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2. Consensus for the diagnosis, prognosis and treatment of canine mammary tumors

Author

Cassali, G. D., Lavalle, G. E., Nardi, A. B., Ferreira, E., Bertagnolli, A. C., Estrela-Lima, A., Alessi, A. C., Daleck, C. R., Salgado, B. S., Fernandes, C. G., Sobral, R. A., Amorim, R. L., Gamba, C. O., Damasceno, K. A., Auler, P. A., Magalhães, G. M., Silva, J. O., Raposo, J. B., Ferreira, A. M. R., Oliveira, L. O., Malm, C., Zuccari, D. A. P. C., Tanaka, N. M., Ribeiro, L. R., Campos, L. C., Souza, C. M., Leite, J. S., Soares, L. M. C., Cavalcanti, M. F., Fonteles, Z. G. C., Schuch, I. D., Paniago, J., Oliveira, T. S., Terra, E. M., Castanheira, T. L. L., Felix, A. O. C., Carvalho, G. D., Guim, T. N., Eduardo Garrido, Fernandes, S. C., Maia, F. C. L., Dagli, M. L. Z., Rocha, N. S., Fukumasu, H., Grandi, F., Machado, J. P., Silva, S. M. M. S., Bezerril, J. E., Frehse, M. S., Almeida, E. C. P., Campos, C. B., Universidade Federal de Minas Gerais (UFMG), Universidade de Franca (UNIFRAN), Universidade Federal de Lavras (UFLA), UNIVALE, Universidade Federal da Bahia (UFBA), Universidade Estadual Paulista (Unesp), Universidade Federal de Pernambuco (UFPE), PROVET - Medicina Veterinária Diagnóstica e de Especialidades, Universidade Federal Fluminense (UFF), Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina de São José do Rio Preto (FAMERP), Universidade Norte do Paraná, Universidade Federal do Piauí (UFPI), IMA - Instituto Mineiro de Agropecuária, IFNMG, Universidade Federal do Pampa (UNIPAMPA), Universidade de São Paulo (USP), Universidade Federal Rural de Pernambuco (UFRPE), UNIVIÇOSA/FACISA, and Universidade Estadual de Londrina (UEL)

Subjects
Dogs, Medical oncology, Animal, Mammary neoplasms, Animalia, Canis familiaris
Abstract

Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:25:56Z No. of bitstreams: 0 Made available in DSpace on 2014-05-27T11:25:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-07-01 The purpose of this paper is to establish criteria that could guide the diagnosis, prognosis and treatment of canine mammary neoplasias. It was elaborated during the Mammary Pathology Meeting: Diagnosis, Prognosis and Treatment of the Canine Mammary Neoplasm, held on November 6 th and 7 th, 2010 in Belo Horizonte - MG, Brazil, sponsored by the Laboratory of Comparative Pathology - UFMG, with the support of the Brazilian Association of Veterinary Pathology (ABPV) and Brazilian Association of Veterinary Oncology (ABROVET). Academics from several regions of Brazil were present and contributed to this work. Laboratório de Patologia Comparada Departamento de Patologia Geral ICB/UFMG, Belo Horizonte - MG Hospital Veterinário Escola de Veterinária UFMG, Belo Horizonte - MG Escola de Medicina Veterinária e Zootecnia UFT Araguaína -TO e Hospital Veterinário, UNIFRAN, Franca - SP Departamento de Medicina Veterinária UFLA, Lavras - MG Faculdade de Ciências da Saúde UNIVALE, Governador Valadares - MG Departamento de Patologia e Clínicas Escola de Medicina Veterinária UFBA, Salvador - BA Departamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Botucatu - SP Departamento de Patologia Animal Faculdade de Veterinária UFPEL, Pelotas - RS Serviço de Oncologia Clínico-Cirúrgica PROVET - Medicina Veterinária Diagnóstica e de Especialidades, São Paulo - SP Setor de Anatomia Patológica Veterinária Departamento de Patologia e Clínica Veterinária Faculdade de Veterinária, UFF, Niteroi - RJ Hospital de Clínicas Veterinárias UFRGS, Porto Alegre - RS Departamento de Clínica e Cirurgia Veterinária Escola de Veterinária UFMG, Belo Horizonte - MG Centro de Estudos no Prognóstico do Câncer Departamento de Biologia Molecular FAMERP, São José do Rio Preto -SP Curso de Medicina Veterinária Centro de Ciências Biológicas e da Saúde Universidade Norte do Paraná, Londrina-PR Oncologia Veterinária, Belo Horizonte - MG Departamento de Clínica e Cirurgia Veterinária UFPI, Teresina - PI Hospital Universitário de Clínicas Veterinária Faculdade de Veterinária UFPEL, Pelotas - RS Laboratório de Saúde Animal IMA - Instituto Mineiro de Agropecuária, Belo Horizonte - MG Departamento de Clínica Veterinária Faculdade de Veterinária UFPEL, Pelotas - RS Laboratório de Patologia IFNMG, Salinas - MG Hospital Universitário Veterinário UNIPAMPA, Uruguaiana - RS Laboratório de Oncologia Experimental Departamento de Radiologia e Oncologia Faculdade de Medicina, USP, São Paulo - SP Departamento de Medicina Veterinária UFRPE, Recife - PE Departamento de Patologia Faculdade de Medicina Veterinária e Zootecnia USP, São Paulo - SP Departamento de Ciências Básicas Faculdade de Zootecnia e Engenharia de Alimentos USP, Pirassununga - SP Patologia Veterinária UNIVIÇOSA/FACISA, Viçosa - MG Departamento de Medicina Veterinária Preventiva UEL, Londrina - PR Departamento de Ciências Básicas Faculdade de Odontologia UFF, Nova Friburgo, RJ Departamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias UNESP, Jaboticabal - SP Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia UNESP, Botucatu - SP

Published
2011

3. Brazilian Journal of Veterinary Pathology

Author

Cassali, Geovanni Dantas, Lavalle, Gleidice E., De Nardi, Andrigo B., Ferreira, Enio, Bertagnolli, Angélica Cavalheiro, Lima, Alessandra Estrela da Silva, Alessi, Antonio C., Daleck, Carlos R., Salgado, Breno S., Fernandes, Cristina G., Sobral, Renata A., Amorim, Renée L., Gamba, Conrado O., Damasceno, Karine Araújo, Auler, Patricia de Alencar, Magalhães, Georgia M., Silva, Juliana O., Raposo, Josiane B., Ferreira, Ana M. R., Oliveira, Luciana O., Malm, Christina, Zuccari, Debora Aparecida Pires de Campos, Tanaka, Neide M., Ribeiro, Lorena R., Campos, Liliane Cunha, Souza, Cristina Maria de, Leite, Juliana S., Soares, Luciana M. C., Cavalcanti, Mariana F., Fonteles, Zilmara G. C., Schuch, Isabel D., Paniago, Juliana, Oliveira, Taismara S., Terra, Erika M., Castanheira, Thais L. L., Felix, Anelize O. C., Carvalho, Gabriel D., Guim, Thomas N., Guim, Tainã N., Garrido, Eduardo, Fernandes, Simone C., Maia, Frederico C. L., Dagli, Maria L. Z., Rocha, Noeme S., Fukumasu, Heidge, Grandi, Fabrizio, Machado, João P., Silva, Silvana M. M. S., Bezerril, Juliana Evangelista, Frehse, Michele S., Almeida, Elan Cardozo Paes de, and Campos, Cecília Bonolo de

Subjects
dogs, Mammary neoplasms, animal, medical oncology
Abstract

Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-10T18:30:55Z No. of bitstreams: 1 Consenso.pdf: 1884898 bytes, checksum: bcdbc659df1c1845ee705b8b9160deb2 (MD5) Made available in DSpace on 2012-02-10T18:30:55Z (GMT). No. of bitstreams: 1 Consenso.pdf: 1884898 bytes, checksum: bcdbc659df1c1845ee705b8b9160deb2 (MD5) Previous issue date: 2011-06 The purpose of this paper is to establish criteria that could guide the diagnosis, prognosis and treatment of canine mammary neoplasias. It was elaborated during the Mammary Pathology Meeting: Diagnosis, Prognosis and Treatment of the Canine Mammary Neoplasm, held on November 6th and 7th, 2010 in Belo Horizonte – MG, Brazil, sponsored by the Laboratory of Comparative Pathology – UFMG, with the support of the Brazilian Association of Veterinary Pathology (ABPV) and Brazilian Association of Veterinary Oncology (ABROVET). Academics from several regions of Brazil were present and contributed to this work.

Published
2011

4. Use of Triticum aestivum in open wound healing: a clinical, pathological, and tensiometric assessment in the rabbit model.

Author

Tillmann, M. T., Felix, A. O. C., Mueller, E. N., Felix, S. R., Alves, G. H., Ramos, T. S., Freitag, R. A., Fernandes, C. G., and Nobre, M. O.

Subjects
WHEAT, SKIN wound treatment, RABBITS, WOUND healing, HISTOPATHOLOGY, WOUNDS & injuries, THERAPEUTICS
Abstract

The article discusses a study that examines the healing of wounds treated with creams with various concentrations of Triticum aestivum extract in the rabbit model for wound healing. Study highlights include use of analysis of variance and Tukey's test to compare means in the clinical assessment for the statistical assays, the decline or lack of crust as common in the proliferative phase, and sample of the histopathological examination of the skin healing process of wounds in the rabbit model.

Published
2014
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5. Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice.

Author

Ramos PT, Pedra NS, Soares MSP, da Silveira EF, Oliveira PS, Grecco FB, da Silva LMC, Ferreira LM, Ribas DA, Gehrcke M, Felix AOC, Stefanello FM, Spanevello RM, Cruz L, and Braganhol E

Subjects
Animals, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics, Cell Line, Chronic Disease, Disease Models, Animal, Drug Liberation, Drug Stability, Edema drug therapy, Humans, Keratinocytes drug effects, Ketoprofen administration & dosage, Ketoprofen pharmacokinetics, Male, Mice, Inbred C57BL, Nanocapsules therapeutic use, Oxidative Stress drug effects, Rosa chemistry, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Inflammation drug therapy, Ketoprofen pharmacology, Nanocapsules chemistry, Plant Oils chemistry
Abstract

This study aimed to develop nanocapsules containing ketoprofen using rose hip oil (Keto-NC) as oil core, and to evaluate their anti-inflammatory activity in acute and chronic ear edema models in mice. Physicochemical characterization, drug release, photostability and cytotoxicity assays were performed for the developed Keto-NC formulations and compared to ketoprofen-loaded nanocapsules using medium chain triglycerides as oil core (Keto-MCT-NC). Anti-inflammatory activity of orally delivered KP (Ketoprofen-free; 10 mg.kg -1 ) or Keto-NC (2.5; 5; 10 mg.kg -1 ) was assessed in mouse acute and chronic ear edema induced by croton oil (CO). Edema histological characteristics were determined by H&E stain, and redox parameters were analyzed in blood plasma and erythrocytes. Keto-MCT-NC and Keto-NC did not exhibit differences regarding physicochemical parameters, including size diameters, polydispersity index, pH, Ketoprofen content, and encapsulation efficiency. However, Keto-NC, which contains rose hip oil as lipid core, decreased drug photodegradation under UVC radiation when compared to Keto-MCT-NC. KP or Keto-NC were not cytotoxic to keratinocyte cultures and produced equal edema inhibition in the acute protocol. Conversely, in the chronic protocol, Keto-NC was more effective in reducing edema (~60-70% on 7-9th days of treatment) when compared to KP (~40% on 8-9th days of treatment). This result was confirmed by histological analysis, which indicated reduction of edema and inflammatory infiltrate. A sub-therapeutic dose of Keto-NC (5 mg.kg -1 ) significantly reduced edema when compared to control. Finally, KP and Keto-NC exhibited similar effects on redox parameters, suggesting that the advantages associated with Ketoprofen nanoencapsulation did not involve oxidative stress pathways. The results showed that Keto-NC was more efficient than KP in reducing chronic inflammation. These data may be important for the development of strategies aiming treatment of chronic inflammatory diseases with fewer adverse effects., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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6. Comparison of systemic interleukin 10 concentrations in healthy dogs and those suffering from recurring and first time Demodex canis infestations.

Author

Felix AO, Guiot EG, Stein M, Felix SR, Silva EF, and Nobre MO

Subjects
Animals, Dog Diseases blood, Dog Diseases metabolism, Dogs, Female, Interleukin-10 metabolism, Male, Mite Infestations metabolism, Mite Infestations parasitology, Recurrence, Dog Diseases parasitology, Interleukin-10 blood, Mite Infestations veterinary
Abstract

Objective: The objective of this study was to assess the interleukin 10 (IL-10) concentrations in the sera of dogs suffering from demodicosis., Methods: Twenty-six dogs were distributed into three groups: demodicosis groups G1, n=11 (recurring disease) and G2, n=6 (first time occurrence), and a control group, G3, n=9 (healthy dogs). All the animals were subjected to skin scrape tests and blood harvesting for serum extraction. In G1 and G2 only those animals with Demodex canis positive skin tests were included, while healthy dogs were included in G3. To assess IL-10 levels the commercial Quantikine Canine IL-10 Immunoassay(®) (R&D Systems) kit was used., Results: The mean IL-10 level obtained for G1 was 269.4 pg/ml (sd=290.8 pg/ml), for G2 it was 28.5 pg/ml (sd=19.7 pg/ml) while the mean for G3 was 11.9 pg/ml (sd=2.3 pg/ml). There was a significant difference between G1 and the other two groups., Conclusions: According to our results, dogs with reoccurring demodicosis have higher IL-10 levels than healthy dogs and those suffering the disease for the first time., (Copyright © 2012 Elsevier B.V. All rights reserved.)

Published
2013
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