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294 results on '"Feller, K."'

6. Association of Institutes for Bee Research Report of the 55th Seminar in Hohen Neuendorf 11–13March 2008

Author

Scheiner, R., Alkattea, R., Steidle, H., Rosenkranz, P., Grünewald, B., Bartsch, C., Giurfa, M., Devaud, J. -M., Lein, J., Becher, M., Moritz, R. F. A., Fuchs, S., Riessberger-Gallé, U., Vollmann, J., Brodschneider, R., Aupinel, P., Crailsheim, K., Elmi, M. Pour, Haddad, N., de Miranda, J. R., Siede, R., König, M., Büchler, R., Thiel, H. -J., Gisder, S., Aumeier, P., Yue, C., Genersch, E., Šekulja, D., Garrido, C., Bienefeld, K., Ehrhardt, K., Ziegelmann, B., Steidle, J., Joachimsmeier, I., Kirchner, W. H., Ashiralieva, A., Fünfhaus, A., Borriss, R., Randolt, K., Gimple, O., Gätschenberger, H., Beier, H., Tautz, J., Loncaric, I., Derakhshifar, I., Köglberger, H., Moosbeckhofer, R., Oberlerchner, J., Riedel, M., Yue, D., Nordhoff, M., Wieler, L. H., Harz, M., Rademacher, E., Berg, S., Schürzinger, F., Illies, I., Radtke, J., Neuberger, P., Kovac, H., Bartzsch, C., Trompelt, J., Feller, K. -H., Schmidt, W., and Etzold, E.

Published
2008
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13. An altered heparan sulfate structure in the articular cartilage protects against osteoarthritis

Author

Severmann, A. -C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J., Pap, T., Hoffmann, D., Vortkamp, A., Severmann, A. -C., Jochmann, K., Feller, K., Bachvarova, V., Piombo, V., Stange, R., Holzer, T., Brachvogel, B., Esko, J., Pap, T., Hoffmann, D., and Vortkamp, A.

Abstract

Objective: Osteoarthritis (OA) is a progressive degenerative disease of the articular cartilage caused by an unbalanced activity of proteases, cytokines and other secreted proteins. Since heparan sulfate (HS) determines the activity of many extracellular factors, we investigated its role in OA progression. Methods: To analyze the role of the HS level, OA was induced by anterior cruciate ligament transection (ACLT) in transgenic mice carrying a loss-of-function allele of Ext1 in clones of chondrocytes (Col2-rtTA-Cre;Ext1(e2fl/e2fl)). To study the impact of the HS sulfation pattern, OA was surgically induced in mice with a heterozygous (Ndst1(+/-)) or chondrocyte-specific (Col2-Cre;Ndst1(fl/fl)) loss-of-function allele of the sulfotransferase Ndst1. OA progression was evaluated using the OARSI scoring system. To investigate expression and activity of cartilage degrading proteases, femoral head explants of Ndst1(+/-) mutants were analyzed by qRT-PCR, Western Blot and gelatin zymography. Results: All investigated mouse strains showed reduced OA scores (Col2-rtTA-Cre;Ext1(e2fl/e2fl): 0.83; 95% HDI 0.72-0.96; Ndst1(+/-): 0.83, 95% HDI 0.74-0.9; Col2-Cre;Ndst1(fl/fl): 0.87, 95% HDI 0.76-1). Using cartilage explant cultures of Ndst1 animals, we detected higher amounts of aggrecan degradation products in wildtype samples (NITEGE 4.24-fold, 95% HDI 1.05-18.55; VDIPEN 1.54-fold, 95% HDI 1.54-2.34). Accordingly, gelatin zymography revealed lower Mmp2 activity in mutant samples upon RA-treatment (0.77-fold, 95% HDI: 0.60-0.96). As expression of major proteases and their inhibitors was not altered, HS seems to regulate cartilage degeneration by affecting protease activity. Conclusion: A decreased HS content or a reduced sulfation level protect against OA progression by regulating protease activity rather than expression. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-N

Published
2020

16. Der exulzerierte Sternumtumor bei einer geriatrischen Hochrisikopatientin

Author

Farzaliyev, F, Feller, K, Touma, A, Steinau, HU, and Podleska, LE

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Chondrosarkome sind die häufigsten aller primären Sternumtumore. Eine radikale R0-Resektion stellt die einzige kurative Therapieoption dar. Totale oder partielle Sternumresektionen sollten mittels eines gestielten, gut vaskularisierten Hautmuskellappens gedeckt werden. Ein transossär [zum vollständigen Text gelangen Sie über die oben angegebene URL], 49. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 23. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC)

Published
2018
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29. Wavelength and intensity-dependent transient degenerate four-wave mixing in pseudoisocyanine...

Author

Gadonas, R., Feller, K.-H., Pugzlys, A., Jonusauskas, G., Oberle, J., and Rulliere, C.

Subjects
*SUPERFLUIDITY, *EXCITON theory
Abstract

Focuses on transient degenerate four-wave mixing (DFWM) and pump-probe spectroscopy in pseudoisocyanine aggregates. Spectral dispersion of DFWM efficienty within the J-band and near exciton resonance; Effect of nonthermal photons produced as a result of decay of two-exciton states; Intensity-dependent evolution of excess dynamic disorder.

Published
1997
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