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Our aim was to examine the significance of single-fiber electromyography (SFEMG) in patients diagnosed with amyotrophic lateral sclerosis (ALS) and determine the best correlating parameter with SFEMG parameters and clinical scales across different muscles including facial muscles.

Introduction: Epilepsy is a widespread disease requiring long-term drug treatment. The aim of this study was to collect information on reported suspected adverse drug reactions (sADRs) of antiseizure medications (ASMs) and study their seriousness and outcomes in various system organ classifications (SOCs). We intended to compare old and new ASMs’ ADRs. Methods: Using EudraVigilance (EV) database, we extracted line listings of reported sADRs with different ASMs over the period from January 2012 to December 2021. The list of ASMs was compiled according to the Anatomical therapeutic chemical classification system. The Medical Dictionary for Regulatory Activities version 24.0 was used for determining the SOCs of individual reported preferred terms (PTs) sADRs. In addition, we calculated the Reporting Odds Ratio (ROR), 95% confidence interval (95% CI), p-value (statistically significant if p< 0.05) and chi-square statistics. Results: A total of 276,694 reports were contained in the exported line listings which included 1,051,142 individual sADRs reported as PTs such as seizure (3.49%), drug ineffective (2.46%), somnolence (1.32%), dizziness (1.29%) and represented four SOCs: nervous system disorders (19.26%), general disorders and administration site conditions (14.39%), psychiatric disorders (11.29%) and injury, poisoning and procedural complications (9.79). Among patients, the age group between 18 and 64 years had the highest percentage (52.40%), followed by those aged over 64 years (18.75%). Of all the reported PTs, 882,706 (83.98%) had reported seriousness. Old ASMs had a significant positive association with “caused/prolonged hospitalisation”, “congenital anomaly”, “disabling”, “life threatening” and “results in death”, while new ASMS with ‘other medically important condition’. There were 386 (0.04%) PTs related to Sudden Unexpected Death in Epilepsy (SUDEP). Conclusion: In our study, we examined 10 years’ reported sADRs of ASMs in the EV international database. The majority of PTs were serious. Old ASMs were generally more commonly associated with undesired outcomes and seriousness. Considering their expected seriousness and outcomes, the safety profile of the different ASMs, can play a cardinal role in the selection of ASMs. [ABSTRACT FROM AUTHOR]

Urban vegetation, especially urban trees could act as ecological archives, as they reflect various elements of their environment. The main aim of the study is to evaluate the spatial and temporal variations of environmental conditions in the city of Szeged (Hungary) based on long-term monitoring of the heavy metal content of tree-rings (soft wood). In general, the living conditions of the urban trees (and other organisms as well) at Szeged was the worst in 2001/05, when the heavy metal pollution was the greatest, therefore the biomass production of the sampled trees decreased. Fortunately, the environmental conditions became better, only there are some points in the industrial area, where the heavy metal pollution of the environment is gradually increases. The temporal change in lead pollution (considerable decline in 2013/17) could be explained by the obligatory usage of lead-free petrol since 1999 and the diversion of through-traffic from the town (2011). The introduction of unleaded petrol had delayed favourable results, as the dust particles containing lead probably circulated in the air for a while before they were gradually become fixed in the soil or they were washed out from the town during heavy rains. The cadmium pollution also declined after the traffic diversion, as it is connected to the usage of brake-linings. Whilst the lead and cadmium content of the tree-rings decreased during the studied decades, the trees accumulated increasing amount of zinc throughout the studied periods, as this element could be up-taken from the ground-water, as the larger the canopy of a tree the denser and deeper its root system is.