47 results on '"Fellows, Mick"'
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2. Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq
3. Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article.
4. A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10
5. Application of Microphysiological Systems for Nonclinical Evaluation of Cell Therapies.
6. In vivo CRISPR editing with no detectable genome-wide off-target mutations
7. International evaluation study of a highly efficient culture assay for detection of residual human pluripotent stem cells in cell therapies
8. Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase
9. Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
10. The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions
11. The Mouse Lymphoma TK Assay
12. List of Contributors
13. A rapid, semi-automated method for scoring micronuclei in mononucleated mouse lymphoma cells
14. In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop
15. Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)
16. The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) for in vitro genetic toxicity assessment
17. Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells
18. Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
19. The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing – The report of an ECVAM–EFPIA workshop
20. Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq
21. Extracellular vesicles induce minimal hepatotoxicity and immunogenicity
22. Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study
23. Chapter 5 - The Mouse Lymphoma TK Assay
24. A pharma-wide approach to address the genotoxicity prediction of primary aromatic amines
25. In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations
26. 2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells
27. Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells
28. Investigating Mesenchymal Stem Cell Sources for VEGFA mRNA Transfection and In Vivo Protein Exposure
29. The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions
30. Targeting safety in the clinic for precise genome editing using CRISPR: a genotoxicologist’s perspective
31. Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing
32. Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity
33. The utility of metabolic activation mixtures containing human hepatic post-mitochondrial supernatant (S9) forin vitrogenetic toxicity assessment
34. The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for pototoxicity testing
35. Correlation ofIn VivoVersusIn VitroBenchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study
36. New approaches to advance the use of genetic toxicology analyses for human health risk assessment
37. The spectral karyotype of L5178Y TK+/−mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase (tk) locus in the microtitre mouse lymphoma assay
38. Genotoxicity assessment of peptide/ protein-related biotherapeutics: points to consider before testing.
39. Abstract 5413: Is a non-conjugated triple-helix forming oligonucleotide targeting the genomic HPRT locus capable of sequence specific mutagenesis
40. The spectral karyotype of L5178Y TK+/− mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase ( tk) locus in the microtitre mouse lymphoma assay.
41. Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity
42. The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for pototoxicity testing
43. Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
44. Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure-activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-beta-D-ribose 2 '-oxidase
45. Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
46. Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells.
47. The spectral karyotype of L5178Y TK⁺/⁻ mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase (tk) locus in the microtitre mouse lymphoma assay.
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