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5. 3rd EACTS Meeting on Cardiac and Pulmonary Regeneration Berlin-Brandenburgische Akademie, Berlin, Germany, 14-15 December 2012

Author

Bader, A, Brodarac, A, Hetzer, R, Kurtz, A, Stamm, C, Baraki, H, Kensah, G, Asch, S, Rojas, S, Martens, A, Gruh, I, Haverich, A, Kutschka, I, Cortes Dericks, L, Froment, L, Kocher, G, Schmid, Ra, Delyagina, E, Schade, A, Scharfenberg, D, Skorska, A, Lux, C, Li, W, Steinhoff, G, Drey, F, Lepperhof, V, Neef, K, Fatima, A, Wittwer, T, Wahlers, T, Saric, T, Choi, Yh, Fehrenbach, D, Lehner, A, Herrmann, F, Hollweck, T, Pfeifer, S, Wintermantel, E, Kozlik Feldmann, R, Hagl, C, Akra, B, Gyöngyösi, M, Zimmermann, M, Pavo, N, Mildner, M, Lichtenauer, M, Maurer, G, Ankersmit, J, Hacker, S, Mittermayr, R, Haider, T, Nickl, S, Beer, L, Lebherz Eichinger, D, Schweiger, T, Mitterbauer, A, Keibl, C, Werba, G, Frey, M, Ankersmit, Hj, Herrmann, S, Lux, Ca, Holfeld, J, Tepeköylü, C, Wang, Fs, Kozaryn, R, Schaden, W, Grimm, M, Wang, Cj, Urbschat, A, Zacharowski, K, Paulus, P, Avaca, Mj, Kempf, H, Malan, D, Sasse, P, Fleischmann, B, Palecek, J, Dräger, G, Kirschning, A, Zweigerdt, R, Martin, U, Katsirntaki, K, Haller, R, Ulrich, S, Sgodda, M, Puppe, V, Duerr, J, Schmiedl, A, Ochs, M, Cantz, T, Mall, M, Mauritz, C, Lara, Ar, Dahlmann, J, Schwanke, K, Hegermann, J, Skvorc, D, Gawol, A, Azizian, A, Wagner, S, Krause, A, Klopsch, C, Gaebel, R, Kaminski, A, Chichkov, B, Jockenhoevel, S, Klose, K, Roy, R, Kang, Ks, Bieback, K, Nasseri, B, Polchynska, O, Kruttwig, K, Brüggemann, C, Xu, G, Baumgartner, A, Hasun, M, Podesser, Bk, Ludwig, M, Tölk, A, Noack, T, Margaryan, R, Assanta, N, Menciassi, Arianna, Burchielli, S, Matteucci, Marco, Lionetti, Vincenzo, Luchi, C, Cariati, E, Coceani, F, Murzi, B, Rojas, Sv, Rotärmel, A, Nasseri, Ba, Ebell, W, Dandel, M, Kukucka, M, Gebker, R, Mutlak, H, Ockelmann, P, Tacke, S, Scheller, B, Pereszlenyi, A, Meier, M, Schecker, N, Rathert, C, Becher, Pm, Drori Carmi, N, Bercovich, N, Zahavi Goldstein, E, Jack, M, Netzer, N, Pinzur, L, Chajut, A, Tschöpe, C, Ruch, U, Strauer, Be, Tiedemann, G, Schlegel, F, Dhein, S, Akhavuz, O, Mohr, Fw, Dohmen, Pm, Salameh, A, Oelmann, K, Kiefer, P, Merkert, S, Templin, C, Jara Avaca, M, Müller, S, von Haehling, S, Slavic, S, Curato, C, Altarche Xifro, W, Unger, T, Li, J, Zhang, Y, Li, Wz, Ou, L, Ma, N, Haase, A, Alt, R, and Martin, U.

Published
2013

6. Energy efficiency in the German pulp and paper industry - A model-based assessment of saving potentials

Author

Fleiter, T., Fehrenbach, D., Worrell, E., Eichhammer, W., Energy and Resources, The demand for energy and materials, Sub Science, Technology & Society begr., Section Innovation Studies, Energy and Resources, The demand for energy and materials, Sub Science, Technology & Society begr., Section Innovation Studies, and Publica

Subjects
Engineering, energy-efficient technology, Process (engineering), business.industry, Mechanical Engineering, energy saving potential, conservation supply curve, Building and Construction, Pulp and paper industry, Pollution, Energy engineering, Industrial and Manufacturing Engineering, Energy accounting, pulp and paper, bottom-up, Energy conservation, General Energy, Heat recovery ventilation, Fuel efficiency, Electricity, Electrical and Electronic Engineering, business, energy efficiency, Civil and Structural Engineering, Efficient energy use
Abstract

Paper production is an energy-intensive process and accounted for about 9% of industrial energy demand in Germany in 2008. There have only been slow improvements in energy efficiency in the paper industry over the past twenty years. Policies can accelerate the progress made, but knowledge about the remaining efficiency potentials and their costs is a prerequisite for their success. We assess 17 process technologies to improve energy efficiency in the German pulp and paper industry up to 2035 using a techno-economic approach. These result in a saving potential of 34 TJ/a for fuels and 12 TJ/a for electricity, which equal 21% and 16% of fuel and electricity demand, respectively. The energy savings can be translated into mitigated CO2 emissions of 3 Mt. The larger part of this potential is found to be cost-effective from a firm's perspective. The most influential technologies are heat recovery in paper mills and the use of innovative paper drying technologies. In conclusion, significant saving potentials are still available, but are limited if we assume that current paper production processes will not change radically. Further savings would be available if the system boundaries of this study were extended to e.g. include cross-cutting technologies.

Published
2012

8. 3rd EACTS Meeting on Cardiac and Pulmonary Regeneration Berlin-Brandenburgische Akademie, Berlin, Germany, 14-15 December 2012

Author

Bader, A., primary, Brodarac, A., additional, Hetzer, R., additional, Kurtz, A., additional, Stamm, C., additional, Baraki, H., additional, Kensah, G., additional, Asch, S., additional, Rojas, S., additional, Martens, A., additional, Gruh, I., additional, Haverich, A., additional, Kutschka, I., additional, Cortes-Dericks, L., additional, Froment, L., additional, Kocher, G., additional, Schmid, R. A., additional, Delyagina, E., additional, Schade, A., additional, Scharfenberg, D., additional, Skorska, A., additional, Lux, C., additional, Li, W., additional, Steinhoff, G., additional, Drey, F., additional, Lepperhof, V., additional, Neef, K., additional, Fatima, A., additional, Wittwer, T., additional, Wahlers, T., additional, Saric, T., additional, Choi, Y.- H., additional, Fehrenbach, D., additional, Lehner, A., additional, Herrmann, F., additional, Hollweck, T., additional, Pfeifer, S., additional, Wintermantel, E., additional, Kozlik-Feldmann, R., additional, Hagl, C., additional, Akra, B., additional, Gyongyosi, M., additional, Zimmermann, M., additional, Pavo, N., additional, Mildner, M., additional, Lichtenauer, M., additional, Maurer, G., additional, Ankersmit, J., additional, Hacker, S., additional, Mittermayr, R., additional, Haider, T., additional, Nickl, S., additional, Beer, L., additional, Lebherz-Eichinger, D., additional, Schweiger, T., additional, Mitterbauer, A., additional, Keibl, C., additional, Werba, G., additional, Frey, M., additional, Ankersmit, H. J., additional, Herrmann, S., additional, Lux, C. A., additional, Holfeld, J., additional, Tepekoylu, C., additional, Wang, F.- S., additional, Kozaryn, R., additional, Schaden, W., additional, Grimm, M., additional, Wang, C.- J., additional, Urbschat, A., additional, Zacharowski, K., additional, Paulus, P., additional, Avaca, M. J., additional, Kempf, H., additional, Malan, D., additional, Sasse, P., additional, Fleischmann, B., additional, Palecek, J., additional, Drager, G., additional, Kirschning, A., additional, Zweigerdt, R., additional, Martin, U., additional, Katsirntaki, K., additional, Haller, R., additional, Ulrich, S., additional, Sgodda, M., additional, Puppe, V., additional, Duerr, J., additional, Schmiedl, A., additional, Ochs, M., additional, Cantz, T., additional, Mall, M., additional, Mauritz, C., additional, Lara, A. R., additional, Dahlmann, J., additional, Schwanke, K., additional, Hegermann, J., additional, Skvorc, D., additional, Gawol, A., additional, Azizian, A., additional, Wagner, S., additional, Krause, A., additional, Klopsch, C., additional, Gaebel, R., additional, Kaminski, A., additional, Chichkov, B., additional, Jockenhoevel, S., additional, Klose, K., additional, Roy, R., additional, Kang, K.- S., additional, Bieback, K., additional, Nasseri, B., additional, Polchynska, O., additional, Kruttwig, K., additional, Bruggemann, C., additional, Xu, G., additional, Baumgartner, A., additional, Hasun, M., additional, Podesser, B. K., additional, Ludwig, M., additional, Tolk, A., additional, Noack, T., additional, Margaryan, R., additional, Assanta, N., additional, Menciassi, A., additional, Burchielli, S., additional, Matteucci, M., additional, Lionetti, V., additional, Luchi, C., additional, Cariati, E., additional, Coceani, F., additional, Murzi, B., additional, Rojas, S. V., additional, Rotarmel, A., additional, Nasseri, B. A., additional, Ebell, W., additional, Dandel, M., additional, Kukucka, M., additional, Gebker, R., additional, Mutlak, H., additional, Ockelmann, P., additional, Tacke, S., additional, Scheller, B., additional, Pereszlenyi, A., additional, Meier, M., additional, Schecker, N., additional, Rathert, C., additional, Becher, P. M., additional, Drori-Carmi, N., additional, Bercovich, N., additional, Zahavi-Goldstein, E., additional, Jack, M., additional, Netzer, N., additional, Pinzur, L., additional, Chajut, A., additional, Tschope, C., additional, Ruch, U., additional, Strauer, B.- E., additional, Tiedemann, G., additional, Schlegel, F., additional, Dhein, S., additional, Akhavuz, O., additional, Mohr, F. W., additional, Dohmen, P. M., additional, Salameh, A., additional, Oelmann, K., additional, Kiefer, P., additional, Merkert, S., additional, Templin, C., additional, Jara-Avaca, M., additional, Muller, S., additional, von Haehling, S., additional, Slavic, S., additional, Curato, C., additional, Altarche-Xifro, W., additional, Unger, T., additional, Li, J., additional, Zhang, Y., additional, Li, W. Z., additional, Ou, L., additional, Ma, N., additional, Haase, A., additional, and Alt, R., additional

Published
2013
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9. Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.

Author

Dikalova A, Fehrenbach D, Mayorov V, Panov A, Ao M, Lantier L, Amarnath V, Lopez MG, Billings FT 4th, Sack MN, and Dikalov S

Subjects
Animals, Female, Humans, Male, Mice, Acetylation, Angiotensin II, Cells, Cultured, Endothelial Cells metabolism, Endothelial Cells enzymology, Mice, Inbred C57BL, Mice, Knockout, Mitochondrial Proteins metabolism, Mitochondrial Proteins genetics, Nerve Tissue Proteins, Oxidative Stress, Endothelium, Vascular metabolism, Endothelium, Vascular physiopathology, Hypertension metabolism, Hypertension physiopathology, Hypertension genetics, Mitochondria metabolism, Sirtuin 3 metabolism, Sirtuin 3 genetics
Abstract

Background: Nearly half of adults have hypertension, a major risk factor for cardiovascular disease. Mitochondrial hyperacetylation is linked to hypertension, but the role of acetylation of specific proteins is not clear. We hypothesized that acetylation of mitochondrial CypD (cyclophilin D) at K166 contributes to endothelial dysfunction and hypertension., Methods: To test this hypothesis, we studied CypD acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific GCN5L1 (general control of amino acid synthesis 5 like 1)-deficient mice using an Ang II (angiotensin II) model of hypertension., Results: Arterioles from hypertensive patients had 280% higher CypD acetylation coupled with reduced Sirt3 (sirtuin 3) and increased GCN5L1 levels. GCN5L1 regulates mitochondrial protein acetylation and promotes CypD acetylation, which is counteracted by mitochondrial deacetylase Sirt3. In human aortic endothelial cells, GCN5L1 depletion prevents superoxide overproduction. Deacetylation mimetic CypD-K166R mice were protected from vascular oxidative stress, endothelial dysfunction, and Ang II-induced hypertension. Ang II-induced hypertension increased mitochondrial GCN5L1 and reduced Sirt3 levels resulting in a 250% increase in GCN5L1/Sirt3 ratio promoting CypD acetylation. Treatment with mitochondria-targeted scavenger of cytotoxic isolevuglandins (mito2HOBA) normalized GCN5L1/Sirt3 ratio, reduced CypD acetylation, and attenuated hypertension. The role of mitochondrial acetyltransferase GCN5L1 in the endothelial function was tested in endothelial-specific GCN5L1 knockout mice. Depletion of endothelial GCN5L1 prevented Ang II-induced mitochondrial oxidative stress, reduced the maladaptive switch of vascular metabolism to glycolysis, prevented inactivation of endothelial nitric oxide, preserved endothelial-dependent relaxation, and attenuated hypertension., Conclusions: These data support the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension. We suggest that targeting cytotoxic mitochondrial isolevuglandins and GCN5L1 reduces CypD acetylation, which may be beneficial in cardiovascular disease., Competing Interests: Disclosures None.

Published
2024
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10. In vitro biological and mechanical evaluation of various scaffold materials for myocardial tissue engineering.

Author

Herrmann FE, Lehner A, Hollweck T, Haas U, Fano C, Fehrenbach D, Kozlik-Feldmann R, Wintermantel E, Eissner G, Hagl C, and Akra B

Subjects
Biomechanical Phenomena drug effects, Collagen pharmacology, Elastic Modulus drug effects, Humans, Mesenchymal Stem Cells cytology, Mesenchymal Stem Cells drug effects, Mesenchymal Stem Cells metabolism, Microscopy, Electron, Scanning, Mitochondria drug effects, Mitochondria metabolism, Polytetrafluoroethylene pharmacology, Polyurethanes pharmacology, Propidium metabolism, Staining and Labeling, Materials Testing, Myocardium metabolism, Tissue Engineering methods, Tissue Scaffolds chemistry
Abstract

A cardiac patch is a construct devised in regenerative medicine to replace necrotic heart tissue after myocardial infarctions. The cardiac patch consists of a scaffold seeded with stem cells. To identify the best scaffold for cardiac patch construction we compared polyurethane, Collagen Cell Carriers, ePTFE, and ePTFE SSP1-RGD regarding their receptiveness to seeding with mesenchymal stem cells isolated from umbilical cord tissue. Seeding was tested at an array of cell seeding densities. The bioartificial patches were cultured for up to 35 days and evaluated by scanning electron microscopy, microscopy of histological stains, fluorescence microscopy, and mitochondrial assays. Polyurethane was the only biomaterial which resulted in an organized multilayer (seeding density: 0.750 × 10(6) cells/cm(2)). Cultured over 35 days at this seeding density the mitochondrial activity of the cells on polyurethane patches continually increased. There was no decrease in the E Modulus of polyurethane once seeded with cells. Seeding of CCC could only be realized at a low seeding density and both ePTFE and ePTFE SSP1-RGD were found to be unreceptive to seeding. Of the tested scaffolds polyurethane thus crystallized as the most appropriate for seeding with mesenchymal stem cells in the framework of myocardial tissue engineering., (Copyright © 2013 Wiley Periodicals, Inc.)

Published
2014
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