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10 results on '"Feng, Xueqiong"'

4. Study on Damage Analysis and Random Vibration Detection of Transportation Goods

Author

Zhang, Hanyue, Feng, Xueqiong, Angrisani, Leopoldo, Series editor, Arteaga, Marco, Series editor, Chakraborty, Samarjit, Series editor, Chen, Jiming, Series editor, Chen, Tan Kay, Series editor, Dillmann, Ruediger, Series editor, Duan, Haibin, Series editor, Ferrari, Gianluigi, Series editor, Ferre, Manuel, Series editor, Hirche, Sandra, Series editor, Jabbari, Faryar, Series editor, Kacprzyk, Janusz, Series editor, Khamis, Alaa, Series editor, Kroeger, Torsten, Series editor, Ming, Tan Cher, Series editor, Minker, Wolfgang, Series editor, Misra, Pradeep, Series editor, Möller, Sebastian, Series editor, Mukhopadhyay, Subhas Chandra, Series editor, Ning, Cun-Zheng, Series editor, Nishida, Toyoaki, Series editor, Panigrahi, Bijaya Ketan, Series editor, Pascucci, Federica, Series editor, Samad, Tariq, Series editor, Seng, Gan Woon, Series editor, Veiga, Germano, Series editor, Wu, Haitao, Series editor, Zhang, Junjie James, Series editor, Zhao, Pengfei, editor, Ouyang, Yun, editor, Xu, Min, editor, Yang, Li, editor, and Ren, Yuhui, editor

Published
2018
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9. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

Author

Su, Meng, primary, Qiu, Lin, additional, Deng, Youchao, additional, Ruiz, Claudia H., additional, Rudolf, Jeffrey D., additional, Dong, Liao-Bin, additional, Feng, Xueqiong, additional, Cameron, Michael D., additional, Shen, Ben, additional, Duan, Yanwen, additional, and Huang, Yong, additional

Published
2019
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10. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureusin Topical and Systemic Infection Mouse Models

Author

Su, Meng, Qiu, Lin, Deng, Youchao, Ruiz, Claudia H., Rudolf, Jeffrey D., Dong, Liao-Bin, Feng, Xueqiong, Cameron, Michael D., Shen, Ben, Duan, Yanwen, and Huang, Yong

Abstract

Staphylococcus aureusis one of the most common pathogens causing hospital-acquired and community-acquired infections. Methicillin-resistant S. aureus(MRSA)-formed biofilms in wounds are difficult to treat with conventional antibiotics. By targeting FabB/FabF of bacterial fatty acid synthases, platensimycin (PTM) was discovered to act as a promising natural antibiotic against MRSA infections. In this study, PTM and its previously synthesized sulfur-Michael derivative PTM-2tcould reduce over 95% biofilm formation by S. aureusATCC 29213 when used at 2 μg/mL in vitro. Topical application of ointments containing PTM or PTM-2t(2 × 4 mg/day/mouse) was successfully used to treat MRSA infections in a BABL/c mouse burn wound model. As a potential prodrug lead, PTM-2tshowed improved in vivo efficacy in a mouse peritonitis model compared with PTM. Our study suggests that PTM and its analogue may be used topically or locally to treat bacterial infections. In addition, the use of prodrug strategies might be instrumental to improve the poor pharmacokinetic properties of PTM.

Published
2019
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