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Knowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation. We show that IL10 + CpG-mediated cell proliferation of MYClow cells depends on glutaminolysis. By 13C- and 15N-tracing of glutamine metabolism and metabolite rescue experiments, we demonstrate that GOT2 provides aspartate and nucleotides to cells with activated or aberrant Jak/STAT and NF-κB signaling. A model of GOT2 transcriptional regulation is proposed, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-κB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma underscoring the current findings and importance of stromal factors in lymphoma biology., Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addiction.

New results on extremophiles and observations of Mars missions regarding the detailed mineralogy, the occurrence of water in the equatorial region of Mars [1-3], new announcements of MSL findings and their implications for the surface condi-tions at Gale crater [4, 5] as well as measurements of the Mars surface radiation environment [6] fuel the debate about possible developments of life on Mars. Based on previous studies [7-8] we examined water vapor interaction and water-bearing properties of B. frigida before and after UVC irradiation. The meas-urements have been partially conducted after simula-tion of environmental conditions which are supposed to be Mars-like. Lichens are symbiotic organisms that are able to colonize a broad range of extreme habitats and, therefore, represent useful model systems in as-trobiological research. Our aim is to contribute to an improved under-standing of extremophiles under exobiological aspects within the frame of BIOMEX (Biology and Mars Ex-periment) at the ISS, in respect to irradiation effects on water retention properties. The results may also sup-port data evaluation of in-situ missions such as MSL and ExoMars. References: [1] Feldmann W.C. et al. (2004) JGR 109 E 09006. [2] Bibring, J.-P. et al. Science 307, 1576-1581. [3] Poulet F. et al. (2005) Nature 438, 623- 627. [4] Vaniman D.T. et al. (2013) Science DOI: 10.1126/science.1243480. [5] Ming D.W. et al. (2013) Science DOI: 10.1126/science.1245267 [6] Hassler D.M. et al. (2013) Science DOI: 10.1126/science. 1244797.[7] Jänchen J. et al. (2006) Icarus, 180, 353- 358. [8] Jänchen J. et al. (2013) 44th LPSC Abstract No. 1504.

The well-known Goldschmidt reaction, i.e. the reaction of (2 Al + α-Fe2O3), was investigated upon mechanochemical activation by employing Mössbauer and ESR spectroscopy in combination with thermal analysis (TA), magnetic susceptibility measurements and X-ray powder diffraction (XRD).

Fragestellung: Die Transplantathypertrophie (THY) stellt eine der häufigsten Komplikationen bei der Behandlung von umschriebenen Knorpeldefekten mit der autologen Chondrozyten Implantation mittels Periostlappen dar. Das Auftreten und die klinische Relevanz der THY nach Matrix basierter ACI (mb-ACI)[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2012)

Fragestellung: Das klinische Ergebnis einer Matrix gestützten Autologen Chondrozytentransplantation (MACT) am Kniegelenk wird durch zahlreiche Faktoren beeinflusst. Die MACT ist zwar mittlerweile eine etablierte Methode zur Therapie großer fokaler Knorpelschäden, doch sind die Ursache[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 75. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 97. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 52. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Fragestellung: Eine etablierte Methode zur Therapie großer fokaler Knorpelschäden ist die Matrix gestützte Autologe Chondrozytentransplantation (MACT). Diese Studie untersucht, ob es biologische Parameter gibt welche zur prognostischen Einschätzung des klinischen Outcome genutzt [for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 75. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 97. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 52. Tagung des Berufsverbandes der Fachärzte für Orthopädie