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1. Generation of the human induced pluripotent stem cell line (IBKMOLi003-A) from PBMCs of a vascular Ehlers-Danlos syndrome (vEDS) patient carrying the heterozygous nonsense mutation c.430C > T (p.Q105*) in the COL3A1 gene

Author

Höpperger, Sabrina, primary, Spathopoulou, Angeliki, additional, Mayer-Suess, Lukas, additional, Suarez-Cubero, Marta, additional, Sillaber, Katharina, additional, Spreiz, Ana, additional, Kiechl, Stefan, additional, Edenhofer, Frank, additional, and Fellner, Lisa, additional

Published
2024
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4. Models of Multiple System Atrophy

Author

Fellner, Lisa, Wenning, Gregor K., Stefanova, Nadia, Geyer, Mark A., Series editor, Ellenbroek, Bart A., Series editor, Marsden, Charles A., Series editor, Barnes, Thomas R.E., Series editor, Nguyen, Hoa Huu Phuc, editor, and Cenci, M. Angela, editor

Published
2015
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9. Guanosine Protects Neuronal PC12 Cells from Serum Deprivation-induced Cell Death

Author

Thauerer Bettina, Baeumer Bastian E., Fellner Lisa, Kuzdas Daniela, Ramberger Melanie, and Baier-Bitterlich Gabriele

Subjects
guanosine, cell death, serum deprivation, and pc12 cells, Crystallography, QD901-999
Abstract

Survival of neurons is dependent on the presence of trophic and non-trophic factors. Previous findings showed that purine nucleosides have the potential to rescue cells from hypoxia-induced cell death. Here we demonstrate that purine nucleoside guanosine can efficiently rescue neuronal PC12 cells from serum deprivation-induced cell death. By means of Hoechst/propidium iodide staining and fluorescence analysis a 31.1% decrease of cell death was detected. These data support current efforts to propagate purine nucleosides as neuroprotective and neuroregenerative substances.

Published
2012
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24. Glia and alpha-synuclein in neurodegeneration: A complex interaction

Author

Brück, Dominik, Wenning, Gregor K., Stefanova, Nadia, and Fellner, Lisa

Subjects
α-Synuclein, Parkinson's disease, Dementia with Lewy bodies, Neurodegenerative Diseases, Multiple system atrophy, Article, lcsh:RC321-571, nervous system diseases, Oligodendroglia, Astroglia, Neurology, nervous system, Nerve Degeneration, mental disorders, alpha-Synuclein, Animals, Humans, Glial cytoplasmic inclusions, Microglia, Lewy bodies, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Neuroglia
Abstract

α-Synucleinopathies (ASP) comprise adult-onset, progressive neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) that are characterized by α-synuclein (AS) aggregates in neurons or glia. PD and DLB feature neuronal AS-positive inclusions termed Lewy bodies (LB) whereas glial cytoplasmic inclusions (GCIs, Papp–Lantos bodies) are recognized as the defining hallmark of MSA. Furthermore, AS-positive cytoplasmic aggregates may also be seen in astroglial cells of PD/DLB and MSA brains. The glial AS-inclusions appear to trigger reduced trophic support resulting in neuronal loss. Moreover, microgliosis and astrogliosis can be found throughout the neurodegenerative brain and both are key players in the initiation and progression of ASP. In this review, we will highlight AS-dependent alterations of glial function and their impact on neuronal vulnerability thereby providing a detailed summary on the multifaceted role of glia in ASP.

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