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2 results on '"Federica Tordo Caprioli"'

1. Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?

Author

Benedetta Perna, Valeria Raparelli, Federica Tordo Caprioli, Oana Teodora Blanaru, Cecilia Malacarne, Cecilia Crosetti, Andrea Portoraro, Alex Zanotto, Francesco Maria Strocchi, Alessandro Rapino, Anna Costanzini, Martina Maritati, Roberto Lazzari, Michele Domenico Spampinato, Carlo Contini, Roberto De Giorgio, and Matteo Guarino

Subjects
sex, gender, septic shock, norepinephrine, vasoactive agents, precision medicine, Biology (General), QH301-705.5
Abstract

Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43.2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines.

Published
2024
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2. Long-term risk of stroke after transient global amnesia in two prospective cohorts

Author

Paolo Calabresi, Michele Venti, Maria Giulia Mosconi, Fabrizio Stracci, Peter M. Rothwell, Michele Romoli, Iain McGurgan, Federica Tordo Caprioli, Paola Sarchielli, Antonio Lotti, Paolo Eusebi, Linxin Li, Lucilla Parnetti, Maurizio Paciaroni, Stefano Ricci, Nicola Salvadori, M A Tuna, David Giannandrea, and Alessio Gili

Subjects
Adult, Male, medicine.medical_specialty, Population, primary prevention, Amnesia, population, Cohort Studies, amnesia, Amnesia, Transient Global, Primary prevention, Risk, Syndrome, Aged, Case-Control Studies, Female, Humans, Ischemic Attack, Transient, Middle Aged, Prospective Studies, Registries, Risk Factors, Stroke, Internal medicine, medicine, Transient Global, education, risk, syndrome, Advanced and Specialized Nursing, education.field_of_study, business.industry, Ischemic Attack, Transient, medicine.disease, Settore MED/26 - NEUROLOGIA, Relative risk, Cohort, Transient global amnesia, Population study, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, Dyslipidemia
Abstract

Background and Purpose— Transient global amnesia (TGA) is known as a benign syndrome, but recent data from neuroradiological studies support an ischemic cause in some cases, which might suggest an increased susceptibility to cerebrovascular events. We determined the long-term risk of stroke after a first TGA in 2 independent prospective cohorts. Methods— In 2 independent prospective cohorts of patients with TGA (OXVASC [Oxford Vascular Study], population-based; NU (Northern Umbria) cohort, TGA registry), cardiovascular risk factors and long-term outcomes, including stroke and major cardiovascular events, were identified on follow-up. Cardiovascular risk factors were treated according to primary prevention guidelines. In OXVASC, the age-/sex-adjusted risk of stroke during follow-up was compared with that expected from the rate in the underlying study population. Results— Among 525 patients with TGA (425 NU and 100 OXVASC), mean (SD) age was 65.1 (9.5) years and 42.5% male. Hypertension (58.1%), dyslipidemia (40.4%), and smoking (36.4%) were the most frequent cardiovascular risk factors. The risk of stroke was similar in the 2 cohorts, with a pooled annual risk of 0.6% (95% CI, 0.4–0.9) and a 5-year cumulative risk of 2.7% (1.1–4.3). Moreover, the stroke risk in OXVASC cases was no greater than that expected in the underlying study population (adjusted relative risk=0.73; 0.12–4.54; P =0.74). Conclusions— TGA does not carry an increased risk of stroke, at least when cardiovascular risk factors are treated according to primary prevention guidelines.

Published
2019

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