14 results on '"Federica Barreca"'
Search Results
2. Consistent Symbiodiniaceae community assemblage in a mesophotic-specialist coral along the Saudi Arabian Red Sea
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Silvia Vimercati, Tullia I. Terraneo, Carolina Bocanegra Castano, Federica Barreca, Benjamin C. C. Hume, Fabio Marchese, Mustapha Ouhssain, Alexandra Steckbauer, Giovanni Chimienti, Ameer A. Eweida, Christian R. Voolstra, Mattie Rodrigue, Vincent Pieribone, Sam J. Purkis, Mohammed Qurban, Burt H. Jones, Carlos M. Duarte, and Francesca Benzoni more...
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MCEs ,zooxanthellae ,next generation sequencing ,ITS2 ,SymPortal ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
IntroductionThe Red Sea is a narrow rift basin characterized by latitudinal environmental gradients which shape the diversity and distribution of reef-dwelling organisms. Studies on Symbiodiniaceae associated with select hard coral taxa present species- specific assemblages and concordant variation patterns from the North to southeast Red Sea coast at depths shallower than 30 m. At mesophotic depths, however, algal diversity studies are rare. Here, we characterize for the first-time host-associated algal communities of a mesophotic specialist coral species, Leptoseris cf. striatus, along the Saudi Arabian Red Sea coast.MethodsWe sampled 56 coral colonies spanning the eastern Red Sea coastline from the Northern Red Sea to the Farasan Banks in the South, and across two sampling periods, Fall 2020 and Spring 2022. We used Next Generation Sequencing of the ITS2 marker region in conjunction with SymPortal to denote algal assemblages.Results and discussionOur results show a relatively stable coral species-specific interaction with algae from the genus Cladocopium along the examined latitudinal gradient, with the appearance, in a smaller proportion, of presumed thermally tolerant algal taxa in the genera Symbiodinium and Durusdinium during the warmer season (Fall 2020). Contrary to shallow water corals, our results do not show a change in Symbiodiniaceae community composition from North to South in this mesophotic specialist species. However, our study highlights for the first time that symbiont communities are subject to change over time at mesophotic depth, which could represent an important phenomenon to address in future studies. more...
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- 2024
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3. Infertility in Fabry’s Disease: role of hypoxia and inflammation in determining testicular damage
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Luigi Sansone, Federica Barreca, Manuel Belli, Michele Aventaggiato, Andrea Russo, Giulietta A. Perrone, Matteo A. Russo, Marco Tafani, and Andrea Frustaci
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Fabry’s disease ,hypoxia ,inflammation ,cellular and molecular rehabilitation ,testicular damage ,new therapeutic targets for infertility rehabilitation ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionFabry’s disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the lysosomes of many tissues. FD is due to loss-of-function mutations of α-galactosidase, a key-enzyme for lysosomal catabolism of glycosphingolipids, which accumulate as glycolipid bodies (GB). In homozygous males the progressive deposition of GB3 into the cells leads to clinical symptoms in CNS, skin, kidney, etc. In testis GB accumulation causes infertility and alterations of spermatogenesis. However, the precise damaging mechanism is still unknown. Our hypothesis is that GB accumulation reduces blood vessel lumen and increases the distance of vessels from both stromal cells and seminiferous parenchyma; this, in turn, impairs oxygen and nutrients diffusion leading to subcellular degradation of seminiferous epithelium and sterility.MethodsTo test this hypothesis, we have studied a 42-year-old patient presenting a severe FD and infertility, with reduced number of spermatozoa, but preserved sexual activity. Testicular biopsies were analyzed by optical (OM) and transmission electron microscopy (TEM). Activation and cellular localization of HIF-1α and NFκB was analyzed by immunofluorescence (IF) and RT-PCR on homogeneous tissue fractions after laser capture microdissection (LCMD).ResultsOM and TEM showed that GB were abundant in vessel wall cells and in interstitial cells. By contrast, GB were absent in seminiferous epithelium, Sertoli’s and Leydig’s cells. However, seminiferous tubular epithelium and Sertoli’s cells showed reduced diameter, thickening of basement membrane and tunica propria, and swollen or degenerated spermatogonia. IF showed an accumulation of HIF-1α in stromal cells but not in seminiferous tubules. On the contrary, NFκB fluorescence was evident in tubules, but very low in interstitial cells. Finally, RT-PCR analysis on LCMD fractions showed the expression of pro-inflammatory genes connected to the HIF-1α/NFκB inflammatory-like pathway.ConclusionOur study demonstrates that infertility in FD may be caused by reduced oxygen and nutrients due to GB accumulation in blood vessels cells. Reduced oxygen and nutrients alter HIF-1α/NFκB expression and localization while activating HIF-1α/NFκB driven-inflammation-like response damaging seminiferous tubular epithelium and Sertoli’s cells. more...
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- 2024
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4. Pharmacological Activation of SIRT3 Modulates the Response of Cancer Cells to Acidic pH
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Michele Aventaggiato, Tania Arcangeli, Enza Vernucci, Federica Barreca, Luigi Sansone, Laura Pellegrini, Elena Pontemezzo, Sergio Valente, Rossella Fioravanti, Matteo Antonio Russo, Antonello Mai, and Marco Tafani more...
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sirtuins ,acidic microenvironment ,autophagy ,carbonic anhydrase ,cancer ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Cancer cells modulate their metabolism, creating an acidic microenvironment that, in turn, can favor tumor progression and chemotherapy resistance. Tumor cells adopt strategies to survive a drop in extracellular pH (pHe). In the present manuscript, we investigated the contribution of mitochondrial sirtuin 3 (SIRT3) to the adaptation and survival of cancer cells to a low pHe. SIRT3-overexpressing and silenced breast cancer cells MDA-MB-231 and human embryonic kidney HEK293 cells were grown in buffered and unbuffered media at pH 7.4 and 6.8 for different times. mRNA expression of SIRT3 and CAVB, was measured by RT-PCR. Protein expression of SIRT3, CAVB and autophagy proteins was estimated by western blot. SIRT3-CAVB interaction was determined by immunoprecipitation and proximity ligation assays (PLA). Induction of autophagy was studied by western blot and TEM. SIRT3 overexpression increases the survival of both cell lines. Moreover, we demonstrated that SIRT3 controls intracellular pH (pHi) through the regulation of mitochondrial carbonic anhydrase VB (CAVB). Interestingly, we obtained similar results by using MC2791, a new SIRT3 activator. Our results point to the possibility of modulating SIRT3 to decrease the response and resistance of tumor cells to the acidic microenvironment and ameliorate the effectiveness of anticancer therapy. more...
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- 2024
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5. Mesophotic and Bathyal Palaemonid Shrimp Diversity of the Red Sea, with the Establishment of Two New Genera and Two New Species
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Arthur Anker, Silvia Vimercati, Federica Barreca, Fabio Marchese, Giovanni Chimienti, Tullia I. Terraneo, Mattie Rodrigue, Ameer A. Eweida, Mohammed Qurban, Carlos M. Duarte, Vincent Pieribone, and Francesca Benzoni more...
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marine biodiversity ,mesophotic benthos ,crustaceans ,symbiosis ,phylogeny ,deep-water shrimps ,Biology (General) ,QH301-705.5 - Abstract
The diversity and evolution of the Red Sea invertebrates in mesophotic and deep-water benthic ecosystems remain largely unexplored. The Palaemonidae is a diversified family of caridean shrimps with numerous taxa in need of taxonomic revisions based on recent molecular analyses. The Red Sea mesophotic and bathyal palaemonid shrimps are largely unstudied. During recent expeditions off the Red Sea coast of Saudi Arabia, several palaemonid specimens were collected at a depth range of 88–494 m, spanning the mesophotic and bathyal zones. This material was examined morphologically and genetically to infer phylogenetic relationships among the Red Sea taxa and several other palaemonid genera. The concordant morphological and genetic data led to the description of two new genera and two new species. Moreover, one species was recorded in the Red Sea for the first time, with a new host record, whereas three further deep-water species, which do not occur in the Red Sea, were formally transferred to a different genus. As more exploration efforts are deployed, research on the diversity and evolutionary relationships among marine invertebrates from the Red Sea will further underline the uniqueness of its mesophotic and bathyal fauna. more...
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- 2023
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6. SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS
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Federica Barreca, Michele Aventaggiato, Laura Vitiello, Luigi Sansone, Matteo Antonio Russo, Antonello Mai, Sergio Valente, and Marco Tafani
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autophagy ,mitophagy ,ROS ,sirtuins ,glutamine ,glutaminase ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the triple-negative subtype, have a high expression of GLS. Our recent study demonstrated that GLS activity and ammonia production are inhibited by sirtuin 5 (SIRT5). We developed MC3138, a selective SIRT5 activator. Treatment with MC3138 mimicked the deacetylation effect mediated by SIRT5 overexpression. Moreover, GLS activity was regulated by inorganic phosphate (Pi). Considering the interconnected roles of GLS, SIRT5 and Pi in cancer growth, our hypothesis is that activation of SIRT5 and reduction in Pi could represent a valid antitumoral strategy. Treating cells with MC3138 and lanthanum acetate, a Pi chelator, decreased cell viability and clonogenicity. We also observed a modulation of MAP1LC3B and ULK1 with MC3138 and lanthanum acetate. Interestingly, inhibition of the mitophagy marker BNIP3 was observed only in the presence of MC3138. Autophagy and mitophagy modulation were accompanied by an increase in cytosolic and mitochondrial reactive oxygen species (ROS). In conclusion, our results show how SIRT5 activation and/or Pi binding can represent a valid strategy to inhibit cell proliferation by reducing glutamine metabolism and mitophagy, leading to a deleterious accumulation of ROS. more...
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- 2023
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7. Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
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Michele Aventaggiato, Federica Barreca, Laura Vitiello, Simone Vespa, Sergio Valente, Dante Rotili, Antonello Mai, Lavinia Vittoria Lotti, Luigi Sansone, Matteo A. Russo, Mariano Bizzarri, Elisabetta Ferretti, and Marco Tafani more...
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simulated microgravity ,sirtuins ,SIRT3 ,muscle tissue ,ROS ,mitochondria ,Cytology ,QH573-671 - Abstract
Life on Earth has evolved in the presence of a gravity constraint. Any change in the value of such a constraint has important physiological effects. Gravity reduction (microgravity) alters the performance of muscle, bone and, immune systems among others. Therefore, countermeasures to limit such deleterious effects of microgravity are needed considering future Lunar and Martian missions. Our study aims to demonstrate that the activation of mitochondrial Sirtuin 3 (SIRT3) can be exploited to reduce muscle damage and to maintain muscle differentiation following microgravity exposure. To this effect, we used a RCCS machine to simulate microgravity on ground on a muscle and cardiac cell line. During microgravity, cells were treated with a newly synthesized SIRT3 activator, called MC2791 and vitality, differentiation, ROS and, autophagy/mitophagy were measured. Our results indicate that SIRT3 activation reduces microgravity-induced cell death while maintaining the expression of muscle cell differentiation markers. In conclusion, our study demonstrates that SIRT3 activation could represent a targeted molecular strategy to reduce muscle tissue damage caused by microgravity. more...
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- 2023
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8. Sirtuins and Hypoxia in EMT Control
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Michele Aventaggiato, Federica Barreca, Luigi Sansone, Laura Pellegrini, Matteo A. Russo, Marco Cordani, and Marco Tafani
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epithelial–mesenchymal transition ,sirtuins ,hypoxia ,fibrosis ,HIF ,nanoparticles ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Epithelial–mesenchymal transition (EMT), a physiological process during embryogenesis, can become pathological in the presence of different driving forces. Reduced oxygen tension or hypoxia is one of these forces, triggering a large number of molecular pathways with aberrant EMT induction, resulting in cancer and fibrosis onset. Both hypoxia-induced factors, HIF-1α and HIF-2α, act as master transcription factors implicated in EMT. On the other hand, hypoxia-dependent HIF-independent EMT has also been described. Recently, a new class of seven proteins with deacylase activity, called sirtuins, have been implicated in the control of both hypoxia responses, HIF-1α and HIF-2α activation, as well as EMT induction. Intriguingly, different sirtuins have different effects on hypoxia and EMT, acting as either activators or inhibitors, depending on the tissue and cell type. Interestingly, sirtuins and HIF can be activated or inhibited with natural or synthetic molecules. Moreover, recent studies have shown that these natural or synthetic molecules can be better conveyed using nanoparticles, representing a valid strategy for EMT modulation. The following review, by detailing the aspects listed above, summarizes the interplay between hypoxia, sirtuins, and EMT, as well as the possible strategies to modulate them by using a nanoparticle-based approach. more...
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- 2022
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9. Putative Receptors for Gravity Sensing in Mammalian Cells: The Effects of Microgravity
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Michele Aventaggiato, Federica Barreca, Enza Vernucci, Mariano Bizzarri, Elisabetta Ferretti, Matteo A. Russo, and Marco Tafani
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microgravity ,mechanosensor ,cystein-rich proteins ,sirtuins ,cellular and molecular rehabilitation ,muscle lim protein ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Gravity is a constitutive force that influences life on Earth. It is sensed and translated into biochemical stimuli through the so called “mechanosensors”, proteins able to change their molecular conformation in order to amplify external cues causing several intracellular responses. Mechanosensors are widely represented in the human body with important structures such as otholiths in hair cells of vestibular system and statoliths in plants. Moreover, they are also present in the bone, where mechanical cues can cause bone resorption or formation and in muscle in which mechanical stimuli can increase the sensibility for mechanical stretch. In this review, we discuss the role of mechanosensors in two different conditions: normogravity and microgravity, emphasizing their emerging role in microgravity. Microgravity is a singular condition in which many molecular changes occur, strictly connected with the modified gravity force and free fall of bodies. Here, we first summarize the most important mechanosensors involved in normogravity and microgravity. Subsequently, we propose muscle LIM protein (MLP) and sirtuins as new actors in mechanosensing and signaling transduction under microgravity. more...
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- 2020
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10. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
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Serena Saladini, Michele Aventaggiato, Federica Barreca, Emanuela Morgante, Luigi Sansone, Matteo A. Russo, and Marco Tafani
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autophagy ,cell death ,glutaminase ,metabolism ,molecular rehabilitation. ,Cytology ,QH573-671 - Abstract
Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic patients. Since tumour cells are addicted to glutamine and often show an overexpression of glutaminase, we hypothesize that the antitumoral mechanism of metformin could be ascribed to inhibition of GLS and reduction of ammonia and ammonia-induced autophagy. Our results show that, in different tumour cell lines, micromolar doses of metformin prevent cell growth by reducing glutamate, ammonia accumulation, autophagy markers such as MAP1LC3B-II and GABARAP as well as degradation of long-lived proteins. Reduced autophagy is then accompanied by increased BECN1/BCL2 binding and apoptotic cell death. Interestingly, GLS-silenced cells reproduce the effect of metformin treatment showing reduced MAP1LC3B-II and GABARAP as well as ammonia accumulation. Since metformin is used as adjuvant drug to increase the efficacy of Cisplatin-based neoadjuvant chemotherapy, we co-treated tumour cells with micromolar doses of metformin in the presence of cisplatin observing a marked reduction of MAP1LC3B-II and an increase of caspase 3 cleavage. In conclusion, our work demonstrates that the anti-tumoral action of metformin is due to the inhibition of glutaminase and autophagy and could be used to improve the efficacy of chemotherapy. more...
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- 2019
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11. High mobility group box 1 in women with unexplained recurrent pregnancy loss
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Carlo Ticconi, Stefania Mardente, Emanuela Mari, Federica Barreca, Manuela Montanaro, Alessandro Mauriello, Giuseppe Rizzo, and Alessandra Zicari
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recurrent pregnancy loss ,Settore MED/40 ,high mobility group box 1 (HMGB1) ,Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology ,endometrium ,microvesicles - Abstract
Objectives To investigate whether high mobility group box 1 (HMGB1) is involved in unexplained recurrent pregnancy loss (uRPL). Methods Plasma levels of HMGB1 were measured by ELISA in non-pregnant women with (n=44) and without (n=53 controls) uRPL. Their platelets and plasma-derived microvesicles (MVs) were also assayed for HMGB1. Endometrial biopsies were taken in selected uRPL (n=5) and control women (n=5) and the tissue expression of HMGB1 was determined by western blot and immunohistochemistry (IHC). Results plasma levels of HMGB1 were significantly higher in women with uRPL than in control women. HMGB1 content in platelets and MVs obtained from women with uRPL was significantly higher than that obtained from control women. HMGB1 expression in endometrium was higher in tissues obtained from women with uRPL than in tissues obtained from control women. IHC analysis revealed that HMGB1 is expressed in endometrium with different patterns between uRPL and control women. Conclusions HMGB1 could be involved in uRPL. more...
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- 2023
12. Sirtuins and Hypoxia in EMT Control
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Michele Aventaggiato, Federica Barreca, Luigi Sansone, Laura Pellegrini, Matteo A. Russo, Marco Cordani, and Marco Tafani
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Bioquímica ,sirtuins ,Biología celular ,hypoxia ,fibrosis ,Drug Discovery ,HIF ,Pharmaceutical Science ,Molecular Medicine ,nanoparticles ,epithelial–mesenchymal transition ,Oncología - Abstract
Epithelial–mesenchymal transition (EMT), a physiological process during embryogenesis, can become pathological in the presence of different driving forces. Reduced oxygen tension or hypoxia is one of these forces, triggering a large number of molecular pathways with aberrant EMT induction, resulting in cancer and fibrosis onset. Both hypoxia-induced factors, HIF-1α and HIF-2α, act as master transcription factors implicated in EMT. On the other hand, hypoxia-dependent HIF-independent EMT has also been described. Recently, a new class of seven proteins with deacylase activity, called sirtuins, have been implicated in the control of both hypoxia responses, HIF-1α and HIF-2α activation, as well as EMT induction. Intriguingly, different sirtuins have different effects on hypoxia and EMT, acting as either activators or inhibitors, depending on the tissue and cell type. Interestingly, sirtuins and HIF can be activated or inhibited with natural or synthetic molecules. Moreover, recent studies have shown that these natural or synthetic molecules can be better conveyed using nanoparticles, representing a valid strategy for EMT modulation. The following review, by detailing the aspects listed above, summarizes the interplay between hypoxia, sirtuins, and EMT, as well as the possible strategies to modulate them by using a nanoparticle-based approach. more...
- Published
- 2021
13. Sirtuins' control of autophagy and mitophagy in cancer
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Matteo Antonio Russo, Marco Tafani, Enza Vernucci, Federica Barreca, and Michele Aventaggiato
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0301 basic medicine ,Pharmacology ,Cellular differentiation ,Autophagy ,Cancer ,Cancer stem cells ,Glutamine metabolism ,Mitophagy ,Sirtuins ,Animals ,Neoplasms ,Inflammation ,Mitochondrion ,Biology ,Cell biology ,03 medical and health sciences ,Metabolic pathway ,030104 developmental biology ,0302 clinical medicine ,Cancer stem cell ,030220 oncology & carcinogenesis ,Cancer cell ,medicine ,Pharmacology (medical) ,medicine.symptom - Abstract
Mammalian cells use a specialized and complex machinery for the removal of altered proteins or dysfunctional organelles. Such machinery is part of a mechanism called autophagy. Moreover, when autophagy is specifically employed for the removal of dysfunctional mitochondria, it is called mitophagy. Autophagy and mitophagy have important physiological implications and roles associated with cellular differentiation, resistance to stresses such as starvation, metabolic control and adaptation to the changing microenvironment. Unfortunately, transformed cancer cells often exploit autophagy and mitophagy for sustaining their metabolic reprogramming and growth to a point that autophagy and mitophagy are recognized as promising targets for ongoing and future antitumoral therapies. Sirtuins are NAD+ dependent deacylases with a fundamental role in sensing and modulating cellular response to external stresses such as nutrients availability and therefore involved in aging, oxidative stress control, inflammation, differentiation and cancer. It is clear, therefore, that autophagy, mitophagy and sirtuins share many common aspects to a point that, recently, sirtuins have been linked to the control of autophagy and mitophagy. In the context of cancer, such a control is obtained by modulating transcription of autophagy and mitophagy genes, by post translational modification of proteins belonging to the autophagy and mitophagy machinery, by controlling ROS production or major metabolic pathways such as Krebs cycle or glutamine metabolism. The present review details current knowledge on the role of sirtuins, autophagy and mitophagy in cancer to then proceed to discuss how sirtuins can control autophagy and mitophagy in cancer cells. Finally, we discuss sirtuins role in the context of tumor progression and metastasis indicating glutamine metabolism as an example of how a concerted activation and/or inhibition of sirtuins in cancer cells can control autophagy and mitophagy by impinging on the metabolism of this fundamental amino acid. more...
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- 2020
14. Putative Receptors for Gravity Sensing in Mammalian Cells: The Effects of Microgravity
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Mariano Bizzarri, Enza Vernucci, Elisabetta Ferretti, Marco Tafani, Michele Aventaggiato, Matteo Antonio Russo, and Federica Barreca
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Gravity force ,muscle lim protein ,lcsh:Technology ,Molecular conformation ,Cellular and molecular rehabilitation ,Cystein-rich proteins ,Mechanosensor ,Microgravity ,Muscle LIM protein ,Sirtuins ,lcsh:Chemistry ,03 medical and health sciences ,0302 clinical medicine ,sirtuins ,General Materials Science ,Receptor ,Instrumentation ,lcsh:QH301-705.5 ,030304 developmental biology ,Fluid Flow and Transfer Processes ,Vestibular system ,0303 health sciences ,Chemistry ,lcsh:T ,Process Chemistry and Technology ,General Engineering ,Signaling transduction ,microgravity ,cystein-rich proteins ,cellular and molecular rehabilitation ,lcsh:QC1-999 ,Computer Science Applications ,Cell biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Gravity Sensing ,lcsh:TA1-2040 ,lcsh:Engineering (General). Civil engineering (General) ,030217 neurology & neurosurgery ,mechanosensor ,lcsh:Physics - Abstract
Gravity is a constitutive force that influences life on Earth. It is sensed and translated into biochemical stimuli through the so called “mechanosensors”, proteins able to change their molecular conformation in order to amplify external cues causing several intracellular responses. Mechanosensors are widely represented in the human body with important structures such as otholiths in hair cells of vestibular system and statoliths in plants. Moreover, they are also present in the bone, where mechanical cues can cause bone resorption or formation and in muscle in which mechanical stimuli can increase the sensibility for mechanical stretch. In this review, we discuss the role of mechanosensors in two different conditions: normogravity and microgravity, emphasizing their emerging role in microgravity. Microgravity is a singular condition in which many molecular changes occur, strictly connected with the modified gravity force and free fall of bodies. Here, we first summarize the most important mechanosensors involved in normogravity and microgravity. Subsequently, we propose muscle LIM protein (MLP) and sirtuins as new actors in mechanosensing and signaling transduction under microgravity. more...
- Published
- 2020
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