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426 results on '"Felsberg, J"'

1. Bevacizumab plus hypofractionated radiotherapy versus radiotherapy alone in elderly patients with glioblastoma: the randomized, open-label, phase II ARTE trial

Author

Wirsching, H.-G., Tabatabai, G., Roelcke, U., Hottinger, A.F., Jörger, F., Schmid, A., Plasswilm, L., Schrimpf, D., Mancao, C., Capper, D., Conen, K., Hundsberger, T., Caparrotti, F., von Moos, R., Riklin, C., Felsberg, J., Roth, P., Jones, D.T.W., Pfister, S., Rushing, E.J., Abrey, L., Reifenberger, G., Held, L., von Deimling, A., Ochsenbein, A., and Weller, M.

Published
2018
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15. Tumour-infiltrating effector T-cells and false-positive identification of tumour progression by MRI and 18FET-PET after dendritic cell vaccination in newly-diagnosed glioblastoma patients

Author

Rapp, M, Datsi, A, Felsberg, J, Galldiks, N, Kamp, MA, Sorg, RV, and Sabel, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: In the phase II GlioVax trial, patients with newly diagnosed glioblastoma are treated with dendritic cell vaccination as add-on to standard radiochemotherapy after fluorescence-guided surgery. Currently, it is not clear, whether dendritic cell vaccination results in effector T cell infiltration[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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21. OC-0322: 4-miRNA signature and MGMT promoter methylation improve risk stratification in glioblastoma.

Author

Unger, K., primary, Fleischmann, D.F., additional, Ruf, V., additional, Felsberg, J., additional, Piehlmaier, D., additional, Samaga, D., additional, Heß, J., additional, Mittelbronn, M., additional, Lauber, K., additional, Budach, W., additional, Sabel, M., additional, Rödel, C., additional, Reifenberger, G., additional, Herms, J., additional, Tonn, J., additional, Zitzelsberger, H., additional, Belka, C., additional, and Niyazi, M., additional

Published
2020
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22. 360O Telomerase reverse transcriptase (TERT) promoter mutation and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation-mediated sensitivity to temozolomide in IDH-wildtype glioblastoma: Is there a link?

Author

Weller, M., primary, Gramatzki, D., additional, Felsberg, J., additional, Hentschel, B., additional, Wolter, M., additional, Schackert, G., additional, Westphal, M., additional, Regli, L., additional, Thon, N., additional, Tatagiba, M., additional, Wick, W., additional, Schlegel, U., additional, Krex, D., additional, Roth, P., additional, Rushing, E., additional, Pietsch, T., additional, von Deimling, A., additional, Sabel, M., additional, Loeffler, M., additional, and Reifenberger, G., additional

Published
2020
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23. Prediction of survival in patients with IDH-wildtype astrocytic gliomas using dynamic O-(2-[ 18 F]-fluoroethyl)-L-tyrosine PET

Author

Bauer, E. K, additional, Stoffels, G, additional, Blau, T, additional, Reifenberger, G, additional, Felsberg, J, additional, Werner, JM, additional, Lohmann, P, additional, Rosen, J, additional, Ceccon, G, additional, Tscherpel, C, additional, Rapp, M, additional, Sabel, M, additional, Filss, CP, additional, Shah, NJ, additional, Neumaier, B, additional, Fink, GR, additional, Langen, KJ, additional, and Galldiks, N, additional

Published
2020
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25. Entwicklung, Implementierung und Evaluation eines interdisziplinären Inverted Classrooms über Hirntumoren: Bericht über Entwicklungsprozess

Author

Malzkorn, B., Felsberg, J., Kamp, M., Hofer, M., and Rotthoff, T.

Subjects
ddc: 610, ddc:610, 610 Medical sciences, Medicine
Abstract

Problemstellung/Ziele: In einem durch Vorlesungen geprägten und von Studierenden kritisierten Studienblock sollten interdisziplinäre, multimodale, individualisierte Lernkonzepte entwickelt werden, in denen Studierende theoretische Kenntnisse im Eigenstudium erwerben und die Präsenzzeit[zum vollständigen Text gelangen Sie über die oben angegebene URL], Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA)

Published
2019

38. OS2.2 Chemotherapy for spinal gliomas in adults

Author

Gramatzki, D, primary, Felsberg, J, additional, Bähr, O, additional, Hentschel, B, additional, Westphal, M, additional, Schackert, G, additional, Tonn, J C, additional, Herrlinger, U, additional, Löffler, M, additional, Pietsch, T, additional, Steinbach, J, additional, Reifenberger, G, additional, Roth, P, additional, and Weller, M, additional

Published
2019
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39. P14.108 Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma

Author

Seystahl, K, primary, Hentschel, B, additional, Loew, S, additional, Gramatzki, D, additional, Felsberg, J, additional, Herrlinger, U, additional, Westphal, M, additional, Schackert, G, additional, Thon, N, additional, Schlegel, U, additional, Tatagiba, M, additional, Pietsch, T, additional, Reifenberger, G, additional, Löffler, M, additional, Wick, W, additional, and Weller, M, additional

Published
2019
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43. Gliomatosis cerebri: molecular pathology and clinical course

Author

Herrlinger, U, Felsberg, J, Küker, W, Bornemann, A, Plasswilm, L, Knobbe, CB, Strik, H, Wick, W, Meyermann, R, Dichgans, J, Bamberg, M, Reifenberger, G, and Weller, M

Subjects
neoplasms
Abstract

Gliomatosis cerebri is a rare, diffusely growing neuroepithelial tumor characterized by extensive brain infiltration involving more than two cerebral lobes. Among 13 patients with gliomatosis cerebri (median age, 46 years), biopsies showed features of diffuse astrocytoma (n = 4), oligoastrocytoma (n = 1), anaplastic astrocytoma (n = 5), anaplastic oligoastrocytoma (n = 1), or glioblastoma (n = 2). Molecular genetic investigation showed TP53 mutations in three of seven tumors and both PTEN mutation and epidermal growth factor receptor overexpression in one tumor. Amplification of CDK4 or MDM2 or homozygous deletion of CDKN2A was not detected. Three of 10 patients receiving radiotherapy showed a partial response (one patient) or had stable disease (two patients) lasting for more than 1 year. Four of six patients treated with procarbazine, carmustine, vincristine chemotherapy demonstrated partial remission (one patient), minor response (two patients), or stable disease (one patient). Median survival time from diagnosis was 14 months (range, 4-91+ months). Infratentorial involvement was associated with shorter survival. We conclude that (1) the molecular genetic alterations in gliomatosis cerebri resemble those in diffuse astrocytomas; (2) the prognosis of gliomatosis cerebri is variable but for at least 50% of patients as poor as for glioblastoma; and (3) some patients respond to radiotherapy and/or procarbazine, carmustine, vincristine chemotherapy.

Published
2016
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44. Angiosarkom des Os temporale

Author

Thomas K. Hoffmann, Cohnen M, Schubert O, Hindersin S, Felsberg J, and Joerg Schipper

Subjects
Mastoiditis, medicine.medical_specialty, Palsy, business.industry, medicine.medical_treatment, Mastoidectomy, medicine.disease, Surgery, Pneumonia, Skull, medicine.anatomical_structure, Otorhinolaryngology, Temporal bone, medicine, Angiosarcoma, business, Histological examination
Abstract

Angiosarcoma of the temporal bone is an extremely rare malignant tumor, which originates from vascular endothelium. We describe a case of a 57-year-old woman, initially presenting with progressive hearing loss, otorrhea as well as facial palsy diagnosed as a mastoiditis elsewhere. After subtotal mastoidectomy histological examination revealed an angiosarcoma of the mastoid. Since the tumor was not completely removed lateral petrosectomy and postoperative radiotherapy were performed. Afterwards the patient developed local recurrence with intracerebral tumor extension. During palliative polychemotherapy the patient developed a pneumonia and deceased. In this manuscript the morphology, imaging characteristics and current treatment options of angiosarcomas of the lateral skull base are reviewed and discussed.

Published
2008
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45. P03.21 Casp9 germline mutation in a family with multiple brain tumors

Author

Ronellenfitsch, M. W., primary, Oh, J., additional, Satomi, K., additional, Sumi, K., additional, Harter, P. N., additional, Steinbach, J. P., additional, Felsberg, J., additional, Capper, D., additional, Voegele, C., additional, Schittenhelm, J., additional, Mittelbronn, M., additional, and Ohgaki, H., additional

Published
2017
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46. Assessment and prognostic significance of the epidermal growth factor receptor vIII mutation in glioblastoma patients treated with concurrent and adjuvant temozolomide radiochemotherapy

Author

Weller, M, Kaulich, K, Hentschel, B, Felsberg, J, Gramatzki, D, Pietsch, T, Simon, M, Westphal, M, Schackert, G, Tonn, J C, von Deimling, A, Davis, T, Weiss, W A, Loeffler, M, Reifenberger, G, University of Zurich, and Weller, M

Subjects
Cancer Research, Oncology, 610 Medicine & health, 2730 Oncology, 1306 Cancer Research, 10040 Clinic for Neurology
Published
2014

47. [Untitled]

Author

Jaroslav Spizek, Jiri Janata, Felsberg J, Jitka Novotná, Lucie Najmanova, and K. Hola

Subjects
Genetics, Streptomyces lincolnensis, biology, Protein family, General Medicine, biology.organism_classification, medicine.disease_cause, Microbiology, DNA gyrase, Lincomycin, Open reading frame, Gene cluster, medicine, Molecular Biology, Escherichia coli, Gene, medicine.drug
Abstract

The lincomycin-production gene cluster of the industrial overproduction strain Streptomyces lincolnensis 78-11 has been sequenced (Peschke et al. 1995) and twenty-seven putative open reading frames with biosynthetic or regulatory functions (lmb genes) identified. Two distinct hypothetical genes, lmbI and lmbH, were found downstream of the lmbJ gene, coding for LmbJ protein, which is believed to participate in the last lincomycin biosynthetic step, i.e. conversion of N-demethyllincomycin (NDL) to lincomycin. In the present study, we demonstrate the presence of a single larger open reading frame, called lmbIH, in the lincomycin low-production type strain Streptomyces lincolnensis ATCC 25466, instead of two smaller lmbI and lmbH genes. The product, LmbIH, is a protein of an unknown function and is homologous with the TldD protein family. Escherichia coli TldD protein was previously shown to be involved in the control of DNA gyrase by LetD protein. Moreover, our experiments indicate co-regulation of lmbJ and lmbIH expression. This translation coupling probably reflects an eight nucleotide overlap between the lmbJ and lmbIH genes, as well as the lack of a Shine-Dalgarno sequence upstream of the lmbIH gene.

Published
2001
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48. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Author

Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., et al., Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., and et al.

Abstract

Item does not contain fulltext, Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

49. Combined alterations in MAPK pathway genes, CDKN2A/B and ATRX characterize anaplastic pilocytic astrocytoma

Author

Kratz, A, Sahm, F, Schrimpf, D, Jones, DT, Reuss, D, Koelsche, C, Huang, K, Wefers, AK, Hovestadt, V, Gramatzki, D, Felsberg, J, Koch, A, Thomale, UW, Reifenberger, G, Becker, A, Hans, V, Prinz, M, Staszewski, O, Acker, T, Dohmen-Scheufler, H, Hartmann, C, Mueller, W, Tuffaha, MSA, Paulus, W, Heß, K, Brokinkel, B, Schittenhelm, J, Monoranu, CM, Kessler, AF, Loehr, M, Buslei, R, Deckert, M, Mawrin, C, Kohlhof, P, Hewer, E, Olar, A, Rodriguez, F, Giannini, C, NageswaraRao, AA, Weller, M, Pohl, U, Brandner, S, Pfister, SM, von Deimling, A, Capper, D, Kratz, A, Sahm, F, Schrimpf, D, Jones, DT, Reuss, D, Koelsche, C, Huang, K, Wefers, AK, Hovestadt, V, Gramatzki, D, Felsberg, J, Koch, A, Thomale, UW, Reifenberger, G, Becker, A, Hans, V, Prinz, M, Staszewski, O, Acker, T, Dohmen-Scheufler, H, Hartmann, C, Mueller, W, Tuffaha, MSA, Paulus, W, Heß, K, Brokinkel, B, Schittenhelm, J, Monoranu, CM, Kessler, AF, Loehr, M, Buslei, R, Deckert, M, Mawrin, C, Kohlhof, P, Hewer, E, Olar, A, Rodriguez, F, Giannini, C, NageswaraRao, AA, Weller, M, Pohl, U, Brandner, S, Pfister, SM, von Deimling, A, and Capper, D

Published
2016

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