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2. Impact of COVID-19 pandemic on the incidence of otitis media with effusion in adults and children: a multicenter study

Author

Iannella, Giannicola, Magliulo, Giuseppe, Lechien, Jerome R., Maniaci, Antonino, Perrone, Tiziano, Frasconi, Pier Carlo, De Vito, Andrea, Martone, Chiara, Ferlito, Salvatore, Cocuzza, Salvatore, Cammaroto, Giovanni, Meccariello, Giuseppe, Monticone, Valentina, Greco, Antonio, de Vincentiis, Marco, Ralli, Massimo, Savastano, Vincenzo, Bertin, Serena, Pace, Annalisa, Milani, Alessandro, Polimeni, Roberta, Pelucchi, Stefano, Ciorba, Andrea, and Vicini, Claudio

Published
2022
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3. Cognitive Impairment and Mild to Moderate Dysphagia in Elderly Patients: A Retrospective Controlled Study.

Author

Maniaci, Antonino, Lechien, Jérome R, La Mantia, Ignazio, Iannella, Giannicola, Ferlito, Salvatore, Albanese, Gianluca, Magliulo, Giuseppe, Pace, Annalisa, Cammaroto, Giovanni, Di Mauro, Paola, Vicini, Claudio, and Cocuzza, Salvatore

Subjects
NEUROLOGIC examination, QUESTIONNAIRES, SEVERITY of illness index, ENDOSCOPIC surgery, DESCRIPTIVE statistics, AGE distribution, RETROSPECTIVE studies, FIBER optics, COGNITION disorders, ANALYSIS of variance, DEGLUTITION, ENDOSCOPY, DEGLUTITION disorders, EVALUATION, DISEASE risk factors, OLD age
Abstract

Background : To investigate whether cognitive impairment in elderly patients could correlate with the severity of swallowing disorders detectable through the endoscopic fiber optic evaluation. Methods : Elderly patients (≥65 years) performing a swallowing evaluation were included and divided according to the Dysphagia outcome and severity scale (DOSS). Neurological evaluation and Mini-Mental test examination (MMET) were administered to detect cognitive impairment. Results : Significantly worse swallowing function was reported in the cognitive impairment group than the control one (40% vs 19%; P =.001). A different significant distribution of swallowing performance was detected according to the patient's MMET score (P <.001; P <.001; P =.01). At the ANOVA test among dependent variables assessed, only age>65 and MMET<10 were significantly correlated with swallowing function (F = 3.862, P =.028; F = 17.49, P =.000). Conclusions: The elderly patient has an increased risk for unrecognized swallowing disorders, with a prevalence of mild to moderate forms. Assessment of cognitive performance could facilitate the identification of swallowing disorders by providing a higher level of suspicion for silent aspiration in subjects with poor MMET scores. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Combining early lower eyelid surgery with neuromuscular retraining for synkinesis prevention after facial palsy: the role of the eye in aberrant facial nerve regeneration.

Author

Di Stadio, Arianna, Ralli, Massimo, De Luca, Pietro, Sossamon, Jake, Frohman, Teresa C., Altieri, Marta, La Mantia, Ignazio, Ferlito, Salvatore, Frohman, Elliot M., and Brenner, Michael J.

Subjects
MAGNETIC resonance imaging, OPHTHALMIC plastic surgery, FACIAL expression, FACIAL paralysis, FACIAL nerve
Abstract

Background: Facial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions. Treatment of synkinesis is challenging, and preventive methods are needed. Aim: This study evaluated the efficacy of physical facial nerve rehabilitation (PFNR) therapy alone vs. PNFR with eyelid surgery to correct lagophthalmos and prevent the onset of synkinesis. Methods: Twenty five outpatients were randomized to receive either PFNR alone (neuromuscular retraining and Kabat proprioceptive neuromuscular facilitation) or PNFR and early (90 days after FP onset) eyelid surgery (involving a conservative oculoplastic correction for lagophthalmos with epiphora or ectropion). Comprehensive otolaryngological assessments and Magnetic Resonance Imaging (MRI) were conducted. Synkinesis progression was measured using Another Disease Scale (ADS) at baseline, 3-, 6-, 12-, and 24-months post-treatment. The data were analyzed with ANOVA, τ-test, Chi-Square analyses. Results: Patients undergoing eyelid surgery with PFNR showed faster (p < 0.001) and better recovery of facial movements (p < 0.05) than patients receiving PFNR alone comparing T0 and T12 (p < 0.0001). No synkinesis were observed in the PFNR plus surgery group while 37% of patients in PFNR alone had synkinesis (p = 0.03). At 24months, none of the patients in the surgery group presented synkinesis. Conclusion: Combining early surgical treatment of paralytic lagophthalmos or epiphora with PFNR accelerated functional recovery and reduced synkinesis in patients with FP compared to facial rehabilitation alone. Further investigations in larger populations with long-term follow-up are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Dysphagia Severity and Quality of Life in Nasopharyngeal Cancer Patients after Intensity Modulated Radiotherapy (IMRT).

Author

Cocuzza, Salvatore, Parisi, Federica Maria, Spatola, Corrado, La Mantia, Ignazio, Lechien, Jerome Rene, Chiesa-Estomba, Carlos, Ferlito, Salvatore, Albanese, Gianluca, Lentini, Mario, Mayo-Yanez, Miguel, Fakhry, Nicolas, La Rocca, Madalina, and Maniaci, Antonino

Subjects
PLATELET lymphocyte ratio, INTENSITY modulated radiotherapy, NEUTROPHIL lymphocyte ratio, NASOPHARYNX cancer, PROGNOSIS, DEGLUTITION disorders
Abstract

Background: Patients treated with definitive radiotherapy for nasopharyngeal carcinoma (NPC) develop severe dysphagia, affecting their quality of life. Traditional prognosis biomarkers are insufficient, leading to a search for new predictors like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Methods: We retrospectively enrolled 44 NPC patients who underwent definitive radiotherapy between 2010 and 2018. EQUATOR and STROBE network guidelines were adopted. Pre-treatment evaluations were conducted, and post-treatment oropharyngeal dysphagia was assessed using the Sydney Swallow Questionnaire (SSQ) and FEES, then assigning a Dysphagia Outcome and Severity Scale (DOSS) level. Patients were divided based on NLR and PLR cut-offs, comparing subjective dysphagia (SSQ) scores and DOSS results at baseline and after a 5-year follow-up. Multiple linear regression was used for analysis. Results: At baseline, the mean NLR was 2.52 ± 1.10, and the PLR was 208.40 ± 94.35. Multivariate analysis indicated NLR and PLR as significant predictors of DOSS outcomes (p < 0.001). Conclusions: Baseline inflammation markers, such as NLR and PLR, may be used to predict dysphagia severity in NPC patients undergoing definitive radiotherapy. These markers could help identify patients at higher risk for severe dysphagia and implement tailored therapeutic and rehabilitative strategies to improve their quality of life. Further studies with larger cohorts are needed to confirm these findings and explore additional prognostic factors for dysphagia outcomes in NPC patients. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Saccharin test: Methodological validation and systematic review of the literature.

Author

Caponnetto, Pasquale, Emma, Rosalia, Benfatto, Francesca, Ferlito, Salvatore, Gulino, Alessandro, Maniaci, Antonino, Lechien, Jerome R, Ingrassia, Angelo, Cocuzza, Salvatore, and Polosa, Riccardo

Subjects
NASAL cavity, SELF-evaluation, RESEARCH funding, SCIENTIFIC observation, MUCOCILIARY system, SACCHARIN, DESCRIPTIVE statistics, SYSTEMATIC reviews, LONGITUDINAL method, MEDLINE, INTRACLASS correlation, RESEARCH methodology, ONLINE information services, REGRESSION analysis
Abstract

Objectives: Saccharin test (ST) is a convenient method to assess the efficiency of mucociliary clearance, the primary defense mechanism of the upper airways' tract. The study objectives are to: (1) substantiate its short- (3 days) and long-term (30 days) repeatability; (2) assess its tolerability; (3) conduct a systematic literature review and to compare our results with the existing evidence. Methods: Twenty-nine healthy subjects were enrolled in an observational prospective study to perform an ST on three separate visits (at baseline; at follow-up visits at day 3 and at day 30). Transit times were recorded and self-reported nasal and general symptoms noted. A systematic review of the literature was conducted to compare our results with the existing literature. Results: The mean values (±SD) of ST transit time (STTT) were 7.085 (±2.19), 7.788 (±2.11), and 7.790 (±2.06) minutes at baseline, day 3, and day 30, respectively. Significant linear regression analysis was observed between day 3 and baseline (r =.193; P =.019) and day 30 and baseline (r =.182 P =.024). Significant agreement for the intrasession repeatability was observed with an ICC =.354 (P =.001). Outcomes' comparisons between baseline vs day 3 (P =.197) and baseline vs day 30 (P =.173) were not statistically significant. ST was well tolerated. Concordance with existing literature's data and high level of STTT repeatability were confirmed by the qualitative analysis. Conclusion: STTT reproducibility was good both in the short- and long-term. ST tolerability was very good. Our study data are consistent with the existing literature, indicating ST as a sound methodology for detection of early respiratory health changes and for specific regulatory application in respiratory research. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Autosomal Dominant Non-Syndromic Hearing Loss (DFNA): A Comprehensive Narrative Review

Author

Aldè, Mirko, primary, Cantarella, Giovanna, additional, Zanetti, Diego, additional, Pignataro, Lorenzo, additional, La Mantia, Ignazio, additional, Maiolino, Luigi, additional, Ferlito, Salvatore, additional, Di Mauro, Paola, additional, Cocuzza, Salvatore, additional, Lechien, Jérôme René, additional, Iannella, Giannicola, additional, Simon, Francois, additional, and Maniaci, Antonino, additional

Published
2023
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11. Comparative Analysis of Intellectual Quotient in Developmental Population with Severe Hearing Loss: Hearing Aids vs. Cochlear Implant Users.

Author

Di Stadio, Arianna, De Luca, Pietro, Ippolito, Valentina, Vedova, Paola, Garofalo, Sabina, Turchetta, Rosaria, Ferlito, Salvatore, and della Volpe, Antonio

Subjects
COCHLEAR implants, HEARING disorders, HEARING aids, DEAFNESS, COMPARATIVE studies, COGNITIVE ability, SPEECH therapy, AGENESIS of corpus callosum, NEUROLINGUISTICS
Abstract

The development of language, memory and intellectual functions is linked to normal hearing and correct sounds interpretation. Hearing loss (HL), especially in its severe form, negatively affects the development of these functions. This prospective study aimed at comparing the Intelligent Quotients (IQ) of children with cochlear implants (CI) with the ones of people wearing hearing aids (HA) after one year of hearing rehabilitation. 21 subjects with severe/profound bilateral hearing loss (deafness) were included in this study. Eleven children with congenital profound HL underwent CI and ten children with moderate to severe HL (congenital and acquired) were rehabilitated by HA. Children's IQs were assessed at enrolment (T0) and 12 months after hearing aids/CI use plus speech therapy. Statistical analyses were performed to analyze the data within and between groups. Comparison of IQs showed no statistically significant differences between CI and HA none at T0 and T1. The subtests showed lower scores in verbal comprehension and process speed index in patients treated with HA when compared to CI. This study showed that auditory rehabilitation can support the normal development of cognitive function in children between six and eight years of age. The use of the correct hearing aids based on the patient's hearing thresholds is important to maximize the rehabilitation outcomes. Due to the small sample size, although stratified for age, our results must be considered preliminary and further analyses on larger samples are needed to confirm our data. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Type 1 Tympanoplasty Outcomes between Cartilage and Temporal Fascia Grafts: A Long-Term Retrospective Study

Author

Ferlito, Salvatore, primary, Fadda, Gianluca, additional, Lechien, Jerome Rene, additional, Cammaroto, Giovanni, additional, Bartel, Ricardo, additional, Borello, Andrea, additional, Cavallo, Giovanni, additional, Piccinini, Francesca, additional, La Mantia, Ignazio, additional, Cocuzza, Salvatore, additional, Merlino, Federico, additional, Achena, Andrea, additional, Brucale, Cristina, additional, Mat, Quentin, additional, Gargula, Stéphane, additional, Fakhry, Nicolas, additional, and Maniaci, Antonino, additional

Published
2022
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16. Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives

Author

Santonocito, Simona, primary, Ferlito, Salvatore, additional, Polizzi, Alessandro, additional, Ronsivalle, Vincenzo, additional, Sclafani, Rossana, additional, Valletta, Alessandra, additional, Lo Giudice, Antonino, additional, Cavalcanti, Raffaele, additional, Spagnuolo, Gianrico, additional, and Isola, Gaetano, additional

Published
2022
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18. Long-Term Anatomical and Hearing Outcomes of Canal Wall down Tympanoplasty for Tympano-Mastoid Cholesteatoma: A 20-Year Retrospective Study

Author

Ferlito, Salvatore, primary, La Mantia, Ignazio, additional, Merlino, Federico, additional, Cocuzza, Salvatore, additional, Di Stadio, Arianna, additional, Cammaroto, Giovanni, additional, Bartel, Ricardo, additional, Fadda, Gianluca, additional, Iannella, Giannicola, additional, Mat, Quentin, additional, Gargula, Stéphane, additional, Michel, Justin, additional, Fakhry, Nicolas, additional, and Maniaci, Antonino, additional

Published
2022
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20. Critical appraisal of the European Union Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) Preliminary Opinion on electronic cigarettes

Author

O'Leary, Renée, Polosa, Riccardo, Li Volti, Giovanni, Bertino, Gaetano, Ferlito, Salvatore, Tomaselli, Venera, Nocera, Francesco, Zanoli, Luca, Alaimo, Salvatore, Anfuso, CARMELINA DANIELA, Barbagallo, IGNAZIO ALBERTO, Basile, Francesco, Battiato, Sebastiano, Bianchi, Alberto, Antonio, G Biondi, Maria Luisa Brandi, Cacciola, Emma, Cacciola, Rossella Rosaria, Cacopardo, Bruno Santi, Calogero, Aldo Eugenio, Cambria, Maria Teresa, Campagna, Davide, Caraci, Filippo, Cariola, Agatino, Caruso, Massimo, Caponnetto, Pasquale, Fabio, Cibella, DI MAURO, Maurizio, DI NUOVO, Santo, Adriana Di Stefano, Drago, Filippo, Failla, Salvatore, Rosario, Faraci, Salvatore, Ferlito, Ferrante, Margherita, Alfredo, Ferro, Giancarlo, A Ferro, Frasca, Francesco, Frittitta, Lucia, Furneri, Pio Maria, Giovanni, Gallo, Galvano, Fabio, Gagliano, Antonio, Grasso, Giuseppe, Francesca, Guarino, Gulino, Antonino, Emmanuele, A Jannini, LA VIGNERA, SANDRO SALVUCCIO MARIA, Lazzarino, Giuseppe, Antonio, Longo, Lupo, Gabriella, Mario, Malerba, Marletta, Luigi, Nicolosi, Guido, OLIVERI CONTI, GEA MARZIA, Parenti, Rosalba, Pulvirenti, Alfredo, Purrello, Francesco, Rapisarda, Francesco, Rapisarda, Venerando, Michele, Reibaldi, Rizzo, Renata, Ronsisvalle, Simone, Ruggieri, Martino, Santagati, Maria Carmela, Satriano, Cristina, Sciacca, Laura, Signorelli, MARIA SALVINA, Marco, Tatullo, Daniele, Tibullo, Venera, Tomaselli, Zanoli, LUCA MARIA, and Zappala', Agata

Subjects
Opinion, Adolescent, Medicine (miscellaneous), SCHEER, Population health, Electronic Nicotine Delivery Systems, 030204 cardiovascular system & hematology, Scientific evidence, European Union Tobacco Products Directive, 03 medical and health sciences, 0302 clinical medicine, Political science, e-cigarettes, ENDS, Gateway, Risk assessment, Tobacco harm reduction, Humans, media_common.cataloged_instance, European Union, 030212 general & internal medicine, European union, media_common, Social work, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Tobacco Products, Public relations, Psychiatry and Mental health, Health psychology, Critical appraisal, Smoking Cessation, business, Citation, Environmental Health
Abstract

Background In preparation for the 2021 revision of the European Union Tobacco Products Directive, the Scientific Committee on Health, Environmental and Emerging Risks (SCHEER) has posted its Preliminary Opinion on Electronic Cigarettes. They concluded that e-cigarettes only achieve a sub-optimal level of protection of human health. In this paper, we provide evidence that the Opinion’s conclusions are not adequately backed up by scientific evidence and did not discuss the potential health benefits of using alternative combustion-free nicotine-containing products as substitute for tobacco cigarettes. Methods Searches for articles were conducted in PubMed and by citation chasing in Google Scholar. Articles were also retrieved with a review of references in major publications. Primary data from World Health Organization surveys, the conclusions of reviews, and peer-reviewed non-industry studies were cited to address errors and omissions identified in the Opinion. Results The Opinion omitted reporting on the individual and population health benefits of the substitution of e-cigarettes (ENDS) for cigarette smoking. Alternative hypotheses to the gateway theory were not evaluated. Its assessment of cardiovascular risk is contradicted by numerous reviews. It cites ever-use data that do not represent current patterns of use. It did not report non-nicotine use. It presented erroneous statements on trends in ENDS prevalence. It over-emphasized the role of flavours in youth ENDS initiation. It did not discuss cessation in sufficient length. Conclusions For the delivery of a robust and comprehensive final report, the members of the Working Group of the Scientific Committee on Health, Environmental and Emerging Risks will need to consider (1) the potential health benefits of ENDS substitution for cigarette smoking, (2) alternative hypotheses and contradictory studies on the gateway effect, (3) its assessment of cardiovascular risk, (4) the measurements of frequency of use, (5) non-nicotine use, (6) the role of flavours, and (7) a fulsome discussion of cessation.

Published
2021

21. Endoscopic Endonasal Repair of Congenital Choanal Atresia: Predictive Factors of Surgical Stability and Healing Outcomes

Author

Ferlito, Salvatore, primary, Maniaci, Antonino, additional, Dragonetti, Alberto Giulio, additional, Cocuzza, Salvatore, additional, Lechien, Jerome Rene, additional, Calvo-Henríquez, Christian, additional, Maza-Solano, Juan, additional, Locatello, Luca Giovanni, additional, Caruso, Sebastiano, additional, Nocera, Francesco, additional, Achena, Andrea, additional, Mevio, Niccolò, additional, Mantini, Gabriella, additional, Ormellese, Giorgio, additional, Placentino, Angelo, additional, and La Mantia, Ignazio, additional

Published
2022
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22. High Definition Three-Dimensional Exoscope (VITOM 3D) in E.N.T. Surgery: A Systematic Review of Current Experience

Author

Ferlito, Salvatore, primary, La Mantia, Ignazio, additional, Caruso, Sebastiano, additional, Cammaroto, Giovanni, additional, Chiesa-Estomba, Carlos Miguel, additional, Iannella, Giannicola, additional, Nocera, Francesco, additional, Ingrassia, Angelo, additional, Cocuzza, Salvatore, additional, Vicini, Claudio, additional, Hans, Stephane, additional, Lechien, Jerome Rene, additional, and Maniaci, Antonino, additional

Published
2022
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23. Endoscopic Endonasal Repair of Congenital Choanal Atresia: Predictive Factors of Surgical Stability and Healing Outcomes

Author

Universidad de Sevilla. Departamento de Cirugía, Ferlito, Salvatore, Maniaci, Antonino, Dragonetti, Alberto Giulio, Cocuzza, Salvatore, Lechien, Jerome Rene, Calvo Henriquez, Christian, Maza Solano, Juan Manuel, La Mantia, Ignazio, Universidad de Sevilla. Departamento de Cirugía, Ferlito, Salvatore, Maniaci, Antonino, Dragonetti, Alberto Giulio, Cocuzza, Salvatore, Lechien, Jerome Rene, Calvo Henriquez, Christian, Maza Solano, Juan Manuel, and La Mantia, Ignazio

Abstract

Background: To assess the long-term outcomes and independent predictors of surgical success of a one-stage minimally invasive surgical procedure for congenital choanal atresia (C.C.A.). Methods: a retrospective multicentric study was conducted between 2010 and 2022. An endonasal endoscopic approach was performed in 38 unilateral or bilateral C.C.A. children. All the patients were clinically and radiologically assessed and followed for at least 2 years. Seven outcome measures were applied. Consequently, surgical success was correlated with all the independent variables reported. Results: 18/38 (47.36%) patients presented normal postoperative healing, 8/38 (21.05) had moderate restenosis (<50%), while 12/38 (31.57%) cases were severe (>50%), requiring a surgical revision. No statistical significance was found for average hospital stay between stenosis >50% and <50% patients (p = 0.802) and postoperative pain (p = 0.075); instead, the severe restenosis group demonstrated a higher delay of breast suction (p < 0.001). Among the independent variables predictors of surgical success, the presence of Charge syndrome and rhinopharyngeal stenosis demonstrated higher risks for surgical revision (OR: 4.00, 95% CI: 0.57–28.01, and OR: 2.75, 95% CI: 0.55–13.69, respectively). On the contrary, the hypoplastic inferior turbinate and bilateral C.C.A. showed a lower risk for severe restenosis by a higher endoscopic surgical space and creating a single larger opening (OR: 0.88, 95% CI: 0.22–3.52, and OR: 0.45, 95% CI: 0.10–2.08). Conclusion: Several independent variables could influence the surgical success after C.C.A. endoscopic repair; however, more high-quality evidence is needed to generate an effective predictive model.

Published
2022

24. Cognitive Impairment and Mild to Moderate Dysphagia in Elderly Patients: A Retrospective Controlled Study

Author

Maniaci, Antonino, primary, Lechien, Jérome R, additional, La Mantia, Ignazio, additional, Iannella, Giannicola, additional, Ferlito, Salvatore, additional, Albanese, Gianluca, additional, Magliulo, Giuseppe, additional, Pace, Annalisa, additional, Cammaroto, Giovanni, additional, Di Mauro, Paola, additional, Vicini, Claudio, additional, and Cocuzza, Salvatore, additional

Published
2022
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25. Endoscopic Endonasal Repair of Congenital Choanal Atresia: Predictive Factors of Surgical Stability and Healing Outcomes

Author

Ferlito, Salvatore, Maniaci, Antonino, Dragonetti, Alberto Giulio, Cocuzza, Salvatore, Lechien, Jerome Rene, Calvo Henriquez, Christian, Maza Solano, Juan Manuel, La Mantia, Ignazio, and Universidad de Sevilla. Departamento de Cirugía

Subjects
Transnasal approach, Surgical predictors, Choanal atresia, Long-term outcomes, Endoscopic repair
Abstract

Background: To assess the long-term outcomes and independent predictors of surgical success of a one-stage minimally invasive surgical procedure for congenital choanal atresia (C.C.A.). Methods: a retrospective multicentric study was conducted between 2010 and 2022. An endonasal endoscopic approach was performed in 38 unilateral or bilateral C.C.A. children. All the patients were clinically and radiologically assessed and followed for at least 2 years. Seven outcome measures were applied. Consequently, surgical success was correlated with all the independent variables reported. Results: 18/38 (47.36%) patients presented normal postoperative healing, 8/38 (21.05) had moderate restenosis (50%), requiring a surgical revision. No statistical significance was found for average hospital stay between stenosis >50% and

Published
2022

26. Saccharin Test: Methodological Validation And Systematic Review Of The Literature

Author

Caponnetto, Pasquale, Emma, Rosalia, Benfatto, Francesca, Ferlito, Salvatore, Gulino, Alessandro, Maniaci, Antonino, Lechien, Jerom R., Ingrassia, Riccardo, Cocuzza, Salvatore, and Polosa, Riccardo

Subjects
mucociliary clearance transit time, saccharin transit time test, mucociliary clearance, saccharin test, tolerability, reproducibility
Abstract

Objectives Saccharin test (ST) is a convenient method to assess the efficiency of mucociliary clearance, the primary defense mechanism of the upper airways’ tract. The study objectives are to: (1) substantiate its short- (3 days) and long-term (30 days) repeatability; (2) assess its tolerability; (3) conduct a systematic literature review and to compare our results with the existing evidence. Methods Twenty-nine healthy subjects were enrolled in an observational prospective study to perform an ST on three separate visits (at baseline; at follow-up visits at day 3 and at day 30). Transit times were recorded and self-reported nasal and general symptoms noted. A systematic review of the literature was conducted to compare our results with the existing literature. Results The mean values (±SD) of ST transit time (STTT) were 7.085 (±2.19), 7.788 (±2.11), and 7.790 (±2.06) minutes at baseline, day 3, and day 30, respectively. Significant linear regression analysis was observed between day 3 and baseline (r = .193; P = .019) and day 30 and baseline (r = .182 P = .024). Significant agreement for the intrasession repeatability was observed with an ICC = .354 (P = .001). Outcomes’ comparisons between baseline vs day 3 (P = .197) and baseline vs day 30 (P = .173) were not statistically significant. ST was well tolerated. Concordance with existing literature’s data and high level of STTT repeatability were confirmed by the qualitative analysis. Conclusion STTT reproducibility was good both in the short- and long-term. ST tolerability was very good. Our study data are consistent with the existing literature, indicating ST as a sound methodology for detection of early respiratory health changes and for specific regulatory application in respiratory research.

Published
2021
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27. Post-stroke aphasia at the time of COVID-19 pandemic: a telerehabilitation perspective

Author

Cassarino, Laura, primary, Santoro, Franca, primary, Gelardi, Donatella, primary, Panerai, Simonetta, primary, Papotto, Maurizio, primary, Tripodi, Mariangela, primary, Cosentino, Filomena Irene Ilaria, primary, Neri, Vincenzo, primary, Ferri, Raffaele, primary, Ferlito, Salvatore, primary, Modica, Daniela, primary, Fisicaro, Francesco, primary, Pennisi, Manuela, primary, Bella, Rita, primary, and Lanza, Giuseppe, primary

Published
2022
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35. Universal newborn hearing screening in the Italian Region of Sicily in 2018

Author

Ferlito, Salvatore, primary, Maniaci, Antonino, additional, Cocuzza, Salvatore, additional, La Mantia, Ignazio, additional, Di Mauro, Paola, additional, Poli, Graziella, additional, Maiolino, Luigi, additional, Coco, Salvatore, additional, Merlino, Federico, additional, Maltese, Marina, additional, Ragliani, Margherita, additional, Russo, Michele, additional, Gulino, Alessandro, additional, Azieli, Carmen, additional, Martines, Francesco, additional, Galletti, Francesco, additional, and Bubbico, Luciano, additional

Published
2021
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37. Impact of COVID-19 pandemic on the incidence of otitis media with effusion in adults and children: a multicenter study

Author

Iannella, Giannicola, primary, Magliulo, Giuseppe, additional, Lechien, Jerome R., additional, Maniaci, Antonino, additional, Perrone, Tiziano, additional, Frasconi, Pier Carlo, additional, De Vito, Andrea, additional, Martone, Chiara, additional, Ferlito, Salvatore, additional, Cocuzza, Salvatore, additional, Cammaroto, Giovanni, additional, Meccariello, Giuseppe, additional, Monticone, Valentina, additional, Greco, Antonio, additional, de Vincentiis, Marco, additional, Ralli, Massimo, additional, Savastano, Vincenzo, additional, Bertin, Serena, additional, Pace, Annalisa, additional, Milani, Alessandro, additional, Polimeni, Roberta, additional, Pelucchi, Stefano, additional, Ciorba, Andrea, additional, and Vicini, Claudio, additional

Published
2021
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38. SACCHARIN TRANSIT TIME IN EXCLUSIVE E-CIGARETTES AND HEATED TOBACCO PRODUCTS USERS: A CROSS-SECTIONAL STUDY

Author

Polosa, Riccardo, Emma, Rosalia, Cibella, Fabio, Caruso, Massimo, Conte, Gianluca, Benfatto, Francesca, Ferlito, Salvatore, Gulino, Alessandro, Malerba, Mario, and Caponnetto, Pasquale

Subjects
Smoking, Mucociliary Clearance Transit Time, Saccharin Test, E-cigarette, Heated Tobacco Products, Smoking
Abstract

Tobacco smoking impairs mucociliary clearance (MCC) efficiency as shown by prolonged saccharin test transit time (STTT). Avoiding exposure to tobacco smoke from combustible cigarettes may restore MCC function and former smokers have been shown to exhibit similar STTT as never smokers. The impact of switching from smoking to combustion-free tobacco products such as e-cigarettes (ECs) and heated tobacco products (HTPs) on STTT is not known. We report STTT of exclusive EC and HTP users. Test results were compared to those obtained in current, former, and never smokers. STTT were obtained from 39 current, 40 former, 40 never smokers and from 20 EC and 20 HTP users. Comparison of STTT values showed significant difference among the five study groups (p< 0.00001) with current smokers having a median (IQR) STTT of 13.15 min, which was significantly longer compared to that of all other study groups. In particular, compared to former (7.26 min) and never smokers (7.24 min), exclusive EC users and exclusive HTP users had similar STTT at 7.00 and 8.00 min respectively. Ex-smokers who have switched to exclusive regular use of combustion-free nicotine delivery systems (i.e. ECs and HTPs) exhibit similar saccharin transit time as never and former smokers. This suggests that combustion-free nicotine delivery technologies are unlikely to have detrimental effects on MCC function.

Published
2020

40. Community Use of Face Masks against the Spread of COVID-19

Author

Bubbico, Luciano, primary, Mastrangelo, Giuseppe, additional, Larese-Filon, Francesca, additional, Basso, Paolo, additional, Rigoli, Roberto, additional, Maurelli, Martina, additional, Ferlito, Salvatore, additional, Capelli, Marco, additional, Gisabella, Claudio, additional, Javanbakht, Mohammad, additional, Bellizzi, Saverio, additional, and Cegolon, Luca, additional

Published
2021
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41. Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients

Author

Maniaci, Antonino, primary, Iannella, Giannicola, additional, Cocuzza, Salvatore, additional, Vicini, Claudio, additional, Magliulo, Giuseppe, additional, Ferlito, Salvatore, additional, Cammaroto, Giovanni, additional, Meccariello, Giuseppe, additional, De Vito, Andrea, additional, Nicolai, Alice, additional, Pace, Annalisa, additional, Artico, Marco, additional, and Taurone, Samanta, additional

Published
2021
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46. Voice-Related Quality of Life in Post-Laryngectomy Rehabilitation: Tracheoesophageal Fistula’s Wellness

Author

Cocuzza, Salvatore, primary, Maniaci, Antonino, additional, Grillo, Calogero, additional, Ferlito, Salvatore, additional, Spinato, Giacomo, additional, Coco, Salvatore, additional, Merlino, Federico, additional, Stilo, Giovanna, additional, Santoro, Giovanni Paolo, additional, Iannella, Giannicola, additional, Vicini, Claudio, additional, and Mantia, Ignazio La, additional

Published
2020
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47. Complications and sequelae following tympanostomy tube placement in children with effusion otitis media: Single center experience and review of literature

Author

Ferlito, Salvatore, Cocuzza, SALVATORE GIUSEPPE, Grillo, Calogero, LA MANTIA, Ignazio, Alessandro, Gulino, Bruno, Galletti, Coco, Salvatore, Renna, Claudia, Cipolla, Federica, Milena Di Luca, and Maniaci, Antonino

Subjects
complications, Otitis Media with Effusion, ventilating tube, Otitis Media with Effusion, ventilating tube, complications
Published
2020

50. Therapeutical innovations and medical responsibility: What's new in otolaryngology

Author

Spinato, Giacomo, Cazzato, Giorgio, Ferlito, Salvatore, Tirelli, Giancarlo, Rizzo, Paolo Boscolo, da Mosto, Maria Cristina, Galletti, Bruno, Tonoli, Giovanni, Politi, Doriano, Conti, Angelo, Campione, Gianluca, di Luca, Milena, Gatto, Annalisa, Piovesana, Marco, and Serra, Agostino

Subjects
Molecular biology, Medicine (all), Legally valid consent, Professional responsibility, Law Gelli Bianco, New technologies, Therapeutical innovation
Published
2018

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