1. Plasma leptin levels do not change in healthy humans shortly after a hydrocortisone challenge
- Author
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Fehmann Hc, Werner F. Blum, Johannes Hebebrand, Krieg Jc, and Lautenbacher S
- Subjects
Adult ,Leptin ,Male ,medicine.medical_specialty ,Time Factors ,Hydrocortisone ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Biology ,Endocrinology ,Reference Values ,Internal medicine ,Blood plasma ,Healthy volunteers ,Internal Medicine ,medicine ,Humans ,Insulin ,digestive, oral, and skin physiology ,General Medicine ,Steroid hormone ,Plasma cortisol ,Female ,hormones, hormone substitutes, and hormone antagonists ,Glucocorticoid ,medicine.drug - Abstract
The acute response of plasma leptin levels to a hydrocortisone challenge was measured in 16 healthy volunteers. We additionally asessed insulin which is known to play a regulatory role in the leptin system. While plasma cortisol levels increased significantly after the administration of hydrocortisone, this rise was not associated with any change in leptin and insulin concentrations during the 3.5-hour experimental period. This result corroborates the assumption that glucocorticoid-induced increases in leptin levels, as described in the literature, occur delayed and are due rather to an activation of leptin synthesis than to a mere leptin release.
- Published
- 2009