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391 results on '"Fercher, A. F."'

26. Enhanced visualization of choroidal vessels using ultrahigh resolution ophthalmic OCT at 1050nm

Author

Považay, Boris, Bizheva, K, Hermann, Boris, Unterhuber, Angelika, Sattmann, Harald, Fercher, Adolf F., Drexler, Wolfgang, Schubert, C., Ahnelt, Peter, Mei, M., Holzwarth, R., Wadsworth, W. J., Knight, J., and Russell, P. St. J.

Subjects
genetic structures, sense organs, eye diseases
Abstract

In this article the ability of ultrahigh resolution ophthalmic optical coherence tomography (OCT) to image small choroidal blood vessels below the highly reflective and absorbing retinal pigment epithelium is demonstrated for the first time. A new light source (?c= 1050 nm, ??? = 165 nm, Pout= 10 mW), based on a photonic crystal fiber pumped by a compact, self-starting Ti:Al2O3 laser has therefore been developed. Ex-vivo ultrahigh resolution OCT images of freshly excised pig retinas acquired with this light source demonstrate enhanced penetration into the choroid and better visualization of choroidal vessels as compared to tomograms acquired with a state-of-the art Ti:Al2O3 laser (Femtolasers Compact Pro, lc= 780 nm, ???= 160 nm, Pout= 400 mW), normally used in clinical studies for in vivo ultrahigh resolution ophthalmic OCT imaging. These results were also compared with retinal tomograms acquired with a novel, spectrally broadened fiber laser (MenloSystems, ?c= 1350 nm, ???= 470 nm, Pout = 4 mW) permitting even greater penetration in the choroid. Due to high water absorption at longer wavelengths retinal OCT imaging at ~1300 nm may find applications in animal ophthalmic studies. Detection and follow-up of choroidal neovascularization improves early diagnosis of many retinal pathologies, e.g. age-related macular degeneration or diabetic retinopathy and can aid development of novel therapy approaches.

Published
2003

29. Intracellular phthalocyanine localization: confocal laser scanning microscopy studies

Author

Chernyaeva, Elena B., Greve, Jan, de Grooth, Bart G., Leeuwen, A.M., Fercher, Adolf F., Lewis, Aaron, Podbielska, Halina, Schneckenburger, Herbert, and Wilson, Tony

Subjects
Materials science, Membrane permeability, medicine.medical_treatment, Analytical chemistry, Photodynamic therapy, Golgi apparatus, Fluorescence, symbols.namesake, Cytoplasm, Microscopy, medicine, symbols, Biophysics, Intracellular, Cellular compartment
Abstract

Phthalocyanines (Pc) are promising second-generation photosensitizers for the photodynamic therapy (PDT) of cancer. We report on the tetrasulfonated aluminum phthalocyanine (AlPcS4) localization in cultured Chinese hamster lung cells studied by means of confocal laser scanning microscopy (CLSM). In these cells AlPcS4 was found in granules surrounding Golgi apparatus and in the peripheral cytoplasmic region. Peripheral Pc-containing granules partially coincided with the acidic cellular compartments. The effect of irradiation with light on Pc intracellular distribution was also studied. In the Pc-free medium disruption of some Pc- containing granules was observed followed by appearance of Pc fluorescence in the cell plasma membrane, the nuclear envelope, and the near-nuclear region. When cells were irradiated in the presence of Pc in external medium a drastic increase of membrane permeability to Pc was observed, followed by Pc binding the cell plasma membrane, nuclear envelope, and some structures in the cytoplasm. Diffusive Pc fluorescence in the nucleus was also observed. The implication of observed Pc redistribution caused by irradiation with light for the PDT protocol is discussed.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Published
1994
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35. ULTRAHIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY OF MACULAR HOLES

Author

SCHOLDA, CHRISTOPH, primary, WIRTITSCH, MATTHIAS, additional, HERMANN, BORIS, additional, UNTERHUBER, ANGELIKA, additional, ERGUN, ERDEM, additional, SATTMANN, HARALD, additional, KO, TONY H., additional, FUJIMOTO, JAMES G., additional, FERCHER, ADOLF F., additional, STUR, MICHAEL, additional, SCHMIDT-ERFURTH, URSULA, additional, and DREXLER, WOLFGANG, additional

Published
2006
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45. Criteria in the simultaneous presentation of the images provided by a stand alone OCT/SLO system

Author

Altshuler, Gregory B., Andersson Engels, Stefan, Birngruber, Reginald, Bjerring, PEter, Fercher, Adolf F., Geschwind, Herbert J., Hibst, Raimund, Honigsmann, Herbert, Laffitte, Frederic, Sterenborg, Hericus J.C., Podoleanu, Adrian Gh., Rogers, John A., Webb, David J., Jackson, David A., Altshuler, Gregory B., Andersson Engels, Stefan, Birngruber, Reginald, Bjerring, PEter, Fercher, Adolf F., Geschwind, Herbert J., Hibst, Raimund, Honigsmann, Herbert, Laffitte, Frederic, Sterenborg, Hericus J.C., Podoleanu, Adrian Gh., Rogers, John A., Webb, David J., and Jackson, David A.

Abstract

A new instrument for simultaneous display of an en-face optical coherence tomography (OCT) image and of a confocal image (similar with that produced by the scanning laser ophthalmoscope (SLO)) for the retina in vivo is demonstrated. The system is based on a fiberised OCT configuration, where a separate bulk optical confocal receiver is introduced between the transversal galvanometer scanner and the OCT fiber arm. Criteria for presenting the two images are discussed. These address the resulting impact on the quality of each image as result of differences in the two imaging techniques, low coherence interferometry and confocal imaging. The transversal and depth pixel size are governed by different principles and consequently are generally different. Additionally, the OCT image is disturbed by Doppler shifts introduced by the transversal scanning and speckle.

Published
1999

47. Quantification of photoreceptor layer thickness in different macular pathologies using ultrahigh-resolution optical coherence tomography

Author

Drexler, Wolfgang, primary, Hermann, Boris, additional, Unterhuber, Angelika, additional, Sattmann, Harald, additional, Wirtitsch, Matthias, additional, Stur, Michael, additional, Scholda, Christoph, additional, Ergun, Erdem, additional, Anger, Elisabeth, additional, Ko, Tony H., additional, Schubert, Christian, additional, Ahnelt, Peter K., additional, Fujimoto, James G., additional, and Fercher, Adolf F., additional

Published
2004
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