundera DN, Kheterpal S, Moore RH, Smith AK, Tosi LL, Looke T, Mehta S, Fleisher L, Hruslinski J, Ramsey L, Langlois C, Mezenghie L, Montgomery B, Oduwole S, and Rose T

Subjects
Aged, Analgesics therapeutic use, Anesthesia, General adverse effects, Canada, Female, Humans, Male, Pain, Pain, Postoperative drug therapy, Patient Satisfaction, Anesthesia, Spinal adverse effects, Hip Fractures surgery
Abstract

Background: The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal versus general anesthesia for hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, and patient satisfaction have not yet been reported., Objective: To compare pain, analgesic use, and satisfaction after hip fracture surgery with spinal versus general anesthesia., Design: Preplanned secondary analysis of a pragmatic randomized trial. (ClinicalTrials.gov: NCT02507505)., Setting: 46 U.S. and Canadian hospitals., Participants: Patients aged 50 years or older undergoing hip fracture surgery., Intervention: Spinal or general anesthesia., Measurements: Pain on postoperative days 1 through 3; 60-, 180-, and 365-day pain and prescription analgesic use; and satisfaction with care., Results: A total of 1600 patients were enrolled. The average age was 78 years, and 77% were women. A total of 73.5% (1050 of 1428) of patients reported severe pain during the first 24 hours after surgery. Worst pain over the first 24 hours after surgery was greater with spinal anesthesia (rated from 0 [no pain] to 10 [worst pain imaginable]; mean difference, 0.40 [95% CI, 0.12 to 0.68]). Pain did not differ across groups at other time points. Prescription analgesic use at 60 days occurred in 25% (141 of 563) and 18.8% (108 of 574) of patients assigned to spinal and general anesthesia, respectively (relative risk, 1.33 [CI, 1.06 to 1.65]). Satisfaction was similar across groups., Limitation: Missing outcome data and multiple outcomes assessed., Conclusion: Severe pain is common after hip fracture. Spinal anesthesia was associated with more pain in the first 24 hours after surgery and more prescription analgesic use at 60 days compared with general anesthesia., Primary Funding Source: Patient-Centered Outcomes Research Institute .

Published
2022
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