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26 results on '"Fernandez, Paulina"'

9. Desalination of Polymer-Flooding Produced Water at Increased Water Recovery and Minimized Energy

Author

Sosa-Fernandez, Paulina A., Post, Jan W., Karemore, Apurva, Bruning, Harry, Rijnaarts, Huub H.M., Sosa-Fernandez, Paulina A., Post, Jan W., Karemore, Apurva, Bruning, Harry, and Rijnaarts, Huub H.M.

Abstract

When desalinating an industrial stream like polymer-flooding produced water via electrodialysis (ED), high water recoveries, low energy consumption, and reduced membrane area are all desirable. However, little effort has been done until now to experimentally achieve these goals. Encouraged by recent and promising results obtained using aliphatic membranes and pulsed electric field, this study experimentally evaluated different strategies and operational conditions to increase the water recovery while keeping a low energy consumption. The results obtained were analyzed to understand the trade-offs in operative time, water recovery, and energy consumption. Finally, the experimental data was employed to perform an economic analysis, which indicated that although further optimization should be possible, current conditions already make ED desalination of polymer-flooding produced water a sound case from an economical point of view.

Published
2020

11. Neurologic Damage and Behavior Disorder in Rubella Children.

Author

Chess, Stella and Fernandez, Paulina

Abstract

A longitudinal study of 214 rubella deaf children (13 to 14 years old) revealed a low incidence (10%) of neurologica damage among those with normal intelligence, but a high incidence (51% to 70%) among those who were mentally retarded or blind. (Author)

Published
1980

12. Impulsivity in Rubella Deaf Children: A Longitudinal Study.

Author

Chess, Stella and Fernandez, Paulina

Abstract

In a longitudinal study of children with congenital rubella, 85 deaf adolescents, 85 deaf multihandicapped, and 34 normal controls were studied with respect to impulsivity. (Author/PHR)

Published
1980

13. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo

Author

Vickers, Clare F., primary, Silva, Ana P. G., additional, Chakraborty, Ajanta, additional, Fernandez, Paulina, additional, Kurepina, Natalia, additional, Saville, Charis, additional, Naranjo, Yandi, additional, Pons, Miquel, additional, Schnettger, Laura S., additional, Gutierrez, Maximiliano G., additional, Park, Steven, additional, Kreiswith, Barry N., additional, Perlin, David S., additional, Thomas, Eric J., additional, Cavet, Jennifer S., additional, and Tabernero, Lydia, additional

Published
2018
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14. Overexpression of LOXIN Protects Endothelial Progenitor Cells From Apoptosis Induced by Oxidized Low Density Lipoprotein

Author

Veas, Carlos, primary, Jara, Casandra, additional, Willis, Naomi D., additional, Pérez-Contreras, Karen, additional, Gutierrez, Nicolas, additional, Toledo, Jorge, additional, Fernandez, Paulina, additional, Radojkovic, Claudia, additional, Zuñiga, Felipe A., additional, Escudero, Carlos, additional, and Aguayo, Claudio, additional

Published
2016
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17. Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosisSurvival and Infection Burden in Vivo

Author

Vickers, Clare F., Silva, Ana P. G., Chakraborty, Ajanta, Fernandez, Paulina, Kurepina, Natalia, Saville, Charis, Naranjo, Yandi, Pons, Miquel, Schnettger, Laura S., Gutierrez, Maximiliano G., Park, Steven, Kreiswith, Barry N., Perlin, David S., Thomas, Eric J., Cavet, Jennifer S., and Tabernero, Lydia

Abstract

Mycobacterium tuberculosisprotein-tyrosine-phosphatase B (MptpB) is a secreted virulence factor that subverts antimicrobial activity in the host. We report here the structure-based design of selective MptpB inhibitors that reduce survival of multidrug-resistant tuberculosis strains in macrophages and enhance killing efficacy by first-line antibiotics. Monotherapy with an orally bioavailable MptpB inhibitor reduces infection burden in acute and chronic guinea pig models and improves the overall pathology. Our findings provide a new paradigm for tuberculosis treatment.

Published
2018
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21. Adenosine A2Aand A3Receptors Are Involved in the Human Endothelial Progenitor Cells Migration

Author

Fernandez, Paulina, Jara, Casandra, Aguilera, Valeria, Caviedes, Liska, Diaz, Francisca, Radojkovic, Claudia, Veas, Carlos, Lamperti, Liliana, Escudero, Carlos, and Aguayo, Claudio

Abstract

Human endothelial progenitor cells (hEPC) are recruited to sites of neovascularization where they differentiate into endothelial cells. The signalsfactors responsible for hEPC migration and adhesion to sites of injury are not well understood. Elevated levels of adenosine are known to increase mature endothelial cell migration in response to tissue injury. However, the understanding of the role of adenosine in the physiology of hEPC is very limited. Using quantitative polymerase chain reaction and western blot analyses, we detected the expression of the adenosine receptors A2A, A2B, and A3in hEPC. Stimulation of adenosine receptors using adenosine or the nonselective agonist adenosine-5'-N-ethylcarboxamide (NECA) increased hEPC migration in 1.4-fold and 2.1-fold (P< 0.01), respectively. Stimulation of hEPC using the A2A-specific agonist CGS-21680 resembled the effect observed in migration when using adenosine or NECA. Consequently, NECA and CGS-21680-stimulated migration of hEPC were reverted using the A2Areceptor antagonist ZM-241385. NECA-stimulated migration was inhibited in dose-dependent manner using MRS-1523 (Kiof 147 ± 0.016 nM), MRS-1754 (Kiof 1900 ± 0.02 nM), or ZM-241385 (Kiof 0.2 ± 0.01 nM). In conclusion, adenosine stimulates hEPC migration by activating A2Aand A3but not A2Breceptors and provides evidence to support a role of adenosine in modulating angiogenic capacity of hEPC.

Published
2012
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