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Twenty-eight patients with previously untreated diffuse histiocytic lymphoma (DHL) were identified to be in pathologic stage (PS) I (11), IE(3), II (8), or IIE(6) by exploratory laparotomy and splenectomy. Six patients were treated with total nodal radiotherapy; 14 with an extended mantle; 5 with an inverted Y or whole abdomen; and 3 with an involved field. Twenty-six patients achieved a complete remission (93%) and 2 patients had persistent local disease. The median survival and disease-free survival and for the complete response group are 56 and 51.5 mo, respectively. Ten of the 11 stage I or IEpatients had supradiaphragmatic lymph node disease. Patients with stage I or IEdisease (n =14) demonstrated a median survival of 72.5 mo and a median disease-free survival of 69.5 mo; there was 1 disease-related death. Patients with stage II or IIEdisease (n =14) demonstrated a median survival of 33 mo and median disease-free survival of 29.5 mo; there were 10 relapses or deaths. Patients in stages I, IE, II, or IIEwith infradiaphragmatic disease (n= 7) had a median survival of 36 mo, while patients with supradiaphragmatic presentation (n = 21) demonstrated median survival of 68 mo (p= 0.37). The data indicate that patients with diffuse histiocytic lymphoma with stage I supradiaphragmatic lymph node disease are curable using radiotherapy alone, achieving a 93% 11-yr actuarial disease-free survival. Patients with stage II or IIEdisease are not readily curable with radiation therapy alone, achieving a 33% 11-yr actuarial disease-free survival; radiotherapy with adjuvant chemotherapy or chemotherapy alone should be considered for this group.

A total of 2,005 fecal samples collected quarterly over a 5-year period from native Nebraska cows, ages 1 to 6, were examined for internal parasites. Incidence and level of roundworms decreased (P<.05) in older cattle with tendency for lower coccidia infection. Season of the year affected (P<.05) incidence with roundworms and tapeworms being lower in June than in October, January or March and coccidia being greater in October than January, March or June. No clinical cases of internal parasites were observed.