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1. Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Author

Pathologie Groep Derksen, Cancer, Pathologie, Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R, Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E, Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien Hm, Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, Ter Hoeve, Natalie D, Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne-Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick Wb, van Diest, Paul J, Vincent-Salomon, Anne, Kreipe, Hans, Pathologie Groep Derksen, Cancer, Pathologie, Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R, Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E, Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien Hm, Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, Gonzalez, Claudia Aura, Ter Hoeve, Natalie D, Kooreman, Loes, Krech, Till, Kristiansen, Glen, Kulka, Janina, Laenger, Florian, Lafos, Marcel, Lehmann, Ulrich, Martin-Martinez, Maria Dolores, Mueller, Sophie, Pelz, Enrico, Raap, Mieke, Ravarino, Alberto, Reineke-Plaass, Tanja, Schaumann, Nora, Schelfhout, Anne-Marie, De Schepper, Maxim, Schlue, Jerome, Van de Vijver, Koen, Waelput, Wim, Wellmann, Axel, Graeser, Monika, Gluz, Oleg, Kuemmel, Sherko, Nitz, Ulrike, Harbeck, Nadia, Desmedt, Christine, Floris, Giuseppe, Derksen, Patrick Wb, van Diest, Paul J, Vincent-Salomon, Anne, and Kreipe, Hans

Published
2022

2. First report from the German COVID-19 autopsy registry

Author

von Stillfried, Saskia, primary, Bülow, Roman David, additional, Röhrig, Rainer, additional, Boor, Peter, additional, Böcker, Jana, additional, Schmidt, Jens, additional, Tholen, Pauline, additional, Majeed, Raphael, additional, Wienströer, Jan, additional, Weis, Joachim, additional, Bremer, Juliane, additional, Knüchel, Ruth, additional, Breitbach, Anna, additional, Cacchi, Claudio, additional, Freeborn, Benita, additional, Wucherpfennig, Sophie, additional, Spring, Oliver, additional, Braun, Georg, additional, Römmele, Christoph, additional, Märkl, Bruno, additional, Claus, Rainer, additional, Dhillon, Christine, additional, Schaller, Tina, additional, Sipos, Eva, additional, Hirschbühl, Klaus, additional, Wittmann, Michael, additional, Kling, Elisabeth, additional, Kröncke, Thomas, additional, Heppner, Frank L., additional, Meinhardt, Jenny, additional, Radbruch, Helena, additional, Streit, Simon, additional, Horst, David, additional, Elezkurtaj, Sefer, additional, Quaas, Alexander, additional, Göbel, Heike, additional, Hansen, Torsten, additional, Titze, Ulf, additional, Lorenzen, Johann, additional, Reuter, Thomas, additional, Woloszyn, Jaroslaw, additional, Baretton, Gustavo, additional, Hilsenbeck, Julia, additional, Meinhardt, Matthias, additional, Pablik, Jessica, additional, Sommer, Linna, additional, Holotiuk, Olaf, additional, Meinel, Meike, additional, Mahlke, Nina, additional, Esposito, Irene, additional, Crudele, Graziano, additional, Seidl, Maximilian, additional, Amann, Kerstin U., additional, Coras, Roland, additional, Hartmann, Arndt, additional, Eichhorn, Philip, additional, Haller, Florian, additional, Lange, Fabienne, additional, Schmid, Kurt Werner, additional, Ingenwerth, Marc, additional, Rawitzer, Josefine, additional, Theegarten, Dirk, additional, Birngruber, Christoph G., additional, Wild, Peter, additional, Gradhand, Elise, additional, Smith, Kevin, additional, Werner, Martin, additional, Schilling, Oliver, additional, Acker, Till, additional, Gattenlöhner, Stefan, additional, Stadelmann, Christine, additional, Metz, Imke, additional, Franz, Jonas, additional, Stork, Lidia, additional, Thomas, Carolina, additional, Zechel, Sabrina, additional, Ströbel, Philipp, additional, Wickenhauser, Claudia, additional, Fathke, Christine, additional, Harder, Anja, additional, Ondruschka, Benjamin, additional, Dietz, Eric, additional, Edler, Carolin, additional, Fitzek, Antonia, additional, Fröb, Daniela, additional, Heinemann, Axel, additional, Heinrich, Fabian, additional, Klein, Anke, additional, Kniep, Inga, additional, Lohner, Larissa, additional, Möbius, Dustin, additional, Püschel, Klaus, additional, Schädler, Julia, additional, Schröder, Ann-Sophie, additional, Sperhake, Jan-Peter, additional, Aepfelbacher, Martin, additional, Fischer, Nicole, additional, Lütgehetmann, Marc, additional, Pfefferle, Susanne, additional, Glatzel, Markus, additional, Krasemann, Susanne, additional, Matschke, Jakob, additional, Jonigk, Danny, additional, Werlein, Christopher, additional, Schirmacher, Peter, additional, Domke, Lisa Maria, additional, Hartmann, Laura, additional, Klein, Isabel Madeleine, additional, Schwab, Constantin, additional, Röcken, Christoph, additional, Friemann, Johannes, additional, Langer, Dorothea, additional, Roth, Wilfried, additional, Strobl, Stephanie, additional, Rudelius, Martina, additional, Stock, Konrad Friedrich, additional, Weichert, Wilko, additional, Delbridge, Claire, additional, Kasajima, Atsuko, additional, Kuhn, Peer-Hendrik, additional, Slotta-Huspenina, Julia, additional, Weirich, Gregor, additional, Barth, Peter, additional, Wardelmann, Eva, additional, Evert, Katja, additional, Büttner, Andreas, additional, Manhart, Johannes, additional, Nigbur, Stefan, additional, Bittmann, Iris, additional, Fend, Falko, additional, Bösmüller, Hans, additional, Granai, Massimo, additional, Klingel, Karin, additional, Warm, Verena, additional, Steinestel, Konrad, additional, Umathum, Vincent Gottfried, additional, Rosenwald, Andreas, additional, Kurz, Florian, additional, and Vogt, Niklas, additional

Published
2022
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3. Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure : a nationwide register study report

Author

von Stillfried, Saskia, Bülow, Roman David, Wienströer, Jan, Pfefferle, Susanne, Glatzel, Markus, Krasemann, Susanne, Matschke, Jakob, Jonigk, Danny, Werlein, Christopher, Schirmacher, Peter, Domke, Lisa Maria, Hartmann, Laura, Klein, Isabel Madeleine, Weis, Joachim, Schwab, Constantin, Röcken, Christoph, Friemann, Johannes, Langer, Dorothea, Roth, Wilfried, Strobl, Stephanie, Rudelius, Martina, Stock, Konrad Friedrich, Weichert, Wilko, Delbridge, Claire, Bremer, Juliane, Kasajima, Atsuko, Kuhn, Peer-Hendrik, Slotta-Huspenina, Julia, Weirich, Gregor, Barth, Peter, Wardelmann, Eva, Schnepper, Alexander, Evert, Katja, Büttner, Andreas, Manhart, Johannes, Knüchel, R., Nigbur, Stefan, Bittmann, Iris, Fend, Falko, Bösmüller, Hans, Granai, Massimo, Klingel, Karin, Warm, Verena, Steinestel, Konrad, Umathum, Vincent Gottfried, Rosenwald, Andreas, Breitbach, Anna, Kurz, Florian, Vogt, Niklas, Cacchi, Claudio, Freeborn, Benita, Wucherpfennig, Sophie, Spring, Oliver, Braun, Georg, Röhrig, Rainer, Römmele, Christoph, Märkl, Bruno, Claus, Rainer, Dhillon, Christine, Schaller, Tina, Sipos, Eva, Hirschbühl, Klaus, Wittmann, Michael, Kling, Elisabeth, Kröncke, Thomas, Meybohm, Patrick, Heppner, Frank L., Meinhardt, Jenny, Radbruch, Helena, Streit, Simon, Horst, David, Elezkurtaj, Sefer, Quaas, Alexander, Göbel, Heike, Hansen, Torsten, Titze, Ulf, Boor, Peter, Lorenzen, Johann, Reuter, Thomas, Woloszyn, Jaroslaw, Baretton, Gustavo, Hilsenbeck, Julia, Meinhardt, Matthias, Pablik, Jessica, Sommer, Linna, Holotiuk, Olaf, Meinel, Meike, DeRegCOVID Collaborators, Mahlke, Nina, Esposito, Irene, Crudele, Graziano, Seidl, Maximilian, Amann, Kerstin U., Coras, Roland, Hartmann, Arndt, Eichhorn, Philip, Haller, Florian, Lange, Fabienne, Böcker, Jana, Schmid, Kurt Werner, Ingenwerth, Marc, Rawitzer, Josefine, Theegarten, Dirk, Birngruber, Christoph G., Wild, Peter, Gradhand, Elise, Smith, Kevin, Werner, Martin, Schilling, Oliver, Schmidt, Jens, Acker, Till, Gattenlöhner, Stefan, Stadelmann, Christine, Metz, Imke, Franz, Jonas, Stork, Lidia, Thomas, Carolina, Zechel, Sabrina, Ströbel, Philipp, Wickenhauser, Claudia, Tholen, Pauline, Fathke, Christine, Harder, Anja, Ondruschka, Benjamin, Dietz, Eric, Edler, Carolin, Fitzek, Antonia, Fröb, Daniela, Heinemann, Axel, Heinrich, Fabian, Klein, Anke, Majeed, Raphael, Kniep, Inga, Lohner, Larissa, Möbius, Dustin, Püschel, Klaus, Schädler, Julia, Schröder, Ann-Sophie, Sperhake, Jan-Peter, Aepfelbacher, Martin, Fischer, Nicole, and Lütgehetmann, Marc

Subjects
ddc:610
Published
2022

4. Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma

Author

Christgen, Matthias, primary, Kandt, Leonie Donata, additional, Antonopoulos, Wiebke, additional, Bartels, Stephan, additional, Bockstal, Mieke R, additional, Bredt, Martin, additional, Brito, Maria Jose, additional, Christgen, Henriette, additional, Colpaert, Cecile, additional, Cserni, Bálint, additional, Cserni, Gábor, additional, Daemmrich, Maximilian E, additional, Danebrock, Raihanatou, additional, Dedeurwaerdere, Franceska, additional, Deurzen, Carolien HM, additional, Erber, Ramona, additional, Fathke, Christine, additional, Feist, Henning, additional, Fiche, Maryse, additional, Gonzalez, Claudia Aura, additional, Hoeve, Natalie D, additional, Kooreman, Loes, additional, Krech, Till, additional, Kristiansen, Glen, additional, Kulka, Janina, additional, Laenger, Florian, additional, Lafos, Marcel, additional, Lehmann, Ulrich, additional, Martin‐Martinez, Maria Dolores, additional, Mueller, Sophie, additional, Pelz, Enrico, additional, Raap, Mieke, additional, Ravarino, Alberto, additional, Reineke‐Plaass, Tanja, additional, Schaumann, Nora, additional, Schelfhout, Anne‐Marie, additional, Schepper, Maxim, additional, Schlue, Jerome, additional, Van de Vijver, Koen, additional, Waelput, Wim, additional, Wellmann, Axel, additional, Graeser, Monika, additional, Gluz, Oleg, additional, Kuemmel, Sherko, additional, Nitz, Ulrike, additional, Harbeck, Nadia, additional, Desmedt, Christine, additional, Floris, Giuseppe, additional, Derksen, Patrick WB, additional, Diest, Paul J, additional, Vincent‐Salomon, Anne, additional, and Kreipe, Hans, additional

Published
2021
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5. Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma.

Author

Christgen, Matthias, Kandt, Leonie Donata, Antonopoulos, Wiebke, Bartels, Stephan, Van Bockstal, Mieke R, Bredt, Martin, Brito, Maria Jose, Christgen, Henriette, Colpaert, Cecile, Cserni, Bálint, Cserni, Gábor, Daemmrich, Maximilian E, Danebrock, Raihanatou, Dedeurwaerdere, Franceska, van Deurzen, Carolien HM, Erber, Ramona, Fathke, Christine, Feist, Henning, Fiche, Maryse, and Gonzalez, Claudia Aura

Subjects
LOBULAR carcinoma, COHEN'S kappa coefficient (Statistics), MISSENSE mutation, HORMONE receptors, CADHERINS
Abstract

Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly driven by loss of E‐cadherin expression. Correct classification of BC as ILC is important for patient treatment. This study assessed the degree of agreement among pathologists for the diagnosis of ILC. Two sets of hormone receptor (HR)‐positive/HER2‐negative BCs were independently reviewed by participating pathologists. In set A (61 cases), participants were provided with hematoxylin/eosin (HE)‐stained sections. In set B (62 cases), participants were provided with HE‐stained sections and E‐cadherin immunohistochemistry (IHC). Tumor characteristics were balanced. Participants classified specimens as non‐lobular BC versus mixed BC versus ILC. Pairwise inter‐observer agreement and agreement with a pre‐defined reference diagnosis were determined with Cohen's kappa statistics. Subtype calls were correlated with molecular features, including CDH1/E‐cadherin mutation status. Thirty‐five pathologists completed both sets, providing 4,305 subtype calls. Pairwise inter‐observer agreement was moderate in set A (median κ = 0.58, interquartile range [IQR]: 0.48–0.66) and substantial in set B (median κ = 0.75, IQR: 0.56–0.86, p < 0.001). Agreement with the reference diagnosis was substantial in set A (median κ = 0.67, IQR: 0.57–0.75) and almost perfect in set B (median κ = 0.86, IQR: 0.73–0.93, p < 0.001). The median frequency of CDH1/E‐cadherin mutations in specimens classified as ILC was 65% in set A (IQR: 56–72%) and 73% in set B (IQR: 65–75%, p < 0.001). Cases with variable subtype calls included E‐cadherin‐positive ILCs harboring CDH1 missense mutations, and E‐cadherin‐negative ILCs with tubular elements and focal P‐cadherin expression. ILCs with trabecular growth pattern were often misclassified as non‐lobular BC in set A but not in set B. In conclusion, subtyping of BC as ILC achieves almost perfect agreement with a pre‐defined reference standard, if assessment is supported by E‐cadherin IHC. CDH1 missense mutations associated with preserved E‐cadherin protein expression, E‐ to P‐cadherin switching in ILC with tubular elements, and trabecular ILC were identified as potential sources of discordant classification. [ABSTRACT FROM AUTHOR]

Published
2022
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7. Comparison of six breast cancer classifiers using qPCR

Author

Berchtold, Evi, primary, Vetter, Martina, additional, Gündert, Melanie, additional, Csaba, Gergely, additional, Fathke, Christine, additional, Ulbrich, Susanne E, additional, Thomssen, Christoph, additional, Zimmer, Ralf, additional, and Kantelhardt, Eva J, additional

Published
2019
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8. Survival of breast cancer patients in rural Ethiopia

Author

Eber-Schulz, Pia, primary, Tariku, Wakuma, additional, Reibold, Christian, additional, Addissie, Adamu, additional, Wickenhauser, Claudia, additional, Fathke, Christine, additional, Hauptmann, Steffen, additional, Jemal, Ahmedin, additional, Thomssen, Christoph, additional, and Kantelhardt, Eva Johanna, additional

Published
2018
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9. First report from the German COVID-19 autopsy registry

Author

Saskia von Stillfried, Roman David Bülow, Rainer Röhrig, Peter Boor, Jana Böcker, Jens Schmidt, Pauline Tholen, Raphael Majeed, Jan Wienströer, Joachim Weis, Juliane Bremer, Ruth Knüchel, Anna Breitbach, Claudio Cacchi, Benita Freeborn, Sophie Wucherpfennig, Oliver Spring, Georg Braun, Christoph Römmele, Bruno Märkl, Rainer Claus, Christine Dhillon, Tina Schaller, Eva Sipos, Klaus Hirschbühl, Michael Wittmann, Elisabeth Kling, Thomas Kröncke, Frank L. Heppner, Jenny Meinhardt, Helena Radbruch, Simon Streit, David Horst, Sefer Elezkurtaj, Alexander Quaas, Heike Göbel, Torsten Hansen, Ulf Titze, Johann Lorenzen, Thomas Reuter, Jaroslaw Woloszyn, Gustavo Baretton, Julia Hilsenbeck, Matthias Meinhardt, Jessica Pablik, Linna Sommer, Olaf Holotiuk, Meike Meinel, Nina Mahlke, Irene Esposito, Graziano Crudele, Maximilian Seidl, Kerstin U. Amann, Roland Coras, Arndt Hartmann, Philip Eichhorn, Florian Haller, Fabienne Lange, Kurt Werner Schmid, Marc Ingenwerth, Josefine Rawitzer, Dirk Theegarten, Christoph G. Birngruber, Peter Wild, Elise Gradhand, Kevin Smith, Martin Werner, Oliver Schilling, Till Acker, Stefan Gattenlöhner, Christine Stadelmann, Imke Metz, Jonas Franz, Lidia Stork, Carolina Thomas, Sabrina Zechel, Philipp Ströbel, Claudia Wickenhauser, Christine Fathke, Anja Harder, Benjamin Ondruschka, Eric Dietz, Carolin Edler, Antonia Fitzek, Daniela Fröb, Axel Heinemann, Fabian Heinrich, Anke Klein, Inga Kniep, Larissa Lohner, Dustin Möbius, Klaus Püschel, Julia Schädler, Ann-Sophie Schröder, Jan-Peter Sperhake, Martin Aepfelbacher, Nicole Fischer, Marc Lütgehetmann, Susanne Pfefferle, Markus Glatzel, Susanne Krasemann, Jakob Matschke, Danny Jonigk, Christopher Werlein, Peter Schirmacher, Lisa Maria Domke, Laura Hartmann, Isabel Madeleine Klein, Constantin Schwab, Christoph Röcken, Johannes Friemann, Dorothea Langer, Wilfried Roth, Stephanie Strobl, Martina Rudelius, Konrad Friedrich Stock, Wilko Weichert, Claire Delbridge, Atsuko Kasajima, Peer-Hendrik Kuhn, Julia Slotta-Huspenina, Gregor Weirich, Peter Barth, Eva Wardelmann, Katja Evert, Andreas Büttner, Johannes Manhart, Stefan Nigbur, Iris Bittmann, Falko Fend, Hans Bösmüller, Massimo Granai, Karin Klingel, Verena Warm, Konrad Steinestel, Vincent Gottfried Umathum, Andreas Rosenwald, Florian Kurz, Niklas Vogt, Weis, Joachim, Glatzel, Markus, Krasemann, Susanne, Matschke, Jakob, Jonigk, Danny, Werlein, Christopher, Schirmacher, Peter, Domke, Lisa Maria, Hartmann, Laura, Klein, Isabel Madeleine, Schwab, Constantin, Bremer, Juliane, Röcken, Christoph, Friemann, Johannes, Langer, Dorothea, Roth, Wilfried, Strobl, Stephanie, Rudelius, Martina, Stock, Konrad Friedrich, Weichert, Wilko, Delbridge, Claire, Kasajima, Atsuko, Knüchel-Clarke, Ruth, Kuhn, Peer-Hendrik, Slotta-Huspenina, Julia, Weirich, Gregor, Barth, Peter, Wardelmann, Eva, Evert, Katja, Büttner, Andreas, Manhart, Johannes, Nigbur, Stefan, Bittmann, Iris, Breitbach, Anna, Fend, Falko, Bösmüller, Hans, Granai, Massimo, Klingel, Karin, Warm, Verena, Steinestel, Konrad, Umathum, Vincent Gottfried, Rosenwald, Andreas, Kurz, Florian, Vogt, Niklas, Cacchi, Claudio, Freeborn, Benita, Wucherpfennig, Sophie, Spring, Oliver, Braun, Georg, Römmele, Christoph, Märkl, Bruno, Claus, Rainer, Dhillon, Christine, Schaller, Tina, Sipos, Eva, Hirschbühl, Klaus, Wittmann, Michael, Kling, Elisabeth, Kröncke, Thomas, Heppner, Frank L., Meinhardt, Jenny, Radbruch, Helena, Streit, Simon, Horst, David, Elezkurtaj, Sefer, Quaas, Alexander, Göbel, Heike, Hansen, Torsten, Titze, Ulf, Lorenzen, Johann, Reuter, Thomas, Woloszyn, Jaroslaw, Baretton, Gustavo, Hilsenbeck, Julia, Meinhardt, Matthias, Pablik, Jessica, Sommer, Linna, Holotiuk, Olaf, Meinel, Meike, Mahlke, Nina, Böcker, Jana, Esposito, Irene, Crudele, Graziano, Seidl, Maximilian, Amann, Kerstin U., Coras, Roland, Hartmann, Arndt, Eichhorn, Philip, Haller, Florian, Lange, Fabienne, Schmid, Kurt Werner, Schmidt, Jens, Ingenwerth, Marc, Rawitzer, Josefine, Theegarten, Dirk, Birngruber, Christoph G., Wild, Peter, Gradhand, Elise, Smith, Kevin, Werner, Martin, Schilling, Oliver, Acker, Till, Tholen, Pauline, Gattenlöhner, Stefan, Stadelmann, Christine, Metz, Imke, Franz, Jonas, Stork, Lidia, Thomas, Carolina, Zechel, Sabrina, Ströbel, Philipp, Wickenhauser, Claudia, Fathke, Christine, Majeed, Raphael, Harder, Anja, Ondruschka, Benjamin, Dietz, Eric, Edler, Carolin, Fitzek, Antonia, Fröb, Daniela, Heinemann, Axel, Heinrich, Fabian, Klein, Anke, Kniep, Inga, Wienströer, Jan, Lohner, Larissa, Möbius, Dustin, Püschel, Klaus, Schädler, Julia, Schröder, Ann-Sophie, Sperhake, Jan-Peter, Aepfelbacher, Martin, Fischer, Nicole, Lütgehetmann, Marc, and Pfefferle, Susanne

Subjects
Oncology, Health Policy, Internal Medicine, Medizin, ddc:610
Abstract

The lancet / Regional health. Europe 15, 100330 (2022). doi:10.1016/j.lanepe.2022.100330, Published by Elsevier, [Amsterdam]

Published
2022

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