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2. Correction: Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID‑19 infection: insights from a genome‑wide DNA methylation study

Author

Calzari, Luciano, Dragani, Davide Fernando, Zanotti, Lucia, Inglese, Elvira, Danesi, Romano, Cavagnola, Rebecca, Brusati, Alberto, Ranucci, Francesco, Di Blasio, Anna Maria, Persani, Luca, Campi, Irene, De Martino, Sara, Farsetti, Antonella, Barbi, Veronica, Gottardi Zamperla, Michela, Baldrighi, Giulia Nicole, Gaetano, Carlo, Parati, Gianfranco, and Gentilini, Davide

Published
2024
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4. Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study

Author

Calzari, Luciano, Dragani, Davide Fernando, Zanotti, Lucia, Inglese, Elvira, Danesi, Romano, Cavagnola, Rebecca, Brusati, Alberto, Ranucci, Francesco, Di Blasio, Anna Maria, Persani, Luca, Campi, Irene, De Martino, Sara, Farsetti, Antonella, Barbi, Veronica, Gottardi Zamperla, Michela, Baldrighi, Giulia Nicole, Gaetano, Carlo, Parati, Gianfranco, and Gentilini, Davide

Published
2024
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7. Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer

Author

Pecci, Valeria, Troisi, Fabiola, Aiello, Aurora, De Martino, Sara, Carlino, Angela, Fiorentino, Vincenzo, Ripoli, Cristian, Rotili, Dante, Pierconti, Francesco, Martini, Maurizio, Porru, Manuela, Pinto, Francesco, Mai, Antonello, Bassi, Pier Francesco, Grassi, Claudio, Gaetano, Carlo, Pontecorvi, Alfredo, Strigari, Lidia, Farsetti, Antonella, and Nanni, Simona

Published
2024
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14. Epigenetic patterns, accelerated biological aging, and enhanced epigenetic drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study.

Author

Luciano, Calzari, Fernando, Dragani Davide, Lucia, Zanotti, Elvira, Inglese, Romano, Danesi, Rebecca, Cavagnola, Alberto, Brusati, Francesco, Ranucci, Maria, Di Blasio Anna, Luca, Persani, Irene, Campi, Sara, De Martino, Antonella, Farsetti, Veronica, Barbi, Michela, Gottardi Zamperla, Nicole, Baldrighi Giulia, Carlo, Gaetano, Gianfranco, Parati, and Davide, Gentilini

Published
2024
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15. Nitric oxide donor increases umbilical vein blood flow and fetal oxygenation in fetal growth restriction. A pilot study.

Author

Farsetti, Daniele, Pometti, Francesca, Vasapollo, Barbara, Novelli, Gian Paolo, Nardini, Sara, Lupoli, Benedetta, Lees, Christoph, and Valensise, Herbert

Abstract

To evaluate the maternal and fetal hemodynamic effects of treatment with a nitric oxide donor and oral fluid in pregnancies complicated by fetal growth restriction. 30 normotensive participants with early fetal growth restriction were enrolled. 15 participants were treated until delivery with transdermal glyceryl trinitrate and oral fluid intake (Treated group), and 15 comprised the untreated group. All women underwent non-invasive assessment of fetal and maternal hemodynamics and repeat evaluation 2 weeks later. In the treated group, maternal hemodynamics improved significantly after two weeks of therapy compared to untreated participants. Fetal hemodynamics in the treated group showed an increase in umbilical vein diameter by 18.87 % (p < 0.01), in umbilical vein blood flow by 48.16 % (p < 0.01) and in umbilical vein blood flow corrected for estimated fetal weight by 30.03 % (p < 0.01). In the untreated group, the characteristics of the umbilical vein were unchanged compared to baseline. At the same time, the cerebro-placental ratio increased in the treated group, while it was reduced in the untreated group, compared to baseline values. The treated group showed a higher birthweight centile (p = 0.03) and a lower preeclampsia rate (p = 0.04) compared to the untreated group. The combined therapeutic approach with nitric oxide donor and oral fluid intake in fetal growth restriction improves maternal hemodynamics, which becomes more hyperdynamic (volume-dominant). At the same time, in the fetal circuit, umbilical vein flow increased and fetal brain sparing improved. Although a modest sample size, there was less preeclampsia and a higher birthweight suggesting beneficial maternal and fetal characteristics of treatment. • Early fetal growth restriction is characterized by altered maternal hemodynamics. • NO donor improves maternal hemodynamics reducing vascular resistance. • NO donor increases fetal umbilical vein blood flow and fetal oxygenation. • NO donor might reduce the incidence of preeclampsia and improve the birthweight. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Tenoplasty in suspension with or without tendon interposition: A prospective randomized study in the treatment of advanced thumb carpometacarpal arthritis

Author

Fidanza, Andrea, Rovere, Giuseppe, Colafarina, Olivo, Chiarolanza, Fabrizio, Fulchignoni, Camillo, Smakaj, Amarildo, Liuzza, Francesco, Farsetti, Pasquale, and Logroscino, Giandomenico

Abstract

The aim of this prospective and randomized study is to analyze and compare the outcomes of two surgical techniques for trapeziometacarpal joint osteoarthritis (Eaton-Littler grade III and IV).

Published
2024
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29. Intramedullary Nailing for Lower Limb Polyostotic Fibrous Dysplasia in Children: A Long-term Follow-up Study

Author

Ippolito, E, Farsetti, P, Caterini, R, Micciulli, E, Gorgolini, G, and Ruzzini, L

Subjects
Adult, Adolescent, Fibrous Dysplasia of Bone, General Medicine, Bone Nails, Fibrous Dysplasia, Polyostotic, Fracture Fixation, Intramedullary, Settore MED/33, Fractures, Bone, Young Adult, Treatment Outcome, Lower Extremity, Pediatrics, Perinatology and Child Health, Humans, Orthopedics and Sports Medicine, Femur, Child, Femoral Fractures, Follow-Up Studies
Abstract

In children, intramedullary nailing (IN) has been proposed as the best treatment when the femur and tibia are totally affected by fibrous dysplasia (FD). However, in younger children IN must be repeated to maintain stabilization of the affected skeletal segment during growth. We report the long-term results in a cohort of patients in whom more than two-thirds of cases had IN repeated during growth.Twenty-nine femurs and 14 tibias totally affected by FD were treated by IN in 21 patients with polyostotic FD and McCune-Albright syndrome. Thirteen patients with 35 femoral and tibial deformities had a painful limp whereas 8 presented fractures. The patients had their first IN at a mean age of 9.26±2.68 years (range: 4 to 14 y). IN was repeated during growth in the younger patients, and all the patients underwent a mean of 2.13 femoral and 1.50 tibial IN per limb. The last IN was performed at a mean age of 16.42±1.95 years (range: 11 to 19 y). Titanium elastic nails and adult humeral nails were used in younger children, whereas adult femoral cervicodiaphyseal and interlocking tibial nails were used in older children and adolescents. At the latest follow-up, the patients were evaluated with a clinicoradiographic scale. All the data were statistically analyzed.The mean length of follow-up from the last IN was 6.47±3.10 years (range: 3 to 14 y), and the mean age of the patients at follow-up was 22.85±3.53 years (range: 14 to 29 y) when lower limbs were fully grown in all but 1 patient. Satisfactory long-term results were obtained in about 81% of our patients, while complications occurred in 32.5% of the 43 cases.Lower limb IN-that was repeated in younger children during growth-provided satisfactory long-term results in most of our patients, with fracture and deformity prevention and pain control, regardless of the high rate of complications that mainly affected the femoral cases. Missing scheduled follow-ups was the main predictor of a poor result.Level IV-case series.

Published
2022
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30. An update on osteochondritis dissecans of the knee

Author

Tudisco, C, Bernardi, G, Manisera, Mt, De Maio, F, Gorgolini, G, and Farsetti, P

Subjects
Settore MED/33, osteoarthritis, knee, articular cartilage, Orthopedics and Sports Medicine, General, Osteochondritis dissecans
Abstract

Osteochondritis dissecans of the knee (OCD) is a multifactorial pathology in where repetitive microtrauma plays a central role in the etiopathogenesis. Knee MRI is indicated in young, active patients who have knee pain and/or effusion, to make an early diagnosis and decide about treatment, according essentially to the MRI stability signs. The choice of treatment should be also tailored, based on the patient’s skeletal maturity, as well as the size and location of the lesion. Conservative treatment with restricting sports activities is the first line treatment and often sufficient to ensure healing in patients with open physes. Surgical treatment depends on the persistence of symptoms after 6 months of conservative treatment and/or based on the development of signs of instability of the lesion. Stable lesions with intact articular cartilage may be treated by drilling of the subchondral bone aiming to stimulate vascular ingrowth and subchondral bone healing. Every attempt should be made to retain the osteochondral fragment when possible. Instable lesions should be fixed or “replaced” with salvage procedures to prevent the onset of early osteoarthritis in this young population. Furthers studies are needed to improve the knowledge and optimizing non-operative and surgical treatment and to develop noninvasive diagnostic tools to predict with more accuracy the fragment’s stability.

Published
2022
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33. Treatment of olecranon fractures in childhood: A systematic review

Author

De Maio, F, Gorgolini, G, Caterini, A, Luciano, C, Covino, D, and Farsetti, P

Subjects
surgery, Settore MED/33, pediatric, children, fracture, Pediatrics, Perinatology and Child Health, upper limb, olecranon, surgical treament, surgical procedures
Abstract

BackgroundLiterature over the last 20 years provides evidence for a surgical treatment of displaced olecranon fractures in children, this is usually obtained with commonly proposed methods, although there is no general agreement about the best recommended technique.AimIdentifying the best surgical technique in displaced olecranon fractures in children and the role of associated fractures in the prognosis of these lesions, by analyzing the most relevant studies on this topic.MethodsA literature search was performed in MEDLINE database and Scopus database. Articles reporting clinical outcomes of pediatric patients affected by olecranon fractures treated surgically were identified.ResultsThe initial search produced 111 studies, with 8 fulfilling the eligibility criteria of our study. Selected articles (2002–2022) included 122 patients overall.ConclusionDisplaced olecranon fractures, occurring during skeletal growth and surgically treated, generally have good results, although we are unable to recommend the best surgical treatment based on our review. In most cases, they are intra-articular fractures; thus, the overall goal is to get an anatomic reduction that in some cases cannot be obtained by percutaneous techniques. Tension band suture is the preferred device, although it is not recommended in adolescence for the high risk of fixation failure. Associated lesions may affect results.

Published
2022
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35. Anacardic acid and thyroid hormone enhance cardiomyocytes production from undifferentiated mouse ES cells along functionally distinct pathways

Author

Re, Agnese, Nanni, Simona, Aiello, Aurora, Granata, Serena, Colussi, Claudia, Campostrini, Giulia, Spallotta, Francesco, Mattiussi, Stefania, Pantisano, Valentina, D’Angelo, Carmen, Biroccio, Annamaria, Rossini, Alessandra, Barbuti, Andrea, DiFrancesco, Dario, Trimarchi, Francesco, Pontecorvi, Alfredo, Gaetano, Carlo, and Farsetti, Antonella

Published
2016
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38. Early return to activity of daily living after total hip arthroplasty: a systematic review and meta-analysis

Author

Zampogna, Biagio, Papalia, Giuseppe Francesco, Parisi, Francesco Rosario, Luciano, Claudia, Gregori, Pietro, Vorini, Ferruccio, Marinozzi, Andrea, Farsetti, Pasquale, and Papalia, Rocco

Abstract

Background: Total hip arthroplasty (THA) is an orthopaedic procedure that improves the quality of life in patients suffering from hip pain related to osteoarthritis, fractures, and avascular osteonecrosis of the femoral head. Different surgical approaches can be used for THA leading to different recovery times. Because of the lowering medium age of people undergoing THA, it is important to focus on the earlier return of physiological activity after surgery.Aim: To evaluate the best approach for THA in terms of earlier return to activity.Method: Studies comparing the postoperative outcomes in patients who underwent THA through different approaches were analysed focusing on patients’ self-reported outcomes, ADL score and UCLA activity score with a short follow-up.Results: A total of 1990 articles were identified in the search, and 14 met the inclusion criteria. The Review Manager software version 5.4 was used to conduct a meta-analysis to compare the direct anterior (DAA) and posterior (PA) approaches, which are the most adopted approaches. An earlier return to walk without aids and to independent ADLs were reported with DAA, but without statistical significance (respectively p=0.06 and p=0.10). The time to return to drive was similar among the 2 groups (p=0.88). The return to work was faster with PA, but no statistical significance was reported (p=0.47).Conclusions: Further studies are needed with a larger number of patients, that present homogeneous outcomes, follow-ups and rehabilitation programmes, and that compare similar surgical approaches to assess the early return to activity of daily living after THA.

Published
2023
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49. Heterotopic ossification around the lesser trochanter of the femur simulating a malignant lesion. A case report with long-term follow-up and revision of literature

Author

Caterini, A, Potenza, V, De Maio, F, Marsiolo, M, Corsi, A, and Farsetti, P

Subjects
Adult, tumor, hip, lesser trochanter, Ossification, Heterotopic, Settore MED/33, Radiography, heterotopic ossification, Humans, Female, Femur, Range of Motion, Articular, Follow-Up Studies
Abstract

We report the case of a 28-year-old female who complained of groin pain and restricted range of motion of the hip for the previous two months. A plain radiograph, CT scan and MRI of the pelvis showed a bone mass of uncertain origin around the lesser trochanter, simulating malignancy. An open biopsy was performed to obtain a correct diagnosis. The histological examination excluded a malignant lesion. Two months later, the mass was surgically excised and at follow-up, 9 years after surgery, the patient was completely asymptomatic, without any radiographic sign of recurrence. This is a rare case of heterotopic ossification of the proximal part of the femur, that appeared without any significant trauma or other predisposing risk factors; because the lesion led us to suspect a malignant disease, an open biopsy was needed to make the diagnosis. From an accurate review of the literature, heterotopic ossifications mimicking a malignant lesion that appeared without any predisposing factors are extremely rare.

Published
2020

50. Infection rate of intramedullary nailing for treatment of lower limb polyostotic fibrous dysplasia

Author

Giulio Gorgolini, Efremov, K., Maio, F., Potenza, V., Caterini, R., Ippolito, E., and Farsetti, P.

Subjects
Settore MED/33, Polyostotic, Treatment Outcome, Lower Extremity, Tibia, Humans, Femur, Bone Nails, Fibrous Dysplasia, Polyostotic, Femoral Fractures, Fibrous Dysplasia, Fracture Fixation, Intramedullary
Abstract

Polyostotic fibrous dysplasia (PFD) generally cause deformities and fractures of femur and tibia and surgery is often required. The current surgical treatment for deformities is based on single or multiple osteotomies followed by stabilization with intramedullary nails, which are commonly used also for fractures. One of the most common surgical complications of intramedullary nailing is represented by surgical site infection with possible extension to the whole skeletal segment. In the present study we evaluated the incidence of surgical site infections in 44 patients affected by PFD in which 91 femurs or tibiae underwent intramedullary nailing to treat deformities or fractures. We never observed any infection of the operated femurs or tibiae until the final follow-up. The only post surgical infection was present in a patient with monomelic involvement at the contralateral non affected limb, which was surgically treated for limb length inequality, by femur shortening osteotomy stabilized by an intramedullary nail. The most likely hypothesis to explain the complete absence of infections in these patients may be related to the high local concentration of prophylactic antibiotic in the highly vascularized fibrodysplastic bone.

Published
2020

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