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Your search keyword '"Fernández-Susavila, Héctor"' showing total 14 results
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14 results on '"Fernández-Susavila, Héctor"'

1. Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

Author

Capelo-Diz, Alba, Lachiondo-Ortega, Sofía, Fernández-Ramos, David, Cañas-Martín, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, González-Rellan, Maria J., Mosca, Laura, Blazquez-Vicens, Joan, Tinahones-Ruano, Alberto, Fondevila, Marcos F., Buyan, Mason, Delgado, Teresa C., Gutierrez de Juan, Virginia, Ayuso-García, Paula, Sánchez-Rueda, Alejandro, Velasco-Avilés, Sergio, Fernández-Susavila, Héctor, Riobello-Suárez, Cristina, Dziechciarz, Bartlomiej, Montiel-Duarte, Cristina, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, Bilbao-García, Jon, Bernardo-Seisdedos, Ganeko, Senra, Ana, Soriano-Navarro, Mario, Millet, Oscar, Díaz-Lagares, Ángel, Crujeiras, Ana B., Bao-Caamano, Aida, Cabrera, Diana, van Liempd, Sebastiaan, Tamayo-Caro, Miguel, Borzacchiello, Luigi, Gomez-Santos, Beatriz, Buqué, Xabier, Sáenz de Urturi, Diego, González-Romero, Francisco, Simon, Jorge, Rodríguez-Agudo, Rubén, Ruiz, Asier, Matute, Carlos, Beiroa, Daniel, Falcon-Perez, Juan M., Aspichueta, Patricia, Rodríguez-Cuesta, Juan, Porcelli, Marina, Pajares, María A., Ameneiro, Cristina, Fidalgo, Miguel, Aransay, Ana M., Lama-Díaz, Tomas, Blanco, Miguel G., López, Miguel, Villa-Bellosta, Ricardo, Müller, Timo D., Nogueiras, Rubén, Woodhoo, Ashwin, Martínez-Chantar, María Luz, and Varela-Rey, Marta

Published
2023
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2. Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination

Author

Ayuso-García, Paula, primary, Sánchez-Rueda, Alejandro, additional, Velasco-Avilés, Sergio, additional, Tamayo-Caro, Miguel, additional, Ferrer-Pinós, Aroa, additional, Huarte-Sebastian, Cecilia, additional, Alvarez, Vanesa, additional, Riobello, Cristina, additional, Jiménez-Vega, Selene, additional, Buendia, Izaskun, additional, Cañas-Martin, Jorge, additional, Fernández-Susavila, Héctor, additional, Aparicio-Rey, Adrián, additional, Esquinas-Román, Eva M., additional, Ponte, Carlos Rodríguez, additional, Guhl, Romane, additional, Laville, Nicolas, additional, Pérez-Andrés, Encarni, additional, Lavín, José L., additional, González-Lopez, Monika, additional, Cámara, Nuria Macías, additional, Aransay, Ana M., additional, Lozano, Juan José, additional, Sutherland, James D., additional, Barrio, Rosa, additional, Martinez-Chantar, María Luz, additional, Azkargorta, Mikel, additional, Elortza, Félix, additional, Soriano-Navarro, Mario, additional, Matute, Carlos, additional, Sánchez-Gómez, María Victoria, additional, Bayón-Cordero, Laura, additional, Pérez-Samartín, Alberto, additional, Bravo, Susana B., additional, Kurz, Thimo, additional, Lama-Díaz, Tomas, additional, Blanco, Miguel G., additional, Haddad, Saif, additional, Record, Christopher J., additional, van Hasselt, Peter M., additional, Reilly, Mary M., additional, Varela-Rey, Marta, additional, and Woodhoo, Ashwin, additional

Published
2024
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4. Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome

Author

Ávila-Gómez, Paulo, primary, Vieites-Prado, Alba, additional, Dopico-López, Antonio, additional, Bashir, Saima, additional, Fernández-Susavila, Héctor, additional, Gubern, Carme, additional, Pérez-Mato, María, additional, Correa-Paz, Clara, additional, Iglesias-Rey, Ramón, additional, Sobrino, Tomás, additional, Bustamante, Alejandro, additional, Wellmann, Sven, additional, Montaner, Joan, additional, Serena, Joaquín, additional, Castillo, José, additional, Hervella, Pablo, additional, and Campos, Francisco, additional

Published
2020
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5. Human iPSCs use as preclinical model for drug study in cerebrovascular diseases

Author

Fernández Susavila, Héctor, Castillo Sánchez José Antonio, Sobrino Moreiras, Tomás, Campos Pérez, Francisco, Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS), Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde, and Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular

Subjects
Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología [Materias], NOTCH3, Investigación::24 Ciencias de la vida::2407 Biología celular::240701 Cultivo celular [Materias], Human induced pluripotent stem cells, CADASIL
Abstract

Stroke is the main cause of mortality and morbidity in developed countries. A relevant percentage of strokes is due to several cerebrovascular pathologies with genetic background. While the study of these diseases in animal models is proving inefficient, with the development of the cellular reprogramming technology in 2006, a new approach appeared to overcome the existing barriers found in these models. Thanks to the cellular reprogramming technology, the current thesis supposes the first time that an in vitro cellular model with the patient's own cells is achieved for the study of one of these cerebrovascular pathologies, CADASIL, focusing on the abnormal behavior of the mutated protein NOTCH3.

Published
2019

7. Blood glutamate EAAT2-cell grabbing therapy in cerebral ischemia

Author

Pérez-Mato, María, primary, Iglesias-Rey, Ramón, additional, Vieites-Prado, Alba, additional, Dopico-López, Antonio, additional, Argibay, Bárbara, additional, Fernández-Susavila, Héctor, additional, da Silva-Candal, Andrés, additional, Pérez-Díaz, Amparo, additional, Correa-Paz, Clara, additional, Günther, Anne, additional, Ávila-Gómez, Paulo, additional, Isabel Loza, M., additional, Baumann, Arnd, additional, Castillo, José, additional, Sobrino, Tomás, additional, and Campos, Francisco, additional

Published
2019
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8. Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation

Author

Fernández-Susavila, Héctor, primary, Mora, Cristina, additional, Aramburu-Núñez, Marta, additional, Quintas-Rey, Rita, additional, Arias, Susana, additional, Collado, Manuel, additional, López-Arias, Esteban, additional, Sobrino, Tomás, additional, Castillo, José, additional, Dell'Era, Patrizia, additional, and Campos, Francisco, additional

Published
2018
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9. Heads and Tails of Natriuretic Peptides: Neuroprotective Role of Brain Natriuretic Peptide.

Author

Fernández‐Susavila, Héctor, Rodríguez‐Yáñez, Manuel, Dopico‐López, Antonio, Arias, Susana, Santamaría, María, Ávila‐Gómez, Paulo, Doval‐García, Juan M., Sobrino, Tomás, Iglesias‐Rey, Ramón, Castillo, José, Campos, Francisco, Fernández-Susavila, Héctor, Rodríguez-Yáñez, Manuel, Dopico-López, Antonio, Ávila-Gómez, Paulo, Doval-García, Juan M, and Iglesias-Rey, Ramón

Published
2017
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13. Model of Disc Degeneration in Rat Tail Induced Through a Vascular Isolation of Vertebral Endplates.

Author

Fernández-Susavila, Héctor, Pardo-Seco, Juan Pablo, Iglesias-Rey, Ramón, Sobrino, Tomás, Campos, Francisco, and Díez-Ulloa, Máximo Alberto

Subjects
*DEGENERATION (Pathology), *TAILS, *BACKACHE, *PATHOLOGY, *EXTREMITIES (Anatomy)
Abstract

Back pain is a major health problem. The degenerative cascade of the spine begins in the intervertebral disc, due to an impairment in the blood supply through the vertebral endplates. Our objective was to develop a novel disc degeneration model based on these premises, akin to the process in humans, in contrast to other proposed models (puncture, enzyme injection, aberrant loads,…) Material and methods: 37 Sprague-Dawley rats, 2 arms: (a) histological (n = 17, one died), en- bloc sections, Van Gieson staining, (Nisimura-Mochida criteria) and also collagen VI staining (tissue oxidative stress), four animals were euthanized every 2 weeks (2-8); and (b) imaging (n = 20, six wound sloughs), MRI 9.4 Tesla protocol, sequential disc volumetric analysis (24 h-8 weeks) in all animals. Disc degeneration was induced by means of vascular isolation of tail discs endplates either from one side or both. Results: Isolation from both sides caused a progressive degeneration of the disc (p < 0.001 vs. controls), bigger than isolation from one side (p < 0.01 vs. both sides and p < 0.05 vs. controls), as rated by volumetric reduction; furthermore, tissue structural changes (Nisimura-Mochida) and collagen VI deposition confirmed these results. Conclusion: the model here described represents a novel and translational tool that reproduces the intervertebral disc degeneration in a similar way to that taking place in human beings. [ABSTRACT FROM AUTHOR]

Published
2018
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14. Blood glutamate EAAT 2 -cell grabbing therapy in cerebral ischemia.

Author

Pérez-Mato M, Iglesias-Rey R, Vieites-Prado A, Dopico-López A, Argibay B, Fernández-Susavila H, da Silva-Candal A, Pérez-Díaz A, Correa-Paz C, Günther A, Ávila-Gómez P, Isabel Loza M, Baumann A, Castillo J, Sobrino T, and Campos F

Subjects
Animals, Brain Ischemia metabolism, Cell Line, Disease Models, Animal, Excitatory Amino Acid Transporter 2, Glutamate Plasma Membrane Transport Proteins metabolism, HEK293 Cells, Humans, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells cytology, Rats, Transfection, Brain Ischemia therapy, Glutamate Plasma Membrane Transport Proteins genetics, Glutamic Acid blood, Mesenchymal Stem Cells metabolism
Abstract

Background: Excitatory amino acid transporter 2 (EAAT 2 ) plays a pivotal role in glutamate clearance in the adult brain, thereby preventing excitotoxic effects. Considering the high efficacy of EAAT 2 for glutamate uptake, we hypothesized that the expression of this transporter in mesenchymal stem cells (MSCs) for systemic administration could yield a cell-based glutamate-grabbing therapy, combining the intrinsic properties of these cells with excitotoxic protection., Methods: To address this hypothesis, EAAT 2 -encoding cDNA was introduced into MSCs and human embryonic kidney 293 cells (HEK cells) as the control cell line. EAAT 2 expression and functionality were evaluated by in vitro assays. Blood glutamate-grabbing activity was tested in healthy and ischemic rat models treated with 3 × 10 6 and 9 × 10 6 cells/animal., Findings: The expression of EAAT 2 in both cell types conferred the expected glutamate-grabbing activity in in vitro and in vivo studies. The functional improvement observed in ischemic rats treated with EAAT 2 -HEK at low dose, confirmed that this effect was indeed mediated by the glutamate-grabbing activity associated with EAAT 2 functionality. Unexpectedly, both cell doses of non-transfected MSCs induced higher protection than transfected EAAT 2 -MSCs by another mechanism independent of the glutamate-grabbing capacity., Interpretation: Although the transfection procedure most likely interferes with some of the intrinsic protective mechanisms of mesenchymal cells, the results show that the induced expression of EAAT 2 in cells represents a novel alternative to mitigate the excitotoxic effects of glutamate and paves the way to combine this strategy with current cell therapies for cerebral ischemia., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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