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LiNixCoyMn1−x−yO2 (x ≥ 0.6, NCM) has attracted much attention due to its high specific capacity and energy density. However, capacity attenuation caused by Li+/Ni2+ mixing and structural instability inhibit its development and application. In order to solve these problems, we report a simple method to synthesize NCM cathodes via a one-step Ce4+-doping and CeO2-coating technique, which can reduce the degree of Li+/Ni2+ mixing and improve the structural stability. The Ce4+-doping not only effectively reduces the degree of Li+/Ni2+ mixing, but also enhances the (001) interplanar distance of NCM and improves Li+ diffusion. Furthermore, the CeO2-coating can reduce the direct contact between the NCM particles and electrolyte, which can reduce the harmful interface reaction, thus making the impedance increase more slowly. The Ce4+-doping and CeO2-coating of NCM particles led to a capacity retention of 96.3% at 1C (1C = 280 mA g−1) after 100 cycles. Therefore, the synthesis of NCM cathodes via a one-step Ce4+-doping and CeO2-coating technique is a superb way to improve the electrochemical properties of the NCM cathode in lithium-ion batteries. [ABSTRACT FROM AUTHOR]

Inflammation plays an important role in stroke. Many inflammatory markers in peripheral blood are proved to be associated with stroke severity or prognosis. But few comprehensive models or scales to evaluate the severity of stroke have been reported. Systemic immune-inflammation index (SII) and platelet-albumin-bilirubin (PALBI) grade as new markers of inflammation have shown their positive association with liver cancer. The relation between SII, or PALBI and stroke remains uncertain. To investigate the relationship between SII, PALBI grade and stroke severity. Patients with ischemic stroke with hospital admission <24 h after symptom onset were prospectively included in a stroke registry. Demographic, clinical, and laboratory data were collected immediately after admission in all patients. The National Institutes of Health Stroke Scale (NIHSS) was used to assess stroke severity upon admission. Minor stroke was defined as NIHSS score < =5, moderate-to-severe stroke as NIHSS score >5. SII, calculated as platelet × neutrophil/lymphocyte was divided into four groups according to interquartile range: lowest SII (SII < 353.9 × 109/L), low SII (353.9–532.8 × 109/L), high SII (532.8–783.9 × 109/L), and highest SII (>783.9 × 109/L) group. A total of 362 patients with ischemic stroke were included, and between minor and moderate-to-severe stroke significant difference was found in SII (p < 0.0001), NLR (p < 0.0001), and PLR (p = 0.001), respectively. After multivariate regression analyses, SII groups (Odd ratio = 1.351, 95% confidence interval 1.084–1.684, p = 0.007) not PALBI was an independent risk factor for stroke severity. We found that SII but not PALBI, which both are markers of inflammation, was independently associated with stroke severity. [ABSTRACT FROM AUTHOR]

Emphasis is placed on the performance of a two-stage pump equipped with an eroded impeller. Non-contact reverse engineering technique is utilized to acquire the point data constituting the three-dimensional geometrical model of the eroded impeller. With computational fluid dynamics, both the operation performance of the pump and flow patterns adjacent to the eroded blade surface are obtained. For comparison, the corresponding undamaged impeller is investigated as well. Preferable fidelity of the approach of constructing geometrical model of the damaged impeller is substantiated. The mechanism underlying performance degradation of the pump with the eroded impeller is evidenced. Local flow patterns near the eroded area are featured by explicit irregularity. Furthermore, between the defective and the undamaged pumps, disparity in positions where cavitation occurs is negligible. [ABSTRACT FROM AUTHOR]

This paper firstly analyzes the main problems existing in operation process of the desulfurization and decarbonization device with capacity of 4×106 m³/d in the first purification plant in Changqing Oilfield Company. Then it describes the newly installed high efficiency fine filter and improvement measures of overall purification of amine solution in detail. Finally it evaluates the transformation effect. [ABSTRACT FROM AUTHOR]

We report on the growth and structural, electrical and magnetotransport characteristics of epitaxial manganese perovskite (Pr1−xSrx)yMnO3−δ (PSMO) thin films by oxygen plasma assisted molecular beam epitaxy (MBE). Special attention was given to the non-stoichiometric phase, which exhibits interesting properties such as different phase transition temperatures and marked low field magnetoresistance. Under appropriate growth conditions, 2D step-flow growth mode has been realized with super smooth film surfaces. The structure characterization and magnetoresistance properties were studied and analyzed. [Copyright &y& Elsevier]

Hospital embedded system has put the hospital into a giant computer has Problem is, the burden of infectious diseases is relatively large, resistant infections and patients is particularly acute in developing countries, or have access to, generally than the first stage has a complex regimen, expensive it is low at line drugs likely to be able to afford to buy a second line treatments such as bone joint drug infection find and classification process such unsanitary, supply of unreliable water, embedded system and analysis presence of ongoing deterioration factors such as increased immune compromised number of patients due to the prevalence of drug infection further diffusion of resistant pathogens easily can increase the burden of antimicrobial resistance by making it discussed the causes and burden of drug-resistant, to evaluate the resistance problem intervention at the address developing countries. A strategy based on the rationale that local antibiotics released from bone cement or other carriers establish a second antibacterial frontline in and around the prosthesis is considered complementary to the administration of systemic antibiotics. Occur through a wireless network. To generate historical reports in MS Excel format that can be referenced by a physician. [ABSTRACT FROM AUTHOR]

Background: Inflammation is the natural defense mechanism of the body in response to injury, infection, or other stimuli. Excessive or persistent inflammatory responses can lead to the development of inflammatory diseases. Therefore, elucidating the regulatory mechanisms of inflammatory cells is crucial for understanding the pathogenesis of such diseases and devising novel therapeutic approaches. Moreover, miR-144/451 plays an important role in erythroid maturity and tumour development. Herein, we have reviewed the regulatory role of miR-144/451 in inflammation., Methods: Papers on miR-144, miR-451, and inflammation were retrieved from PubMed and Web of Science to be analysed and summarised., Results: miR-144/451 plays a significant role in modulating inflammatory responses. Pro- and anti-inflammatory gene transcription is regulated by miR-144/451 binding to the 3' untranslated regions. Studies have shown that miR-451 inhibits the activation of various inflammatory cells, including macrophages, neutrophils, and T lymphocytes, thereby reducing the release of inflammatory mediators. However, miR-144 expression varies in different inflammatory diseases. miR-144 expression is downregulated in macrophages after induction by lipopolysaccharide, cysteine, or Mycobacterium tuberculosis, which promotes the secretion of inflammatory mediators; nonetheless, miR-144-3p overexpression in macrophages can aggravate atherosclerosis. Meanwhile, miR-144 overexpression prevents disruption of the lung endothelial cell barrier, whereas it exacerbates endothelial cell injury in Crohn's disease., Conclusion: miR-144/451 may serve as a potential target for the treatment of inflammatory diseases., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Context: Type I hypersensitivity affects approximately one-third of the global population. As the pathophysiology underlying the development of type I hypersensitivity (asthma, food allergy, and anaphylactic shock, etc.) is complex and heterogeneous, animal model studies continue to be the key to identifying novel molecular pathways and providing therapeutic strategies., Objective: Selection of the animal model should be done with careful consideration of the protocol variables, animal species, and strains to accurately reflect the clinical symptoms typical of humans., Methods: The following databases were searched: PubMed and Web of Science., Results and Conclusion: Foreign allergens include allergenic proteins and chemical haptens. This review summarizes the various methods used for designing animal models of common allergenic protein-induced type I hypersensitivity, namely, passive anaphylaxis model, active systemic anaphylaxis/anaphylaxis shock model, food allergy model, asthma model, and IgE-mediated cell models. Additionally, we summarize shrimp tropomyosin-induced type I hypersensitivity models from our previous studies and discuss their advantages and limitations compared with that of ovalbumin-induced models., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2024 Feng, Xu, Zhang, Bin, Pang, He and Fang.)

Objective: Severe pneumonia in children represents a significant clinical challenge due to its high incidence and associated mortality. This study aimed to assess the distribution of pathogens and patterns of infection in pediatric patients with severe pneumonia., Methods: This study included 110 pediatric patients diagnosed with severe pneumonia, who were admitted to Guangxi Maternal and Child Health Hospital between July 2021 and November 2023. Pathogen-targeted next-generation sequencing (tNGS) was employed to identify respiratory pathogens in these cases., Results: Pathogens were detected in 109 out of 110 cases, yielding a positive detection rate of 99.09%. Among these cases, 25 (22.72%) involved single-pathogen infections, while 84 (76.36%) were characterized by mixed infections. The infection pattern in children with severe pneumonia was relatively common with bacterial-viral coinfection (28.2%, 31/110). A total of 39 pathogens were identified from the 110 children with severe pneumonia, with the top three pathogens being Mycoplasma pneumoniae (30.91%, 34/110), Human Respiratory Syncytial Virus Type A (26.36%, 29/110), and Human Herpesvirus (18.18%, 20/110). Notably, 38.2% (13/34) of the cases were found to have macrolide-resistant Mycoplasma pneumoniae (MRMP). Additionally, 40% (44/110) of the children required admission to the intensive care unit (ICU)., Conclusion: The application of tNGS demonstrates significant utility in the detection of pathogens in pediatric patients with severe pneumonia. The predominant pathogens identified in this study are Mycoplasma pneumoniae, Human Respiratory Syncytial Virus, and Human Herpesvirus. Furthermore, mixed infections involving multiple pathogens were observed in 76.36% of the cases, and a substantial proportion (40%) of these patients necessitated intensive care., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Objective: a network meta-analysis was performed to compare the strength and weakness of negative pressure wound therapy (NPWT) with ultrasound debridement (UD) as for diabetic foot ulcers (DFU)., Methods: PubMed, Ovid EMBASE, Web of Science, Cochrane library databases, and Chinese Biomedical Literature Database were searched till February 2015. Clinical compared studies of negative pressure wound therapy and ultrasound debridement were enrolled. The primary efficacy outcomes included healed ulcers, reduction of ulcer areas and time to closure. Secondary amputation including major and minor amputations was used to assess the safety profile., Results: Out of 715 studies, 32 were selected which enrolled 2880 diabetic patients. The pooled analysis revealed that NPWT including vacuum assisted closure (VAC) and vacuum sealing drainage (VSD) were as efficacious as ultrasound debridement improving healed ulcers, odds ratio, 0.86; 95% CI 0.28 to 2.6 and 1.2; 95% CI 0.38 to 4, respectively. However, both were better to standard wound care in wound healing patients. Compared with the standard wound care treated diabetic foot ulcers, NPWT and UD resulted in a significantly superior efficacy in time to wound closure and decrement in area of wound. No significances were observed between NPWT and UD groups in both indicators. Fewer patients tended to receive amputation in NPWT and UD groups compared to standard wound care group., Conclusions: The results of the network meta-analysis indicated that negative pressure wound therapy was similar to ultrasound debridement for diabetic foot ulcers, but better than standard wound care both in efficacy and safety profile.