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Your search keyword '"Fauchère, Florent"' showing total 8 results
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8 results on '"Fauchère, Florent"'

1. Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Published
2022
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2. Tolerance induction through early feeding to prevent food allergy in infants with eczema (TEFFA): rationale, study design, and methods of a randomized controlled trial

Author

Kalb, Birgit, Meixner, Lara, Trendelenburg, Valérie, Unterleider, Nathalie, Dobbertin-Welsch, Josefine, Heller, Stephanie, Dölle-Bierke, Sabine, Roll, Stephanie, Lau, Susanne, Lee, Young-Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Worm, Margitta, and Beyer, Kirsten

Published
2022
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3. Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation

Author

Kemmler, Emmanuel, Braun, Julian, Fauchère, Florent, Dölle-Bierke, Sabine, Beyer, Kirsten, Preissner, Robert, Worm, Margitta, and Banerjee, Priyanka

Abstract

Peanut allergy is majorly related to severe food induced allergic reactions. Several food including cow’s milk, hen’s eggs, soy, wheat, peanuts, tree nuts (walnuts, hazelnuts, almonds, cashews, pecans and pistachios), fish and shellfish are responsible for more than 90 % of food allergies. Here, we provide promising insights using a large-scale data-driven analysis, comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts, tree nuts (walnuts, almonds, cashews, pecans and pistachios) and soybean. Additionally, we have analysed the chemical compositions of peanuts in different processed form raw, boiled and dry-roasted. Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors (PPARs) and its isoform and their interaction with dietary lipids may have significant effect on allergic response. The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

Published
2024
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5. An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium

Author

Worm, Margitta, primary, Alexiou, Aikaterina, additional, Höfer, Veronika, additional, Birkner, Till, additional, Jeanrenaud, Alexander C. S. N., additional, Fauchère, Florent, additional, Pazur, Kristijan, additional, Steinert, Carolin, additional, Arnau‐Soler, Aleix, additional, Banerjee, Priyanka, additional, Diefenbach, Andreas, additional, Dobbertin‐Welsch, Josefine, additional, Dölle‐Bierke, Sabine, additional, Francuzik, Wojciech, additional, Ghauri, Ahla, additional, Heller, Stephanie, additional, Kalb, Birgit, additional, Löber, Ulrike, additional, Marenholz, Ingo, additional, Markó, Lajos, additional, Scheffel, Jörg, additional, Potapenko, Olena, additional, Roll, Stephanie, additional, Lau, Susanne, additional, Lee, Young‐Ae, additional, Braun, Julian, additional, Thiel, Andreas, additional, Babina, Magda, additional, Altrichter, Sabine, additional, Forslund, Sofia Kirke, additional, and Beyer, Kirsten, additional

Published
2022
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6. An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

Author

Worm, Margitta M., Alexiou, Aikaterina, Höfer, Veronika, Birkner, Till, Jeanrenaud, Alexander C.S.N., Fauchère, Florent, Pažur, Kristijan, Steinert, Carolin, Arnau-Soler, Aleix, Banerjee, Priyanka, Diefenbach, Andreas, Dobbertin-Welsch, Josefine, Dölle-Bierke, Sabine, Francuzik, W., Ghauri, Ahla, Heller, Stephanie, Kalb, Birgit, Löber, Ulrike, Marenholz, Ingo, Markó, Lajos, Scheffel, Jörg, Potapenko, Olena, Roll, Stephanie, Lau, Susanne, Lee, Young-ae, Braun, Julian, Thiel, Andreas, Babina, Magda, Altrichter, Sabine, Forslund, Sofia Kirke, Beyer, Kirsten, and Publica

Subjects
food allergy, epigenetics, Cardiovascular and Metabolic Diseases, biomarker, microbiome, peanut allergy
Abstract

Background: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. Methods: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.

Published
2022

7. Additional file 3 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 3. Consent Form (in German).

Published
2022
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8. Additional file 1 of Tolerance induction through non-avoidance to prevent persistent food allergy (TINA) in children and adults with peanut or tree nut allergy: rationale, study design and methods of a randomized controlled trial and observational cohort study

Author

Trendelenburg, Valérie, Dölle-Bierke, Sabine, Unterleider, Nathalie, Alexiou, Aikaterina, Kalb, Birgit, Meixner, Lara, Heller, Stephanie, Lau, Susanne, Lee, Young- Ae, Fauchère, Florent, Braun, Julian, Babina, Magda, Altrichter, Sabine, Birkner, Till, Roll, Stephanie, Dobbertin-Welsch, Josefine, Worm, Margitta, and Beyer, Kirsten

Abstract

Additional file 1. The SPIRIT Checklist.

Published
2022
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