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Abstract We report the unusual case of a 72-year-old man who developed acute and extensive necrosis of the nasal skin and soft-tissue envelope while undergoing chemotherapy for Waldenstrom's macroglobulinemia, a [...]

Objective  To statistically analyze the long-term results of osteotomy after rhinoplasty.Design  In a consecutive series of 51 patients who underwent reduction rhinoplasty from May 1, 2000, through September 30, 2003, all underwent the same method of bilateral lateral osteotomies, performed by one of us. Twenty patients agreed to participate in this study. The follow-up ranged from 7 to 36 months (mean, 12.6 months). By using preoperative and postoperative photographs, comparisons were made of the change in the dorsal width of the nose (the anterior junction of the nasal bones) and of the ventral width of the nose (where the nasal processes of the maxilla meet the body of the maxilla).Results  There was a significant change (P = .003) in the ventral width of the nose after nasal bone osteotomy. There was no significant change (P = .24) in the dorsal width of the nose.Conclusions  By using this technique of osteotomy, it is possible to narrow the ventral width of the nose with statistical significance. The dorsal width of the nose is maintained in reduction rhinoplasty. To our knowledge, this is the first attempt to quantify the amount of narrowing achieved after nasal osteotomies.

Fall Out: World War II and the Shaping of Postwar Europe. By Peter Calvocoressi. London: Longman, 1997.Green Thought in German Culture. Historical and Contemporary Perspectives. Edited by Colin Riordan. Cardiff: University of Wales Press, 1997. £40 hb.Ökologische Kommunikation in Deutschland. By Karl-Werner Brand, Klaus Eder, Angelika Poferl in collaboration with Josef Deisböck, Marion Dreyer, Reiner Keller and Sven Kesselring. Opladen: Westdeutscher Verlag, 1997. DM 56.Kulturpolitik und Nationale Identität. Kulturpolitik zwischen staatlicher Steuerung und gesellschaftlicher Autonomie. By Klaus Von Beyme. Opladen/Wiesbaden: Westdeutscher Verlag, 1998. DM 48.Öffentliche Kunstförderung zwischen Kunstfreiheitsgarantie und Kulturstaat. By Wolfgang Palm. Berlin: Duncker & Humblot, 1998. DM 98.Education and Society in Germany. By H.-J. Hahn. Oxford, New York: Berg, 1998. £14.99 pb.Politischer Umbruch und Neubeginn in Wismar von 1989 bis 1990. By Sven Abrokat. Hamburg: Krämer Verlag, 1997.Stabilität im Umbruch. Wahlbeständigkeit und Parteienwettbewerb im 'Superwahljahr' 1994. By Richard Stöss. Opladen: Westdeutscher Verlag, 1997. DM 38.Parteiendemokratie in Deutschland. Edited by Oscar W. Gabriel, Oskar Niedermayer and Richard Stöss. Opladen: Westdeutscher Verlag, 1997. DM 54.Die PDS: Profil einer antidemokratischen Partei. By Patrick Moreau. Munich: Hanns-Seidel-Stiftung, 1998.Germany's 'Unity Election': Voters and the Media. By Holli A. Semetko and Klaus Schoenbach. Cresskill, NJ: Hampton Press, 1996.Wahlen in der Bundesrepublik. By Karl-Rudolf Korte. Bonn: Bundeszentrale für politische Bildung, 1998.Party Politics in the New Germany. By Geoffrey K. Roberts. London: Pinter, 1997.Konrad Adenauer. German Politician and Statesman in a Period of War, Revolution and Reconstruction. Vol 2 The Statesman. 1952-1967. By Hans-Peter Schwartz. Oxford: Berghahn Books, 1997.Deutsche Bundesbank und Demokratieprinzip. Eine verfassungsrechtliche Studie zur Bundesbankautonomie vor und nach der dritten Stufe der Europäischen Währungsunion. By Frauke Brosius-Gersdorf. Berlin: Duncker & Humblot 1997. DM 128.Österreich im 20. Jahrhundert Volume 1: Von der Monarchie bis zum Zweiten Weltkrieg. Volume 2: Vom Zweiten Weltkrieg bis zur Gegenwart. Edited by Rolf Steininger and Michael Gehler. Wien: Böhlau, 1997. ATS 380/DM 56 each volume, pb.Öffentliche Verwaltung in Deutschland. Edited by Klaus König and Heinrich Siedentopf. Baden-Baden: Nomos Verlagsgesellschaft, 1997. DM 98.Germany since Unification. The Domestic and External Consequences. Edited by Klaus Larres. Basingstoke and New York: MacMillan Press, 1998.The Economics of German Unification: An Introduction. By Thomas Lange and Geoffrey Pugh. Cheltenham: Edward Elgar, 1998.Europapolitik der deutschen Länder. Bilanz und Perspektiven nach dem Gipfel von Amsterdam. Edited by Franz H.U. Borkenhagen. Opladen: Leske und Budrich, 1998. DM 48.German Universities: Past and Future. Crisis or Renewal? Edited by Mitchell G. Ash. Providence and Oxford: Berghahn 1997.

Interleukin-6 (IL-6) is supposed to be a growth factor in multiple myeloma (MM). Applying a bioassay and a modified ELISA, we measured serum IL-6 values in 64 patients with overt MM, seven patients with smouldering myeloma (SMM), 57 patients with monoclonal gammopathy of undetermined significance (MGUS) and 40 healthy volunteers as controls. IL-6 failed to discriminate between MGUS and MM, stage I, whereas comparison of MM, stage I and stage II/III (p = 0.0143), or comparison of stable disease/remission and progressive disease (p < 0.0001) revealed significant differences. Furthermore, we found significantly higher IL-6 values in overt MM compared to SMM (p = 0.0018). Using a Ki67/CD38 immunohistological double staining method we found a significant correlation between proliferation of bone marrow myeloma cells and serum IL-6 values in 15 patients (p = 0.005). These data demonstrate that IL-6 is a parameter of disease activity in MM and, beside its role in tumor biology, may become a valuable supplement to the established risk factors when selecting patients with unfavourable clinical course for more aggressive treatment modalities.