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4. Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug

Author

Cutano, Valentina, primary, Ferreira Mendes, Jessica Marianne, additional, Escudeiro-Lopes, Sara, additional, Machado, Susana, additional, Vinaixa Forner, Judith, additional, Gonzales-Morena, Juan M, additional, Prevorovsky, Martin, additional, Zemlianski, Viacheslav, additional, Feng, Yuxiong, additional, Kralova Viziova, Petra, additional, Hartmanova, Andrea, additional, Malcekova, Beata, additional, Jakoube, Pavel, additional, Iyer, Sonia, additional, and Keckesova, Zuzana, additional

Published
2023
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6. LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug

Author

Cutano, Valentina, primary, Ferreira Mendes, Jessica Marianne, additional, Escudeiro-Lopes, Sara, additional, Machado, Susana, additional, Vinaixa Forner, Judith, additional, Gonzales-Morena, Juan M, additional, Prevorovsky, Martin, additional, Zemlianski, Viacheslav, additional, Feng, Yuxiong, additional, Kralova Viziova, Petra, additional, Hartmanova, Andrea, additional, Malcekova, Beata, additional, Jakoube, Pavel, additional, Iyer, Sonia, additional, and Keckesova, Zuzana, additional

Published
2022
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9. Dual role for inositol‐requiring enzyme 1α in promoting the development of hepatocellular carcinoma during diet‐induced obesity in mice

Author

Wu, Ying, primary, Shan, Bo, additional, Dai, Jianli, additional, Xia, Zhixiong, additional, Cai, Jie, additional, Chen, Tianwei, additional, Lv, Songya, additional, Feng, Yuxiong, additional, Zheng, Ling, additional, Wang, Yan, additional, Liu, Jianfeng, additional, Fang, Jing, additional, Xie, Dong, additional, Rui, Liangyou, additional, Liu, Jianmiao, additional, and Liu, Yong, additional

Published
2018
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14. Abstract P2-07-01: EMT activates PERK-eIF2α signaling and sensitizes cells to perturbations in endoplasmic reticulum function

Author

Feng, Yuxiong, primary, Sokol, Ethan S, additional, Del Vecchio, Catherine A, additional, Sanduja, Sandhya, additional, Claessen, Jasper HL, additional, Proia, Theresa A, additional, Jin, Dexter X, additional, Reinhardt, Ferenc, additional, Ploegh, Hidde L, additional, Wang, Qiu, additional, and Gupta, Piyush B, additional

Published
2015
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15. De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

Author

Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Sokol, Ethan Samuel, Tillman, Erik J., Gupta, Piyush, Del Vecchio, Catherine A., Feng, Yuxiong, Sanduja, Sandhya, Reinhardt, Ferenc, Massachusetts Institute of Technology. Department of Biology, Koch Institute for Integrative Cancer Research at MIT, Sokol, Ethan Samuel, Tillman, Erik J., Gupta, Piyush, Del Vecchio, Catherine A., Feng, Yuxiong, Sanduja, Sandhya, and Reinhardt, Ferenc

Abstract

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-differentiation is not known. Here, we examine this question by using global transcriptional profiling to identify ROS-induced genes that are already up-regulated in de-differentiated cells, even in the absence of oxidative damage. Using this approach, we found that the Nrf2 transcription factor, which is the master regulator of cellular responses to oxidative stress, is preactivated in de-differentiated cells. In de-differentiated cells, Nrf2 is not activated by oxidation but rather through a noncanonical mechanism involving its phosphorylation by the ER membrane kinase PERK. In contrast, differentiated cells require oxidative damage to activate Nrf2. Constitutive PERK-Nrf2 signaling protects de-differentiated cells from chemotherapy by reducing ROS levels and increasing drug efflux. These findings are validated in therapy-resistant basal breast cancer cell lines and animal models, where inhibition of the PERK-Nrf2 signaling axis reversed the MDR of de-differentiated cancer cells. Additionally, analysis of patient tumor datasets showed that a PERK pathway signature correlates strongly with chemotherapy resistance, tumor grade, and overall survival. Collectively, these results indicate that de-differentiated cells up-regulate MDR genes via PERK-Nrf2 signaling and suggest that targeting this pathway could sensitize drug-resistant cells to chemotherapy., Breast Cancer Research Program (U.S.) (Award No. W81XWH-12-BCRP-POSTDOC2), Breast Cancer Alliance (Young Investigator Grant), National Science Foundation (U.S.) (Graduate Research Fellowship Grant No. 1122374), Richard and Susan Smith Family Foundation (Excellence in Biomedical Research award)

Published
2014

18. Quick comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan by high performance liquid chromatography coupled with monolithic columns and their chemical pattern recognition

Author

Feng Yuxiong, Peng Bing, Peng Yong, Wang Zhe, Xiao Pei-gen, and He Chunnian

Subjects
Monolithic HPLC column, Chromatography, Traditional medicine, principal component analysis, Formic acid, monolithic column, fingerprint, Pharmaceutical Science, Chinese herbs, High-performance liquid chromatography, Radix Paeonia Alba, Radix Paeonia Rubra, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Cortex (anatomy), Drug Discovery, medicine, Gradient elution, Separation method, Original Article, Radix, Cortex Moutan, high performance liquid chromatography coupled
Abstract

Background: Radix Paeoniae Alba, Radix Paeoniae Rubra, and Cortex Moutan are important Chinese herbs. Their bioactivities and efficacies are similar. However, they have different superior benefits clinically; so, a comprehensive investigation of the chemical difference is necessary and is of great importance for more reasonable quality assessment and proper clinical application of these three herbal medicines. Objective: To establish a high-performance liquid chromatography (HPLC) fingerprint method for the quality control of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan, and to compare their main constituents. Materials and Methods: The separations of Radix Paeoniae Alba, Radix Paeoniae Rubra, and Cortex Moutan was carried out, respectively, through a gradient elution using a monolithic column and a mobile phase consisting of water (containing 0.1% formic acid) and acetonitrile (containing 0.1% formic acid) at a flow rate of 5.0 ml/min. The detection wavelength was set at 230 nm. The data calculation was performed with CHROMAP v1.51 and Statistical Package for the Social Sciences (SPSS) 18.0 software for principal component analysis. Results: A rapid separation method based on high-performance liquid chromatography with diode-array detection (HPLC-DAD) with monolithic columns and a fingerprint analysis method was established. Fifteen Radix Paeonia Alba, 45 Radix Paeonia Rubra, and 21 Cortex Moutan samples were analyzed and 11 chromatographic peaks were identified. Differences of chromatographic peaks among these three herbal medicines in chemical compositions were revealed. Conclusion: The separation and analysis method are fast and simple, which can be used for chemical fingerprint comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan. The results for the evaluation of the three medicines could provide experimental evidence for chemical affinity.

Published
2012

19. Quick comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan by high performance liquid chromatography coupled with monolithic columns and their chemical pattern recognition.

Author

He Chunnian, Peng Yong, Feng Yuxiong, Peng Bing, Wang Zhe, and Xiao Peigen

Subjects
HIGH performance liquid chromatography, MEDICINAL plants, HERBAL medicine, CHEMICAL affinity, PHYSICAL & theoretical chemistry
Abstract

Background: Radix Paeoniae Alba, Radix Paeoniae Rubra, and Cortex Moutan are important Chinese herbs. Their bioactivities and efficacies are similar. However, they have different superior benefits clinically; so, a comprehensive investigation of the chemical difference is necessary and is of great importance for more reasonable quality assessment and proper clinical application of these three herbal medicines. Objective: To establish a high-performance liquid chromatography (HPLC) fingerprint method for the quality control of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan, and to compare their main constituents. Materials and Methods: The separations of Radix Paeoniae Alba, Radix Paeoniae Rubra, and Cortex Moutan was carried out, respectively, through a gradient elution using a monolithic column and a mobile phase consisting of water (containing 0.1% formic acid) and acetonitrile (containing 0.1% formic acid) at a flow rate of 5.0 ml/min. The detection wavelength was set at 230 nm. The data calculation was performed with CHROMAP v1.51 and Statistical Package for the Social Sciences (SPSS) 18.0 software for principal component analysis. Results: A rapid separation method based on high-performance liquid chromatography with diode-array detection (HPLC-DAD) with monolithic columns and a fingerprint analysis method was established. Fifteen Radix Paeonia Alba, 45 Radix Paeonia Rubra, and 21 Cortex Moutan samples were analyzed and 11 chromatographic peaks were identified. Differences of chromatographic peaks among these three herbal medicines in chemical compositions were revealed. Conclusion: The separation and analysis method are fast and simple, which can be used for chemical fingerprint comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan. The results for the evaluation of the three medicines could provide experimental evidence for chemical affinity. [ABSTRACT FROM AUTHOR]

Published
2012
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