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1. Quantitative in vitro to in vivo extrapolation for human toxicology and drug development

Author

Cattelani, Luca, del Giudice, Giusy, Serra, Angela, Fratello, Michele, Saarimäki, Laura Aliisa, Fortino, Vittorio, Federico, Antonio, Tsiros, Periklis, Mannerström, Marika, Toimela, Tarja, Serchi, Tommaso, Lynch, Iseult, Doganis, Philip, Sarimveis, Haralambos, and Greco, Dario

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Traditional animal testing for toxicity is expensive, time consuming, ethically questioned, sometimes inaccurate because of the necessity to extrapolate from animal to human, and in most cases not formally validated according to modern standards. This is driving regulatory bodies and companies in backing alternative methods focusing on in silico and in vitro approaches. These are complex to implement and validate, and their wide adoption is not yet established despite legal directives providing an imperative. It is difficult to link a cell level response to effects on a whole organism, but the advances in high-throughput toxicogenomics towards elucidating the mechanism of action of substances are gradually reducing this gap and fostering the adoption of Next Generation Safety Assessment approaches. Quantitative in vitro to in vivo extrapolation (QIVIVE) methods hold the promise to reveal how to use in vitro -omics data to predict the potential for in vivo toxicity. They could improve lead compounds prioritisation, reduce time and costs, also in numbers of animal lives, and help with the complexity of extrapolating between species. We provide a description of QIVIVE state of the art, including how the problems of dosing and timing are being approached, how in silico simulation can take into account the variability of individuals, and how multiple techniques can be integrated to face complex tasks like the prediction of long term toxicity, including a close look into the open problems and challenges ahead., Comment: We authors have decided to withdraw the preprint from arXiv at this time. This decision stems from our desire to revisit and refine certain specific points in our work

Published
2024

5. List of contributors

Author

Akortia, Eric, primary, Alla, Sai Radha Mani, additional, Alves, Vinicius M., additional, Andrade, Carolina H., additional, Avram, Speranta, additional, Bao, Tong, additional, Benfenati, Emilio, additional, Braga, Rodolpho C., additional, Buiu, Catalin, additional, Chakravarti, Suman K., additional, Chen, Jingwen, additional, Chen, Minjun, additional, Ciura, Krzesimir, additional, Colombo, Erika, additional, Cross, Kevin P., additional, Cui, Shixuan, additional, del Giudice, Giusy, additional, Dong, Fan, additional, Duchowicz, Pablo R., additional, Egbi, Courage, additional, Egodawatta, Prasanna, additional, Elakkiya, Elango, additional, Federico, Antonio, additional, Fratello, Michele, additional, Fu, Zhiqiang, additional, Furuhama, Ayako, additional, Gao, Yuchen, additional, Garro Martinez, Juan C., additional, Gbeddy, Gustav, additional, Giner, Beatriz, additional, Glover, Eric, additional, Goonetilleke, Ashantha, additional, Greco, Dario, additional, Gromelski, Maciej, additional, Gu, Yaxin, additional, Gui, Binxin, additional, Guo, Jing, additional, Guo, Wenjing, additional, He, Jiale, additional, He, Minghui, additional, Hong, Huixiao, additional, Honma, Masamitsu, additional, Huang, Shuheng, additional, Huang, Ruili, additional, Huang, Meiling, additional, Jaeger, Martin, additional, Jillella, Gopala Krishna, additional, Johnson, Candice, additional, Kasamatsu, Toshio, additional, Khan, Pathan Mohsin, additional, Koster, Sander, additional, Kusko, Rebecca, additional, Lee, Myeongsang, additional, Li, Chao, additional, Li, Fei, additional, Li, Bohao, additional, Li, Menglong, additional, Li, Dongying, additional, Li, Jinjie, additional, Li, Xuehua, additional, Li, Zoe, additional, Liao, Tsung-Jen, additional, Liu, Yuan, additional, Liu, Huihui, additional, Liu, Jie, additional, Liu, Wenjia, additional, Lomba, Laura, additional, Lou, Chaofeng, additional, Ma, Guangcai, additional, Manganelli, Serena, additional, Mei, Hu, additional, Mendonca, Sabrina S., additional, Mizuno, Tadahaya, additional, Myatt, Glenn J., additional, Ngan, Deborah K., additional, Ning, Baitang, additional, Pandit, Shraddha, additional, Parthasarathi, Ramakrishnan, additional, Patterson, Tucker A., additional, Pavel, Alisa, additional, Prabhu, Paulraj, additional, Puzyn, Tomasz, additional, Qu, Jiao, additional, Roncaglioni, Alessandra, additional, Roy, Kunal, additional, Saarimäki, Laura Aliisa, additional, Saavedra, Laura M., additional, Sanches, Igor H., additional, Schilter, Benoit, additional, Selvaraj, Chandrabose, additional, Serra, Angela, additional, Shi, Wei, additional, Singh, Prakrity, additional, Singh, Sanjeev Kumar, additional, Sogor, Catalina, additional, Song, Meng, additional, Sosnowska, Anita, additional, Su, Limin, additional, Sugiyama, Kei-ichi, additional, Swirog, Marta, additional, Tang, Yun, additional, Teng, Yuefa, additional, Tong, Weida, additional, Tropsha, Alexander, additional, Udrea, Ana-Maria, additional, Velmurugan, Devadasan, additional, Voigt, Melanie, additional, Wang, Haobo, additional, Wang, Xiaoqing, additional, Wang, Zhongyu, additional, Wang, Xueyu, additional, Wei, Xiaoxuan, additional, Wen, Zhining, additional, Wu, Yiqu, additional, Wyrzykowska, Ewelina, additional, Xiao, Fang, additional, Xie, Hong-Bin, additional, Xu, Tuan, additional, Xu, Liang, additional, Yang, Xianhai, additional, Yu, Haiying, additional, Zhang, Yuxuan, additional, Zhang, Jiachen, additional, Zhao, Jingwen, additional, Zhao, Yuanhui, additional, Zhu, Minghua, additional, Zhuang, Shulin, additional, and Zou, Wen, additional

Published
2024
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9. Hippocampal atrophy and white matter lesions characteristics can predict evolution to dementia in patients with vascular mild cognitive impairment

Author

Manco, Carlo, Cortese, Rosa, Leoncini, Matteo, Plantone, Domenico, Gentile, Giordano, Luchetti, Ludovico, Zhang, Jian, Di Donato, Ilaria, Salvadori, Emilia, Poggesi, Anna, Cosottini, Mirco, Mascalchi, Mario, Federico, Antonio, Dotti, Maria Teresa, Battaglini, Marco, Inzitari, Domenico, Pantoni, Leonardo, and De Stefano, Nicola

Published
2024
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13. Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study

Author

Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, M’Pembele, René, Tenge, Theresa, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Zacharowski, Kai, Meybohm, Patrick, Lindau, Simone, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Ovezov, Alexey, Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Kuzmanovska, Biljana, Malinovska-Nikolovska, Liljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Golubović, Mladjan, Fleischmann, Edith, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Buggy, Donal J., Bonnet, Jean François, Cusack, Barbara, Calleja, Paul, Hasani, Antigona, Nallbani, Rajmonda, Mauermann, Eckhard, Ionescu, Daniela, Szczeklik, Wojciech, De Hert, Stefan, Filipovic, Miodrag, Beck Schimmer, Beatrice, Spadaro, Savino, Matute, Purificación, Ganter, Michael T., Turhan, Sanem C., van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Gupta, Anil, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Larmann, Jan, Corneci, Dan, Howell, Simon J., and Lurati Buse, Giovanna

Published
2024
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16. Towards needed improvements in inherited metabolic medicine in adulthood: The SIMMESN adult metabolic working group and MetabERN Joint Position Statement

Author

Bond, Simon, Bordugo, Andrea, Brodosi, Lucia, Camilot, Marta, Carubbi, Francesca, Dardis, Andrea, Dianin, Alice, Vici, Carlo Dionisi, Donati, Maria Alice, Fasan, Ilaria, Federico, Antonio, Filosto, Massimiliano, Gasperini, Serena, La Marca, Giancarlo, Martinelli, Diego, Noto, Davide, Spada, Marco, Toscano, Antonio, Vitturi, Nicola, Sechi, Annalisa, Urban, Maria Letizia, Murphy, Elaine, Pession, Andrea, and Scarpa, Maurizio

Published
2024
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18. MORPHOLOGICAL DIVERSITY OF Ardisia compressa Kunth FROM NORTHEAST OF CHIAPAS, MEXICO

Author

Jesús Rigoberto Molina Maldonado, Rubén Humberto Andueza Noh, Esaú Ruíz Sánchez, Rene Garruña, Federico Antonio Gutiérrez Miceli, and Luis Filipe da Conceiςão-Dos Santos

Subjects
fenotipo, cualitativo, cuantitativo, análisis multivariado, Agriculture, Agriculture (General), S1-972
Abstract

Background. Ardisia compressa Kunth, is a wild species native from tropical evergreen forests of Mexico, it produces fruits with phytochemical, ecological and dietary potencial. Its fruits are appreciated by people from local communities. However, in Mexico there are no studies that allow knowing the state of its phenotypic diversity. Objective. Characterize the morphological diversity of A. compressa populations from Chiapas state, Mexico. Methodology. Ninety individuals of nine wild populations of A. compressa were evaluated using 45 morphological traits (16 qualitative and 29 quantitative). The qualitative data were subjected to descriptive analysis and quantitative data were used in an analysis of variance (ANOVA) and finally the qualitative and quantitative data were analyzed simultaneously by means of a multivariate analysis with the Ward-MLM Method. Results. The qualitative traits showed phenotypic variability in the characteristics of leaf and fruit color. The quantitative data showed significant differences (P≤ 0.05) in all traits evaluated. The results of the principal component analysis (PCA) and cluster analysis (UPGMA) grouped the populations into three morphological groups differentiated by the similarity of the morphological traits of the populations and not by their geographical origin. Implications. The results in this study should be considered to implementing strategies of plant production and conservation of A. compressa. Conclusion. A wide phenotypic variability was found organized into three morphological groups defined base on characteristics of tree height, number of fruits, number of flowers and ratio of length to thickness leaf. The quantitative traits allowed us to observe the greatest morphological variability in the populations of A. compressa.

Published
2023
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20. Risk assessment for major adverse cardiovascular events after noncardiac surgery using self-reported functional capacity: international prospective cohort study

Author

Lurati, Giovanna, Spadaro, Savino, Matute, Purificación, Ionescu, Daniela, Bolliger, Daniel, Szczeklik, Wojciech, Turhan, Sanem Cakar, van Waes, Judith, Lagarto, Filipa, Theodoraki, Kassiani, Howell, Simon J., Gupta, Anil, De Hert, Stefan, Ovezov, Alexey, Tollinche, Luis E., Kuzmanovska, Biljana, Barisin, Stjepan, Poredos, Peter, Arabadzhieva, Daniela, Unic-Stojanovic, Dragana, Fleischmann, Edith, Meistelman, Claude, Buggy, Donal J., Calleja, Paul, Hasani, Antigona, Kemper, Johann, Kohaupt, Lena, Witzler, Jette, Tuzhikov, Michael, Roth, Sebastian, Stroda, Alexandra, Schultze, Cornelia, Verbarg, Nele, Gehrke, Christian, Klemann, Anna Katharina, Hagebölling, Friederike, Albrecht, Svenja, Stroeder, Jakob, Schubert, Ann-Kristin, Espeter, Florian, Russe, Benedikt, Weigand, Markus A., Bergmann, Lars, Unterberg, Matthias, Bischoff, Petra, Pirzer, Raphael, Rach, Patric Rene, Ott, Klaus, Zarbock, Alexander, Kowark, Ana, Neumann, Claudia, Marchand, Bahareh, Sponholz, Christoph, Rueffert, Henrik, Kramer, Mira, Piekarski, Florian, Carollo, Melissa, Novazzi, Cecilia, Toso, Fiorenza, Bacuzzi, Alessandro, Ragazzi, Riccardo, Volta, Carlo Alberto, De Giorgi, Francesco, Bacer, Barbara, Federico, Antonio, Chiumello, Davide, Vetrugno, Luigi, Castella, Alberto, Tesoro, Simonetta, Cotoia, Antonella, Bignami, Elena, Bellissima, Agrippino, Cortegiani, Andrea, Crisman, Marco, Toninelli, Arturo, Piazza, Ornella, Mirabella, Lucia, Bossolasco, Matteo, Bona, Francesco, Perdomo, Juan Manuel, Coca-Martinez, Miquel, Carramiñana, Albert, Servén, Marta Giné, González, Astrid Batalla, Gil Sánchez, José Maria, Becerra-Bolaños, Ángel, Rodríguez-Pérez, Aurelio, Soler, Anna Artigas, Basso, Morena, Font, Anna Peig, Vernetta, Diana, Santos, Julia Hernando, Muñoz, Enrique Alday, Olivares, Mercedes Cabellos, Marco, Gregorio, Lopez, Maria Bermudez, Barrio, Javier, Forés, María Isabel, Boix, Estefanía, Ayuso, Mercedes, Petre, Bogdan Sorel, Oprea, Ioana Sorina, Latiș, Mihai Dan, Margarit, Simona, Vasian, Horatiu, Tomescu, Dana, Cîndea, Iulia, Dirzu, Dan Sebastian, Copotoiu, Sanda-Maria, Moise, Alida, Bubenek-Turconi, Serban, Valeanu, Liana, Wanner, Patrick Mark, Djurdjevic, Mirjana, Nuth, Sandra, Seeberger, Esther, Goettel, Nicolai, Kamber, Firmin, Ganter, Michael Thomas, Gerber, Thomas Jan, Schneebeli, Daniela, Pregernig, Andreas, Grape, Sina, Tomala, Simon, Pinto, Bernardo Bollen, Żukowski, Maciej, Zegan-Barańska, Małgorzata, Karolak, Igor, Krzych, Lukasz, Czajka, Szymon, Studzińska, Dorota, Kluzik, Anna, Koszel, Tomasz, Pabjańczyk, Izabela, Gajdosz, Anna, Erkoc, Suheyla Karadag, Meco, Basak Ceyda, Koltka, Ahmet Kemalettin, Dincer, Muserref Beril, Ekmekçi, Perihan, Saracoglu, Kemal Tolga, Solmaz, Filiz Alkaya, Ozcelik, Menekse, Arun, Oguzhan, Dilmen, Ozlem Korkmaz, Preckel, Benedikt, Hollmann, Markus W., Hazen, Yannick, Donald de Boer, Hans, Epema, Anne, Koopman, Seppe, Van Lier, Felix, Pinto, Rita, Carrão, André, Ribeiro, Daniel, Mourão, Joana, Coelho, Miguel, Losa, Nuno, Santos, Nuno, Cabral, Luis, Afonso, Diana, Zenha, Sérgio, Ramos, Cristina, Hipólito, Carla, Vasilaki, Maria, Andreeva, Antonia, Zaimi, Donika, Chalkias, Athanasios, Spyraki, Maria, Rekatsina, Martina, Tsaousi, Georgia, Short, Anthony, Meier, Sonja, Madhuri, Thumuluru Kavitha, Latham, Scott, Knock, James, Drummond, Andrew, Ramsden, Fiona, Kubisz-Pudelko, Agnieszka, Walker, James, Moppett, Iain, White, Louise, Jackson, Matthew, Reschreiter, Henrik, Innes, Richard, Chew, Michelle, Kalman, Sigridur, Wallden, Jakob, Schening, Anna, Jonikaite, Lina, Enlund, Anna, De Baerdemaeker, Luc, Morrison, Stuart, Rex, Steffen, Alexis, Alexandros, Khoronenko, Viktoria E., Belskii, Vladislav, Kaznacheeva, Kseniya, Gritsan, Alexey, Yeoh, Cindy B., Malinovska-Nikolovska, Liljana, Golubović, Mladjan, Kotzinger, Oskar, Des Deserts, Marc Danguy, Ducrocq, Nicolas, Bonnet, Jean François, Cusack, Barbara, Nallbani, Rajmonda, Daamen, Sylvia, Plichon, Benoit, Harlet, Pierre, Farsi, Slama, Sepehr, Saman Homayun, Espinosa, David, Lurati Buse, Giovanna A., Mauermann, Eckhard, Filipovic, Miodrag, Beck-Schimmer, Beatrice, Gillmann, Hans-Jörg, Guzzetti, Luca, Kotfis, Katarzyna, Wulf, Hinnerk, Larmann, Jan, Corneci, Dan, and Chammartin-Basnet, Frederique

Published
2023
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22. Pathological findings associated with the updated European Society of Cardiology 2022 guidelines for preoperative cardiac testing: an observational cohort modelling study

Author

Stroda, Alexandra, primary, Mauermann, Eckhard, additional, Ionescu, Daniela, additional, Szczeklik, Wojciech, additional, De Hert, Stefan, additional, Filipovic, Miodrag, additional, Beck Schimmer, Beatrice, additional, Spadaro, Savino, additional, Matute, Purificación, additional, Ganter, Michael T., additional, Ovezov, Alexey, additional, Turhan, Sanem C., additional, van Waes, Judith, additional, Lagarto, Filipa, additional, Theodoraki, Kassiani, additional, Gupta, Anil, additional, Gillmann, Hans-Jörg, additional, Guzzetti, Luca, additional, Kotfis, Katarzyna, additional, Larmann, Jan, additional, Corneci, Dan, additional, Buggy, Donal J., additional, Howell, Simon J., additional, Lurati Buse, Giovanna, additional, Kemper, Johann, additional, Kohaupt, Lena, additional, Witzler, Jette, additional, Tuzhikov, Michael, additional, Roth, Sebastian, additional, Stroda, Alexandra, additional, M’Pembele, René, additional, Tenge, Theresa, additional, Schultze, Cornelia, additional, Verbarg, Nele, additional, Gehrke, Christian, additional, Klemann, Anna Katharina, additional, Hagebölling, Friederike, additional, Albrecht, Svenja, additional, Stroeder, Jakob, additional, Schubert, Ann-Kristin, additional, Espeter, Florian, additional, Russe, Benedikt, additional, Weigand, Markus A., additional, Bergmann, Lars, additional, Unterberg, Matthias, additional, Bischoff, Petra, additional, Pirzer, Raphael, additional, Rach, Patric Rene, additional, Ott, Klaus, additional, Zarbock, Alexander, additional, Kowark, Ana, additional, Neumann, Claudia, additional, Marchand, Bahareh, additional, Sponholz, Christoph, additional, Rueffert, Henrik, additional, Kramer, Mira, additional, Zacharowski, Kai, additional, Meybohm, Patrick, additional, Lindau, Simone, additional, Carollo, Melissa, additional, Novazzi, Cecilia, additional, Toso, Fiorenza, additional, Bacuzzi, Alessandro, additional, Ragazzi, Riccardo, additional, Volta, Carlo Alberto, additional, De Giorgi, Francesco, additional, Bacer, Barbara, additional, Federico, Antonio, additional, Chiumello, Davide, additional, Vetrugno, Luigi, additional, Castella, Alberto, additional, Tesoro, Simonetta, additional, Cotoia, Antonella, additional, Bignami, Elena, additional, Bellissima, Agrippino, additional, Cortegiani, Andrea, additional, Crisman, Marco, additional, Toninelli, Arturo, additional, Piazza, Ornella, additional, Mirabella, Lucia, additional, Bossolasco, Matteo, additional, Bona, Francesco, additional, Perdomo, Juan Manuel, additional, Coca-Martinez, Miquel, additional, Carramiñana, Albert, additional, Servén, Marta Giné, additional, González, Astrid Batalla, additional, Gil Sánchez, José Maria, additional, Becerra-Bolaños, Ángel, additional, Rodríguez-Pérez, Aurelio, additional, Soler, Anna Artigas, additional, Basso, Morena, additional, Font, Anna Peig, additional, Vernetta, Diana, additional, Santos, Julia Hernando, additional, Muñoz, Enrique Alday, additional, Olivares, Mercedes Cabellos, additional, Marco, Gregorio, additional, Lopez, Maria Bermudez, additional, Barrio, Javier, additional, Forés, María Isabel, additional, Boix, Estefanía, additional, Ayuso, Mercedes, additional, Petre, Bogdan Sorel, additional, Oprea, Ioana Sorina, additional, Latiș, Mihai Dan, additional, Margarit, Simona, additional, Vasian, Horatiu, additional, Tomescu, Dana, additional, Cîndea, Iulia, additional, Dirzu, Dan Sebastian, additional, Copotoiu, Sanda-Maria, additional, Moise, Alida, additional, Bubenek-Turconi, Serban, additional, Valeanu, Liana, additional, Wanner, Patrick Mark, additional, Djurdjevic, Mirjana, additional, Nuth, Sandra, additional, Seeberger, Esther, additional, Goettel, Nicolai, additional, Kamber, Firmin, additional, Ganter, Michael Thomas, additional, Gerber, Thomas Jan, additional, Schneebeli, Daniela, additional, Pregernig, Andreas, additional, Grape, Sina, additional, Tomala, Simon, additional, Pinto, Bernardo Bollen, additional, Żukowski, Maciej, additional, Zegan-Barańska, Małgorzata, additional, Karolak, Igor, additional, Krzych, Lukasz, additional, Czajka, Szymon, additional, Studzińska, Dorota, additional, Kluzik, Anna, additional, Koszel, Tomasz, additional, Pabjańczyk, Izabela, additional, Gajdosz, Anna, additional, Erkoc, Suheyla Karadag, additional, Meco, Basak Ceyda, additional, Koltka, Ahmet Kemalettin, additional, Dincer, Muserref Beril, additional, Ekmekçi, Perihan, additional, Saracoglu, Kemal Tolga, additional, Solmaz, Filiz Alkaya, additional, Ozcelik, Menekse, additional, Arun, Oguzhan, additional, Dilmen, Ozlem Korkmaz, additional, Preckel, Benedikt, additional, Hollmann, Markus W., additional, Hazen, Yannick, additional, Donald de Boer, Hans, additional, Epema, Anne, additional, Koopman, Seppe, additional, Van Lier, Felix, additional, Pinto, Rita, additional, Carrão, André, additional, Ribeiro, Daniel, additional, Mourão, Joana, additional, Coelho, Miguel, additional, Losa, Nuno, additional, Santos, Nuno, additional, Cabral, Luis, additional, Afonso, Diana, additional, Zenha, Sérgio, additional, Ramos, Cristina, additional, Hipólito, Carla, additional, Vasilaki, Maria, additional, Andreeva, Antonia, additional, Zaimi, Donika, additional, Chalkias, Athanasios, additional, Spyraki, Maria, additional, Rekatsina, Martina, additional, Tsaousi, Georgia, additional, Short, Anthony, additional, Meier, Sonja, additional, Madhuri, Thumuluru Kavitha, additional, Latham, Scott, additional, Knock, James, additional, Drummond, Andrew, additional, Ramsden, Fiona, additional, Kubisz-Pudelko, Agnieszka, additional, Walker, James, additional, Moppett, Iain, additional, White, Louise, additional, Jackson, Matthew, additional, Reschreiter, Henrik, additional, Innes, Richard, additional, Chew, Michelle, additional, Kalman, Sigridur, additional, Wallden, Jakob, additional, Schening, Anna, additional, Jonikaite, Lina, additional, Enlund, Anna, additional, De Baerdemaeker, Luc, additional, Morrison, Stuart, additional, Rex, Steffen, additional, Alexis, Alexandros, additional, Khoronenko, Viktoria E., additional, Belskii, Vladislav, additional, Kaznacheeva, Kseniya, additional, Gritsan, Alexey, additional, Kuzmanovska, Biljana, additional, Malinovska-Nikolovska, Liljana, additional, Barisin, Stjepan, additional, Poredos, Peter, additional, Arabadzhieva, Daniela, additional, Unic-Stojanovic, Dragana, additional, Golubović, Mladjan, additional, Fleischmann, Edith, additional, Kotzinger, Oskar, additional, Des Deserts, Marc Danguy, additional, Ducrocq, Nicolas, additional, Bonnet, Jean François, additional, Cusack, Barbara, additional, Calleja, Paul, additional, Hasani, Antigona, additional, and Nallbani, Rajmonda, additional

Published
2024
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26. Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: the EFICAN randomized controlled trial

Author

Soriano-Maldonado, Alberto, Díez-Fernández, David M., Esteban-Simón, Alba, Rodríguez-Pérez, Manuel A., Artés-Rodríguez, Eva, Casimiro-Artés, Miguel A., Moreno-Martos, Herminia, Toro-de-Federico, Antonio, Hachem-Salas, Nur, Bartholdy, Cecilie, Henriksen, Marius, and Casimiro-Andújar, Antonio J.

Published
2022
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28. POLR3A variants in hereditary spastic paraparesis and ataxia: clinical, genetic, and neuroradiological findings in a cohort of Italian patients

Author

Di Donato, Ilaria, Gallo, Antonio, Ricca, Ivana, Fini, Nicola, Silvestri, Gabriella, Gurrieri, Fiorella, Cirillo, Mario, Cerase, Alfonso, Natale, Gemma, Matrone, Federica, Riso, Vittorio, Melone, Mariarosa Anna Beatrice, Tessa, Alessandra, De Michele, Giovanna, Federico, Antonio, Filla, Alessandro, Dotti, Maria Teresa, and Santorelli, Filippo Maria

Published
2022
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31. Ébrica: una filosofía de la embriaguez

Author

López Silvestre, Federico Antonio, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Filosofía, Vila Leirós, José Luis, López Silvestre, Federico Antonio, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Filosofía, and Vila Leirós, José Luis

Abstract

Esta obra está dedicada a la investigación de la embriaguez y al esbozo de un campo de reflexión propio de ella: he denominado a ese campo Ébrica. Para llevarla a cabo me he apoyado en ciertas referencias, mayormente, de la historia de la filosofía. Las principales son Friedrich Nietzsche y algunos de los autores influidos por él. Propongo a Nietzsche como referencia por la importancia que tiene en su obra el concepto de embriaguez. Alrededor de dicho concepto ensayaré esta ébrica, que toma su nombre de la palabra griega hybris. Esta palabra podría traducirse por «desmesura» y, pensada en sentido nietzscheano, denuncia las interpretaciones excesivamente moralizantes sobre el comportamiento humano y el mundo, pero también sobre la embriaguez, así como la predisposición a castigar cruelmente ciertas acciones y actitudes identificadas con una satisfacción contraria al dictado de los dioses.

Published
2024

32. Bonediol Production in Bonellia macrocarpa Hairy Root Culture

Author

Alvarez-Gutiérrez, Peggy Elizabeth, Ruiz-Ramirez, Luis Alberto, Godoy-Hernández, Gregorio del Carmen, Gutiérrez-Miceli, Federico Antonio, Mérillon, Jean-Michel, Series Editor, Ramawat, Kishan Gopal, Series Editor, Ekiert, Halina Maria, editor, and Goyal, Shaily, editor

Published
2021
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35. A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes.

Author

del Giudice, Giusy, Serra, Angela, Pavel, Alisa, Torres Maia, Marcella, Saarimäki, Laura Aliisa, Fratello, Michele, Federico, Antonio, Alenius, Harri, Fadeel, Bengt, and Greco, Dario

Subjects
TOXICOLOGY, BIOLOGICAL systems, LIFE sciences, NANOSTRUCTURED materials, SYSTEMS theory, SYSTEMS biology
Abstract

Hazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity. However, systems toxicology emphasizes how system properties significantly contribute to the observed response. Hence, systems theory states that interactions store more information than individual elements, leading to the adoption of network based models to represent complex systems in many fields of life sciences. Here, they develop a network‐based approach to characterize toxicological responses in the context of a biological system, inferring biological system specific networks. They directly link molecular alterations to the adverse outcome pathway (AOP) framework, establishing direct connections between omics data and toxicologically relevant phenotypic events. They apply this framework to a dataset including 31 engineered nanomaterials with different physicochemical properties in two different in vitro and one in vivo models and demonstrate how the biological system is the driving force of the observed response. This work highlights the potential of network‐based methods to significantly improve their understanding of toxicological mechanisms from a systems biology perspective and provides relevant considerations and future data‐driven approaches for the hazard assessment of nanomaterials and other advanced materials. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Structural validity of the physical fitness test battery

Author

S. Palevych, V. Kirpenko, A. Piddubny, S. Bozhko, Z. Tzymbaliyk, Michael Anthonny Martinez Velez, Federico Anibal Martinez Velez, Jorge Armando Moreta Vinueza, and Federico Antonio Martinez Leon

Subjects
validity, physical fitness, confirmatory factor analysis, military personnel., Sports, GV557-1198.995, Recreation leadership. Administration of recreation services, GV181.35-181.6
Abstract

Purpose: of the study was to examine the validity of the Army Combat Fitness Test tests on a sample of air defense personnel in the Ukrainian Ground Forces. Material and methods. The respondents to this study were 271 air defense servicemen of the ground forces aged 18 to 40 years (73 cadets of the Ivan Kozhedub Kharkiv National Air Force University and 198 military personnel). The structural validity was evaluated using a confirmatory factor analysis. Results. Compliance was achieved with the two-factor model obtained in the course of exploratory factor analysis, as evidenced by the following indixes: χ2 (8, Critical N = 465.29) = 10.43; χ2 / df = 1.303; Non-Normed Fit Index = 0.98; Normed Fit Index = 0.97; Root Mean Square Error of Approximation = 0.035 (90 Percent Confidence Interval for Root Mean Square Error of Approximation = (0.0; 0.088), Comparative Fit Index = 0.99. In addition, all factor loadings were statistically significant at the p < 0.01 level, that indicates that these two factors were well designed at every stage. Correlation between factors was weak, which confirms the discriminant validity of the test. The significant correlation found between the items and the overall test score confirmed the validity of the test. Conclusions. It was found that Army Combat Fitness Test is a suitable tool for evaluating the physical fitness condition of air defense personnel into the Ground Forces. The dilemmas about the possible use of Army Combat Fitness Test for all age groups of military personnel regardless of gender require further study.

Published
2021
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40. Association between self-reported functional capacity and general postoperative complications: analysis of predefined outcomes of the MET-REPAIR international cohort study

Author

Roth, Sebastian, primary, M'Pembele, René, additional, Nienhaus, Johannes, additional, Mauermann, Eckhard, additional, Ionescu, Daniela, additional, Szczeklik, Wojciech, additional, De Hert, Stefan, additional, Filipovic, Miodrag, additional, Beck-Schimmer, Beatrice, additional, Spadaro, Savino, additional, Matute, Purificación, additional, Bolliger, Daniel, additional, Turhan, Sanem C., additional, van Waes, Judith, additional, Lagarto, Filipa, additional, Theodoraki, Kassiani, additional, Gupta, Anil, additional, Gillmann, Hans-Jörg, additional, Guzzetti, Luca, additional, Kotfis, Katarzyna, additional, Wulf, Hinnerk, additional, Larmann, Jan, additional, Corneci, Dan, additional, Chammartin, Frédérique, additional, Howell, Simon J., additional, Lurati Buse, Giovanna, additional, Roth, Sebastian, additional, Kemper, Johann, additional, Kohaupt, Lena, additional, Witzler, Jette, additional, Tuzhikov, Michael, additional, Stroda, Alexandra, additional, Tenge, Theresa, additional, Huhn, Ragnar, additional, Schultze, Cornelia, additional, Verbarg, Nele, additional, Gehrke, Christian, additional, Klemann, Anna Katharina, additional, Hagebölling, Friederike, additional, Albrecht, Svenja, additional, Stroeder, Jakob, additional, Schubert, Ann-Kristin, additional, Espeter, Florian, additional, Russe, Benedikt, additional, Weigand, Markus A., additional, Bergmann, Lars, additional, Unterberg, Matthias, additional, Bischoff, Petra, additional, Pirzer, Raphael, additional, Rach, Patric Rene, additional, Ott, Klaus, additional, Zarbock, Alexander, additional, Kowark, Ana, additional, Neumann, Claudia, additional, Marchand, Bahareh, additional, Sponholz, Christoph, additional, Rueffert, Henrik, additional, Kramer, Mira, additional, Piekarski, Florian, additional, Carollo, Melissa, additional, Novazzi, Cecilia, additional, Toso, Fiorenza, additional, Bacuzzi, Alessandro, additional, Ragazzi, Riccardo, additional, Volta, Carlo Alberto, additional, De Giorgi, Francesco, additional, Bacer, Barbara, additional, Federico, Antonio, additional, Chiumello, Davide, additional, Vetrugno, Luigi, additional, Castella, Alberto, additional, Tesoro, Simonetta, additional, Cotoia, Antonella, additional, Bignami, Elena, additional, Bellissima, Agrippino, additional, Cortegiani, Andrea, additional, Crisman, Marco, additional, Toninelli, Arturo, additional, Piazza, Ornella, additional, Mirabella, Lucia, additional, Bossolasco, Matteo, additional, Bona, Francesco, additional, Perdomo, Juan Manuel, additional, Coca-Martinez, Miquel, additional, Carramiñana, Albert, additional, Servén, Marta Giné, additional, González, Astrid Batalla, additional, Gil Sánchez, José Maria, additional, Becerra-Bolaños, Ángel, additional, Rodríguez-Pérez, Aurelio, additional, Soler, Anna Artigas, additional, Basso, Morena, additional, Font, Anna Peig, additional, Vernetta, Diana, additional, Santos, Julia Hernando, additional, Muñoz, Enrique Alday, additional, Olivares, Mercedes Cabellos, additional, Marco, Gregorio, additional, Lopez, Maria Bermudez, additional, Barrio, Javier, additional, Forés, María Isabel, additional, Boix, Estefanía, additional, Ayuso, Mercedes, additional, Petre, Bogdan Sorel, additional, Oprea, Ioana Sorina, additional, Latiș, Mihai Dan, additional, Margarit, Simona, additional, Vasian, Horatiu, additional, Tomescu, Dana, additional, Cîndea, Iulia, additional, Dirzu, Dan Sebastian, additional, Copotoiu, Sanda-Maria, additional, Moise, Alida, additional, Bubenek-Turconi, Serban, additional, Valeanu, Liana, additional, Wanner, Patrick Mark, additional, Djurdjevic, Mirjana, additional, Nuth, Sandra, additional, Seeberger, Esther, additional, Goettel, Nicolai, additional, Kamber, Firmin, additional, Ganter, Michael Thomas, additional, Gerber, Thomas Jan, additional, Schneebeli, Daniela, additional, Pregernig, Andreas, additional, Grape, Sina, additional, Tomala, Simon, additional, Pinto, Bernardo Bollen, additional, Żukowski, Maciej, additional, Zegan-Barańska, Małgorzata, additional, Karolak, Igor, additional, Krzych, Lukasz, additional, Czajka, Szymon, additional, Studzińska, Dorota, additional, Kluzik, Anna, additional, Koszel, Tomasz, additional, Pabjańczyk, Izabela, additional, Gajdosz, Anna, additional, Erkoc, Suheyla Karadag, additional, Meco, Basak Ceyda, additional, Koltka, Ahmet Kemalettin, additional, Dincer, Muserref Beril, additional, Ekmekçi, Perihan, additional, Saracoglu, Kemal Tolga, additional, Solmaz, Filiz Alkaya, additional, Ozcelik, Menekse, additional, Arun, Oguzhan, additional, Dilmen, Ozlem Korkmaz, additional, Preckel, Benedikt, additional, Hollmann, Markus W., additional, Hazen, Yannick, additional, Donald de Boer, Hans, additional, Epema, Anne, additional, Koopman, Seppe, additional, Van Lier, Felix, additional, Pinto, Rita, additional, Carrão, André, additional, Ribeiro, Daniel, additional, Mourão, Joana, additional, Coelho, Miguel, additional, Santos, Nuno, additional, Cabral, Luis, additional, Afonso, Diana, additional, Zenha, Sérgio, additional, Ramos, Cristina, additional, Hipólito, Carla, additional, Vasilaki, Maria, additional, Andreeva, Antonia, additional, Zaimi, Donika, additional, Chalkias, Athanasios, additional, Spyraki, Maria, additional, Rekatsina, Martina, additional, Tsaousi, Georgia, additional, Short, Anthony, additional, Meier, Sonja, additional, Madhuri, Thumuluru Kavitha, additional, Latham, Scott, additional, Knock, James, additional, Drummond, Andrew, additional, Ramsden, Fiona, additional, Kubisz-Pudelko, Agnieszka, additional, Walker, James, additional, Moppett, Iain, additional, White, Louise, additional, Jackson, Matthew, additional, Reschreiter, Henrik, additional, Innes, Richard, additional, Chew, Michelle, additional, Kalman, Sigridur, additional, Wallden, Jakob, additional, Schening, Anna, additional, Jonikaite, Lina, additional, Enlund, Anna, additional, De Baerdemaeker, Luc, additional, Morrison, Stuart, additional, Rex, Steffen, additional, Alexis, Alexandros, additional, Khoronenko, Viktoria E., additional, Ovezov, Alexey, additional, Belskii, Vladislav, additional, Kaznacheeva, Kseniya, additional, Gritsan, Alexey, additional, Kuzmanovska, Biljana, additional, Malinovska-Nikolovska, Liljana, additional, Barisin, Stjepan, additional, Poredos, Peter, additional, Arabadzhieva, Daniela, additional, Unic-Stojanovic, Dragana, additional, Golubović, Mladjan, additional, Fleischmann, Edith, additional, Kotzinger, Oskar, additional, Des Deserts, Marc Danguy, additional, Ducrocq, Nicolas, additional, Buggy, Donal J., additional, Bonnet, Jean François, additional, Cusack, Barbara, additional, Calleja, Paul, additional, Hasani, Antigona, additional, and Nallbani, Rajmonda, additional

Published
2024
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42. Beyond Basic Characterization and Omics: Immunomodulatory Roles of Platelet-Derived Extracellular Vesicles Unveiled by Functional Testing

Author

Palviainen, Mari, primary, Puutio, Johanna, additional, Østergaard, Rikke Halse, additional, Eble, Johannes A, additional, Maaninka, Katariina, additional, Ndika, Joseph, additional, Kari, Otto K, additional, Kamali-Moghaddam, Masood, additional, Kjær-Sørensen, Kasper, additional, Oxvig, Claus, additional, Aransay, Ana M, additional, Falcon-Perez, Juan M, additional, Federico, Antonio, additional, Greco, Dario, additional, Laitinen, Saara, additional, Hayashi, Yuya, additional, and Siljander, Pia R-M, additional

Published
2024
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50. Longitudinal changes in MoCA performances in patients with mild cognitive impairment and small vessel disease. Results from the VMCI-Tuscany Study

Author

Salvadori, Emilia, Poggesi, Anna, Pracucci, Giovanni, Chiti, Alberto, Ciolli, Laura, Del Bene, Alessandra, Di Donato, Ilaria, Marini, Sandro, Nannucci, Serena, Orlandi, Giovanni, Pasi, Marco, Pescini, Francesca, Valenti, Raffaella, Federico, Antonio, Dotti, Maria Teresa, Bonuccelli, Ubaldo, Inzitari, Domenico, and Pantoni, Leonardo

Published
2021
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