1. AST/ALT ratio as a potential predictor of 1-year mortality in elderly patients operated for femoral neck fracture.
- Author
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Günaydın F, Kılınç Ö, Sakarya B, Demirtaş İ, Aydın M, and Çelik A
- Subjects
- Humans, Male, Female, Aged, Retrospective Studies, Aged, 80 and over, Postoperative Complications mortality, Postoperative Complications blood, Arthroplasty, Replacement, Hip mortality, Arthroplasty, Replacement, Hip adverse effects, Middle Aged, Predictive Value of Tests, Risk Factors, Biomarkers blood, Femoral Neck Fractures surgery, Femoral Neck Fractures mortality, Femoral Neck Fractures blood, Aspartate Aminotransferases blood, Alanine Transaminase blood
- Abstract
Purpose: Hip fractures in elderly individuals are associated with high mortality rates, even with advanced treatment options. Identifying factors correlated with mortality could guide potential preventive strategies. Elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as well as the AST/ALT ratio (AAR), have been associated with mortality in various diseases, but their association with hip fracture mortality remains underexplored. This study investigates the correlation between AST, ALT, AAR, and routine laboratory parameters with 1-year mortality in elderly patients undergoing partial hip arthroplasty for femoral neck fractures., Methods: This retrospective cohort study analyzed data from 179 elderly patients (≥60 years) who underwent partial hip replacement for femoral neck fracture between January 2019 and December 2021., Results: Of the 179 patients, 29.6% died within one year of surgery. The deceased patients were older, predominantly male, and had higher rates of postoperative complications and transfusions. Univariate analysis identified age, sex, blood type, comorbidities, postoperative complications, transfusions, and laboratory parameters (including AAR, creatinine, and lymphocyte count) as associated with mortality. Multivariate analysis further highlighted advanced age, male sex, blood group A, postoperative transfusions, elevated creatinine levels, and high AAR (>2.1) as independent predictors of mortality., Conclusion: Our findings suggest that preoperative AAR may serve as an independent predictor of mortality in elderly patients undergoing hip fracture surgery, highlighting its potential utility in preoperative risk stratification., Competing Interests: Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. This research has been approved by the Mersin Üniversitesi Rektörlüğü Klinik Araştırmalar Etik Kurulu (Mersin University Clinical Research Ethics Committee) (Decision date and no: 01/11/2023, 21/740). Informed consent was obtained from all individual participants included in the study as part of a routine process in our hospital for scientific research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)
- Published
- 2025
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