14 results on '"Feitosa RNM"'
Search Results
2. Exposure to Treponema pallidum among Female Sex Workers: A Retrospective Study Conducted in the State of Pará, Brazilian Amazon.
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Carvalho TMDS, Laurindo PDSODC, Araújo DO, Fonseca RRS, Laurentino RV, Monteiro JC, Feitosa RNM, Costa FAMD, Santos LMD, Oliveira-Filho AB, and Machado LFA
- Abstract
Background: Syphilis remains a significant global public health issue, and female sex workers (FSWs) are highly vulnerable to the etiological agent of this disease. This study aimed to describe the prevalence of exposure to Treponema pallidum , as well as the vulnerability factors among FSWs in the state of Pará, Brazilian Amazon., Methods: A cross-sectional, retrospective study involving 360 FSWs from five cities in Pará was conducted from 2005 to 2007. Blood samples were collected for treponemal and non-treponemal testing, and epidemiological information was obtained through interviews., Results: The exposure rate to T. pallidum was 37.7% (136/360), and the majority of FSWs had serological results indicating past exposure (21.1%). Among the FSWs exposed to T. pallidum , most of them were single, aged 23 to 42 years old, had less than 8 years of schooling, and had a family income of between 1 and 3 minimum wages. They reported using condoms during sexual intercourse and had no history of sexually transmitted infection (STI). Furthermore, many of the FSWs exposed to T. pallidum reported having more than 20 sexual partners per month, and had partners from other Brazilian states, but not from other countries. An age over 42 years and a reduced level of education were factors associated with exposure to T. pallidum . Finally, a high rate of exposure to T. pallidum among FSWs in the Brazilian state of Pará (from 2005 to 2007) was detected. In later years, epidemiological studies conducted with FSWs recorded that this rate remained high. Measures to control, treat, and prevent syphilis among FSWs were necessary between 2005 and 2007, and they are still imperative today. Actions related to educational programs and STI control, treatment, and prevention measures contained in Brazilian policies aimed at women's health have not changed the vulnerability scenario of FSWs regarding their exposure to T. pallidum , even after 16 years, and must be reviewed and adapted to the conditions of the Brazilian Amazon.
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- 2024
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3. Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles.
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Soares SR, da Silva Torres MK, Lima SS, de Sarges KML, Santos EFD, de Brito MTFM, da Silva ALS, de Meira Leite M, da Costa FP, Cantanhede MHD, da Silva R, de Oliveira Lameira Veríssimo A, Vallinoto IMVC, Feitosa RNM, Quaresma JAS, Chaves TDSS, Viana GMR, Falcão LFM, Santos EJMD, Vallinoto ACR, and da Silva ANMR
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- Humans, Antibodies, Viral, Antibody Formation, Immunoglobulin G, Nucleocapsid Proteins, Post-Acute COVID-19 Syndrome, SARS-CoV-2, Spike Glycoprotein, Coronavirus, COVID-19
- Abstract
The first case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Brazil was diagnosed on February 26, 2020. Due to the important epidemiological impact of COVID-19, the present study aimed to analyze the specificity of IgG antibody responses to the S1, S2 and N proteins of SARS-CoV-2 in different COVID-19 clinical profiles. This study enrolled 136 individuals who were diagnosed with or without COVID-19 based on clinical findings and laboratory results and classified as asymptomatic or as having mild, moderate or severe disease. Data collection was performed through a semistructured questionnaire to obtain demographic information and main clinical manifestations. IgG antibody responses to the S1 and S2 subunits of the spike (S) protein and the nucleocapsid (N) protein were evaluated using an enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's instructions. The results showed that among the participants, 87.5% (119/136) exhibited IgG responses to the S1 subunit and 88.25% (120/136) to N. Conversely, only 14.44% of the subjects (21/136) displayed S2 subunit responses. When analyzing the IgG antibody response while considering the different proteins of the virus, patients with severe disease had significantly higher antibody responses to N and S1 than asymptomatic individuals ( p ≤ 0.0001), whereas most of the participants had low antibody titers against the S2 subunit. In addition, individuals with long COVID-19 showed a greater IgG response profile than those with symptomatology of a short duration. Based on the results of this study, it is concluded that levels of IgG antibodies may be related to the clinical evolution of COVID-19, with high levels of IgG antibodies against S1 and N in severe cases and in individuals with long COVID-19.
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- 2023
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4. The FOXP3-924 A/G Single Nucleotide Polymorphism May Be Associated with Predictive Factors for Human T Lymphotropic Virus 1 Associated Myelopathy.
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Madureira MWS, Queiroz MAF, Lima SS, Pereira LMS, da Costa CA, de Sousa MS, Feitosa RNM, Monteiro JC, Ishak R, Vallinoto ACR, and Rangel da Silva ANM
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- Humans, Polymorphism, Single Nucleotide, Forkhead Transcription Factors genetics, Viral Load, Proviruses genetics, Proviruses metabolism, Paraparesis, Tropical Spastic genetics, Human T-lymphotropic virus 1 genetics, HTLV-I Infections genetics
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Human T lymphotropic virus 1 (HTLV-1) is a retrovirus associated with inflammatory diseases, including HTLV-1-associated myelopathy (HAM), and host genetic factors may be involved in disease evolution. The forkhead Box P3 (FOXP3) transcription factor is linked to homeostasis of the immune system, and the presence of polymorphisms in the promoter region of the FOXP3 gene should reflect its expression levels and consequent activation of regulatory T cells, which may contribute to severe inflammatory disorders, such as HAM. This study evaluated the rs2232365 polymorphism (-924 A/G) located in the promoter region of the FOXP3 gene and its association with HAM. Forty DNA samples from asymptomatic carriers and 25 samples from HAM patients were used, in addition to 130 control samples. The polymorphism was genotyped by conducting real-time polymerase chain reaction (PCR) (quantitative PCR [qPCR]) on extracted DNA. The proviral loads (PVLs) and CD4
+ and CD8+ T lymphocyte counts were determined by qPCR and FACSCalibur flow cytometry, respectively. The PVLs, CD4+ T lymphocyte concentrations, and tumor necrosis factor- α dosages were considered predictive factors of the clinical profiles of HTLV-1 infection, all of which had higher levels in the HAM group. Carriers of the GG genotype for the polymorphism rs2232365 had high PVLs and CD4+ T lymphocyte concentrations.- Published
- 2023
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5. Seroprevalence of Chlamydia trachomatis and Associated Factors among Vulnerable Riverine in the Brazilian Amazon.
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Galvão JJDS, Cunha CLF, Pinho ECC, Paiva DJDS, de Castro NJC, Nascimento VGC, de Azevedo Junior WS, da Silva RAR, Feitosa RNM, Vallinoto ACR, Botelho EP, and Ferreira GRON
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- Humans, Adolescent, Adult, Chlamydia trachomatis, Seroepidemiologic Studies, Cross-Sectional Studies, Prevalence, Chlamydia Infections epidemiology, Chlamydia Infections diagnosis, Sexually Transmitted Diseases epidemiology
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Due to social and individual conditions and access to health services, Amazonian riverside populations are highly vulnerable to sexually transmitted infections, including Chlamydia trachomatis . The aim is to estimate the seroprevalence of Chlamydia trachomatis and analyze the associated factors among riverside dwellers in a capital city in the Brazilian Amazon. A cross-sectional study was carried out with residents of the Combu Island, Belém. The study sample was calculated using the population survey technique in the EPI INFO. Only people aged 18 and over were included. ELISA serology was performed to detect antibodies against Chlamydia trachomatis . For data collection, a form containing vulnerability factor questions was applied. Binary regression analysis was performed using the Minitab 20 program. The study sample consisted of 325 participants. The prevalence of IgG/IgM antibodies against Chlamydia trachomatis was 22.2% and 5.5%, respectively. In the multiple regression, only participants with a broken condom were more likely to have antibodies against the bacteria (OR: 1.90; 95% CI: 1.01; 3.37; p = 0.046). Seroprevalence was associated with condom breakage. This factor demonstrates that despite having an attitude towards condom use, probably, they may have inadequate knowledge about the correct practice of introduction.
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- 2022
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6. Prevalence and Risk Factors for HTLV-1/2 Infection inRiverside and Rural Populations of the State of Pará.
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de Lima ACR, Lopes FT, de Oliveira Freitas V, Assad MN, de Sousa RS, Gonçalves JSS, Gomes JLC, Dos Santos BC, Lima CNC, Abreu IN, Dos Santos Brito WR, Pereira KAS, da Silva Torres MK, Lima SS, Aben-Athar CYU, Guerreiro JF, Cayres Vallinoto IMV, Vallinoto ACR, and Feitosa RNM
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- Female, Humans, Male, Human T-lymphotropic virus 2 genetics, Prevalence, Risk Factors, Rural Population, HTLV-I Infections diagnosis, HTLV-I Infections epidemiology, HTLV-II Infections diagnosis, HTLV-II Infections epidemiology, Human T-lymphotropic virus 1 genetics
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Human T-lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) infection has been described in several Amazonian populations; however, there is still a lack of data on the prevalence of the virus in riparian populations living in rural areas of the state of Pará. The present study aimed to evaluate the prevalence of HTLV-1/2 infection in four riverine communities and one rural area in the state of Pará and to describe the possible risk factors for infection. A total of 907 individuals responded to an epidemiological survey and gave blood samples collected for anti-HTLV-1/2 antibodies by immunoenzymatic assay (EIA). The serum-reactive samples were subjected to confirmation by an in-line assay (Inno-Lia) and by proviral DNA screening using real-time PCR (qPCR). The total prevalence was 0.8% (7/907) for HTLV-1/2 (CI: 0.2-1.3%), with 0.66% HTLV-1 and 0.11% HTLV-2. The prevalence by sex was 0.7% in women (4/565) and 0.9% in men (3/342). Among seropositive patients, 83.3% (5/7) reported being sexually active, and 57.1% (4/7) reported not having the habit of using condoms during their sexual relations. Intrafamily infection was also observed. The results reinforce the need for public policies to prevent and block the spread of HTLV, especially in riparian communities that are subject to difficulties in accessing the Unified Health System (Sistema Único de Saúde/SUS) because infected individuals need clinical monitoring for surveillance and early diagnosis of symptoms associated with HTLV-1.
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- 2022
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7. Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil.
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Monteiro JC, Tsutsumi MY, de Carvalho DO, da Silva Costa EDC, Feitosa RNM, Laurentino RV, de Souza Fonseca RR, Silvestre RVD, Oliveira-Filho AB, and Machado LFA
- Abstract
Background: Human papillomavirus (HPV) is the most common viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. This study estimated the prevalence, diversity of HPV genotypes, and associated risk factors in women screened for cervical cancer in northern Brazil., Methods: The cross-sectional study was conducted in Belém, Pará, in the Amazon region of Brazil, and it included 162 women who were spontaneously undergoing a Pap-smear routine. Epidemiological, sexual, and health-related information was collected by interviews, and cervical samples were collected for cytological examination and HPV-DNA detection. HPV genotypes were classified as low risk (LR) and high risk (HR) by nucleotide sequencing., Results: In total, 17.3% (28/162) of the participants had HPV-DNA, and LR-HPV was the most prevalent (71.4%). Among the 13 different types of HPV detected, HPV-11 was found most frequently (12/28; 42.9%), followed by HPV-31 (3/28; 10.7%). Of the participants with cytological alterations, HPV infection was detected in only four: two were diagnosed with low-grade squamous intraepithelial lesions (15.4%), one with atypical squamous cells of undetermined significance (7.7%), and one with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (7.7%). Of the 61 women who presented a normal cytology, 13 (21.3%) had positive tests for HPV infection, 4 (8.2%) of which were positive for a high-risk genotype., Conclusion: The prevalence of HPV was high in Belém, Pará, and especially in women who had normal cytology results, which suggests the need for greater screening for HPV infection in women's primary health care.
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- 2022
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8. Seroprevalence and risk factors for COVID-19 in the metropolis of the Brazilian Amazon.
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da Silva Torres MK, Lopes FT, de Lima ACR, Lima CNC, Dos Santos Brito WR, Dos Santos BC, de Sousa RS, Gomes JLC, Botelho BJS, Correa ACA, Machado LFA, Feitosa RNM, Lima SS, Vallinoto IMVC, and Vallinoto ACR
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- Antibodies, Viral, Brazil epidemiology, Humans, Risk Factors, SARS-CoV-2, Seroepidemiologic Studies, COVID-19 epidemiology
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The devastating effect of health system overload was observed after cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peaked in April 2020 in Belém, a capital metropolis in the Brazilian Amazon. Our results showed a high seroprevalence (39.24%) of anti-SARS-CoV-2 IgG antibodies among the population of the capital of the state of Pará after the first wave of the pandemic. Old age, mixed race, a high school education level, low income and contact with infected individuals are risk factors and may be driving seropositivity and exposure to SARS-CoV-2 in this population. This study is one of the first to provide important information to understand the socioeconomic inequalities, behavioral characteristics and viral transmission dynamics associated with the risk of SARS-CoV-2 infection in the capital of the state of Pará, northern Brazil., (© 2022. The Author(s).)
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- 2022
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9. The Relevance of a Diagnostic and Counseling Service for People Living With HTLV-1/2 in a Metropolis of the Brazilian Amazon.
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Lopes FT, de Sousa RS, Carvalho Gomes JL, Vallinoto MC, de Lima ACR, Lima SS, Freitas FB, Feitosa RNM, Rangel da Silva ANM, Machado LFA, Aben-Athar CYP, Maia da Silva EL, Cayres Vallinoto IMV, and Vallinoto ACR
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- Adult, Brazil epidemiology, Counseling, Female, Human T-lymphotropic virus 2, Humans, Male, Middle Aged, HTLV-I Infections diagnosis, HTLV-I Infections epidemiology, HTLV-II Infections complications, HTLV-II Infections diagnosis, HTLV-II Infections epidemiology, Human T-lymphotropic virus 1
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Introduction: To identify the prevalence of infection in the urban area of the capital city of Belém, Brazil, the Laboratory of Virology of the Federal University of Pará implemented, as a public service, serological screening for human T-lymphotropic viruses 1 and 2 (HTLV-1/2) infection and, if necessary, counseling service and referral to specialized medical care. The project is funded by the National Council of Science and Technology, the Ministry of Health of Brazil and the Pan American Health Organization., Methods: From January 2020 to June 2021, 1,572 individuals of both sexes were approached to answer a questionnaire and were tested using an enzyme immunoassay (Murex HTLV-I+II, DiaSorin, Dartford, UK). Seropositive samples were confirmed as HTLV-1 and HTLV-2 infection by line immunoassay (INNO-LIA
® HTLV I/II Score, Fujirebio, Japan) and/or by real-time polymerase chain reaction. G and Fisher's exact tests were applied to identify the association between epidemiological characteristics and HTLV-1/2 infection., Results: Of the 1,572 screened individuals, 63.74% were females between the ages of 30 and 59 years (49.04%). Infection was confirmed in six individuals (0.38%), among whom three (0.19%) were infected with HTLV-1 and three with HTLV-2 (0.19%). Blood transfusion before 1993 was the main risk factor associated with the route of exposure to the virus ( p = 0.0442). The infected individuals were referred to a counseling session with a nursing professional, and two patients who manifested signs and symptoms suggestive of myelopathy associated with HTLV were referred to a neurologist., Conclusion: The implementation of the screening service revealed the occurrence of moderate endemicity of HTLV-1/2 in Belém, reinforcing the importance of continuing the service as a means of establishing an early diagnosis and providing counseling as a measure to prevent and control viral transmission in the general population., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Lopes, de Sousa, Carvalho Gomes, Vallinoto, de Lima, Lima, Freitas, Feitosa, Rangel da Silva, Machado, Aben-Athar, Maia da Silva, Cayres Vallinoto and Vallinoto.)- Published
- 2022
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10. Prevalence of syphilis in female sex workers in three countryside cities of the state of Pará, Brazilian Amazon.
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de Souza RL, Dos Santos Madeira LDP, Pereira MVS, da Silva RM, de Luna Sales JB, Azevedo VN, Feitosa RNM, Monteiro JC, de Oliveira Guimarães Ishak M, Ishak R, Ribeiro ALR, Oliveira-Filho AB, and Machado LFA
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- Adolescent, Adult, Brazil epidemiology, Cities statistics & numerical data, Condoms statistics & numerical data, Cross-Sectional Studies, Educational Status, Female, Humans, Middle Aged, Prevalence, Risk Factors, Sexual Behavior statistics & numerical data, Sexual Partners, Syphilis diagnosis, Syphilis Serodiagnosis, Treponema pallidum immunology, Young Adult, Sex Workers statistics & numerical data, Syphilis epidemiology
- Abstract
Background: Syphilis is a sexually transmitted infection (STI) transmitted from person to person mainly by sexual intercourse or through vertical transmission during pregnancy. Female sex workers (FSWs) are exposed especially to syphilis infection, and besides all the efforts to control the spread of STIs, syphilis prevalence is still rising, mainly occurring in low-income countries. This study aimed to investigate the syphilis prevalence, demographic characteristics and sexual habits among FSWs in the Amazon region of Brazil., Methods: A cross-sectional study was carried out including 184 FSWs from 3 countryside cities of the state of Pará, Amazon region of Brazil. A venereal disease research laboratory test and an indirect immunoenzyme assay to test antibodies against Treponema pallidum were used for screening syphilis infection, while sexual habits and demographic data information were collected through a semi-structured questionnaire. Data was analyzed comparing groups with/without syphilis. Poisson regression models were used to estimate the reasons of prevalence (RP)., Results: The overall prevalence of syphilis was 14.1% (95% CI = 9.8-17.8). FSWs had between 15 and 56 years of age, most were unmarried (65.7%), had attended less than 8 years of formal education (64.1%), had between 10 and 20 partners per week (64.1%), and reported no previous history of STIs (76.1%) and regular use of condom (52.7%). Low level of education attending up to the primary school (RP adjusted = 3.8; 95% CI = 1.4-9.2) and high frequency of anal sex during the past year (RP adjusted = 9.3; 95% CI = 3.5-28.7) were associated with a higher prevalence of syphilis., Conclusions: A high prevalence of syphilis among FSWs in the Brazilian Amazon region was identified, showing that syphilis is more likely to be transmitted in FSW working in low-income areas, which is attributed to the low level of education. Anal intercourse was found as a risk factor associated with syphilis. Health programs focused on risk populations appear as a rational way to control syphilis spread, which is a rising problem in Brazil and in other several countries.
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- 2020
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11. Syphilis Among Newly Diagnosed Therapy-Naive HIV Patients in Belém, Pará, Amazon Region of Brazil.
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Neto PLF, Fernandes ÉMF, do Nascimento MRO, Paes RP, Irias SDF, Avelino MES, Torres MKS, Azevedo VN, Feitosa RNM, Oliveira-Filho AB, Vallinoto ACR, and Machado LFA
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- Adolescent, Adult, Aged, Brazil epidemiology, Cross-Sectional Studies, Female, HIV Infections diagnosis, HIV Infections epidemiology, Humans, Male, Middle Aged, Prevalence, Risk Factors, Syphilis virology, Young Adult, HIV Infections complications, HIV Infections microbiology, Syphilis epidemiology
- Published
- 2019
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12. HIV-1 Transmitted Drug Resistance Mutations in Recently Diagnosed Antiretroviral-Naive Patients in Belém, Pará, Northern Brazil.
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Irias SDF, Torres MKS, Avelino MES, Santos MB, Queiroz MAF, Freitas FB, Azevedo VN, Feitosa RNM, Vallinoto ACR, and Machado LFA
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- Adult, Anti-Retroviral Agents therapeutic use, Brazil, Cross-Sectional Studies, Female, HIV Infections diagnosis, HIV-1 drug effects, Humans, Male, Drug Resistance, Viral, HIV Infections virology, HIV-1 genetics, Mutation
- Published
- 2019
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13. Seroprevalence of HIV, HTLV, CMV, HBV and rubella virus infections in pregnant adolescents who received care in the city of Belém, Pará, Northern Brazil.
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Guerra AB, Siravenha LQ, Laurentino RV, Feitosa RNM, Azevedo VN, Vallinoto ACR, Ishak R, and Machado LFA
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- Adolescent, Antibodies, Viral immunology, Brazil epidemiology, Child, Cross-Sectional Studies, Cytomegalovirus immunology, Cytomegalovirus Infections blood, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections virology, Deltaretrovirus immunology, Deltaretrovirus Infections blood, Deltaretrovirus Infections epidemiology, Deltaretrovirus Infections virology, Female, HIV immunology, HIV Infections blood, HIV Infections epidemiology, HIV Infections virology, Hepatitis B blood, Hepatitis B epidemiology, Hepatitis B virology, Hepatitis B virus immunology, Humans, Infectious Disease Transmission, Vertical prevention & control, Pregnancy, Pregnancy Complications, Infectious blood, Pregnancy Complications, Infectious virology, Prenatal Care, Rubella blood, Rubella epidemiology, Rubella virology, Rubella virus immunology, Seroepidemiologic Studies, Virus Diseases blood, Virus Diseases virology, Antibodies, Viral blood, Maternal Serum Screening Tests statistics & numerical data, Pregnancy Complications, Infectious epidemiology, Pregnancy in Adolescence blood, Virus Diseases epidemiology
- Abstract
Background: Prenatal tests are important for prevention of vertical transmission of various infectious agents. The objective of this study was to describe the prevalence of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), cytomegalovirus (CMV), rubella virus and vaccination coverage against HBV in pregnant adolescents who received care in the city of Belém, Pará, Brazil., Methods: A cross-sectional study was performed with 324 pregnant adolescents from 2009 to 2010. After the interview and blood collection, the patients were screened for antibodies and/or antigens against HIV-1/2, HTLV-1/2, CMV, rubella virus and HBV. The epidemiological variables were demonstrated using descriptive statistics with the G, χ
2 and Fisher exact tests., Results: The mean age of the participants was 15.8 years, and the majority (65.4%) had less than 6 years of education. The mean age at first intercourse was 14.4 years, and 60.8% reported having a partner aged between 12 and 14 years. The prevalence of HIV infection was 0.3%, and of HTLV infection was 0.6%. Regarding HBV, 0.6% of the participants had acute infection, 9.9% had a previous infection, 16.7% had vaccine immunity and 72.8% were susceptible to infection. The presence of anti-HBs was greater in adolescent between 12 and 14 years old (28.8%) while the anti-HBc was greater in adolescent between 15 and 18 years old (10.3%). Most of the adolescents presented the IgG antibody to CMV (96.3%) and rubella (92.3%). None of the participants had acute rubella infection, and 2.2% had anti-CMV IgM., Conclusions: This study is the first report of the seroepidemiology of infectious agents in a population of pregnant adolescents in the Northern region of Brazil. Most of the adolescents had low levels of education, were susceptible to HBV infection and had IgG antibodies to CMV and rubella virus. The prevalence of HBV, HIV and HTLV was similar to that reported in other regions of Brazil. However, the presence of these agents in this younger population reinforces the need for good prenatal follow-up and more comprehensive vaccination campaigns against HBV due to the large number of women susceptible to the virus.- Published
- 2018
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14. GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4 + T lymphocyte count.
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de Miranda BKB, de Sá KSG, da Silva ANR, Feitosa RNM, Cayres-Vallinoto IMV, Ishak R, and Vallinoto ACR
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- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Flaviviridae Infections virology, HIV Infections virology, Hepatitis, Viral, Human virology, Humans, Male, Middle Aged, Young Adult, Coinfection virology, Flaviviridae Infections complications, GB virus C, HIV Infections complications, HIV-1, Hepatitis, Viral, Human complications
- Abstract
GB virus C (GBV-C) is a lymphotropic virus with a low level or non-existent replication in the liver. The interaction between HIV-1 and GBV-C apparently reduces the progression of HIV-1 infection to AIDS and improves the quality of life of HIV-1 infected individuals. A cross-sectional study was established to determine the possible effect of HIV-1/GBV-C coinfection on HIV-1 viral load and CD4
+ T lymphocyte counts. Samples from 313 HIV-1 infected persons from the Virus Laboratory of the Federal University of Pará as well as demographic and clinical information were obtained from medical records. This study used a nested PCR method to determine GBV-C viremia. The prevalence of HIV-1/GBV-C coinfection was 17%. There were no significant differences in the distribution according to age, sex or ethnicity between the groups. The differences in HIV-1 viral load and CD4+ T lymphocyte count between the HIV-1 and HIV-1/GBV-C groups were highly significant, indicating that coinfection results in lower viral loads and higher CD4+ T lymphocyte counts compared to HIV-1 mono-infection. The results indicate a protective effect among coinfected individuals.- Published
- 2017
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