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406 results on '"Feng, Fengqin"'

1. Research Progress on the Role of Medium-Chain Fatty Acids in Improving Metabolic Syndrome by Regulating Intestinal Microecology

Author

FU Xiyu, ZHAO Minjie, FENG Fengqin

Subjects
medium-chain fatty acid, medium-chain triglyceride, gut microbiota, metabolic syndrome, Food processing and manufacture, TP368-456
Abstract

With the improvement of living standards and the change of dietary habits, metabolic syndrome has become a major global public health problem. The gut microbiota is one of the research hotspots in recent years. More and more studies have shown that the gut microbiota can conduct bidirectional signal transduction with different body tissues and organs such as the brain, liver and heart through various pathways, which is closely related to body health. Medium-chain fatty acids (MCFAs) exist in coconut oil, palm kernel oil and dairy products mainly in the form of medium-chain triglycerides (MCTs). MCFAs can be rapidly metabolized for energy in the body, and has good regulatory effects on glucose and lipid metabolism. This article reviews the effects of MCTs on gut microbes and their positive effects on metabolic syndrome in order to provide a reference for future research.

Published
2023
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6. Progress in Research on the Effects of Food Preservatives on Gut Microbiota and Host Health

Author

RUAN Shengyue, LIU Tao, MO Qiufen, FENG Fengqin

Subjects
food preservatives, gut microbiota, food additives, host health, growth, immunoregulation, Food processing and manufacture, TP368-456
Abstract

Food preservatives are widely used in the food industry for their broad antibacterial spectrum and strong antibacterial properties. While the effects of dietary food preservatives on the gut microbiota and host health have been studied, a systematic review is lacking. In this paper, the latest research on food preservatives and the gut microbiota is reviewed. It has been found that food preservatives affect lipid metabolism, immunity and intestinal inflammation by altering the diversity of the gut microbiota and regulating the abundance of conditioned pathogens and beneficial bacteria. The future research trends are also discussed. Through this review, we hope that the ‘food preservatives-gut microbiota-host health’ chain can arouse the attention of researchers and readers, and provide a new perspective for the existing safety evaluation system of food preservatives, which may be of guiding significance for the maintenance of human health.

Published
2023
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33. High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice.

Author

Cai, Haiying, Zhang, Junhui, Liu, Chang, Le, Thanh Ninh, Lu, Yuyun, Feng, Fengqin, and Zhao, Minjie

Subjects
GUT microbiome, FARNESOID X receptor, BILE acids, ENTEROHEPATIC circulation, HOMEOSTASIS, BILE salts, LIPID metabolism
Abstract

The altered circulating bile acids (BAs) modulate gut microbiota, energy metabolism and various physiological functions. BA profiles in liver, serum, ileum and feces of HFD-fed mice were analyzed with normal chow diet (NCD)-fed mice after 16-week feeding. Furthermore, gut microbiota was analyzed and its correlation analysis with BA was performed. The result showed that long-term HFD feeding significantly decreased hepatic and serum BA levels, mainly attributed to the inhibition of hepatic BA synthesis and the reduced reabsorption efficiency of BAs in enterohepatic circulation. It also significantly impaired glucose and lipid homeostasis and gut microbiota in mice. We found significantly higher bile salt hydrolase activity in ileal microbes and a higher ratio of free BAs to conjugated BA content in ileal contents in HFD groups compared with NCD group mice, which might account for the activated intestinal farnesoid X receptor signaling on liver BA synthesis inhibition and reduced ileal reabsorption. The decreased circulating BAs were associated with the dysregulation of the lipid metabolism according to the decreased TGR5 signaling in the ileum and BAT. In addition, it is astonishing to find extremely high percentages of taurocholate and 12-OH BAs in liver and serum BA profiles of both groups, which was mainly attributed to the high substrate selectivity for 12-OH BAs of the intestinal BAs transporter during the ileal reabsorption of enterohepatic circulation. This study revealed a significant effect of long-term HFD feeding on the decreased circulating BA pool in mice, which impaired lipid homeostasis and gut microbiota, and collectively resulted in metabolic disorders and obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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