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1. Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

Author

Tatovic, Danijela, Marwaha, Ashish, Taylor, Peter, Hanna, Stephanie J., Carter, Kym, Cheung, W. Y., Luzio, Steve, Dunseath, Gareth, Hutchings, Hayley A., Holland, Gail, Hiles, Steve, Fegan, Greg, Williams, Evangelia, Yang, Jennie H. M., Domingo-Vila, Clara, Pollock, Emily, Wadud, Muntaha, Ward-Hartstonge, Kirsten, Marques-Jones, Susie, Bowen-Morris, Jane, Stenson, Rachel, Levings, Megan K., Gregory, John W., Tree, Timothy I. M., and Dayan, Colin

Published
2024
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2. Author Correction: Randomised feasibility study of prehospital recognition and antibiotics for emergency patients with sepsis (PhRASe)

Author

Jones, Jenna, Allen, Susan, Davies, Jan, Driscoll, Timothy, Ellis, Gemma, Fegan, Greg, Foster, Theresa, Francis, Nick, Islam, Saiful, Morgan, Matt, Nanayakkara, Prabath W. B., Perkins, Gavin D., Porter, Alison, Rainer, Timothy, Ricketts, Samuel, Sewell, Bernadette, Shanahan, Tracy, Smith, Fang Gao, Smyth, Michael A., Snooks, Helen, and Moore, Chris

Published
2022
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3. Randomised feasibility study of prehospital recognition and antibiotics for emergency patients with sepsis (PhRASe)

Author

Jones, Jenna, Allen, Susan, Davies, Jan, Driscoll, Timothy, Ellis, Gemma, Fegan, Greg, Foster, Theresa, Francis, Nick, Islam, Saiful, Morgan, Matt, Nanayakkara, Prabath W. B., Perkins, Gavin D., Porter, Alison, Rainer, Timothy, Ricketts, Samuel, Sewell, Bernadette, Shanahan, Tracy, Smith, Fang Gao, Smyth, Michael A., Snooks, Helen, and Moore, Chris

Published
2021
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9. MORU Tropical Health Network Annual Report 2021

Author

Day, Nicholas, Dondorp, Arjen M, Limmathurotsakul, Direk, Maude, Richard, Tarning, Joel, Cheah, Phaik Yeong, Pan-ngum, Wirichida, White, Nicholas J, Fegan, Greg, Burton, David, Nosten, François, Ashley, Elizabeth A, Turner, Paul, Smithuis, Frank, Newton, Paul N, Fanello, Caterina, Bleho, John, Day, Nicholas P J, Dondorp, Arjen M, Limmathurotsakul, Direk, Maude, Richard, Tarning, Joel, Cheah, Phaik Yeong, Pan-ngum, Wirichida, White, Nicholas J, Fegan, Greg, Burton, David, Nosten, François, Ashley, Elizabeth A., Turner, Paul, Smithuis, Frank, Newton, Paul N, Fanello, Caterina, and Bleho, John

Subjects
Annual report, Medical research, Tropical medicine, MORU
Abstract

2021 Annual Report for the MORU Tropical Health Network, Mahidol Oxford Tropical Medicine Research Unit

Published
2022
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11. Author Correction:Randomised feasibility study of prehospital recognition and antibiotics for emergency patients with sepsis (PhRASe) (Scientific Reports, (2021), 11, 1, (18586), 10.1038/s41598-021-97979-w)

Author

Jones, Jenna, Allen, Susan, Davies, Jan, Driscoll, Timothy, Ellis, Gemma, Fegan, Greg, Foster, Theresa, Francis, Nick, Islam, Saiful, Morgan, Matt, Nanayakkara, Prabath W. B., Perkins, Gavin D., Porter, Alison, Rainer, Timothy, Ricketts, Samuel, Sewell, Bernadette, Shanahan, Tracy, Smith, Fang Gao, Smyth, Michael A., Snooks, Helen, Moore, Chris, Internal medicine, APH - Quality of Care, APH - Digital Health, and ACS - Diabetes & metabolism

Abstract

The original version of this Article contained errors in Table 1 and Table 3. In Table 1, in the group “Already taking antibiotics at emergency call, n (%)”, the number of patients in “Intervention (n = 62)” and “Control (n = 52)” were interchanged. The incorrect and correct values appear below. Incorrect:(Table preseneted.)

Published
2022
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12. Prehospital recognition and antibiotics for 999 patients with sepsis: protocol for a feasibility study

Author

Moore, Chris, Bulger, Jenna, Morgan, Matt, Driscoll, Timothy, Porter, Alison, Islam, Saiful, Smyth, Mike, Perkins, Gavin, Sewell, Bernadette, Rainer, Timothy, Nanayakkara, Prabath, Okolie, Chukwudi, Allen, Susan, Fegan, Greg, Davies, Jan, Foster, Theresa, Francis, Nick, Smith, Fang Gao, Ellis, Gemma, Shanahan, Tracy, Howe, Robin, and Snooks, Helen

Published
2018
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13. A novel blood based triage test for colorectal cancer in primary care: a pilot study

Author

Jenkins, Cerys, primary, Woods, Freya, additional, Chandler, Susan, additional, Carter, Kym, additional, Jenkins, Rhys, additional, Cunningham, Andrew, additional, Nelson, Kayleigh, additional, Still, Rachel, additional, Walters, Jenna A, additional, Gwynn, Non, additional, Chea, Wilson, additional, Harford, Rachel, additional, O'Neill, Claire, additional, Hepburn, Julie, additional, Hill, Ian, additional, Wilkes, Heather, additional, Fegan, Greg, additional, Dunstan, Peter, additional, and Harris, Dean A, additional

Published
2022
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15. "Happy to close?" The relationship between surgical experience and incisional hernia rates following abdominal wall closure in colorectal surgery.

Author

Smith, Laurie, Coxon‐Meggy, Alexandra, Shinkwin, Michael, Cornish, Julie, Watkins, Alan, Fegan, Greg, Torkington, Jared, Torkington, J., Harries, R., O'Connell, S., Knight, L., Islam, S., Bashir, N., Watkins, A., Fegan, G., Cornish, J., Rees, B., Cole, H., Jarvis, H., and Jones, S.

Subjects
ABDOMINAL wall, PROCTOLOGY, HERNIA, HERNIA surgery, ELECTIVE surgery, SURGICAL complications
Abstract

Aim: Incisional hernia (IH) is a common complication of colorectal surgery, affecting up to 30% of patients at 2 years. Given the associated morbidity and high recurrence rates after attempted repair of IH, emphasis should be placed on prevention. There is an association between surgeon volume and outcomes in hernia surgery, yet there is little evidence regarding impact of the seniority of the surgeon performing abdominal wall closure on IH rate. The aim of our study was to assess the rates of IH at 1 year following abdominal wall closure between junior and senior surgeons in patients undergoing elective colorectal surgery. Methods: This was an exploratory analysis of patients who underwent elective surgery for colorectal cancer between 2014–2018 as part of the Hughes Abdominal Repair Trial (HART), a prospective, multicentre randomised control trial comparing abdominal wall closure methods. Grade of surgeon performing abdominal closure was categorised into "trainee" and "consultant" and compared to IH rate at one year. Results: A total of 663 patients were included in this retrospective analysis of patients in the HART trial. The rate of IH in patients closed by trainees was 20%, compared to 12% in those closed by consultants (p = <0.001). When comparing closure methods, IH rates were significantly higher in the Hughes closure arm between trainees and consultants (20% vs. 12%, p = 0.032), but not high enough in the mass closure arm to reach statistical significance (21% vs. 13%, p = 0.058). On multivariate analysis, age (p = 0.036, OR: 1.02, 95% CI: 1.00–1.04), Male sex (p = 0.049, OR: 1.61, 95% CI: 1.00–2.59) and closure by a trainee (p = 0.006, OR: 1.85, 95% CI: 1.20–2.85) were identified as risk factors for developing IH. Conclusion: Patients who undergo abdominal wall closure by a surgeon in training have an increased risk of developing IH when compared to those closed by a consultant. Further work is needed to determine the impact of supervised and unsupervised trainees on IH rates, but abdominal wall closure should be regarded as a training opportunity in its own right. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Hughes abdominal closure versus standard mass closure to reduce incisional hernias following surgery for colorectal cancer: the HART RCT

Author

O’Connell, Susan, primary, Islam, Saiful, additional, Sewell, Bernadette, additional, Farr, Angela, additional, Knight, Laura, additional, Bashir, Nadim, additional, Harries, Rhiannon, additional, Jones, Sian, additional, Cleves, Andrew, additional, Fegan, Greg, additional, Watkins, Alan, additional, and Torkington, Jared, additional

Published
2022
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20. Dementia Early Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia:randomised controlled trial

Author

Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, Roe, Brenda, Malik, Baber, Robinson, Catherine A, Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, Roe, Brenda, Malik, Baber, and Robinson, Catherine A

Abstract

BACKGROUND Common memory aids for people with dementia at home are recommended. However, rigorous evaluation is lacking, particularly what guidance or support is valued. OBJECTIVE To investigate effects of memory aids and guidance by Dementia Support Practitioners (DSPs) for people in early stage dementia through a pragmatic, randomised controlled trial. METHODS Of 469 people with mild to moderate dementia and their informal carers, 468 were randomised to a DSP with memory aids or to usual care plus existing dementia guide. Allocation was stratified by: Trust/Health Board; time since first attendance at memory service; gender; age; and living with primary carer or not. Primary outcome was Bristol Activities of Daily Living Scale (BADLS) score at 3 and 6 months (primary end-point). Secondary outcomes for people with dementia: quality of life (CASP-19; DEMQOL); cognition and functioning (Clinical Dementia Rating Scale; SMMSE); capability (ICECAP-O); social networks (LSNS-R); and instrumental daily living activities (R-IDDD). Secondary outcomes for carers: psychological health (GHQ-12); sense of competence (SSCQ). RESULTS DSPs were successfully trained, compliance was good and welcomed by participants. Mean 6 months BADLS score increased to 14.6 (SD 10.4) in intervention and 12.6 (SD 8.1) in comparator, indicative of greater dependence in the activities of daily living. Adjusted between group difference was 0.38 (95% confidence interval -0.89 to 1.65, P=0.56). Though this suggests greater dependency in the intervention group the difference was not significant. No differences were found in secondary outcomes. CONCLUSIONS This intervention did not maintain independence in the activities of daily living with no improvement in other outcomes for people with dementia or carers.

Published
2022

21. Dementia Early Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia : randomised controlled trial

Author

Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, Roe, Brenda, Malik, Baber, Robinson, Catherine A, Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, Roe, Brenda, Malik, Baber, and Robinson, Catherine A

Abstract

BACKGROUND Common memory aids for people with dementia at home are recommended. However, rigorous evaluation is lacking, particularly what guidance or support is valued. OBJECTIVE To investigate effects of memory aids and guidance by Dementia Support Practitioners (DSPs) for people in early stage dementia through a pragmatic, randomised controlled trial. METHODS Of 469 people with mild to moderate dementia and their informal carers, 468 were randomised to a DSP with memory aids or to usual care plus existing dementia guide. Allocation was stratified by: Trust/Health Board; time since first attendance at memory service; gender; age; and living with primary carer or not. Primary outcome was Bristol Activities of Daily Living Scale (BADLS) score at 3 and 6 months (primary end-point). Secondary outcomes for people with dementia: quality of life (CASP-19; DEMQOL); cognition and functioning (Clinical Dementia Rating Scale; SMMSE); capability (ICECAP-O); social networks (LSNS-R); and instrumental daily living activities (R-IDDD). Secondary outcomes for carers: psychological health (GHQ-12); sense of competence (SSCQ). RESULTS DSPs were successfully trained, compliance was good and welcomed by participants. Mean 6 months BADLS score increased to 14.6 (SD 10.4) in intervention and 12.6 (SD 8.1) in comparator, indicative of greater dependence in the activities of daily living. Adjusted between group difference was 0.38 (95% confidence interval -0.89 to 1.65, P=0.56). Though this suggests greater dependency in the intervention group the difference was not significant. No differences were found in secondary outcomes. CONCLUSIONS This intervention did not maintain independence in the activities of daily living with no improvement in other outcomes for people with dementia or carers.

Published
2022

24. A novel blood based triage test for colorectal cancer in primary care: a pilot study.

Author

Jenkins, Cerys, Woods, Freya, Chandler, Susan, Carter, Kym, Jenkins, Rhys, Cunningham, Andrew, Nelson, Kayleigh, Still, Rachel, Walters, Jenna A., Gwynn, Non, Chea, Wilson, Harford, Rachel, O'Neill, Claire, Hepburn, Julie, Hill, Ian, Wilkes, Heather, Fegan, Greg, Dunstan, Peter, and Harris, Dean A.

Subjects
PILOT projects, RESEARCH methodology, COLORECTAL cancer, PRIMARY health care, RAMAN spectroscopy, QUALITATIVE research, DESCRIPTIVE statistics, RESEARCH funding, DIAGNOSTIC errors, THEMATIC analysis, LONGITUDINAL method
Abstract

Background: The majority of colorectal cancers (CRCs) are detected after symptomatic presentation to primary care. Given the shared symptoms of CRC and benign disorders, it is challenging to manage the risk of missed diagnosis. Colonoscopy resources cannot keep pace with increasing demand. There is a pressing need for access to simple triage tools in primary care to help prioritise patients for referral. Aim: To evaluate the performance of a novel spectroscopy-based CRC blood test in primary care. Design & setting: Mixed-methods pilot study of test performance and GP focus group discussions in South Wales. Method: Patients on the urgent suspected cancer (USC) pathway were recruited for the Raman spectroscopy (RS) test coupled to machine learning classification (‘Raman-CRC’) to identify CRC within the referred population. Qualitative focus group work evaluated the acceptability of the test in primary care by thematic analysis of focus group theorising. Results: A total of 532 patients aged ≥50 years referred on the USC pathway were recruited from 27 GP practices. Twenty-nine patients (5.0%) were diagnosed with CRC. Raman-CRC identified CRC with sensitivity 95.7%, specificity 69.3% with area under curve (AUC) of 0.80 compared with colonoscopy as the reference test (248 patients). Stage I and II cancers were detected with 78.6% sensitivity. Focus group themes underlined the convenience of a blood test for the patient and the test’s value as a risk assessment tool in primary care. Conclusion: The findings support this novel, non-invasive, blood-based method to prioritise those patients most l [ABSTRACT FROM AUTHOR]

Published
2023
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25. A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: A double-blind, randomized controlled trial

Author

Bandsma, Robert H. J., Voskuijl, Wieger, Chimwezi, Emmanuel, Fegan, Greg, Briend, André, Thitiri, Johnstone, Ngari, Moses, Mwalekwa, Laura, Bandika, Victor, Ali, Rehema, Hamid, Fauzat, Owor, Betty, Mturi, Neema, Potani, Isabel, Allubha, Benjamin, Muller Kobold, Anneke C., Bartels, Rosalie H., Versloot, Christian J., Feenstra, Marjon, van den Brink, Deborah A., van Rheenen, Patrick F., Kerac, Marko, Bourdon, Celine, and Berkley, James A.

Subjects
Care and treatment, Analysis, Usage, Research, Risk factors, Patient outcomes, Clinical trials -- Analysis, Pediatric research, Milk -- Usage -- Research, Child malnutrition -- Care and treatment -- Risk factors -- Patient outcomes -- Research, Mortality, Lactose, Diarrhea, Hospital patients, Edema, HIV, Malnutrition, Health, Public health, Children
Abstract

Author(s): Robert H. J. Bandsma 1,2,3,4,5,6,7,*, Wieger Voskuijl 7,8,9, Emmanuel Chimwezi 8, Greg Fegan 10, André Briend 11,12, Johnstone Thitiri 13, Moses Ngari 13, Laura Mwalekwa 13, Victor Bandika 14, [...], Background Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality and delayed recovery. We tested the hypothesis that a lactose-free, low-carbohydrate F75 milk would serve to limit these risks, thereby reducing the number of days in the stabilization phase. Methods and findings In a multicenter double-blind trial, hospitalized severely malnourished children were randomized to receive standard formula (F75) or isocaloric modified F75 (mF75) without lactose and with reduced carbohydrate. The primary endpoint was time to stabilization, as defined by the World Health Organization (WHO), with intention-to-treat analysis. Secondary outcomes included in-hospital mortality, diarrhea, and biochemical features of malabsorption and refeeding syndrome. The trial was registered at clinicaltrials.gov (NCT02246296). Four hundred eighteen and 425 severely malnourished children were randomized to F75 and mF75, respectively, with 516 (61%) enrolled in Kenya and 327 (39%) in Malawi. Children with a median age of 16 months were enrolled between 4 December 2014 and 24 December 2015. One hundred ninety-four (46%) children assigned to F75 and 188 (44%) to mF75 had diarrhea at admission. Median time to stabilization was 3 days (IQR 2-5 days), which was similar between randomized groups (0.23 [95% CI -0.13 to 0.60], P = 0.59). There was no evidence of effect modification by diarrhea at admission, age, edema, or HIV status. Thirty-six and 39 children died before stabilization in the F75 and in mF75 arm, respectively (P = 0.84). Cumulative days with diarrhea (P = 0.27), enteral (P = 0.42) or intravenous fluids (P = 0.19), other serious adverse events before stabilization, and serum and stool biochemistry at day 3 did not differ between groups. The main limitation was that the primary outcome of clinical stabilization was based on WHO guidelines, comprising clinical evidence of recovery from acute illness as well as metabolic stabilization evidenced by recovery of appetite. Conclusions Empirically treating hospitalized severely malnourished children during the stabilization phase with lactose-free, reduced-carbohydrate milk formula did not improve clinical outcomes. The biochemical analyses suggest that the lactose-free formulae may still exceed a carbohydrate load threshold for intestinal absorption, which may limit their usefulness in the context of complicated SAM. Trial registration ClinicalTrials.gov NCT02246296.

Published
2019
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26. Maternal colonization with Streptococcus agalactiae and associated stillbirth and neonatal disease in coastal Kenya

Author

Seale, Anna C., Koech, Angela C., Sheppard, Anna E., Barsosio, Hellen C., Langat, Joyce, Anyango, Emily, Mwakio, Stella, Mwarumba, Salim, Morpeth, Susan C., Anampiu, Kirimi, Vaughan, Alison, Giess, Adam, Mogeni, Polycarp, Walusuna, Leahbell, Mwangudzah, Hope, Mwanzui, Doris, Salim, Mariam, Kemp, Bryn, Jones, Caroline, Mturi, Neema, Tsofa, Benjamin, Mumbo, Edward, Mulewa, David, Bandika, Victor, Soita, Musimbi, Owiti, Maureen, Onzere, Norris, Walker, A. Sarah, Schrag, Stephanie J., Kennedy, Stephen H., Fegan, Greg, Crook, Derrick W., and Berkley, James A.

Published
2016
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28. Dementia Early-Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia: randomised controlled trial

Author

Clarkson, Paul, primary, Pitts, Rosa, additional, Islam, Saiful, additional, Peconi, Julie, additional, Russell, Ian, additional, Fegan, Greg, additional, Beresford, Rebecca, additional, Entwistle, Charlotte, additional, Gillan, Vincent, additional, Orrell, Martin, additional, Challis, David, additional, Chester, Helen, additional, Hughes, Jane, additional, Kapur, Narinder, additional, Roe, Brenda, additional, Malik, Baber, additional, and Robinson, Catherine, additional

Published
2021
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29. Phase II multicentre, double-blind, randomised trial of ustekinumab in adolescents with new-onset type 1 diabetes (USTEK1D): trial protocol

Author

Gregory, John W, primary, Carter, Kymberley, additional, Cheung, Wai Yee, additional, Holland, Gail, additional, Bowen-Morris, Jane, additional, Luzio, Stephen, additional, Dunseath, Gareth, additional, Tree, Timothy, additional, Yang, Jennie Hsiu Mien, additional, Marwaha, Ashish, additional, Ali, Mohammad Alhadj, additional, Bashir, Nadim, additional, Hutchings, Hayley Anne, additional, Fegan, Greg W, additional, Stenson, Rachel, additional, Hiles, Stephen, additional, Marques-Jones, Susie, additional, Brown, Amy, additional, Tatovic, Danijela, additional, and Dayan, Colin, additional

Published
2021
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30. Mid-upper arm circumference at age of routine infant vaccination to identify infants at elevated risk of death: a retrospective cohort study in the Gambia

Author

Mwangome, Martha K., Fegan, Greg, Fulford, Tony, Prentice, Andrew M., and Berkley, James A.

Subjects
Care and treatment, Usage, Risk factors, Health aspects, Malnutrition -- Risk factors -- Care and treatment, Infant mortality -- Risk factors, Anthropometry -- Usage, Vaccination -- Usage -- Health aspects, Infants -- Patient outcomes
Abstract

Introduction Recent estimates indicate that 8.5 million infants less than 6 months of age throughout the world are wasted by World Health Organization (WHO) growth standards, which define wasting as [...], Mid-upper arm circumference at age of routine infant vaccination to identify infants at elevated risk of death: a retrospective cohort study in the Gambia/Circonference du bras a mi-hauteur a l'age de la vaccination systematique des nourrissons pour identifier les enfants dont le risque de deces est eleve: une etude de cohorte retrospective en Gambie/El perimetro braquial a la edad de la vacunacion infantil rutinaria para identificar a los lactantes con un riesgo de muerte elevado: un estudio de cohorte retrospectivo en Gambia. Objective To determine the predictive value for death before 12 months of age of mid-upper arm circumference (MUAC) and weight-for-length Z score (WFLz). Methods A retrospective cohort analysis of infants living in Keneba, in rural Gambia, was conducted. Anthropometric measures were obtained from demographic surveillance system records for infants registered between February 1974 and July 2008 who had had MUAC and WFLz recorded at 6-14 weeks of age and vital status recorded at least once more. Hazard ratios (HRs), population attributable fractions and areas under receiver operating characteristic (ROC) curves were estimated to assess the predictive value for death in infancy of MUAC and WFLz. Findings Of 2876 infants included in the analysis, 40 died before the age of 12 months. The HR for death in this group versus in well-nourished infants was 5.8 (95% confidence interval, CI: 1.6-21) for a WFLz < -3. HRs for MUACs below the thresholds of 115 mm, 110 mm and 105 mm were 4.5 (95% CI: 1.4-15), 9.5 (95% CI: 2.6-35) and 23 (95% CI: 4.2-122), respectively. The attributable fractions for a MUAC < 130 mm and a WFLz < 0 were 51% and 13%, respectively. The areas under the ROC curve for death in infancy were 0.55 (95% CI: 0.46 to 0.64) for WFLz and 0.64 (95% CI: 0.55 to 0.73) for MUAC. Conclusion Among infants aged 6 to 14 weeks, unadjusted MUAC showed good performance in identifying infants at increased risk of death. Objectif Determiner la valeur predictive de deces avant l'age de 12 mois sur la base de la circonference du bras a mi-hauteur (ou perimetre brachial, soit PB) et du score centre reduit poids-pour-taille (WFLz). Methodes Une analyse de cohorte retrospective a ete effectuee sur des nourrissons vivant a Keneba, dans la Gambie rurale. Les mesures anthropometriques ont ete extraites des dossiers du systeme de surveillance demographique pour les nourrissons inscrits entre fevrier 1974 et juillet 2008, dont le PB et le WFLz avaient ete enregistres entre 6 et 14 semaines, et dont le statut vital avait ete enregistre au moins une fois par la suite. Les ratios de risque (RR), les fractions etiologiques du risque et les zones sous les courbes de caracteristique de fonctionnement du recepteur (ROC) ont ete estimes pour evaluer la valeur du perimetre brachial et du WFLz afin de predire le deces des nourrissons. Resultats Sur 2 876 nourrissons inclus dans l'analyse, 40 sont morts avant l'age de 12 mois. Le RR de deces dans ce groupe, par rapport aux nourrissons bien nourris etait de 5,8 (intervalle de confiance de 95%, IC: 1,6 a 21) pour un WFLz < -3. Les RR des PB en dessous des seuils de 115 mm, 110 mm et 105 mm etaient de 4,5 (IC de 95%: 1,4 a 15), 9,5 (IC de 95%: 2,6 a 35) et 23 (IC de 95%: 4,2 a 122), respectivement. Les fractions etiologiques du risque pour un PB < 130 mm et un WFLz < 0 etaient de 51% et 13%, respectivement. Les zones sous la courbe ROC pour le deces en bas age etaient respectivement de 0,55 (IC de 95%: 0,46 a 0,64) et de 0,64 pour le WFLz (IC de 95%: 0,55 a 0,73) et pour le PB. Conclusion Parmi les nourrissons ages de 6 a 14 semaines, un PB non ajuste s'est revele performant afin d'identifier les nourrissons dont le risque de deces est accru. Objetivo Determinar el valor diagnostico de la muerte antes de los 12 meses de edad del perlmetro braquial y de la puntuacion Z de peso para la talla. Metodos Se llevo a cabo un analisis de cohorte retrospectivo de los lactantes residentes en Keneba, una zona rural de Gambia. Se obtuvieron las medidas antropometricas de los archivos del sistema de vigilancia demografica para lactantes registrados entre febrero de 1974 y julio del 2008 a los que se habla medido el perlmetro braquial y la puntuacion Z de peso para la talla cuando tenlan entre 6 y 14 semanas de edad y cuyo estado vital se registro al menos una vez mas. Se calcularon los indices de peligrosidad, las fracciones atribuibles a la poblacion y las areas con curvas de la caracterlstica operativa del receptor (ROC) para evaluar el valor diagnostico de la muerte en lactantes del perlmetro braquial y la puntuacion Z de peso para la talla. Resultados De los 2876 lactantes incluidos en el analisis, 40 fallecieron antes de alcanzar los 12 meses de edad. El indice de peligrosidad de este grupo comparado con el de lactantes bien alimentados fue del 5,8 (intervalo de confianza del 95%, IC: 1,6-21) para una puntuacion Z de peso para la talla < -3. El indice de peligrosidad para el perlmetro braquial por debajo de los umbrales de 115 mm, 110 mm y 105 mm fue del 4,5% (95% IC: 1,4-15), 9,5 (95% IC: 2,6-35) y 23 (95% IC: 4,2-122). Las fracciones atribuibles para un perlmetro braquial inferior a 130 mm y una puntuacion Z de peso para la talla inferior a 0 fueron del 51% y del 13%, respectivamente. Los resultados en las areas bajo influencia de la curva ROC para la muerte infantil fueron 0,55 (95% IC: 0,46 a 0,64) para la puntuacion Z de peso para la talla y 0,64 (95% IC: 0,55 a 0,73) para el perlmetro braquial. Conclusion El perlmetro braquial no ajustado mostro resultados positivos para la identification de lactantes de entre 6 y 14 semanas de edad con un riesgo de muerte superior.

Published
2012
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32. Components, impacts and costs of dementia home support: a research programme including the DESCANT RCT

Author

Clarkson, Paul, primary, Challis, David, additional, Hughes, Jane, additional, Roe, Brenda, additional, Davies, Linda, additional, Russell, Ian, additional, Orrell, Martin, additional, Poland, Fiona, additional, Jolley, David, additional, Kapur, Narinder, additional, Robinson, Catherine, additional, Chester, Helen, additional, Davies, Sue, additional, Sutcliffe, Caroline, additional, Peconi, Julie, additional, Pitts, Rosa, additional, Fegan, Greg, additional, Islam, Saiful, additional, Gillan, Vincent, additional, Entwistle, Charlotte, additional, Beresford, Rebecca, additional, Abendstern, Michele, additional, Giebel, Clarissa, additional, Ahmed, Saima, additional, Jasper, Rowan, additional, Usman, Adeela, additional, Malik, Baber, additional, and Hayhurst, Karen, additional

Published
2021
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33. Health systems research in a low-income country: easier said than done

Author

English, Mike, Irimu, Grace, Wamae, Annah, Were, Fred, Wasunna, Aggrey, Fegan, Greg, and Peshu, Norbert

Subjects
Developing countries -- Health aspects, Children's hospitals -- Quality management, Medical care -- Quality management, Medical care -- Research
Published
2008

34. Dementia Early Stage Cognitive Aids New Trial (DESCANT) of memory aids and guidance for people with dementia: randomised controlled trial

Author

Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, ROE, BRENDA, Malik, Baber, Robinson , Catherine, Clarkson, Paul, Pitts, Rosa, Islam, Saiful, Peconi, Julie, Russell, Ian, Fegan, Greg, Beresford, Rebecca, Entwistle, Charlotte, Gillan, Vincent, Orrell, Martin, Challis, David, Chester, Helen, Hughes, Jane, Kapur, Narinder, ROE, BRENDA, Malik, Baber, and Robinson , Catherine

Abstract

BACKGROUND Common memory aids for people with dementia at home are recommended. However, rigorous evaluation is lacking, particularly what guidance or support is valued. OBJECTIVE To investigate effects of memory aids and guidance by Dementia Support Practitioners (DSPs) for people in early stage dementia through a pragmatic, randomised controlled trial. METHODS Of 469 people with mild to moderate dementia and their informal carers, 468 were randomised to a DSP with memory aids or to usual care plus existing dementia guide. Allocation was stratified by: Trust/Health Board; time since first attendance at memory service; gender; age; and living with primary carer or not. Primary outcome was Bristol Activities of Daily Living Scale (BADLS) score at 3 and 6 months (primary end-point). Secondary outcomes for people with dementia: quality of life (CASP-19; DEMQOL); cognition and functioning (Clinical Dementia Rating Scale; SMMSE); capability (ICECAP-O); social networks (LSNS-R); and instrumental daily living activities (R-IDDD). Secondary outcomes for carers: psychological health (GHQ-12); sense of competence (SSCQ). RESULTS DSPs were successfully trained, compliance was good and welcomed by participants. Mean 6 months BADLS score increased to 14.6 (SD 10.4) in intervention and 12.6 (SD 8.1) in comparator, indicative of greater dependence in the activities of daily living. Adjusted between group difference was 0.38 (95% confidence interval -0.89 to 1.65, P=0.56). Though this suggests greater dependency in the intervention group the difference was not significant. No differences were found in secondary outcomes. CONCLUSIONS This intervention did not maintain independence in the activities of daily living with no improvement in other outcomes for people with dementia or carers.

Published
2021

35. Components, impacts and costs of dementia home support: a research programme including the DESCANT RCT

Author

Clarkson, Paul, Challis, David, Hughes, Jane, ROE, BRENDA, Davies, Linda, Russell, Ian, Orrell, Martin, Poland, Fiona, Jolley, David, Kapur, Narinder, Robinson, Catherine, Chester, Helen, Davies, Sue, Sutcliffe, Caroline, Peconi, Julie, Pitts, Rosa, Fegan, Greg, Islam, Saiful, Gillan, Vincent, Entwistle, Charlotte, Beresford, Rebecca, Abendstern, Michele, Giebel, Clarissa, Ahmed, Saima, Jasper, Rowan, Usman, Adeela, Malik, Baber, Hayhurst, Karen, Clarkson, Paul, Challis, David, Hughes, Jane, ROE, BRENDA, Davies, Linda, Russell, Ian, Orrell, Martin, Poland, Fiona, Jolley, David, Kapur, Narinder, Robinson, Catherine, Chester, Helen, Davies, Sue, Sutcliffe, Caroline, Peconi, Julie, Pitts, Rosa, Fegan, Greg, Islam, Saiful, Gillan, Vincent, Entwistle, Charlotte, Beresford, Rebecca, Abendstern, Michele, Giebel, Clarissa, Ahmed, Saima, Jasper, Rowan, Usman, Adeela, Malik, Baber, and Hayhurst, Karen

Abstract

Background: Over half of people with dementia live at home. We know little about what home support could be clinically effective or cost-effective in enabling them to live well. Objectives: We aimed to (1) review evidence for components of home support, identify their presence in the literature and in services in England, and develop an appropriate economic model; (2) develop and test a practical memory support package in early-stage dementia, test the clinical effectiveness and cost-effectiveness of routine home support in later-stage dementia and design a toolkit based on this evidence; and (3) elicit the preferences of staff, carers and people with dementia for home support inputs and packages, and evaluate the cost-effectiveness of these approaches in early- and later-stage dementia. Design: We undertook (1) an evidence synthesis, national surveys on the NHS and social care and an economic review; (2) a multicentre pragmatic randomised trial [Dementia Early Stage Cognitive Aids New Trial (DESCANT)] to estimate the clinical effectiveness and cost-effectiveness of providing memory aids and guidance to people with early-stage dementia (the DESCANT intervention), alongside process evaluation and qualitative analysis, an observational study of existing care packages in later-stage dementia along with qualitative analysis, and toolkit development to summarise this evidence; and (3) consultation with experts, staff and carers to explore the balance between informal and paid home support using case vignettes, discrete choice experiments to explore the preferences of people with dementia and carers between home support packages in early- and later-stage dementia, and cost–utility analysis building on trial and observational study. Setting: The national surveys described Community Mental Health Teams, memory clinics and social care services across England. Recruitment to the trial was through memo

Published
2021

36. Components, impacts and costs of dementia home support:a research programme including the DESCANT RCT

Author

Clarkson, Paul, Challis, David, Deactivated, Given Names Deactivated Family Name, Roe, Brenda, Davies, Linda M, Russell, Ian T., Orrell, Martin, Poland, Fiona, Jolley, David, Kapur, Narinder, Robinson, Catherine A, Chester, Helen, Davies, Sue, Sutcliffe, Caroline, Peconi, Julie, Pitts, Rosa, Fegan, Greg, Islam, Saiful, Gillan, Vincent, Entwistle, Charlotte, Beresford, Rebecca, Abendstern, Michele, Giebel, Clarissa, Ahmed, Dr Saima, Jasper, Rowan, Usman, Adeela Usman Mohammed, Malik, Baber, Hayhurst, Karen, Clarkson, Paul, Challis, David, Deactivated, Given Names Deactivated Family Name, Roe, Brenda, Davies, Linda M, Russell, Ian T., Orrell, Martin, Poland, Fiona, Jolley, David, Kapur, Narinder, Robinson, Catherine A, Chester, Helen, Davies, Sue, Sutcliffe, Caroline, Peconi, Julie, Pitts, Rosa, Fegan, Greg, Islam, Saiful, Gillan, Vincent, Entwistle, Charlotte, Beresford, Rebecca, Abendstern, Michele, Giebel, Clarissa, Ahmed, Dr Saima, Jasper, Rowan, Usman, Adeela Usman Mohammed, Malik, Baber, and Hayhurst, Karen

Abstract

Background Over half of people with dementia live at home. We know little about what home support could be effective in enabling them to live well. Objectives We aimed to: (1) review evidence for components of home support, identify their presence in the literature and in services in England, and develop an appropriate economic model; (2) develop and test a practical memory support package in early-stage dementia, test the effectiveness of routine home support in later-stage dementia, and design a toolkit based on this evidence; (3) elicit preferences of staff, carers and people with dementia for home support inputs and packages, and evaluate cost-effectiveness of these approaches in early- and later-stage dementia. Design Thus we undertook: (1) evidence synthesis; national surveys on NHS and social care; and economic review (2) multi-centre pragmatic randomised trial (DESCANT) to estimate the effectiveness of providing memory aids and guidance to people with early-stage dementia (the DESCANT intervention) – alongside process evaluation and qualitative analysis; observational study of existing care packages in later-stage dementia alongside qualitative analysis; and toolkit development to summarise this evidence (3) consultation with experts, staff and carers to explore balance between informal and paid home support using case vignettes; Discrete Choice Experiments to explore the preferences of people with dementia and carers between home support packages in early- and later-stage dementia; and cost-utility analysis building on trial and observational study. Setting The national surveys described Community Mental Health Teams, memory clinics and social care services across England. Recruitment to the trial was through memory services in 9 NHS Trusts in England and one Health Board in Wales. Recruitment to the observational study was through social services in 17 local authorities in England. Recruitment for the vignette and preference studies was through memory serv

Published
2021

45. Excess mortality among people with podoconiosis: secondary analysis of two Ethiopian cohorts

Author

Masraf, Hannah, primary, Azemeraw, Temesgen, additional, Molla, Meseret, additional, Jones, Christopher Iain, additional, Bremner, Stephen, additional, Ngari, Moses, additional, Berkley, James A, additional, Kivaya, Esther, additional, Fegan, Greg, additional, Tamiru, Abreham, additional, Kelemework, Abebe, additional, Lang, Trudie, additional, Newport, Melanie J, additional, and Davey, Gail, additional

Published
2020
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46. A new method to triage colorectal cancer referrals in the UK using serum Raman spectroscopy and machine learning

Author

Jenkins, Cerys A, primary, Chandler, Susan, additional, Jenkins, Rhys, additional, Thorne, Kym, additional, Woods, Freya, additional, Cunningham, Andrew, additional, Nelson, Kayleigh, additional, Still, Rachel, additional, Walters, Jenna, additional, Gywnne, Non, additional, Chea, Wilson, additional, Harford, Rachel, additional, O'Neill, Claire, additional, Hepburn, Julie, additional, Hill, Ian, additional, Wilkes, Heather, additional, Fegan, Greg, additional, Dunstan, Peter, additional, and Harris, Dean A, additional

Published
2020
Full Text
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47. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES

Author

Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, 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Subjects
Abstracts of Poster Presentations, Abstracts of Oral Presentations, Author Index, Abstracts of Presentations in Plenary Sessions, Article, Abstracts of the Eighth Edctp Forum, 6–9 November 2016
Published
2017

50. Additional file 1: of Rapid Analgesia for Prehospital hip Disruption (RAPID): findings from a randomised feasibility study

Author

Jones, Jenna, Evans, Bridie, Fegan, Greg, Ford, Simon, Guy, Katy, Jones, Sian, Keen, Leigh, Ashrafunnesa Khanom, Longo, Mirella, Pallister, Ian, Rees, Nigel, Russell, Ian, Seagrove, Anne, Watkins, Alan, and Snooks, Helen

Subjects
body regions, endocrine system, endocrine system diseases, musculoskeletal system, psychological phenomena and processes
Abstract

Paramedic pathway to perform a landmark guided fascia iliaca compartment block as part of the RAPID Trial. (DOCX 362 kb)

Published
2019
Full Text
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