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Your search keyword '"Feng, Yashu"' showing total 13 results
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13 results on '"Feng, Yashu"'

3. 19 Direct neural recordings from human bed nucleus of stria terminalis link alpha activity in empathy and affect evaluation tasks with depression severity

Author

Sonkusare, Saurabh, primary, Qiong, Ding, additional, Zhao, Yijie, additional, Zhang, Yingying, additional, Feng, Yashu, additional, Wang, Linbin, additional, Yang, Ruoqi, additional, Zhang, Chencheng, additional, Sun, Bomin, additional, Zhan, Shikun, additional, and Voon, Valerie, additional

Published
2023
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4. Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells

Author

Zhu, Yanling, Wang, Tianyu, Gu, Jiaming, Huang, Ke, Zhang, Tian, Zhang, Zhishuai, Liu, He, Tang, Jun, Mai, Yuchan, Zhang, Yanqi, Li, Yuhang, Feng, Yashu, Kang, Baoqiang, Li, Jinbing, Shan, Yongli, Chen, Qianyu, Zhang, Jian, Long, Bing, Wang, Junwei, Gao, Minghui, Zhang, Di, Zhou, Min, Zhong, Xiaofen, Chen, Jiekai, Pei, Duanqing, Nie, Jinfu, Liu, Bing, and Pan, Guangjin

Published
2020
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11. HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8.

Author

Wu, Jieying, Zhang, Ling, Feng, Yashu, Khadka, Bijay, Fang, Zhigang, and Liu, Jiajun

Subjects
ACUTE myeloid leukemia, CELLULAR control mechanisms, INTERLEUKIN-6, DAUNOMYCIN
Abstract

The chemoresistance is one of the major challenges for acute myeloid leukemia (AML) treatment. We found that the expression of histone deacetylase 8 (HDAC8) was increased in daunorubicin (DNR) resistant AML cells, while targeted inhibition of HDAC8 by its specific siRNA or inhibitor can restore sensitivity of DNR treatment. Further, targeted inhibition of HDAC8 can suppress expression of interleukin 6 (IL-6) and IL-8. While recombinant IL-6 (rIL-6) and rIL-8 can reverse si-HDAC8-resored DNR sensitivity of AML cells. Mechanistical study revealed that HDAC8 increased the expression of p65, one of key components of NF-κB complex, to promote the expression of IL-6 and IL-8. It might be due to that HDAC8 can directly bind with the promoter of p65 to increase its transcription and expression. Collectively, our data suggested that HDAC8 promotes DNR resistance of human AML cells via regulation of IL-6 and IL-8. [ABSTRACT FROM AUTHOR]

Published
2021
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