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2. The natural concentration of the conjugated linoleic acid, cis-9,trans-11, in milk fat has antiatherogenic effects in hyperlipidemic hamsters

Author

Valeille, Karine, Ferezou, Jacqueline, Parquet, Michel, Amsler, Ghislaine, Gripois, Daniel, Quignard-Boulange, Annie, and Martin, Jean-Charles

Subjects
Blood cholesterol, Saturated fatty acids, Hamsters, Gene expression, Linoleic acids, Unsaturated fatty acids, Food/cooking/nutrition
Abstract

Milk fat is usually considered to be proatherogenic, although its fatty acid composition can vary, due mainly to farming conditions. No study has evaluated whether such variation can modify the atherogenic properties of dairy fat. Aortic lipid deposition and related risk factors were examined in Syrian hamsters fed diets for 12 wk containing 200 g/kg of 2 commercial milk fats [high content of saturated fatty acids (HSF) and low content of saturated fatty acids (LSF)] contrasting, respectively, in total saturated fatty acids (72 vs. 67 g/100 g), 18:1, trans (4.24 vs. 7.26 g/100g), and conjugated linoleic acid (mainly cis-9,trans-11 or rumenic acid; 0.39 vs. 2.59 g/100 g). Hamsters fed the LSF-diet had 25% less aortic cholesteryl-ester deposition than those fed the HSF-diet; this was accompanied by an improved plasma cholesterol profile (lower LDL cholesterol and LDL:HDL cholesterol ratio), a lower local inflammatory status (aortic gene expression of cyclooxygenase-2), and lower aortic gene expression of vascular cell adhesion molecule-1 (all P < 0.05). Supplementation of the LSF-diet with rumenic acid (up to 9 g/kg) amplified the antiatherogenic effect of the original LSF-diet compared with the HSF-diet, i.e., less aortic cholesterol loading, increased reverse cholesterol transport potential (higher plasma HDL cholesterol concentration and ATP-binding cassette, subfamily A, transporter 1 gene expression in aorta), and decreased LDL-peroxidability index and gene expression of proinflammatory IL-1[beta] in the aorta (all P < 0.05). In conclusion, our results suggest that the atherogenic potential of milk fat can be greatly reduced in products with a naturally high abundance of rumenic acid, and argue for increasing this fatty acid in milk. KEY WORDS: * milk fat * trans-fatty acid * rumenic acid * hamsters * atherosclerosis

Published
2006

3. A cis-9,trans-11-conjugated linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster

Author

Valeille, Karine, Ferezou, Jacqueline, Amsler, Ghislaine, Quignard-Boulange, Annie, Parquet, Michel, Gripois, Daniel, Dorovska-Taran, Victoria, and Martin, Jean-Charles

Subjects
Hamsters -- Physiological aspects, Atherosclerosis -- Risk factors, Linoleic acids, Fish oils, Biological sciences
Abstract

Conjugated linoleic acid (CLA) mixtures demonstrated antiatherogenic properties in several animal models, including hamsters, but the mechanism of action of the main food-derived CLA isomer is unknown in this species. This study thus focused on cis-9,trans-11-CLA (rumenic acid), and its effect was compared with that of fish oil, which is known to influence several aspects of atherogenesis. Syrian hamsters were fed (for 12 wk) diets containing 20% (wt/wt) butter fat (B diet) or the same diet augmented with either 1% (wt/wt) of a cis-9,trans-11-CLA-rich oil (BR diet) or 1% (wt/wt) fish oil (BF diet). The BR diet induced the lowest aortic lipid deposition (from -30% to -45%) among the butter oil-fed hamsters. In this group, plasma also displayed a reduced non-HDL-to-HDL-cholesterol ratio (21% less than in the butter oil group) and inflammatory serum amyloid A levels (70-80%) and an improvement of anti-oxidized LDL paraoxonase activity (all P < 0.05). Compared with the B group, the beneficial effects of the BR diet could be further explained in part by preventing the high VCAM-1 expression rate, increasing (30%) ATP-binding cassette subfamily A I expression in the aorta, and downregulating expression of inflammatory-related genes (TNF-[alpha], IL-1[beta], and cyclooxygenase 2, 2- to 2.8-fold, P < 0.05). This effect was partly associated with an activation of peroxisome proliferator-activating receptor (PPAR)/liver X receptor (LXR)-[alpha] signaling cascade. Interestingly, activation of PPAR/LXR-[alpha] signaling was not observed in hamsters fed the BF diet, in which the early signs of atherogenesis were increased. In conclusion, this study demonstrated that milk fat-rich cis-9,trans-11-CLA reduces the atherogenic process in hyperlipidemic hamsters. fish oil; rumenic acid; atherosclerosis; risk factors

Published
2005

4. Hypercholesterolemia induced by cholesterol- or cystine-enriched diets is characterized by different plasma lipoprotein and apolipoprotein concentrations in rats

Author

Serougne, Colette, Felgines, Catherine, Ferezou, Jacqueline, Hajri, Tahar, Bertin, Catherine, and Mazur, Andrzej

Subjects
Gene expression -- Research, Apolipoproteins -- Research, Hypercholesterolemia -- Research, Cholesterol -- Research, Rats -- Food and nutrition, Cystine -- Research, Blood lipoproteins -- Research, Food/cooking/nutrition
Abstract

This study examined the effects of diet-induced hypercholesterolemia on plasma apolipoprotein (apo) concentrations and hepatic apolipoprotein mRNA levels in rats. Hypercholesterolemia was induced by feeding rats diets containing an excess of either cholesterol or cystine. After cholesterol feeding, plasma apo E and apo B concentrations were lower (-65%, P < 0.001) and greater (+39%, P < 0.01), respectively, compared with control diet-fed rats. After cystine feeding, plasma apo B and apo E concentrations were greater (+46%, P < 0.01 and +75%, P < 0.001, respectively) and plasma apo A-IV concentration was lower (-29%, P < 0.001) than in rats fed control diet. After cholesterol or cystine feeding, a tendency (one-way ANOVA, P = 0.08) for greater apo B mRNA level (+42% and +47%, respectively) was observed compared with control diet-fed rats. No difference emerged between groups for apo E and apo A-I mRNA levels. An opposite effect of cholesterol and cystine feeding was shown for apo A-IV mRNA level, i.e., higher after cholesterol feeding (+47%, P < 0.05) and lower after cystine feeding (-65%, P < 0.01). From this work, it seems that hypercholesterolemia induced by dietary cholesterol or by increased cholesterogenesis in cystine-fed rats is characterized by different plasma lipoprotein and apolipoprotein concentrations and is associated with different apolipoprotein gene expression in the liver. INDEXING KEY WORDS: gene; expression; rats; liver; apolipoproteins; cholesterol; cystine

Published
1995

6. Postprandial appearance of dietary deuterated cholesterol in the chylomicron fraction and whole plasma in healthy subjects

Author

Dubois, Christophe, Armand, Martine, Ferezou, Jacqueline, Beaumier, Gabrielle, Portugal, Henri, Pauli, Anne-Marie, Bernard, Pierre-Marie, Becue, Thierry, Lafont, Huguette, and Lairon, Denis

Subjects
Fiber in human nutrition -- Health aspects, Cholesterol -- Health aspects, Food/cooking/nutrition, Health
Abstract

This study examined the appearance of dietary cholesterol in the chylomicron fraction (chylomicrons plus chylomicron remnants) and whole plasma in healthy normolipidemic subjects during a 0-7-h postprandial period. Six adult males were given two diet sequences in random order: a low-fiber diet (standard Western diet for 14 d) followed by a labeled low-fiber test meal or a fiber-supplemented diet (40 g oat bran/d for 14 d) followed by a labeled oat bran (40 g) test meal. The test meals provided 192.5 mg cholesterol, including 80.1 mg octadeuterated cholesterol. Fasting and hourly postmeal blood samples were obtained for 7 h. Isotopic cholesterol ratios [tracer:(tracer + native cholesterol)] were determined by gas chromatography-mass spectrometry. Chylomicron triacylglycerol and cholesterol concentrations peaked after 2-3 h and returned to baseline after 7 h. After the low-fiber test meal, the isotopic cholesterol ratio continuously increased until 7 h in the chylomicron fraction (4.2 [+ or -] 1.2 X [10.sup.-3]) and whole plasma (1.04 [+ or -] 0.39 X [10.sup.-3]). At 7 h postprandial, the maximum dietary cholesterol concentration in the chylomicron fraction and plasma cholesterol was 1 in 99 and 1 in 397 cholesterol molecules, respectively. No marked differences were obtained after the high-fiber sequence compared with the low-fiber one; there was a comparable isotopic cholesterol ratio and concentration in the chylomicron fraction and a slightly lower (-44%, P < 0.10) 0-7 h area under the curve whole-plasma deuterated cholesterol concentration. Thus, dietary cholesterol supplied as a single meal does not simultaneously appear in the chylomicron fraction postprandially with endogenous cholesterol and triacylglycerols and fiber feeding does not markedly alter this process in healthy normolipidemic humans.

Published
1996

15. Impact d'un régime alimentaire hypercalorique sur la régulation centrale du CNTF et de ses récepteurs dans le noyau arqué de rat

Author

Vacher, Claire-Marie, Aubourg, Alain, Crépin, Delphine, Couvreur, Odile, Bailleux, Virginie, Nicolas, Violaine, Ferezou, Jacqueline, Gripois, Daniel, Gertler, A., Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), and The Hebrew University of Jerusalem (HUJ)

Subjects
CILIARY NEUROTROPHIC FACTOR, [SDV]Life Sciences [q-bio], RAT, NEUROPHYSIOLOGIE, [INFO]Computer Science [cs], REGIME ALIMENTAIRE HYPERCALORIQUE, REGULATION CENTRALE CNTF, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

16. Early post natal leptin blockage induced a long term leptin resistance in rats

Author

Attig, Linda, Solomon, G., Ferezou, Jacqueline, Taouis, Mohammed, Gertler, A., Abdennebi-Najar, L., Djiane, Jean, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), The Hebrew University of Jerusalem (HUJ), and Institut Polytechnique LaSalle Beauvais

Subjects
OBESITY, [SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

17. Effet du blocage de la leptine postnatale sur l'installation à long terme d'une résistance à la leptine et d'une altération de la composition corporelle chez le rat

Author

Attig, Linda, Solomon, G., Ferezou, Jacqueline, Taouis, Mohammed, Gertler, A., Djiane, Jean, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), Institut Polytechnique LaSalle Beauvais, The Hebrew University of Jerusalem (HUJ), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], LEPTINE POSTNATALE, RESISTANCE A LA LEPTINE, [SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], ALTERATION COMPOSITION CORPORELLE, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

18. Long-term consequences of maternal high-fat diet on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

Author

Ferezou, Jacqueline, Roy, Anne-France, Gripois, Daniel, Parquet, Michel, Bailleux, Virginie, Gertler, Arieh, Delplanque, Bernadette, Djiane, Jean, Riottot, Michel, Taouis, Mohammed, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), and Université Paris-Sud - Paris 11 (UP11)

Subjects
DIET-INDUCED OBESITY, MATERNAL HIGH-FAT DIET, HYPOTHALAMIC LEPTIN SENSITIVITY, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], OFFSPRING, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

19. Effets du blocage de la leptine au cours de l'installation des circuits neuronaux de contrôle de la prise alimentaire

Author

Attig, Linda, Solomon, G., Ferezou, Jacqueline, Taouis, Mohammed, Gertler, Arieh, Djiane, Jean, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), and Université Paris-Sud - Paris 11 (UP11)

Subjects
[SDV]Life Sciences [q-bio], PRISE ALIMENTAIRE, [INFO]Computer Science [cs], NEUROBIOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2007

20. The natural concentration of the conjugated linoleic acid, cis-9, trans-11 in milk-fat can modulate the atherogenic risk in hyperlipidemic hamsters

Author

Valeille, Karine, Ferezou, Jacqueline, Amsler, G., Gripois, Daniel, Martin, Jean-Charles, Parquet, Michel, Centre de Recherche Pierre Fabre (Centre de R&D Pierre Fabre), PIERRE FABRE, Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11), Nutrition humaine et lipides : Biodisponibilité, métabolisme et régulation, and Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Université de Provence - Aix-Marseille 1-IFR125-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
ATHEROGENIC RISK, PERIPHERAL VASCULAR DISEASE, LINOLEIC ACID, MILK-FAT, HYPERLIPIDEMIC HAMSTERS, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2006

21. Les CLA peuvent-ils prévenir l'athérogenèse ?

Author

Martin, Jean-Charles, Amsler, Ghislaine, Valeille, Karine, Ferezou, Jacqueline, Parquet, Michel, Gripois, Daniel, ProdInra, Migration, Nutrition humaine et lipides : Biodisponibilité, métabolisme et régulation, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Université de Provence - Aix-Marseille 1-IFR125-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA), and Institut National de la Recherche Agronomique (INRA)

Subjects
ATHEROSCLEROSIS, [SDV.IDA]Life Sciences [q-bio]/Food engineering, INFLAMMATIONLIPOPROTEINS, CLA, [SDV.IDA] Life Sciences [q-bio]/Food engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2005

23. Cholesterol crystallization in gall-bladder bile of pigs given cholesterol-beta-cyclodextrin-enriched diets with either casein or soyabean concentrate as protein sources

Author

Catala, Isabelle, Juste, Catherine, Boehler, N., Ferezou, Jacqueline, André, M., Riottot, Michel, LUTTON, C., Lafont, H., Bornet, Frédéric, CORRING, T., ProdInra, Migration, Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Published
2000

24. Hypocholesterolemic action of beta-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enriched diet

Author

Ferezou, Jacqueline, Riottot, Michel, Cohen-Solal, Corinne, Catala, Isabelle, Alquier, Christian, Parquet, Michel, Juste, Catherine, LAFONT, Huguette, Mathé, Denis, Corring, Tristan, Lutton, Claude, Laboratoire de physiologie de la nutrition, Institut National de la Recherche Agronomique (INRA), Eridiana Béghin-Say, Partenaires INRAE, and Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1997

27. Heat or gamma irradiation sterilization affects the hypocholesterolemic effect of guar gum in the axenic and heteroxenic rats

Author

Alvarez-Leite, J.I., Andrieux, C., Ferezou, Jacqueline, Riottot, Michel, Vieira, E.C., ProdInra, Migration, Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, RAT, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Published
1994

30. Influence of intestinal microflora on the hypocholesterolemic effect of guar gum

Author

Alvarez, Jules, Andrieux, C., Ferezou, Jacqueline, Riottot, Michel, Association Francaise de Nutrition, ., Nutrition Society, ., Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), Institut National de la Recherche Agronomique (INRA), Association Francaise de Nutrition, Partenaires INRAE, Nutrition Society, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], RAT
Published
1992

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