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4. Stress Axis in the Cancer Patient: Clinical Aspects and Management

Author

Felicetti Francesco, Nervo Alice, Gatti Filippo, Rosso Daniela, Brignardello Enrico, and Arvat Emanuela

Subjects
hypothalamus-pituitary-adrenal axis, adrenal insufficiency, adverse event, cancer survivors, chemotherapy, radiotherapy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Hypothalamus–pituitary–adrenal (HPA) axis alterations are common in cancer patients, mainly due to the different antitumoral therapies, which lead to several acute and late endocrine side effects. This review summarizes the most recent evidence regarding HPA derangement, both in patients with active neoplasms and in cancer survivors, with particular attention to the impact of the different antitumoral treatments, focusing on the major clinical aspects. While acute hormone failure usually results from injury caused directly by tumor burden or surgical interventions, short- and long-term effects are generally due to chemotherapy, radiotherapy and, as more recently shown, to different types of targeted- and immuno-therapy. Adrenal insufficiency (AI) is mostly caused by pituitary or hypothalamic injury rather than a direct damage of the adrenal gland. Moreover, other treatments commonly employed as supportive therapy or in the context of palliative care (i.e., glucocorticoids, opioids) can lead to HPA dysfunction. Epidemiology and pathophysiology of stress axis alterations in cancer patients still require clarification. Since AI may represent a life-threatening condition, monitoring adrenal function in cancer patients is mandatory, especially in subjects who experience fatigue or during stress conditions, in order to promptly start replacement treatment when needed.

Published
2021
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7. Preface

Author

Brignardello, Enrico, primary, Felicetti, Francesco, additional, and van Santen, Hanneke M., additional

Published
2021
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10. Maintain Efficacy and Spare Toxicity: Traditional and New Radiation-Based Conditioning Regimens in Hematopoietic Stem Cell Transplantation.

Author

Dogliotti, Irene, Levis, Mario, Martin, Aurora, Bartoncini, Sara, Felicetti, Francesco, Cavallin, Chiara, Maffini, Enrico, Cerrano, Marco, Bruno, Benedetto, Ricardi, Umberto, and Giaccone, Luisa

Subjects
HEMATOPOIETIC stem cell transplantation, DRUG toxicity, RADIOTHERAPY, MEDICAL technology, TREATMENT effectiveness, HOMOGRAFTS, CANCER chemotherapy
Abstract

Simple Summary: We discussed the potential long-term toxicities associated with total body irradiation, its current indications, and the technical advances in radiotherapy that have resulted in the development of total marrow irradiation and total marrow and lymphoid irradiation, which might change the role of radiation-based conditioning regimens in allogeneic hematopoietic stem cell transplantation. Novelty in total body irradiation (TBI) as part of pre-transplant conditioning regimens lacked until recently, despite the developments in the field of allogeneic stem cell transplants. Long-term toxicities have been one of the major concerns associated with TBI in this setting, although the impact of TBI is not so easy to discriminate from that of chemotherapy, especially in the adult population. More recently, lower-intensity TBI and different approaches to irradiation (namely, total marrow irradiation, TMI, and total marrow and lymphoid irradiation, TMLI) were implemented to keep the benefits of irradiation and limit potential harm. TMI/TMLI is an alternative to TBI that delivers more selective irradiation, with healthy tissues being better spared and the control of the radiation dose delivery. In this review, we discussed the potential radiation-associated long-term toxicities and their management, summarized the evidence regarding the current indications of traditional TBI, and focused on the technological advances in radiotherapy that have resulted in the development of TMLI. Finally, considering the most recent published trials, we postulate how the role of radiotherapy in the setting of allografting might change in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Emotional Distress, Self-Management Skills, and Expectations Among Adolescents and Young Adult Childhood Cancer Survivors in Transition from Pediatric to Adult Care: A Brief Report.

Author

Zucchetti, Giulia, Ciappina, Sabrina, Dionisi-Vici, Margherita, Giordano, Mario, Varetto, Antonella, Biasin, Eleonora, Felicetti, Francesco, and Fagioli, Franca

Subjects
SELF-management (Psychology), TRANSITIONAL care, CANCER patients, EMOTIONS
Abstract

The transition from pediatric to adult care poses several emotional and personal challenges to adolescents and young adult (AYA) childhood cancer survivors (CCSs), which need attention to avoid the risk of nonadherence and medical dropout. This brief report describes the condition of AYA-CCSs at the moment of transition in terms of emotional state, personal autonomy, and expectations regarding future care. The results provide insights for clinicians dealing with survivorship care, to enhance AYA-CCSs emotional resilience and to support them in being in charge of their health, thus facilitating their transition to adulthood. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Employment among Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

Author

Godono, Alessandro, primary, Felicetti, Francesco, additional, Conti, Alessio, additional, Clari, Marco, additional, Dionisi-Vici, Margherita, additional, Gatti, Filippo, additional, Ciocan, Catalina, additional, Pinto, Tommaso, additional, Arvat, Emanuela, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, and Pira, Enrico, additional

Published
2022
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20. Work Placement and Job Satisfaction in Long-Term Childhood Cancer Survivors: The Impact of Late Effects

Author

Dionisi-Vici, Margherita, primary, Godono, Alessandro, additional, Castiglione, Anna, additional, Gatti, Filippo, additional, Fortunati, Nicoletta, additional, Clari, Marco, additional, Conti, Alessio, additional, Zucchetti, Giulia, additional, Biasin, Eleonora, additional, Varetto, Antonella, additional, Pira, Enrico, additional, Fagioli, Franca, additional, Brignardello, Enrico, additional, and Felicetti, Francesco, additional

Published
2022
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26. Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications

Author

Felicetti, Francesco, primary, Aimaretti, Eleonora, additional, Dal Bello, Federica, additional, Gatti, Filippo, additional, Godono, Alessandro, additional, Saba, Francesca, additional, Einaudi, Giacomo, additional, Collino, Massimo, additional, Fagioli, Franca, additional, Aragno, Manuela, additional, and Brignardello, Enrico, additional

Published
2022
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31. Impact of allogeneic stem cell transplantation on thyroid function

Author

Felicetti, Francesco, primary, Zavattaro, Marco, additional, Faraci, Danilo, additional, Gatti, Filippo, additional, Dellacasa, Chiara, additional, Busca, Alessandro, additional, Arvat, Emanuela, additional, Rosso, Daniela, additional, Marinelli, Lorenzo, additional, Margherita, Dionisi-Vici, additional, Giaccone, Luisa, additional, Bruno, Benedetto, additional, and Brignardello, Enrico, additional

Published
2021
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33. Optimal Delivery of Follow-Up Care After Allogeneic Hematopoietic Stem-Cell Transplant: Improving Patient Outcomes with a Multidisciplinary Approach

Author

Giaccone,Luisa, Felicetti,Francesco, Butera,Sara, Faraci,Danilo, Cerrano,Marco, Dionisi Vici,Margherita, Brunello,Lucia, Fortunati,Nicoletta, Brignardello,Enrico, and Bruno,Benedetto

Subjects
Journal of Blood Medicine
Abstract

Luisa Giaccone,1,2 Francesco Felicetti,3 Sara Butera,1,2 Danilo Faraci,1,2 Marco Cerrano,1,2 Margherita Dionisi Vici,3 Lucia Brunello,1,2 Nicoletta Fortunati,3 Enrico Brignardello,3,* Benedetto Bruno1,2,* 1Division of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy; 2Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, University of Torino, Torino, Italy; 3Transition Unit for Childhood Cancer Survivors, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy*These authors contributed equally to this workCorrespondence: Luisa GiacconeDivision of Hematology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Via Genova 3, Torino 10126, ItalyTel +39 011-6334354Fax +39 011-6963737Email luisa.giaccone@unito.itAbstract: The increasing indications for allogeneic stem-cell transplant in patients with hematologic malignancies and non-malignant diseases combined with improved clinical outcomes have contributed to increase the number of long-term survivors. However, survivors are at increased risk of developing a unique set of complications and late effects, besides graft-versus-host disease and disease relapse. In this setting, the management capacity of a single health-care provider can easily be overwhelmed. Thus, to provide appropriate survivorship care, a multidisciplinary approach for the long-term follow-up is essential. This review aims at summarizing the most relevant information that a health-care provider should know to establish a follow-up care plan, in the light of individual exposures and risk factors, that includes all organ systems and considers the psychological burden of these patients.Keywords: long-term, complications, allografting

Published
2020

34. Abstracts from the 23rd Italian congress of Cystic Fibrosis and the 13th National congress of Cystic Fibrosis Italian Society

Author

Bevivino, Annamaria, Coiana, Alessandra, Fogazzi, Annalisa, Timelli, Fabiana, Signorini, Sandra, Lucarelli, Marco, Morelli, Patrizia, Padoan, Rita, Giordani, Barbara, Amato, Annalisa, Majo, Fabio, Ferrari, Gianluca, Quattrucci, Serena, Minicucci, Laura, Floridia, Giovanna, Fornaro, Gianna Puppo, Taruscio, Domenica, Salvatore, Marco, Seia, Manuela, Pierandrei, Silvia, Blaconà, Giovanna, Salvati, Valentina, Sette, Giovanni, Cimino, Giuseppe, Sangiuolo, Federica, Eramo, Adriana, Collura, Mirella, Parisi, Elisa, Ferlisi, Annalisa, Traverso, Gabriella, Bertolino, Marcella, Termini, Lisa, Orlando, Maria A., Di Girgenti, Caterina, Pavone, Valeria, Calamia, Maria A., Silvestro, Maria G., Piparo, Caterina Lo, Ficili, Francesca, Colombo, Carla, Tullis, Elizabeth, Davies, Jane C., Mckee, Charlotte, Desouza, Cynthia, Waltz, David, Savage, Jessica, Fisher, Marc, Shilling, Rebecca, Moskowitz, Sam, Robertson, Sarah, Tian, Simon, Taylor-Cousar, Jennifer L., Rowe, Steven M., Beccia, Elisa, Carbone, Annalucia, Favia, Maria, Castellani, Stefano, Angiolillo, Antonella, Casavola, Valeria, Conese, Massimo, Cesana, Bruno M., Falchetti, Diego, Battistini, Fiorella, Bignamini, Elisabetta, Braggion, Cesare, Cirilli, Natalia, Lucanto, Maria C., Lucidi, Vincenzina, Manca, Antonio, Raia, Valeria, Rotolo, Novella, Salvatore, Donatello, Volpi, Sonia, Nazzari, Erica, Guarise, Riccardo, Mileto, Palmiro, Garbarino, Francesca, Alicandro, Gianfranco, Battezzati, Alberto, Di Lullo, Antonella M., Comegna, Marika, Amato, Felice, Iacotucci, Paola, Carnovale, Vincenzo, Cantone, Elena, Iengo, Maurizio, Castaldo, Giuseppe, Orlando, Claudio, Casale, Alida, Sepe, Angela, De Gregorio, Fabiola, De Matteo, Antonia, Castaldo, Alice, Cimbalo, Chiara, Tosco, Antonella, Savi, Daniela, Mordenti, Michela, Bonci, Enea, Troiani, Patrizia, D’Alù, Viviana, Rossi, Paolo, Varchetta, Monica, Perelli, Tamara, Bertasi, Serenella, Palange, Paolo, Tardino, Lucia, Parisi, Giuseppe F., Portale, Anna, Franzonello, Chiara, Papale, Maria, Leonardi, Salvatore, Pennisi, Francesca, Bruno, Sabina M., Licciardello, Giulia, Ferraguti, Giampiero, Sterrantino, Manuela, Testino, Giancarlo, Buzzetti, Roberto, Surace, Cecilia, Sofia, Valentina M., Ullmann, Nicola, Novelli, Antonio, Angioni, Adriano, Liguori, Renato, Manzoni, Francesca, Di Palma, Chiara, Maietta, Sabrina, Zarrilli, Federica, Terlizzi, Vito, Alghisi, Federico, Tuccio, Giuseppe, Tradati, Valentina, di Stefano, Eliana, Dato, Patrizia, Sciarrabone, Maria G., Fondacaro, Carmela, Cresta, Federico, Baglioni, Valentina, Garuti, Silvia, Buffoni, Isabella, Landi, Francesca, Casciaro, Rosaria, Girelli, Daniela, Teri, Antonio, Sottotetti, Samantha, Biffi, Arianna, Vignati, Chiara, D’Accico, Monica, Maraschini, Anna, Arghittu, Milena, Pizzamiglio, Giovanna, Cariani, Elisa, Dolce, Daniela, Ravenni, Novella, Campana, Silvia, Camera, Erica, Castellani, Carlo, Taccetti, Giovanni, Calderone, Eleonora, Bandettini, Roberto, Innocenti, Chiara Degli, Castellani, Chiara, Masi, Eleonora, Cavicchi, Maria Chiara, Ferrari, Beatrice, Pezzotta, Ramona, Poli, Piercarlo, Messali, Serena, Timpano, Silvana, Scaltriti, Erika, Pongolini, Stefano, Fiorentini, Simona, Bresci, Silvia, Corsi, Lorenzo, Borchi, Beatrice, Cavallo, Annalisa, Bartalesi, Filippo, Pistolesi, Massimo, Bartoloni, Alessandro, Arcoleo, Federica, Pensabene, Tiziana, Bacci, Giovanni, Armanini, Federica, Fiscarelli, Ersilia V., Segata, Nicola, Mengoni, Alessio, Di Toppa, Maria V., Popa, Nicoleta, Felicetti, Francesco, Graziano, Sonia, Ciprandi, Riccardo, Pescini, Rita, Graffigna, Guendalina, Barello, Serena, Catastini, Paola, De Masi, Salvatore, Braggion, C., Guarnuto, Lucia, Di Liberti, Emanuela, Patti, Valentina, Castellazzi, Massimo Luca, Daccò, Valeria, Claut, Laura, Giuliari, Matteo, Vicentini, Luana, Tilotta, Fausto, Paciaroni, Antonella, Sala, Sabino Della, Guerzoni, Cristina, Andreatta, Elisa, Dinnella, Grazia, Granata, Orazia M., Aronica, Tommaso S., Crapisi, Mimì, Fogazza, Donatella, Alessi, Luca, Mulè, Flavia, Vitaliti, Marcello, Maresi, Mariarosaria, Catzola, Andrea, Salvadori, Laura, Colangelo, Carmela, Marsicovetere, Giovanni, D’Andria, Michele, Passarella, Domenica, Genovese, Carmela, Orlando, Mari A., Barrale, Stefania, Bonaccorso, Maria R., and D’Arpa, Annalisa

Subjects
lcsh:RJ1-570, lcsh:Pediatrics, Meeting Abstracts
Published
2018

35. Biomarkers for acute and chronic graft versus host disease: state of the art

Author

Giaccone, Luisa, primary, Faraci, Danilo Giuseppe, additional, Butera, Sara, additional, Lia, Giuseppe, additional, Di Vito, Clara, additional, Gabrielli, Giulia, additional, Cerrano, Marco, additional, Mariotti, Jacopo, additional, Dellacasa, Chiara, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Mavilio, Domenico, additional, and Bruno, Benedetto, additional

Published
2020
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37. Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation

Author

Felicetti, Francesco, primary, Cento, Alessia Sofia, additional, Fornengo, Paolo, additional, Cassader, Maurizio, additional, Mastrocola, Raffaella, additional, D'Ascenzo, Fabrizio, additional, Settanni, Fabio, additional, Benso, Andrea, additional, Arvat, Emanuela, additional, Collino, Massimo, additional, Fagioli, Franca, additional, Aragno, Manuela, additional, and Brignardello, Enrico, additional

Published
2019
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38. Advanced glycation end-products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation: possible role in the pathogenesis of cardiovascular late effects

Author

Felicetti, Francesco, primary, Cento, Alessia Sofia, additional, Fornengo, Paolo, additional, Cassader, Maurizio, additional, Mastrocola, Raffaella, additional, D'Ascenzo, Fabrizio, additional, Settanni, Fabio, additional, Benso, Andrea, additional, Arvat, Emanuela, additional, Collino, Massimo, additional, Fagioli, Franca, additional, Aragno, Manuela, additional, and Brignardello, Enrico, additional

Published
2019
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41. Are evidence-based guidelines reflected in clinical practice? An analysis of prospectively collected data of the Italian Thyroid Cancer Observatory (ITCO#1)

Author

Lamartina, Livia, Durante, Cosimo, Lucisano, Giuseppe, Grani, Giorgio, Bellantone, Rocco Alfonso, Lombardi, Celestino Pio, Pontecorvi, Alfredo, Arvat, Emanuela, Felicetti, Francesco, Zatelli, Maria Chiara, Rossi, Roberta, Puxeddu, Efisio, Morelli, Silvia, Torlontano, Massimo, Crocetti, Umberto, Montesano, Teresa, Giubbini, Raffaele, Orlandi, Fabio, Aimaretti, Gianluca, Monzani, Fabio, Attard, Marco, Francese, Cecilia, Antonelli, Alessandro, Limone, Paolo P, Rossetto, Ruth, Fugazzola, Laura, Meringolo, Domenico, Bruno, Rocco, Tumino, Salvatore, Ceresini, Graziano, Centanni, Marco, Monti, Salvatore, Salvatore, Domenico, Mian, Caterina, Spiazzi, Giovanna, Persani, Luca, Barbaro, Daniele, Nicolucci, Antonio, and Filetti, Sebastiano

Subjects
differentiated thyroid cancer, radioiodine remnant ablation, evidence-based guidelines, clinical practice, thyroid surgery
Published
2017

43. Are Evidence-Based Guidelines Reflected in Clinical Practice? An Analysis of Prospectively Collected Data of the Italian Thyroid Cancer Observatory

Author

Lamartina, Livia, primary, Durante, Cosimo, additional, Lucisano, Giuseppe, additional, Grani, Giorgio, additional, Bellantone, Rocco, additional, Lombardi, Celestino Pio, additional, Pontecorvi, Alfredo, additional, Arvat, Emanuela, additional, Felicetti, Francesco, additional, Zatelli, Maria C., additional, Rossi, Roberta, additional, Puxeddu, Efisio, additional, Morelli, Silvia, additional, Torlontano, Massimo, additional, Crocetti, Umberto, additional, Montesano, Teresa, additional, Giubbini, Raffaele, additional, Orlandi, Fabio, additional, Aimaretti, Gianluca, additional, Monzani, Fabio, additional, Attard, Marco, additional, Francese, Cecilia, additional, Antonelli, Alessandro, additional, Limone, Paolo, additional, Rossetto, Ruth, additional, Fugazzola, Laura, additional, Meringolo, Domenico, additional, Bruno, Rocco, additional, Tumino, Salvatore, additional, Ceresini, Graziano, additional, Centanni, Marco, additional, Monti, Salvatore, additional, Salvatore, Domenico, additional, Spiazzi, Giovanna, additional, Mian, Caterina, additional, Persani, Luca, additional, Barbaro, Daniele, additional, Nicolucci, Antonio, additional, and Filetti, Sebastiano, additional

Published
2017
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47. 72nd Congress of the Italian Society of Pediatrics

Author

Braghero, Marco, primary, Staiano, Annamaria, additional, Biasin, Eleonora, additional, Matarazzo, Patrizia, additional, Einaudi, Silvia, additional, Manicone, Rosaria, additional, Felicetti, Francesco, additional, Brignardello, Enrico, additional, Fagioli, Franca, additional, Bignamini, Elisabetta, additional, Nave, Elena, additional, Callea, F., additional, Concato, C., additional, Fiscarelli, E., additional, Garrone, S., additional, de Gasperis, M.Rossi, additional, Calzi, Patrizia, additional, Marinelli, Grazia, additional, Besana, Roberto, additional, Caffarelli, Carlo, additional, Di Peri, Antonio, additional, Lapetina, Irene, additional, Cincinnati, Patrizia, additional, Da Riol, Rosalia Maria, additional, De Curtis, Mario, additional, Dito, Lucia, additional, Protano, Chiara, additional, Esposito, Susanna, additional, Ferrara, Dante, additional, Galiano, Rossella, additional, Novellino, Pasquale, additional, Kossoff, Eric Heath, additional, Krzysztofiak, Andrzej, additional, Bozzola, Elena, additional, Lancella, Laura, additional, Marchesi, Alessandra, additional, Villani, Alberto, additional, Lago, Paola, additional, Garetti, Elisabetta, additional, Pirelli, Anna, additional, Marchisio, Paola, additional, Santagati, Maria, additional, Stefani, Stefania, additional, Principi, Nicola, additional, d’Apolito, Valeria, additional, Memo, Luigi, additional, Selicorni, Angelo, additional, Miniello, Vito Leonardo, additional, Diaferio, Lucia, additional, Palmieri, Antonella, additional, Parola, Luciana, additional, Piro, Ettore, additional, Romano, Claudio, additional, Catena, Maria Ausilia, additional, Cardile, Sabrina, additional, Sacco, Oliviero, additional, Girosi, Donata, additional, Olcese, Roberta, additional, Tosca, Mariangela, additional, Rossi, Giovanni Arturo, additional, Salerno, Sergio, additional, Terranova, Maria Chiara, additional, Santamaria, Francesca, additional, Mancano, Giorgia, additional, Maitz, Silvia, additional, Stallings, Virginia A., additional, Berlolaso, Chiara, additional, McAnlis, Carolyn, additional, Schall, Joan I., additional, Striano, Pasquale, additional, Tanas, Rita, additional, De Iaco, Giulia, additional, Marsella, Maria, additional, Caggese, Guido, additional, Toma, Paolo, additional, Valentini, Piero, additional, Buonsenso, Danilo, additional, Pata, David, additional, Ceccarelli, Manuela, additional, Verduci, Elvira, additional, Brambilla, Marta, additional, Mariani, Benedetta, additional, Lassandro, Carlotta, additional, Dionigi, Alice Re, additional, Vizzuso, Sara, additional, Banderali, Giuseppe, additional, Panzarino, Gianvito, additional, Di Paolantonio, Claudia, additional, Verrotti, Alberto, additional, Cursi, Laura, additional, Grandin, Annalisa, additional, Virdis, Raffaele, additional, Carletti, Patrizia, additional, Weber, Giovanna, additional, Caiulo, Silvana, additional, and Vigone, Maria Cristina, additional

Published
2017
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