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521 results on '"Fayon, M."'

4. Corrélations phénotype-génotype des patients pédiatriques porteurs de mutations bi-alléliques du gène lié au surfactant ABCA3

Author

Fleury, M., primary, Hadchouel, A., additional, Epaud, R., additional, Benhamida, M., additional, Berteloot, L., additional, Brouard, J., additional, L’Herminé, A. Coulomb, additional, Corvol, H., additional, Cros, P., additional, Delacourt, C., additional, Pointe, H. Ducou le, additional, Dubus, J.C., additional, Egron, C., additional, Fanen, P., additional, Fayon, M., additional, Fletcher, C., additional, Forgeron, A., additional, Giovannini-Chami, L., additional, Jedidi, N., additional, Marguet, C., additional, Rouchaud, A. Masson-, additional, Mazenq, J., additional, Petat, H., additional, Renoux, M.C., additional, Roditis, L., additional, Sileo, C., additional, Thumerelle, C., additional, Vigier, C., additional, Legendre, M., additional, De Becdelièvre, A., additional, Louvrier, C., additional, and Nathan, N., additional

Published
2024
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11. Allergen sensitization patterns in the French COBRAPed cohort

Author

Lejeune, S, primary, Bouazza, N, additional, Roland Nicaise, P, additional, Jolaine, V, additional, Roditis, L, additional, Marguet, C, additional, Houdoin, V, additional, Berger, P, additional, Fayon, M, additional, Dubus, J, additional, Pin, I, additional, Reix, P, additional, Pellan, M, additional, Brouard, J, additional, Chiron, R, additional, Giovannini-Chami, L, additional, De Blic, J, additional, Deschildre, A, additional, and Lezmi, G, additional

Published
2022
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12. Allergen sensitization patterns in the French COBRAPed cohort

Author

Lejeune, S, Bouazza, N, Roland Nicaise, P, Jolaine, V, Roditis, L, Marguet, C, Houdoin, V, Berger, P, Fayon, M, Dubus, J, Pin, I, Reix, P, Pellan, M, Brouard, J, Chiron, R, Giovannini-Chami, L, de Blic, J, Deschildre, A, Lezmi, G, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille], Hôpital Jeanne de Flandre [Lille], Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Aquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] (FHU ACRONIM), CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Pédiatrie - CHRU de Grenoble, CHU Grenoble, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Hôpitaux Pédiatriques de Nice Lenval (CHU-Lenval), Centre Hospitalier Universitaire de Nice (CHU Nice), Université de Nice Sophia-Antipolis (UNSA), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Service de Pneumologie et d'Allergologie Pédiatriques

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2022

14. Recommandations sur l’utilisation des nouveaux outils diagnostiques étiologiques des infections respiratoires basses de l’enfant de plus de trois mois

Author

Dubus, J.-C., Delacourt, C., Marguet, C., Houdouin, V., Pouessel, G., Angoulvant, F., Brouard, J., Derelle, J., Fayon, M., Ferroni, A., Gangneux, J.-P., Hau, I., Le Bourgeois, M., Lorrot, M., Menotti, J., Nathan, N., Vabret, A., Wallet, F., Bonacorsi, S., Cohen, R., de Blic, J., Deschildre, A., Gandemer, V., Pin, I., Labbe, A., Le Roux, P., Martinot, A., and Rammaert, B.

Published
2014
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16. Evaluation of nutritional status and support in children with congenital heart disease

Author

Blasquez, A., Clouzeau, H., Fayon, M., Mouton, J.-B., Thambo, J.-B., Enaud, R., and Lamireau, T.

Subjects
Congenital heart disease -- Statistics, Children -- Diseases, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: The objective of this disease was to determine the prevalence of malnutrition in children with congenital heart disease (CHD). SUBJECTS/METHODS: A total of 125 children with CHD, under 6 months of age, were divided into four groups: no pulmonary hypertension (PH) or cyanosis (group 1, n = 47), isolated cyanosis (group 2, n = 52), isolated PH (group 3, n = 16), and PH and cyanosis (group 4, n = 10). Six children died at 6 months (n = 4), 12 months (n = 1) and 19 months (n = 1). The remaining children were followed-up for 24 months. Prevalence of moderate to severe malnutrition (weight/weight for height < 80%), caloric intake and medications were compared between the four groups. RESULTS: Moderate or severe malnutrition was more frequent in group 4 (100%) compared with others groups (group 1, 20%; group 2,16.7% and group 3, 50%; P < 0.05). Low oral caloric intake was more frequent in group 3 (71.4%) and group 4 (75%) than in group 1 (28%) and 2 (28.6%) (P < 0.05). Food enrichment was practised in half of the children of group 4 and rarely in other groups (group 1, 15.8%; group 2, 8.6% and group 3, 11.1%; P < 0.05). Enteral feeding was used more often in groups 3 (33.3%) and 4 (50%) than in groups 1 (15.8%) or 2 (14.3%; P < 0.05). CONCLUSIONS: Moderate or severe malnutrition is present in 15% of children with CHD, and it is more frequent in case of PH. Half of these children demonstrate low caloric intake, whereas few have proper nutritional support. European Journal of Clinical Nutrition (2016) 70, 528-531; doi: 10.1038/ejcn.2015.209; published online 23 December 2015, INTRODUCTION The incidence of moderate and severe forms of congenital heart disease (CHD) is about 6/1000 live births. (1) Most of the children have normal birth weight, but they develop [...]

Published
2016
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17. Évaluation multicentrique et randomisée de l’impact des conseillers en environnement intérieur sur le contrôle de l’asthme : l’étude ECENVIR

Author

Gangneux, J.P., primary, Morel, H., additional, Blanc, F.X., additional, Bonniaud, P., additional, Boza, G., additional, Briault, A., additional, Brouard, J., additional, Charpin, D., additional, Chenivesse, C., additional, Colas, H., additional, Cottereau, A., additional, Dalampira, G., additional, De Blay, F., additional, Debeillex, X., additional, Dumont, P., additional, Elchehaded, K., additional, Fayon, M., additional, Fry, S., additional, Hullo, E., additional, Leblanc, A., additional, Letreut, J., additional, Magnan, A., additional, Mahay, G., additional, Perotin-Collard, J.M., additional, Pegliasco, H., additional, Pin, I., additional, Pison, C., additional, Rossignoli, N., additional, Siao Him Fa, V., additional, Ziani Bey, H., additional, Com-Ruelle, L., additional, Morcet, J., additional, Oger, E., additional, and Le Cann, P., additional

Published
2022
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24. Telehome monitoring of symptoms and lung function in children with asthma

Author

Rose J, Galodé F, A. A. Dalhoumi, A. Fossati, C. Challier, and Fayon M

Subjects
medicine.medical_specialty, Text mining, genetic structures, business.industry, Internal medicine, Medicine, business, medicine.disease, Lung function, Asthma
Abstract

Background: The ability to perceive bronchial obstruction is variable in asthma. This is one of the main causes of inaccurate asthma control assessment, on which therapeutic strategies are based. Objective: Primary: To evaluate the ability of a clinical and spirometric telemonitoring device to characterize symptom perception profile in asthmatic children. Secondary: To evaluate its impact on asthma management (control, treatment, respiratory function variability) and the acceptability of this telemonitoring system. Method: 26 asthmatic children aged 6-18 years equipped with a portable spirometer and a smartphone application were monitored remotely for 3 months. Clinical and spirometric data were automatically transmitted to a secure internet platform. A medical team contacted the patient to optimize management. Three physicians blindly and independently classified the patients according to their perception profile. The impact of telemonitoring on the quantitative data was assessed at the beginning (T0) and end (T3 months) of telemonitoring, using matched statistical tests. Results: Patients could initially be classified according to their perception profile, with a concordance between the 3 observers of 64% (kappa coefficient: 0.55, 95%CI [0.39; 0.71]). After further discussion, a consensus was reached and resulted in 97% concordance (kappa coefficient: 0.97, 95%CI [0.91; 1.00]). There was a trend towards improvement in the ACT score, and a significant > 40% decrease in FEV1 and PEF variability, with good acceptance of the device. Conclusion: Clinical and spirometric telehome monitoring is applicable and can help define the perception profile of bronchial obstruction in asthmatic children. The device was generally well accepted.

Published
2021

32. La fibroscopie bronchique chez l’enfant: Expertise des centres français de pneumologie pédiatrique

Author

Le Roux, P., de Blic, J., Albertini, M., Bellon, G., Body, G., Brémont, F., Caurier, B., Chomienne, F., Counil, F., Dalphin, L., David, V., Delacourt, C., Deneuville, E., Derelle, J., Deschildre, A., Donato, L., Dubus, J.C., Fayon, M., Garcia, J., Heuzé, L., Houzel, A., Just, J., Labbé, A., Lesbros, D., Mahraoui, C., Malfroot, A., Marguet, C., Monrigal, P., Pautard, J.C., Pin, I., Rayet, I., Sardet, A., Scalbert, M., Siret, D., and Troadec, C.

Published
2004
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36. Évaluation de la qualité de vie des enfants atteints de pneumopathies interstitielles diffuses en France

Author

Lauby, C., primary, Boelle, P.Y., additional, Abou Taam, R., additional, Bessaci, K., additional, Brouard, J., additional, Delacourt, C., additional, Delestrain, C., additional, Deschildre, A., additional, Dubus, J.C., additional, Fayon, M., additional, Giovannini-Chami, L., additional, Houdouin, V., additional, Houzel, A., additional, Marguet, C., additional, Pin, I., additional, Reix, P., additional, Renoux, M.C., additional, Schweitzer, C., additional, Tatopoulos, A., additional, Thumerelle, C., additional, Troussier, F., additional, Wanin, S., additional, Weiss, L., additional, Clement, A., additional, Epaud, R., additional, and Nathan, N., additional

Published
2019
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42. Population pharmacokinetics of ceftazidime in critically ill children: impact of cystic fibrosis.

Author

Bui, S, Facchin, A, Ha, P, Bouchet, S, Leroux, S, Nacka, F, Fayon, M, Jacqz-Aigrain, E, and network of Paediatric Clinical Investigation Centres

Subjects
MONTE Carlo method, CRITICALLY ill children, PHARMACOKINETICS, CYSTIC fibrosis, CEFTAZIDIME, HIV-positive children
Abstract

Background: Pharmacokinetics data on ceftazidime are sparse for the paediatric population, particularly for children with cystic fibrosis (CF) or severe infections.Objectives: To characterize the population pharmacokinetics of ceftazidime in critically ill children, identify covariates that affect drug disposition and evaluate the current dosing regimens.Methods: The study was registered with Clinicaltrials.gov (NCT01344512). Children receiving ceftazidime were selected in 13 French hospitals. Plasma concentrations were determined by UPLC-MS/MS. Population pharmacokinetic analyses were performed using NONMEN software.Results: One hundred and eight patients, aged 28 days to 12 years, with CF (n = 32), haematology and/or oncology disorders (n = 47) or severe infection (n = 29) were included. Ceftazidime was administered by continuous or intermittent infusions; 271 samples were available for analysis. A two-compartment model with first-order elimination and allometric scaling was developed and covariate analysis showed that ceftazidime pharmacokinetics were also significantly affected by CLCR and CF. Ceftazidime clearance was 82% higher in CF than in non-CF patients. Monte Carlo simulations showed that the percentage of target attainment (PTA) for the target of T>MIC = 65% was (i) lower in CF than in non-CF children with intermittent infusions and (ii) higher with continuous than intermittent infusion in all children.Conclusions: The population pharmacokinetics model for ceftazidime in children was influenced by body weight, CLCR and CF. A higher PTA was obtained with continuous versus intermittent infusions. Further studies should explore the benefits of continuous versus intermittent infusion of ceftazidime, including current versus increased doses in CF children. [ABSTRACT FROM AUTHOR]

Published
2020
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49. RECURRENCE OF POMPE DISEASE IN FIRST COUSINS

Author

Didier Lacombe, Thambo, J. B., Fayon, M., Goizet, C., and Guffon, N.

Subjects
Male, Glycogen Storage Disease Type II, Child, Preschool, Infant, Newborn, Humans, Family, Female, Infant, Newborn, Diseases
Abstract

We report on the cases of two first-degree non-consanguineous cousins with infantile-onset Pompe disease, a rare autosomal recessive disease. The first patient developed cardiorespiratory failure at age 1 year. When she was 4 her male cousin developed hypotonia during his first month of life. Both infants had cardiac hypertrophy at diagnosis and shared the c.1927GA missense mutation. Since a first degree cousin of an affected patient has 50 times the risk of developing the disease compared with unrelated infants and since cardiac hypertrophy is constant in affected infants, the combination of cardiac symptoms with a history of Pompe disease in a first degree cousin leads to a very high probability of having the condition. Clinically oriented screening based on simple diagnostic procedures such as echocardiogram and anamnesis could accelerate the initiation of enzyme replacement therapy of the deficient acid α-glucosidase which is critical to restoring cardiac function in affected infants.

Published
2015

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