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Background:The expression and function of androgen receptors (AR) and estrogen receptor alpha (ER-ɑ) in laryngeal squamous cell carcinoma (LSCC) have remained controversial for decades. Prolactin receptor (PRLR) is a sex-related hormone, that has been rarely documented in terms of expression or function compared with data on other hormone receptors in laryngeal carcinoma. Methods:This study reports on immunohistochemical and reverse transcription-polymerase chain reaction (RT-PCR) analysis of tumour tissue and adjacent normal tissue in 96 patients with LSCC (82 males and 14 females). The expression levels of the receptors were related to clinicopathologic parameters and survival data. Results:At both protein and mRNA levels, the expression level of AR, ER-ɑ, and PRLR was much higher in LSCC than in adjacent normal tissues (p < .05). Among them, higher PRLR expression in tumour tissues tended to have a significantly poorer survival rate (p = .03) for patients with LSCC. Furthermore, higher expression of ER-ɑ in tumours was correlated with higher expression level of PRLR (r = .823,p = .03). Conclusion:The findings of this study indicate that the sex-related hormone receptors play an important role in the development of LSCC. The PRLR represents a novel prognosticator, because of its negative effect on survival and its interaction with ER-ɑ. [ABSTRACT FROM PUBLISHER]

Abstract: Ectopic thyroid tissue is rare and generally occurs along the thyroglossal duct or in lateral cervical region. We reported 18 F-FDG and 68 Ga-FAPI findings of a 28-year-old woman with previously diagnosed BRAF -mutated lateral lymph node metastasis of unknown primary site. Low 18 F-FDG but increased 68 Ga-FAPI uptake was seen in a submental pretracheal nodular lesion. Postsurgical pathologic report verified the diagnosis of ectopic papillary thyroid carcinoma. High FAP expression in the tumor sample corresponded to its imaging manifestations., Competing Interests: Conflicts of interest and sources of funding: The authors declared no conflict of interest. This study was funded by National Natural Science Foundation of China (81972496) and Medical and Industrial Cross Project of Shanghai Jiao Tong University (YG2021QN41)., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Objective: To compare the different therapeutic effects of modified syringe forearm quantitative injection and forearm brachioradialis intramuscular transplantation after receiving total parathyroidectomy in patients with secondary hyperparathyroidism. Method: One hundred and fifty-two patients with secondary hyperparathyroidism who underwent total parathyroidectomy were divided into the forearm brachioradialis intramuscular transplantation group and the modified syringe forearm quantitative injection group according to the different forearm transplantation methods. The study counted and compared the duration of surgery, preoperative and postoperative parathyroid hormone levels, blood calcium and other indicators. Result: The results showed that there was no statistically significant difference in laboratory test data between the two groups, but the modified syringe forearm quantitative injection method was more convenient, and the recovery time of the parathyroid function was shortened from an average of 6 months to an average of 3 months（ P =0.03）. There was no statistical difference in the recurrence of the two groups of patients after transplantation. Conclusion: The modified syringe forearm quantitative injection method for transplantation of parathyroid gland is relatively simple to operate, saves time, and enables the transplanted parathyroid gland to function faster. It is worthy of being widely used., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Objective: lo discuss the inmtluence of different thyroidectomy on perioperative blood calcium concentration., Method: Total number of patients was 240. These patients of thyroid tumors were recruited. Clinical and follow-up datum were retrospective analyzed., Result: Patients were divided into four groups by different operative methods. Group one was patients taken one-side thyroidectomy, group two taken one-side lymph node dissection plus, group three taken two-sides thyroidectomy,and group four taken one or two sides lymph node dissection plus. Group two was easier to become hypocalcemia and their calcium concentration decreased more remarkably, compared with group one. Patients taken two-sides thyroidectomy had the familiar outcome., Conclusion: Patients taken lymph node dissection were easier to become hypocalcemia, compared with patients only taken thyroidectomy.