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578 results on '"Fernandez, Soledad A."'

1. Limitations of Noninvasive Tests-Based Population-Level Risk Stratification Strategy for Nonalcoholic Fatty Liver Disease

Author

Behari, Jaideep, Bradley, Allison, Townsend, Kevin, Becich, Michael J., Cappella, Nickie, Chuang, Cynthia H., Fernandez, Soledad A., Ford, Daniel E., Kirchner, H. Lester, Morgan, Richard, Paranjape, Anuradha, Silverstein, Jonathan C., Williams, David A., Donahoo, W. Troy, Asrani, Sumeet K., Ntanios, Fady, Ateya, Mohammad, Hegeman-Dingle, Rozelle, McLeod, Euan, and McTigue, Kathleen

Published
2024
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4. Deciphering the complex intermediate role of health coverage through insurance in the context of well-being by network analysis

Author

Cifuentes, Myriam Patricia and Fernandez, Soledad A.

Subjects
Physics - Physics and Society, Computer Science - Social and Information Networks
Abstract

Recent initiatives that overstate health insurance coverage for well-being conflict with the recognized antagonistic facts identified by the determinants of health that identify health care as an intermediate factor. By using a network of controlled interdependences among multiple social resources including health insurance, which we reconstructed from survey data of the U.S. and Bayesian networks structure learning algorithms, we examined why health insurance through coverage, which in most countries is the access gate to health care, is just an intermediate factor of well-being. We used social network analysis methods to explore the complex relationships involved at general, specific and particular levels of the model. All levels provide evidence that the intermediate role of health insurance relies in a strong relationship to income and reproduces its unfair distribution. Some signals about the most efficient type of health coverage emerged in our analyses.

Published
2016

5. Abstract 13914: Additional ASCVD Risk Factors for Patients With Diabetes: FIB-4 Score and NLR Are Higher in Adults With Diabetes and Current Risk Enhancers vs No Risk Enhancers in Real-World Evidence

Author

Chapagain, Himal, Alish, Yousef, Becich, Michael, Bradley, Alison, Fernandez, Soledad, Ford, Dan, Hwang, Wenke, Jeong, Jong, Jurczak, Martha, Kirchner, H Lester, McTigue, Kathleen M, Morgan, Richard, Paranjape, Anuradha, Thomas, Neena, Williams, David, and Arnold, Jonathan

Published
2022
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7. Abstract 12482: Practical Adherence to AHA/ACC 2018 Guidelines Among Secondary Prevention Patients

Author

Kainat, Aleesha, Alish, Yousef, Ateya, Mohammad, Becich, Michael J, Bradley, Alison, Demicco, David A, Fernandez, Soledad, Ford, Dan, Hegeman-Dingle, Rozelle, Hwang, Wenke, Jeong, Jong, Jurczak, Martha O, Kirchner, H Lester, McLeod, Euan, McTigue, Kathleen M, Morgan, Richard S, Paranjape, Anuradha, Saccone, Phillip, Thomas, Neena, Townsend, Kevin A, Williams, David A, and Arnold, Jonathan

Published
2022
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8. The HEALing (Helping to End Addiction Long-term SM) Communities Study: Protocol for a cluster randomized trial at the community level to reduce opioid overdose deaths through implementation of an integrated set of evidence-based practices

Author

Walsh, Sharon L., El-Bassel, Nabila, Jackson, Rebecca D., Samet, Jeffrey H., Aggarwal, Maneesha, Aldridge, Arnie P., Baker, Trevor, Barbosa, Carolina, Barocas, Joshua A., Battaglia, Tracy A., Beers, Donna, Bernson, Dana, Bowers-Sword, Rachel, Bridden, Carly, Brown, Jennifer L., Bush, Heather M., Bush, Joshua L., Button, Amy, Campbell, Aimee N.C., Cerda, Magdalena, Cheng, Debbie M., Chhatwal, Jag, Clarke, Thomas, Conway, Kevin P., Crable, Erika L., Czajkowski, Andrea, David, James L., Drainoni, Mari-Lynn, Fanucchi, Laura C., Feaster, Daniel J., Fernandez, Soledad, Freedman, Darcy, Freisthler, Bridget, Gilbert, Louisa, Glasgow, LaShawn M., Goddard-Eckrich, Dawn, Gutnick, Damara, Harlow, Kristin, Helme, Donald W., Huang, Terry, Huerta, Timothy R., Hunt, Timothy, Hyder, Ayaz, Kerner, Robin, Keyes, Katherine, Knott, Charles E., Knudsen, Hannah K., Konstan, Michael, Larochelle, Marc R., Craig Lefebvre, R., Levin, Frances, Lewis, Nicky, Linas, Benjamin P., Lofwall, Michelle R., Lounsbury, David, Lyons, Michael S., Mann, Sarah, Marks, Katherine R., McAlearney, Ann, McCollister, Kathryn E., McCrimmon, Tara, Miles, Jennifer, Miller, Cortney C., Nash, Denis, Nunes, Edward, Oga, Emmanuel A., Oser, Carrie B., Plouck, Tracy, Rapkin, Bruce, Freeman, Patricia R., Rodriguez, Sandra, Root, Elisabeth, Rosen-Metsch, Lisa, Sabounchi, Nasim, Saitz, Richard, Salsberry, Pamela, Savitsky, Caroline, Schackman, Bruce R., Seiber, Eric E., Slater, Michael D., Slavova, Svetla, Speer, Drew, Martinez, Linda Sprague, Stambaugh, Leyla F., Staton, Michele, Stein, Michael D., Stevens-Watkins, Danelle J., Surratt, Hilary L., Talbert, Jeffery C., Thompson, Katherine L., Toussant, Kim, Vandergrift, Nathan A., Villani, Jennifer, Walker, Daniel M., Walley, Alexander Y., Walters, Scott T., Westgate, Philip M., Winhusen, Theresa, Wu, Elwin, Young, April M., Young, Greg, Zarkin, Gary A., and Chandler, Redonna K.

Published
2020
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9. Limitations of Noninvasive Tests-Based Population-Level Risk Stratification Strategy for Nonalcoholic Fatty Liver Disease

Author

Behari, Jaideep, primary, Bradley, Allison, additional, Townsend, Kevin, additional, Becich, Michael J., additional, Cappella, Nickie, additional, Chuang, Cynthia H., additional, Fernandez, Soledad A., additional, Ford, Daniel E., additional, Kirchner, H. Lester, additional, Morgan, Richard, additional, Paranjape, Anuradha, additional, Silverstein, Jonathan C., additional, Williams, David A., additional, Donahoo, W. Troy, additional, Asrani, Sumeet K., additional, Ntanios, Fady, additional, Ateya, Mohammad, additional, Hegeman-Dingle, Rozelle, additional, McLeod, Euan, additional, and McTigue, Kathleen, additional

Published
2023
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11. Allele‐specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma

Author

Fleming, Jessica L, Dworkin, Amy M, Allain, Dawn C, Fernandez, Soledad, Wei, Lai, Peters, Sara B, Iwenofu, O Hans, Ridd, Katie, Bastian, Boris C, and Toland, Amanda Ewart

Subjects
Prevention, Cancer, Genetics, Biotechnology, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Allelic Imbalance, Carcinoma, Squamous Cell, Chromosome Mapping, Genotype, Histone Deacetylases, Humans, Polymorphism, Single Nucleotide, Repressor Proteins, Skin Neoplasms, HDAC9, cutaneous squamous cell carcinoma, allelic-specific imbalance, Skts5, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

More than 3.5 million nonmelanoma skin cancers were treated in 2006; of these 700,000 were cutaneous squamous cell carcinomas (cSCCs). Despite clear environmental causes for cSCC, studies also suggest genetic risk factors. A cSCC susceptibility locus, Skts5, was identified on mouse chromosome 12 by linkage analysis. The orthologous locus to Skts5 in humans maps to 7p21 and 7q31. These loci show copy number increases in ∼10% of cSCC tumors. Here, we show that an additional 15-22% of tumors exhibit copy-neutral loss of heterozygosity. Furthermore, our previous data identified microsatellite markers on 7p21 and 7q31 that demonstrate preferential allelic imbalance (PAI) in cSCC tumors. On the basis of these results, we hypothesized that the human orthologous locus to Skts5 would house a gene important in human cSCC development and that tumors would demonstrate allele-specific somatic alterations. To test this hypothesis, we performed quantitative genotyping of 108 single nucleotide polymorphisms (SNPs) mapping to candidate genes at human SKTS5 in paired normal and tumor DNAs. Nine SNPs in HDAC9 (rs801540, rs1178108, rs1178112, rs1726610, rs10243618, rs11764116, rs1178355, rs10269422 and rs12540872) showed PAI in tumors. These data suggest that HDAC9 variants may be selected for during cSCC tumorigenesis.

Published
2014

12. CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.

Author

Jijiwa, Mayumi, Demir, Habibe, Gupta, Snehalata, Leung, Crystal, Joshi, Kaushal, Orozco, Nicholas, Huang, Tiffany, Yildiz, Vedat O, Shibahara, Ichiyo, de Jesus, Jason A, Yong, William H, Mischel, Paul S, Fernandez, Soledad, Kornblum, Harley I, and Nakano, Ichiro

Subjects
Tumor Cells, Cultured, Animals, Mice, Inbred NOD, Humans, Mice, Mice, SCID, Antigens, CD44, RNA, Small Interfering, Blotting, Western, Tissue Array Analysis, Flow Cytometry, Immunohistochemistry, Signal Transduction, Proto-Oncogene Proteins c-akt, Osteopontin, Neoplastic Stem Cells, Real-Time Polymerase Chain Reaction, Hyaluronan Receptors, Tumor Cells, Cultured, Inbred NOD, SCID, Antigens, CD44, RNA, Small Interfering, Blotting, Western, General Science & Technology
Abstract

Identification of stem cell-like brain tumor cells (brain tumor stem-like cells; BTSC) has gained substantial attention by scientists and physicians. However, the mechanism of tumor initiation and proliferation is still poorly understood. CD44 is a cell surface protein linked to tumorigenesis in various cancers. In particular, one of its variant isoforms, CD44v6, is associated with several cancer types. To date its expression and function in BTSC is yet to be identified. Here, we demonstrate the presence and function of the variant form 6 of CD44 (CD44v6) in BTSC of a subset of glioblastoma multiforme (GBM). Patients with CD44(high) GBM exhibited significantly poorer prognoses. Among various variant forms, CD44v6 was the only isoform that was detected in BTSC and its knockdown inhibited in vitro growth of BTSC from CD44(high) GBM but not from CD44(low) GBM. In contrast, this siRNA-mediated growth inhibition was not apparent in the matched GBM sample that does not possess stem-like properties. Stimulation with a CD44v6 ligand, osteopontin (OPN), increased expression of phosphorylated AKT in CD44(high) GBM, but not in CD44(low) GBM. Lastly, in a mouse spontaneous intracranial tumor model, CD44v6 was abundantly expressed by tumor precursors, in contrast to no detectable CD44v6 expression in normal neural precursors. Furthermore, overexpression of mouse CD44v6 or OPN, but not its dominant negative form, resulted in enhanced growth of the mouse tumor stem-like cells in vitro. Collectively, these data indicate that a subset of GBM expresses high CD44 in BTSC, and its growth may depend on CD44v6/AKT pathway.

Published
2011

13. Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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14. Supplementary Data from Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

Author

Wu, Jinghai, primary, Liu, Xin, primary, Reeser, Julie A. Wallace, primary, Trimboli, Anthony J., primary, Pécot, Thierry, primary, Sizemore, Gina M., primary, Naidu, Shan K., primary, Fernandez, Soledad A., primary, Yu, Lianbo, primary, Hallett, Michael, primary, Park, Morag, primary, Leone, Gustavo W., primary, Hildreth, Blake E., primary, and Ostrowski, Michael C., primary

Published
2023
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15. Neutralization Escape of Omicron XBB, BR.2, and BA.2.3.20 Subvariants

Author

Faraone, Julia N., primary, Qu, Panke, additional, Evans, John P., additional, Zheng, Yi-Min, additional, Carlin, Claire, additional, Anghelina, Mirela, additional, Stevens, Patrick, additional, Fernandez, Soledad, additional, Jones, Daniel, additional, Lozanski, Gerard, additional, Panchal, Ashish, additional, Saif, Linda J., additional, Oltz, Eugene M., additional, Gumina, Richard J., additional, and Liu, Shan-Lu, additional

Published
2023
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16. Enhanced Evasion of Neutralizing Antibody Response by Omicron XBB.1.5, CH.1.1 and CA.3.1 Variants

Author

Qu, Panke, primary, Faraone, Julia N., additional, Evans, John P., additional, Zheng, Yi-Min, additional, Carlin, Claire, additional, Anghelina, Mirela, additional, Stevens, Patrick, additional, Fernandez, Soledad, additional, Jones, Daniel, additional, Panchal, Ashish R., additional, Saif, Linda J., additional, Oltz, Eugene M., additional, Zhang, Baoshan, additional, Zhou, Tongqing, additional, Xu, Kai, additional, Gumina, Richard J., additional, and Liu, Shan-Lu, additional

Published
2023
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20. Proyecto Arqueológico Taraco Informe de las Excavaciones de la Temporada del 2004 en los Sitios de Kumi Kipa, Sonaji y Chiripa

Author

Hastorf, Christine A., Bandy, Matthew, Whitehead, William, Steadman, Lee, Moore, Katherine, Paz Soria, Jose Luis, Roddick, Andrew, Bruno, Maria, Fernandez, Soledad, Killackey, Kathryn, Logan, Amanda, Ullua Vidaurre, Delfor, Callisaya, Luis, Capriles Flores, José, Stovel, Emily, Raath, Mariana, and Antonites, Xander

Subjects
Archaeological Anthropology, arqueología, anthropología, rituales, botanía, arqueobotanía, microstratígrafía, ethnoarchaeologia, bolivia, andes, latino america, america sur
Published
2005

29. Supplementary Figure 2 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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30. Supplementary Data from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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31. Supplementary Table 1, Figures 1 - 3 from Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma

Author

Bid, Hemant K., primary, Kibler, Aaron, primary, Phelps, Doris A., primary, Manap, Sagymbek, primary, Xiao, Linlin, primary, Lin, Jiayuh, primary, Capper, David, primary, Oswald, Duane, primary, Geier, Brian, primary, DeWire, Mariko, primary, Smith, Paul D., primary, Kurmasheva, Raushan T., primary, Mo, Xiaokui, primary, Fernandez, Soledad, primary, and Houghton, Peter J., primary

Published
2023
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33. Supplementary Figure 1 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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36. Supplementary Figure 3 from Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy

Author

Passaro, Carmela, primary, Alayo, Quazim, primary, DeLaura, Isabel, primary, McNulty, John, primary, Grauwet, Korneel, primary, Ito, Hirotaka, primary, Bhaskaran, Vivek, primary, Mineo, Marco, primary, Lawler, Sean E., primary, Shah, Khalid, primary, Speranza, Maria C., primary, Goins, William, primary, McLaughlin, Eric, primary, Fernandez, Soledad, primary, Reardon, David A., primary, Freeman, Gordon J., primary, Chiocca, E. Antonio, primary, and Nakashima, Hiroshi, primary

Published
2023
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48. Supplementary Figure Legends 1-3 from Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

Author

Williams, Shanté P., primary, Nowicki, Michal O., primary, Liu, Fang, primary, Press, Rachael, primary, Godlewski, Jakub, primary, Abdel-Rasoul, Mahmoud, primary, Kaur, Balveen, primary, Fernandez, Soledad A., primary, Chiocca, E. Antonio, primary, and Lawler, Sean E., primary

Published
2023
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49. Enhanced neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, BA.4.6, BF.7, and BA.2.75.2

Author

Qu, Panke, primary, Evans, John P., additional, Faraone, Julia N., additional, Zheng, Yi-Min, additional, Carlin, Claire, additional, Anghelina, Mirela, additional, Stevens, Patrick, additional, Fernandez, Soledad, additional, Jones, Daniel, additional, Lozanski, Gerard, additional, Panchal, Ashish, additional, Saif, Linda J., additional, Oltz, Eugene M., additional, Xu, Kai, additional, Gumina, Richard J., additional, and Liu, Shan-Lu, additional

Published
2023
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50. Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia

Author

Pitarresi, Jason R., Liu, Xin, Sharma, Sudarshana M., Cuitiño, Maria C., Kladney, Raleigh D., Mace, Thomas A., Donohue, Sydney, Nayak, Sunayana G., Qu, Chunjing, Lee, James, Woelke, Sarah A., Trela, Stefan, LaPak, Kyle, Yu, Lianbo, McElroy, Joseph, Rosol, Thomas J., Shakya, Reena, Ludwig, Thomas, Lesinski, Gregory B., Fernandez, Soledad A., Konieczny, Stephen F., Leone, Gustavo, Wu, Jinghai, and Ostrowski, Michael C.

Published
2016
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