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1. Specific IgE to individual allergen components: Fruits and vegetables

Author: Fernández-Rivas, Montserrat, primary, Vera-Berrios, Rosialzira Natasha, additional, and Marco-Martín, Guadalupe, additional
Published: 2024
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2. Food-Induced Anaphylaxis: Data From the European Anaphylaxis Registry

Author: Dölle-Bierke, Sabine, Höfer, Veronika, Francuzik, Wojciech, Näher, Anatol-Fiete, Bilo, Maria Beatrice, Cichocka-Jarosz, Ewa, Lopes de Oliveira, Lucila C., Fernandez-Rivas, Montserrat, García, Blanca E., Hartmann, Karin, Jappe, Uta, Köhli, Alice, Lange, Lars, Maris, Ioana, Mustakov, Tihomir Bogdanov, Nemat, Katja, Ott, Hagen, Papadopoulos, Nikolaos G., Pföhler, Claudia, Ruëff, Franziska, Sabouraud-Leclerc, Dominique, Spindler, Thomas, Stock, Philippe, Treudler, Regina, Vogelberg, Christian, Wagner, Nicola, and Worm, Margitta
Published: 2023
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3. Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis

Author: Zuberbier, Torsten, Wood, Robert A., Bindslev-Jensen, Carsten, Fiocchi, Alessandro, Chinthrajah, R. Sharon, Worm, Margitta, Deschildre, Antoine, Fernandez-Rivas, Montserrat, Santos, Alexandra F., Jaumont, Xavier, and Tassinari, Paolo
Published: 2023
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4. Participant characteristics and safety outcomes of peanut oral immunotherapy in the RAMSES and ARC011 trials

Author: Assa'ad, Amal H., Bernstein, David I., Bird, J. Andrew, Carr, Tara F., Carr, Warner W., Cheema, Amarjit S., Corren, Jonathan, Darter, Amy Liebl, Dorsey, Morna J., Fineman, Stanley M., Fleischer, David M., Fritz, Stephen B., Gogate, Shaila U., Greiner, Alexander N., Hampel, Frank C., Jr., Jacobs, Joshua S., Jain, Sanjeev, Jarvinen-Seppo, Kirsi, Jeong, David K., Johnston, Douglas T., Kachru, Rita, Kim, Edwin H., Koleilat, Majed, Lanser, Bruce J., Leonard, Stephanie A., Maier, Mary C., Manning, Michael E., Mansfield, Lyndon E., Matz, Jonathan, Nadeau, Kari, Ohayon, Jason A., Perez, Elena, Petroni, Daniel H., Pollard, Stephen J., Ponda, Punita, Portnoy, Jay M., Rachid, Rima, Ratner, Paul H., Robison, Rachel, Rupp, Ned T., Sanders, Georgiana M., Sharma, Hemant P., Sher, Ellen R., Sher, Lawrence D., Sher, Mandel, Shreffler, Wayne G., Siri, Dareen D., Skolnick, Helen S., Soong, Weily, Soteres, Daniel F., Spergel, Jonathan M., Stillerman, Allan, Sussman, Gordon L., Tam, Jonathan, Varshney, Pooja, Waserman, Susan, Windom, Hugh H., Wood, Robert, Yang, William H., Ciaccio, Christina, Goldsobel, Alan B., Anagnostou, Aikaterini, Beyer, Kirsten, Casale, Thomas B., Deschildre, Antoine, Fernández-Rivas, Montserrat, Hourihane, Jonathan O'B., Krawiec, Marta, Lieberman, Jay, Scurlock, Amy M., Vickery, Brian P., Smith, Alex, Tilles, Stephen A., Adelman, Daniel C., and Brown, Kari R.
Published: 2022
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5. Managing food allergy: GA2LEN guideline 2022

Author: Bansal, Priya, Berni–Canani, Roberto, Blumchen, Katharina, Bonertz, Andreas, Bourgoin-Heck, Melisande, Ceylon, Ozlem, Divaret-Chauveau, Amandine, Fleischer, David, Gomez, Maximiliano, Groetch, Marion, Hernandez, Domingo Barber, Hjorth, Betina, Hussey, Lydia Collins, Knulst, André C., Leung, Agnes, Mack, Douglas, Mahler, Vera, Mori, Francesca, Namazova-Baranova, Leyla, Palosuo, Kati, Parisi, Claudio Alberto Salvador, Pastorino, Antonio Carlos, Rudzeviciene, Odilija, Said, Maria, Sawiec, Piotr, Sicherer, Scott, Sato, Sakura, Zubchenko, Svitlana, Muraro, Antonella, de Silva, Debra, Halken, Susanne, Worm, Margitta, Khaleva, Ekaterina, Arasi, Stefania, Dunn-Galvin, Audrey, Nwaru, Bright I., De Jong, Nicolette W., Rodríguez Del Río, Pablo, Turner, Paul J., Smith, Pete, Begin, Philippe, Angier, Elizabeth, Arshad, Hasan, Ballmer-Weber, Barbara, Beyer, Kirsten, Bindslev-Jensen, Carsten, Cianferoni, Antonella, Demoulin, Céline, Deschildre, Antoine, Ebisawa, Motohiro, Fernandez-Rivas, Maria Montserrat, Fiocchi, Alessandro, Flokstra-de Blok, Bertine, Gerdts, Jennifer, Gradman, Josefine, Grimshaw, Kate, Jones, Carla, Lau, Susanne, Loh, Richard, Alvaro Lozano, Montserrat, Makela, Mika, Marchisotto, Mary Jane, Meyer, Rosan, Mills, Clare, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nurmatov, Ulugbek, Pajno, Giovanni, Podestà, Marcia, Poulsen, Lars K., Sampson, Hugh A., Sanchez, Angel, Schnadt, Sabine, Szajewska, Hania, Van Ree, Ronald, Venter, Carina, Vlieg-Boerstra, Berber, Warner, Amena, Wong, Gary, Wood, Robert, Zuberbier, Torsten, and Roberts, Graham
Published: 2022
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6. WAO consensus on DEfinition of Food Allergy SEverity (DEFASE)

Author: Stefania Arasi, MD, PhD, MSc, Ulugbek Nurmatov, MD, Audrey Dunn-Galvin, PhD, Graham Roberts, DM, Paul J. Turner, FRCPCH, PhD, Sayantani B. Shinder, MD, PhD, Ruchi Gupta, MD, MPh, Philippe Eigenmann, MD, Anna Nowak-Wegrzyn, MD, PhD, Ignacio J. Ansotegui, MD, PhD, Montserrat Fernandez Rivas, MD, Stavros Petrou, PhD, Luciana K. Tanno, MD, PhD, Marta Vazquez-Ortiz, MD, PhD, Brian Vickery, MD, PhD, Gary Wong, MD, FRCPC, Montserrat Alvaro-Lozano, MD, PhD, Miqdad Asaria, PhD, Philippe Begin, MD, MSc, Martin Bozzola, MD, Robert Boyle, MD, Helen Brough, MD, PhD, Victoria Cardona, MD, PhD, R. Sharon Chinthrajah, MD, PhD, Antonella Cianferoni, MD, Antoine Deschildre, MD, David Fleischer, MD, Flavio Gazzani, PhD, Jennifer Gerdts, Marilena Giannetti, PhD, Matthew Greenhawt, MD, MBA, MSc, Maria Antonieta Guzmán, MD, Elham Hossny, MD, PhD, FAAAAI, Paula Kauppi, MD, Carla Jones, Francesco Lucidi, PhD, Olga Patricia Monge Ortega, MD, PhD, Daniel Munblit, MD, PhD, Antonella Muraro, MD, Giovanni Pajno, MD, Marcia Podestà, Pablo Rodriguez del Rio, MD, PhD, Maria Said, Alexandra Santos, MD, MSc, MRCPCH, PGCAP, FHEA, PhD, Marcus Shaker, MD, Hania Szajewska, MD, PhD, Carina Venter, PhD, Cristopher Warren, PhD, Tonya Winders, Motohiro Ebisawa, MD, PhD, and Alessandro Fiocchi, MD
Subjects: Consensus, Definition, Food allergy, Severity, e-Delphi study, Immunologic diseases. Allergy, RC581-607
Abstract: Background: While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole. Aim: To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. Methods: Phase 1: We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Phase 2: Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from “strongly agree” to “strongly disagree”. Median scores and percentage agreements were calculated. Consensus was defined a priori as being achieved if 70% or more of panel members rated a statement as “strongly agree” to “agree” after the second round. Based on feedback, 2 additional online voting rounds were conducted. Results: We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score. Conclusions: The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.
Published: 2023
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7. Improving Severity Scoring of Food-Induced Allergic Reactions: A Global “Best-Worst Scaling” Exercise

Author: Stafford, Aisling, Bartra, Joan, Aston, Antony, Mills, E. N. Clare, Fernandez-Rivas, Montserrat, and Turner, Paul J.
Published: 2021
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8. Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study

Author: Sina M. Erhard, Johanna Bellach, Songül Yürek, Sebastian Tschirner, Valérie Trendelenburg, Linus B. Grabenhenrich, Montserrat Fernandez-Rivas, Ronald van Ree, Thomas Keil, and Kirsten Beyer
Subjects: Birch-pollen, Epidemiology, Food allergy, Hazelnut, Seasonal allergic rhinitis, Immunologic diseases. Allergy, RC581-607
Abstract: Background: Primary hazelnut allergy is a common cause of anaphylaxis in children, as compared to birch-pollen associated hazelnut allergy. Population-based data on hazelnut and concomitant birch-pollen allergy in children are lacking. We aimed to investigate the prevalence of primary and pollen-associated hazelnut allergy and sensitization profiles in school-aged children in Berlin, Germany. Methods: 1570 newborn children were recruited in Berlin in 2005–2009. The school-age follow-up (2014–2017) was based on a standardized web-based parental questionnaire and clinical evaluation by a physician including skin prick tests, allergen specific immunoglobulin E serum tests and placebo-controlled double-blind oral food challenges, if indicated. Results: 1004 children (63.9% response) participated in the school-age follow-up assessment (52.1% male). For 1.9% (n = 19, 95%-confidence interval 1.1%–2.9%) of children their parents reported hazelnut-allergic symptoms, for half of these to roasted hazelnut indicating primary hazelnut allergy. Symptoms of birch-pollen allergy were reported for 11.6% (n = 116 95%-CI 9.7%–13.7%) of the children. Both birch-pollen allergy and hazelnut allergy associated symptoms affected 0.6% (n = 6, 95%-CI 0.2%–1.3%) of children. Assessment of allergic sensitization was performed in 261 participants and showed that almost 20% of these children were sensitized to hazelnut, being the most frequent of all assessed food allergens, or birch-pollen, the majority to both. Conclusions: Based on parental reports hazelnut-allergic symptoms were far less common than sensitization to hazelnut. This needs to be considered by physicians to avoid unnecessary changes in diet due to sensitization profiles only, especially when there is a co-sensitization to hazelnut and birch-pollen.
Published: 2021
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9. Primary and pollen-associated hazelnut allergy in school-aged children in Germany: A birth cohort study

Author: Erhard, Sina M., Bellach, Johanna, Yürek, Songül, Tschirner, Sebastian, Trendelenburg, Valérie, Grabenhenrich, Linus B., Fernandez-Rivas, Montserrat, van Ree, Ronald, Keil, Thomas, and Beyer, Kirsten
Published: 2021
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10. Managing food allergy: GA2LEN guideline 2022

Author: Antonella Muraro, MD, Debra de Silva, PhD, Susanne Halken, DM DMSc, Margitta Worm, MD∗, Ekaterina Khaleva, MD MSc, Stefania Arasi, MD PhD, Audrey Dunn-Galvin, PhD, Bright I. Nwaru, PhD, Nicolette W. De Jong, PhD, Pablo Rodríguez Del Río, MD PhD, Paul J. Turner, FRCPCH PhD, Pete Smith, FRACP PhD, Philippe Begin, MD MSc, Elizabeth Angier, MSc, Hasan Arshad, DM, Barbara Ballmer-Weber, PhD, Kirsten Beyer, MD, Carsten Bindslev-Jensen, MD PhD DSc, Antonella Cianferoni, MD PhD, Céline Demoulin, Antoine Deschildre, MD, Motohiro Ebisawa, MD PhD, Maria Montserrat Fernandez-Rivas, DM PhD, Alessandro Fiocchi, MD, Bertine Flokstra-de Blok, PhD, Jennifer Gerdts, Josefine Gradman, MD, Kate Grimshaw, PhD, Carla Jones, Susanne Lau, MD, Richard Loh, FRACP, Montserrat Alvaro Lozano, MD, Mika Makela, MD PhD, Mary Jane Marchisotto, Rosan Meyer, PhD, Clare Mills, PhD, Caroline Nilsson, MD PhD, Anna Nowak-Wegrzyn, MD PhD, Ulugbek Nurmatov, PhD, Giovanni Pajno, MD, Marcia Podestà, Lars K. Poulsen, PhD, Hugh A. Sampson, MD, Angel Sanchez, Sabine Schnadt, Hania Szajewska, MD, Ronald Van Ree, PhD, Carina Venter, PhD, Berber Vlieg-Boerstra, PhD, Amena Warner, Gary Wong, MD FRCPC, Robert Wood, MD, Torsten Zuberbier, MD, Graham Roberts, DM, Priya Bansal, Roberto Berni–Canani, Katharina Blumchen, Andreas Bonertz, Melisande Bourgoin-Heck, Ozlem Ceylon, Amandine Divaret-Chauveau, David Fleischer, Maximiliano Gomez, Marion Groetch, Domingo Barber Hernandez, Betina Hjorth, Lydia Collins Hussey, André C. Knulst, Agnes Leung, Douglas Mack, Vera Mahler, Francesca Mori, Leyla Namazova-Baranova, Kati Palosuo, Claudio Alberto Salvador Parisi, Antonio Carlos Pastorino, Odilija Rudzeviciene, Maria Said, Piotr Sawiec, Scott Sicherer, Sakura Sato, and Svitlana Zubchenko
Subjects: Food allergy, Food hypersensitivity, Children, Adolescent, Adults, Immunologic diseases. Allergy, RC581-607
Abstract: Food allergy affects approximately 2–4% of children and adults. This guideline provides recommendations for managing food allergy from the Global Allergy and Asthma European Network (GA2LEN). A multidisciplinary international Task Force developed the guideline using the Appraisal of Guidelines for Research and Evaluation (AGREE) II framework and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We reviewed the latest available evidence as of April 2021 (161 studies) and created recommendations by balancing benefits, harms, feasibility, and patient and clinician experiences. We suggest that people diagnosed with food allergy avoid triggering allergens (low certainty evidence). We suggest that infants with cow's milk allergy who need a breastmilk alternative use either hypoallergenic extensively hydrolyzed cow's milk formula or an amino acid-based formula (moderate certainty). For selected children with peanut allergy, we recommend oral immunotherapy (high certainty), though epicutaneous immunotherapy might be considered depending on individual preferences and availability (moderate certainty). We suggest considering oral immunotherapy for children with persistent severe hen's egg or cow's milk allergy (moderate certainty). There are significant gaps in evidence about safety and effectiveness of the various strategies. Research is needed to determine the best approaches to education, how to predict the risk of severe reactions, whether immunotherapy is cost-effective and whether biological therapies are effective alone or combined with allergen immunotherapy.
Published: 2022
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11. Wheat Anaphylaxis in Adults Differs from Reactions to Other Types of Food

Author: Kraft, Magdalena, Dölle-Bierke, Sabine, Renaudin, Jean-Marie, Ruëff, Franziska, Scherer Hofmeier, Kathrin, Treudler, Regina, Pföhler, Claudia, Hawranek, Thomas, Poziomkowska-Gęsicka, Iwona, Jappe, Uta, Christoff, George, Müller, Sabine, Fernandez-Rivas, Montserrat, García, Blanca E., De Vicente Jiménez, Talía M., Cardona, Victoria, Kleinheinz, Andreas, Kreft, Burkhard, Bauer, Andrea, Wagner, Nicola, Wedi, Bettina, Wenzel, Markus, Bilò, Maria Beatrice, and Worm, Margitta
Published: 2021
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12. Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study

Author: Vickery, Brian P., Vereda, Andrea, Nilsson, Caroline, du Toit, George, Shreffler, Wayne G., Burks, A. Wesley, Jones, Stacie M., Fernández-Rivas, Montserrat, Blümchen, Katharina, O’B. Hourihane, Jonathan, Beyer, Kirsten, Anagnostou, Aikaterini, Assa’ad, Amal H., Ben-Shoshan, Moshe, Bird, J. Andrew, Carr, Tara F., Carr, Warner W., Casale, Thomas B., Chong, Hey Jin, Ciaccio, Christina E., Dorsey, Morna J., Fineman, Stanley M., Fritz, Stephen B., Greiner, Alexander N., Greos, Leon S., Hampel, Frank C., Jr., Ibáñez, Maria Dolores, Jeong, David K., Johnston, Douglas T., Kachru, Rita, Kim, Edwin H., Lanser, Bruce J., Leonard, Stephanie A., Maier, Mary C., Mansfield, Lyndon E., Muraro, Antonella, Ohayon, Jason A., Oude Elberink, Joanna N.G., Petroni, Daniel H., Pongracic, Jacqueline A., Portnoy, Jay M., Rachid, Rima, Rupp, Ned T., Sanders, Georgiana M., Sharma, Hemant P., Sharma, Vibha, Sher, Ellen R., Sher, Lawrence, Sindher, Sayantani B., Siri, Dareen, Spergel, Jonathan M., Sprikkelman, Aline B., Sussman, Gordon L., Tsoumani, Marina, Varshney, Pooja, Vitalpur, Girish, Wang, Julie, Yang, William H., Zubeldia, José Manuel, Smith, Alex, Ryan, Robert, and Adelman, Daniel C.
Published: 2021
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13. Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review

Author: Arasi, Stefania, Nurmatov, Ulugbek, Dunn-Galvin, Audrey, Daher, Shahd, Roberts, Graham, Turner, Paul J., Shinder, Sayantani B., Gupta, Ruchi, Eigenmann, Philippe, Nowak-Wegrzyn, Anna, Sánchez Borges, Mario A., Ansotegui, Ignacio J., Fernandez-Rivas, Montserrat, Petrou, Stavros, Tanno, Luciana Kase, Vazquez-Ortiz, Marta, Vickery, Brian P., Wong, Gary Wing-Kin, Ebisawa, Motohiro, and Fiocchi, Alessandro
Published: 2021
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14. Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity

Author: Lyons, Sarah A., Datema, Mareen R., Le, Thuy-My, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Fritsche, Philipp, Gislason, David, Hoffmann-Sommergruber, Karin, Jedrzejczak-Czechowicz, Monika, Jongejan, Laurian, Kowalski, Marek L., Kralimarkova, Tanya Z., Lidholm, Jonas, Papadopoulos, Nikolaos G., Pontoppidan, Bo, Popov, Todor A., Prado, Nayade del, Purohit, Ashok, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Vassilopoulou, Emilia, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Welsing, Paco M.J., Mills, E.N. Clare, Ballmer-Weber, Barbara K., Knulst, André C., Fernández-Rivas, Montserrat, and Van Ree, Ronald
Published: 2021
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15. Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Author: Arasi, Stefania, Nurmatov, Ulugbek, Turner, Paul J., Ansotegui, Ignacio J., Daher, Shahd, Dunn-Galvin, Audrey, Ebisawa, Motohiro, Eigenmann, Philippe, Fernandez-Rivas, Montserrat, Gupta, Ruchi, Nowak-Wegrzyn, Anna, Petrou, Stavros, Roberts, Graham, Sánchez Borges, Mario A., Sindher, Sayantani B., Tanno, Luciana Kase, Vazquez-Ortiz, Marta, Vickery, Brian P., Wong, Gary Wing-Kin, and Fiocchi, Alessandro
Published: 2020
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16. Risk Factors and Characteristics of Biphasic Anaphylaxis

Author: Kraft, Magdalena, Scherer Hofmeier, Kathrin, Ruëff, Franziska, Pföhler, Claudia, Renaudin, Jean-Marie, Bilò, Maria Beatrice, Treudler, Regina, Lang, Roland, Cichocka-Jarosz, Ewa, Fernandez-Rivas, Montserrat, Christoff, George, Papadopoulos, Nikolaos G., Ensina, Luis Felipe, Hourihane, Jonathan O’B., Maris, Ioana, Koehli, Alice, García, Blanca E., Jappe, Uta, Vogelberg, Christian, Ott, Hagen, Lange, Lars, Spindler, Thomas, Dölle-Bierke, Sabine, and Worm, Margitta
Published: 2020
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17. Predictors of Food Sensitization in Children and Adults Across Europe

Author: Lyons, Sarah A., Knulst, André C., Burney, Peter G.J., Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara K., Barreales, Laura, Bieli, Christian, Clausen, Michael, Dubakiene, Ruta, Fernández-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kummeling, Ischa, Mustakov, Tihomir B., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Potts, James, Xepapadaki, Paraskevi, Welsing, Paco M.J., Mills, E. N. Clare, van Ree, Ronald, and Le, Thuy-My
Published: 2020
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18. World Allergy Organization Anaphylaxis Guidance 2020

Author: Cardona, Victoria, Ansotegui, Ignacio J., Ebisawa, Motohiro, El-Gamal, Yehia, Fernandez Rivas, Montserrat, Fineman, Stanley, Geller, Mario, Gonzalez-Estrada, Alexei, Greenberger, Paul A., Sanchez Borges, Mario, Senna, Gianenrico, Sheikh, Aziz, Tanno, Luciana Kase, Thong, Bernard Y., Turner, Paul J., and Worm, Margitta
Published: 2020
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19. Prevalence of Food Sensitization and Food Allergy in Children Across Europe

Author: Lyons, Sarah A., Clausen, Michael, Knulst, André C., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Bieli, Christian, Dubakiene, Ruta, Fernandez-Perez, Cristina, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Papadopoulos, Nikolaos G., Popov, Todor A., Xepapadaki, Paraskevi, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Burney, Peter G.J., and Le, Thuy-My
Published: 2020
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20. Comparative Study of Food Allergies in Children from China, India, and Russia: The EuroPrevall-INCO Surveys

Author: Li, Jing, Ogorodova, Ludmila M., Mahesh, Padukudru Anand, Wang, Maggie Haitian, Fedorova, Olga Sergeevna, Leung, Ting Fan, Fernandez-Rivas, Montserrat, Mills, E.N. Clare, Potts, James, Kummeling, Ischa, Versteeg, Serge A., van Ree, Ronald, Yazdanbakhsh, Maria, Burney, Peter G.J., and Wong, Gary W.K.
Published: 2020
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21. Safety of Food Oral Immunotherapy: What We Know, and What We Need to Learn

Author: Vázquez-Cortés, Sonia, Jaqueti, Paloma, Arasi, Stefania, Machinena, Adrianna, Alvaro-Lozano, Montserrat, and Fernández-Rivas, Montserrat
Published: 2020
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22. Evaluation of clinical outcomes of efficacy in food allergen immunotherapy trials, COFAITH EAACI task force

Author: Rodríguez del Río, Pablo, primary, Álvaro‐Lozano, Montserrat, additional, Arasi, Stefania, additional, Bazire, Raphaëlle, additional, Escudero, Carmelo, additional, Patel, Nandinee, additional, Sandoval‐Ruballos, Monica, additional, Vazquez‐Ortiz, Marta, additional, Nowak‐Wegrzyn, Anna, additional, Blümchen, Katharina, additional, Dunn Galvin, Audrey, additional, Deschildre, Antoine, additional, Greenhawt, Matthew, additional, Schnadt, Sabine, additional, Riggioni, Carmen, additional, Remington, Benjamin C., additional, Turner, Paul, additional, and Fernandez Rivas, Montserrat, additional
Published: 2024
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23. Exploratory immunogenicity outcomes of peanut oral immunotherapy: Findings from the PALISADE trial

Author: Nilsson, Caroline, primary, Vereda, Andrea, additional, Borres, Magnus P., additional, Andersson, Mats, additional, Södergren, Eva, additional, Rudengren, Magnus, additional, Smith, Alex, additional, Simon, Reyna J., additional, Ryan, Robert, additional, Fernández‐Rivas, Montserrat, additional, Adelman, Daniel, additional, and Vickery, Brian P., additional
Published: 2024
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24. EAACI Task force Clinical epidemiology of anaphylaxis: experts’ perspective on the use of adrenaline autoinjectors in Europe

Author: Magdalena Kraft, Sabine Dölle-Bierke, Paul J. Turner, Antonella Muraro, Montserrat Fernández-Rivas, Linus Grabenhenrich, and Margitta Worm
Subjects: Anaphylaxis, Anaphylactic reaction, Adrenaline autoinjector, AAI, Epinephrine autoinjector, European Academy of Allergy and Clinical Immunology guidelines, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract Background Worldwide, guidelines recommend the use of adrenaline autoinjectors (AAIs) for self-medication in patients who experience severe allergic reaction. The European Medical Agency recommends the prescription of two AAIs, which should be carried by patients at all times. The European Academy of Allergy and Clinical Immunology guidelines propose to prescribe a second AAI under some defined conditions. In the present study, we aimed to examine the adherence to these guidelines and prescription behavior of allergy experts regarding the number of AAIs prescribed for a given patient. Methods A standardized questionnaire was applied to the participants of the 5th International Conference of the Network of Online Registration for Anaphylaxis (NORA e. V.). Twenty-six experts (medical doctors with at least 2 years of experience in the field of anaphylaxis) answered the questions regarding the number of autoinjectors prescribed and the reasons influencing their decisions. Results Sixty-eight percent of the experts usually prescribed one AAI, while 32% prescribed two. The pediatricians and physicians with less experience tended to prescribe two autoinjectors more frequently. The experts were more likely to prescribe two adrenaline autoinjectors if the patient was a child, had a previous severe reaction, had mastocytosis, asthma, cardiovascular disease, or high body weight, or lived far from the emergency department. Conclusion Our data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines.
Published: 2020
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25. GRAZAX®: a sublingual immunotherapy vaccine for Hay fever treatment: from concept to commercialization

Author: Domingo Barber, Pilar Rico, Carlos Blanco, Montserrat Fernandez-Rivas, Maria Dolores Ibañez, and Maria M. Escribese
Subjects: grazax, allergen immunotherapy, allergy vaccine, sublingual immunotherapy, grass allergy, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract: Allergen immunotherapy has been used for more than 100 y, but only recently underlying immunological mechanisms have started to be understood. New Allergy vaccines are now considered to be full pharmaceutical products, that should comply with general as well as specific pharmaceutical legal framework. GRAZAX® is the first global allergy vaccine developed in compliance with the new legal environment and is thus a reference for developing new allergy vaccines. Here, we provide a rationale description of GRAZAX®, providing a sequential description of its pharmaceutical and clinical development. With more than 25 clinical trials, involving more than 8000 patients, including as well three 5-y prospective clinical trials, GRAZAX® is a key product to understand the unique position of allergen-specific immunotherapy as a disease-modifying intervention.
Published: 2019
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26. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

Author: Westerhout, Joost, Baumert, Joseph L., Blom, W. Marty, Allen, Katrina J., Ballmer-Weber, Barbara, Crevel, René W.R., Dubois, Anthony E.J., Fernández-Rivas, Montserrat, Greenhawt, Matthew J., Hourihane, Jonathan O'B., Koplin, Jennifer J., Kruizinga, Astrid G., Le, Thuy-My, Sampson, Hugh A., Shreffler, Wayne G., Turner, Paul J., Taylor, Steve L., Houben, Geert F., and Remington, Benjamin C.
Published: 2019
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27. Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe

Author: Lyons, Sarah A., Burney, Peter G.J., Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Barreales, Laura, Clausen, Michael, Dubakiene, Ruta, Fernandez-Perez, Cristina, Fritsche, Philipp, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Kralimarkova, Tanya, Kummeling, Ischa, Mustakov, Tihomir B., Lebens, Ans F.M., van Os-Medendorp, Harmieke, Papadopoulos, Nikolaos G., Popov, Todor A., Sakellariou, Alexandros, Welsing, Paco M.J., Potts, James, Mills, E.N. Clare, van Ree, Ronald, Knulst, André C., and Le, Thuy-My
Published: 2019
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28. Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

Author: Rosace, Domenico, Gomez-Casado, Cristina, Fernandez, Paloma, Perez-Gordo, Marina, Dominguez, María del Carmen, Vega, Angel, Belver, María Teresa, Ramos, Tania, Vega, Francisco, Marco, Guadalupe, de Pedro, Manuel, Sanchez, Leticia, Arnas, María de las Mercedes, Santaolalla, Marcela, Saez, Miguel Ángel, Benedé, Sara, Fernandez-Rivas, Montserrat, Blanco, Carlos, Alvarado, Maria Isabel, Escribese, María M., and Barber, Domingo
Published: 2019
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29. Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles

Author: Mareen R. Datema, Sarah A. Lyons, Montserrat Fernández-Rivas, Barbara Ballmer-Weber, André C. Knulst, Riccardo Asero, Laura Barreales, Simona Belohlavkova, Frédéric de Blay, Michael Clausen, Ruta Dubakiene, Cristina Fernández-Perez, Philipp Fritsche, David Gislason, Karin Hoffmann-Sommergruber, Monika Jedrzejczak-Czechowicz, Laurian Jongejan, Marek L. Kowalski, Tanya Z. Kralimarkova, Jonas Lidholm, Nikolaos G. Papadopoulos, Todor A. Popov, Nayade del Prado, Ashok Purohit, Isabel Reig, Suranjith L. Seneviratne, Athanassios Sinaniotis, Emilia Vassilopoulou, Serge A. Versteeg, Stefan Vieths, Paco M. J. Welsing, E. N. Clare Mills, Thuy-My Le, Aeilko H. Zwinderman, and Ronald van Ree
Subjects: EuroPrevall, iFAAM, peanut allergy, severity, prediction, clinical background, Immunologic diseases. Allergy, RC581-607
Abstract: Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA).Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity.Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity.Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanut, family atopy, atopic dermatitis, house dust mite and latex allergy were independently associated with severe PA; birch pollen allergy with mild-to-moderate PA. The cross-validated AUC of all clinical background determinants combined (0.74) was significantly larger than the AUC of tests for sensitization to extract (0.63) or peanut components (0.54–0.64). Although larger skin prick test wheal size, and higher IgE to peanut extract, Ara h 1 and Ara h 2/6, were associated with severe PA, and higher IgE to Ara h 8 with mild-to-moderate PA, addition of these measurements of sensitization to the clinical background model did not significantly improve the AUC.Conclusions: Models combining clinical characteristics and IgE sensitization patterns can help establish the risk of severe reactions for peanut allergic patients, but clinical background determinants are most valuable for predicting severity of probable PA in an individual patient.
Published: 2021
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30. Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register

Author: Grabenhenrich, Linus B., Dölle, Sabine, Ruëff, Franziska, Renaudin, Jean-Marie, Scherer, Kathrin, Pföhler, Claudia, Treudler, Regina, Koehli, Alice, Mahler, Vera, Spindler, Thomas, Lange, Lars, Bilò, Maria Beatrice, Papadopoulos, Nikolaos G., Hourihane, Jonathan O.B., Lang, Roland, Fernández-Rivas, Montserrat, Christoff, George, Cichocka-Jarosz, Ewa, and Worm, Margitta
Published: 2018
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31. EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Author: Santos, Alexandra F., primary, Riggioni, Carmen, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, Akdis, Mubeccel, additional, Alvarez‐Perea, Alberto, additional, Alvaro‐Lozano, Montserrat, additional, Ballmer‐Weber, Barbara, additional, Barni, Simona, additional, Beyer, Kirsten, additional, Bindslev‐Jensen, Carsten, additional, Brough, Helen A., additional, Buyuktiryaki, Betul, additional, Chu, Derek, additional, Del Giacco, Stefano, additional, Dunn‐Galvin, Audrey, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Feeney, Mary, additional, Fernandez‐Rivas, Montserrat, additional, Fisher, Helen R., additional, Fleischer, David M., additional, Giovannini, Mattia, additional, Gray, Claudia, additional, Hoffmann‐Sommergruber, Karin, additional, Halken, Susanne, additional, Hourihane, Jonathan O’B., additional, Jones, Christina J., additional, Jutel, Marek, additional, Knol, Edward, additional, Konstantinou, George N., additional, Lack, Gideon, additional, Lau, Susanne, additional, Marques Mejias, Andreina, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mortz, Charlotte G., additional, Moya, Beatriz, additional, Muraro, Antonella, additional, Nilsson, Caroline, additional, Lopes de Oliveira, Lucila Camargo, additional, O’Mahony, Liam, additional, Papadopoulos, Nikolaos G., additional, Perrett, Kirsten, additional, Peters, Rachel L., additional, Podesta, Marcia, additional, Poulsen, Lars K., additional, Roberts, Graham, additional, Sampson, Hugh A., additional, Schwarze, Jürgen, additional, Smith, Peter, additional, Tham, Elizabeth Huiwen, additional, Untersmayr, Eva, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vickery, Brian P., additional, Vlieg‐Boerstra, Berber, additional, Werfel, Thomas, additional, Worm, Margitta, additional, Du Toit, George, additional, and Skypala, Isabel, additional
Published: 2023
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32. Clinical Practice Guide for Anaphylaxis in Latin America (Galaxia-Latam)

Author: Victoria Cardona, Alberto Álvarez-Perea, Ignacio Javier Ansotegui-Zubeldia, Alfredo Arias-Cruz, Juan Carlos Ivancevich, Sandra Nora González-Díaz, Patricia Latour-Staffeld, Mario Sánchez-Borges, Carlos Serrano, Dirceu Solé, Luciana Tanno, Nieves Cabañes-Higuero, Tomás Chivato, Belén De la Hoz, Montserrat Fernández-Rivas, Iker Gangoiti, Pedro Guardia-Martínez, Miguel Ángel Herranz-Sanz, Juan Carlos Juliá-Benito, Teófilo Lobera-Labairu, Manuel Praena-Crespo, José Ignacio Prieto-Romo, Carlos Sánchez-Salguero, José Ignacio Sánchez-González, Sonia Uixera-Marzal, Arantza Vega, Pedro Villarroel, and Edgardo Jares
Subjects: anafilaxia, reacción alérgica, guía de práctica clínica, adrenalina, Immunologic diseases. Allergy, RC581-607
Abstract: Anaphylaxis is a severe allergic reaction with a rapid onset and it is potentially life-threatening. Its clinical manifestations are varied; they may affect the skin, the cardiovascular system, the respiratory system, and the digestive system, among others. The treatment of choice, which is an intra-muscular injection of epinephrine (adrenaline), must be applied promptly. Therefore, being prepared to recognize it properly is of crucial importance. The objective of this clinical practice guide is to improve the knowledge of health professionals about anaphylaxis and, consequently, to optimize the treatment and long-term management of this reaction. This guide is adapted to the peculiarities of Latin America; especially in matters regarding the treatment. The need to introduce epinephrine auto-injectors in countries that don’t have them yet is highlighted.
Published: 2019
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33. Omalizumab in IgE-Mediated Food Allergy: A Systematic Review and Meta-Analysis

Author: Torsten, Zuberbier, Robert A, Wood, Carsten, Bindslev-Jensen, Alessandro, Fiocchi, R Sharon, Chinthrajah, Margitta, Worm, Antoine, Deschildre, Montserrat, Fernandez-Rivas, Alexandra F, Santos, Xavier, Jaumont, and Paolo, Tassinari
Subjects: Immunology and Allergy
Abstract: A growing number of studies have shown encouraging results with omalizumab (OMA) as monotherapy and as an adjunct to oral immunotherapy (OMA+OIT) in patients with single/multiple food allergies.To evaluate the efficacy and safety of OMA or OMA+OIT in patients with IgE-mediated food allergy.An extensive literature search (inception-December 31, 2020) was performed to identify randomized, controlled, and observational studies that assessed OMA as monotherapy or OMA+OIT in patients with IgE-mediated food allergy.increase in tolerated dose of foods, successful desensitization, sustained unresponsiveness, immunological biomarkers, severity of allergic reactions to food, quality of life (QoL), and safety. A P0.05 was considered significant.In total, 36 studies were included. OMA monotherapy (vs pre-OMA) significantly increased the tolerated dose of multiple foods, increased the threshold of tolerated dose for milk, egg, wheat, and baked milk, improved QoL, and reduced food-induced allergic reactions (all P0.01). OMA+OIT significantly increased the tolerated dose of multiple foods (vs placebo and pre-OMA), desensitization (vs placebo+OIT and pre-OMA) (all P ≤ 0.01), and improved QoL (vs pre-OMA) and IgG4 levels (both P0.01). No major safety concerns were identified.In IgE-mediated food allergy, OMA can help patients for consumption of multiple foods and allow for food dose escalation. As an adjunct to OIT, OMA can also support high-dose desensitization and higher maintenance doses. Further studies are warranted to empirically evaluate the effect of OMA and confirm these findings.
Published: 2023

34. Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review

Author: Stefania Arasi, Ulugbek Nurmatov, Audrey Dunn-Galvin, Shahd Daher, Graham Roberts, Paul J. Turner, Sayantani B. Shinder, Ruchi Gupta, Philippe Eigenmann, Anna Nowak-Wegrzyn, Mario A. Sánchez Borges, Ignacio J. Ansotegui, Montserrat Fernandez-Rivas, Stavros Petrou, Luciana Kase Tanno, Marta Vazquez-Ortiz, Brian P. Vickery, Gary Wing-Kin Wong, Motohiro Ebisawa, and Alessandro Fiocchi
Subjects: Definition, Food allergy, Severity, Systematic review, Mixed-methods study, Immunologic diseases. Allergy, RC581-607
Abstract: Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We undertook a mixed-methods systematic review, which involved searching 11 international biomedical databases for published studies from inception to 31 December 2019. Studies were independently screened against pre-defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta-analyses and, therefore, narrative synthesis of quantitative and qualitative data was performed. Results: We found 23 studies providing eligible primary data on symptom-specific severity of food allergic reactions, and 31 previously published symptom-severity scoring systems referred to food allergic reactions. There were seven studies which assessed quality-of-life measures in patients (and family members) with different food allergy severity and two studies that investigated the economic burden of food allergy severity. Overall, the quality and the global rating of all included studies were judged as being moderate. Conclusions: There is heterogeneity among severity scoring systems used and even outcomes considered in the context of severity of food allergy. No score has been validated. Our results will be used to inform the development of an international consensus to define the severity of food allergy. Systematic review registration: A protocol was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) database with the registration number CRD42020183103 (https://www.crd.york.ac.uk/prospero/#recordDetails).
Published: 2021
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35. Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Author: Stefania Arasi, Ulugbek Nurmatov, Paul J. Turner, Ignacio J. Ansotegui, Shahd Daher, Audrey Dunn-Galvin, Motohiro Ebisawa, Philippe Eigenmann, Montserrat Fernandez-Rivas, Ruchi Gupta, Anna Nowak-Wegrzyn, Stavros Petrou, Graham Roberts, Mario A. Sánchez Borges, Sayantani B. Sindher, Luciana Kase Tanno, Marta Vazquez-Ortiz, Brian P. Vickery, Gary Wing-Kin Wong, and Alessandro Fiocchi
Subjects: Classification, Definition, Food allergy, Severity, Immunologic diseases. Allergy, RC581-607
Abstract: Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised. Ethics and dissemination: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated. PROSPERO registration number: CRD42020183103.
Published: 2020
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36. World allergy organization anaphylaxis guidance 2020

Author: Victoria Cardona, Ignacio J. Ansotegui, Motohiro Ebisawa, Yehia El-Gamal, Montserrat Fernandez Rivas, Stanley Fineman, Mario Geller, Alexei Gonzalez-Estrada, Paul A. Greenberger, Mario Sanchez Borges, Gianenrico Senna, Aziz Sheikh, Luciana Kase Tanno, Bernard Y. Thong, Paul J. Turner, and Margitta Worm
Subjects: Anaphylaxis, Acute systemic allergic reaction, Adrenaline, Cofactors, Epinephrine, Guidance, Immunologic diseases. Allergy, RC581-607
Abstract: Anaphylaxis is the most severe clinical presentation of acute systemic allergic reactions. The occurrence of anaphylaxis has increased in recent years, and subsequently, there is a need to continue disseminating knowledge on the diagnosis and management, so every healthcare professional is prepared to deal with such emergencies. The rationale of this updated position document is the need to keep guidance aligned with the current state of the art of knowledge in anaphylaxis management. The World Allergy Organization (WAO) anaphylaxis guidelines were published in 2011, and the current guidance adopts their major indications, incorporating some novel changes. Intramuscular epinephrine (adrenaline) continues to be the first-line treatment for anaphylaxis. Nevertheless, its use remains suboptimal. After an anaphylaxis occurrence, patients should be referred to a specialist to assess the potential cause and to be educated on prevention of recurrences and self-management. The limited availability of epinephrine auto-injectors remains a major problem in many countries, as well as their affordability for some patients.
Published: 2020
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37. EAACI Task force Clinical epidemiology of anaphylaxis: experts’ perspective on the use of adrenaline autoinjectors in Europe

Author: Kraft, Magdalena, Dölle-Bierke, Sabine, Turner, Paul J., Muraro, Antonella, Fernández-Rivas, Montserrat, Grabenhenrich, Linus, and Worm, Margitta
Published: 2020
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38. Association Between the Seed Storage Proteins 2S Albumin and 11S Globulin and Severe Allergic Reaction After Flaxseed Intake

Author: Javier Cuesta-Herranz, Montserrat Fernandez-Rivas, Sonia Vázquez-Cortés, M de Las Heras, Cristina Bueno-Díaz, Carlos Blanco, Mayte Villalba, C Biserni, Laura Martín-Pedraza, and Eva Batanero
Subjects: Flaxseed extract, Allergy, Immunology, Cross Reactions, medicine.disease_cause, Immunoglobulin E, Cross-reactivity, Allergen, Food allergy, Albumins, Flax, medicine, Humans, Immunology and Allergy, Storage protein, Amino Acid Sequence, Plant Proteins, chemistry.chemical_classification, Nut Proteins, biology, Plant Extracts, business.industry, Seed Storage Proteins, Globulins, Allergens, Antigens, Plant, medicine.disease, chemistry, biology.protein, Nut Hypersensitivity, business, Anaphylaxis
Abstract: Background Given the increased popularity of flaxseed in meals, several cases of allergy to these seeds have been reported. Little is known about allergens implicated in hypersensitivity reactions to these seeds. The present work aimed to identify the allergens involved in IgE-mediated reactions in five patients with a clinical history of severe systemic symptoms after flaxseed consumption. Methods Proteins susceptible to be allergens with IgE-binding capacity were purified from flaxseed extract by chromatographic techniques. Their identification was achieved via MALDI-TOF mass spectrometry. Immunoassays were performed using the five allergic patient's era either by testing them individually or as a pool. Results Proteins susceptible to be allergens with IgE-binding capacity were purified from flaxseed extract by chromatographic techniques. Their identification was achieved via MALDI-TOF mass spectrometry. Immunoassays were performed using the five allergic patient's era either by testing them individually or as a pool. Results: Four out of five patients recognized a low-molecular-mass protein (around 13kDa) by immunoblotting of the flaxseed extract, while two patients recognized a protein of approximately 55 kDa. They were identified by mass spectrometry as flaxseed 2S albumin, included into WHO/IUIS allergen nomenclature as Lin u 1,and 11S globulin, respectively. Inhibition assays revealed in vitro IgE-cross-reactivity of Lin u 1 with peanut and cashew nut proteins, while IgE recognition of 11S globulin by patients' sera was partially inhibited by several plant-derived sources. Conclusions Seed storage proteins from flaxseed were involved in the development of severe symptoms in five individuals and exhibited cross-reactivity with other allergenic sources. Besides the severity of flaxseed allergy in patients sensitized to 2S albumin, it is the first time that the 11S globulin is identified as a potential allergen. We consider that these data should be taken into account for a more accurate diagnosis of patients.
Published: 2022

39. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Author: Guillaume Pouessel, Claire Claverie, Julien Labreuche, Jean-Marie Renaudin, Aimée Dorkenoo, Mireille Eb, Anne Moneret-Vautrin, Antoine Deschildre, Stephane Leteurtre, Linus Grabenhenrich, Margitta Worm, Sabine Dölle, Kathrin Scherer, Isidor Hutteger, Morten Christensen, Carsten Bindslev-Jensen, Charlotte Mortz, Esben Eller, Henrik Fomsgaard Kjaer, Leonor Carneiro-Leão, Jenny Badas, Alice Coimbra, Dikla Pivko Levy, Moshe Ben-Shoshan, Ayelet Rimon, Shira Benor, Nicolette J. T. Arends, Nikki Edelbroek, Hans de Groot, Joyce A. M. Emons, H. Kim A. Brand, Dirk Verhoeven, Leonieke N. van Veen, Nicolette W. de Jong, Geunwoong Noh, Eun Ha Jang, Mariona Pascal, Olga Dominguez, Mònica Piquer, Montserrat Alvaro, Rosa Jimenez-Feijoo, Jaime Lozano, Adriana Machinena, Maria del Mar Folqué, Maria Teresa Giner, Ana María Plaza, Paul Turner, Nandinee Patel, Marta Vazquez-Ortiz, Sarah Lindsley, Lucy Walker, Simon Rosenberg, Adriano Mari, Claudia Alessandri, Ivana Giangrieco, Lisa Tuppo, Chiara Rafaiani, Georg Mitterer, Michela Ciancamerla, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Maurizio Tamburrini, Maria Antonetta Ciardiello, Christian Harwanegg, Antonio Fernandez, Regina Selb, Philippe Egenmann, Michelle Epstein, Karin Hoffmann-Sommergruber, Frits Koning, Martinus Lovik, E. N. Clare Mills, Javier Moreno, Henk van Loveren, Jean-Michel Wal, Susanne Diesner, Cornelia Bergmayr, Barbara Pfitzner, Vera Elisabeth Assmann, Philipp Starkl, David Endesfelder, Thomas Eiwegger, Zsolt Szepfalusi, Heinz Fehrenbach, Erika Jensen-Jarolim, Anton Hartmann, Isabella Pali-Schöll, Eva Untersmayr, Soren Wille, Peter Meyer, Caroline Klingebiel, Jonas Lidholm, Angelica Ehrenberg, Jonas Östling, Isabelle Cleach, Jean-Louis Mège, Joana Vitte, Roberta Aina, Pawel Dubiela, Sabine Pfeifer, Merima Bublin, Christian Radauer, Piotr Humeniuk, Stefan Kabasser, Riccardo Asero, Gador Bogas, Francisca Gomez, Paloma Campo, Maria Salas, Inmaculada Doña, Esther Barrionuevo, Maria Auxiliadora Guerrero, Cristobalina Mayorga, Ana Prieto, Domingo Barber, Maria Jose Torres, Annette Jamin, Andrea Wangorsch, Barbara Ballmer, Stefan Vieths, Stephan Scheurer, Danijela Apostolovic, Jelena Mihailovic, Maja Krstic, Maria Starkhammar, Tanja Cirkovic Velickovic, Carl Hamsten, Marianne van Hage, Francine C. van Erp, Edward F. Knol, Hannah M. Kansen, Bo Pontoppidan, Yolanda Meijer, Cornelis K. van der Ent, André C. Knulst, Rebekah Sayers, Helen Brown, Adnan Custovic, Angela Simpson, Claire Mills, Juliane Schulz, Network for Online Registration of Anaphylaxis (NORA), Jaap Akkerdaas, Muriel Totis, Annabelle Capt, Corinne Herouet-Guicheney, Ronald van Ree, Tushar Banerjee, Antima Banerjee, Mathilde Claude, Grégory Bouchaud, Roberta Lupi, Laure Castan, Olivier Tranquet, Sandra Denery-Papini, Marie Bodinier, Chantal Brossard, Rosella De Poi, Elisa Gritti, Emiliano De Dominicis, Bert Popping, Patrizia Polverino de Laureto, Kati Palosuo, Anna Kaarina Kukkonen, Anna Pelkonen, Mika Mäkelä, Nanju Alice Lee, Johanna Rost, Sridevi Muralidharan, Dianne Campbell, Sam Mehr, Catherine Nock, Joseph Baumert, Steve Taylor, Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Serena Perna, Andrea Di Rienzo Businco, Ifigenia Sfika, Arianna Dondi, Annamaria Bianchi, Carlotta Povesi Dascola, Giampaolo Ricci, Francesca Cipriani, Nunzia Maiello, Michele Miraglia del Giudice, Tullio Frediani, Simone Frediani, Francesco Macrì, Chiara Pistoletti, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Pasquale Comberiati, Loredana Chini, Viviana Moschese, Sandra Lucarelli, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Roberta Olcese, Matteo Moretti, Anastasia Cirisano, Diego Faggian, Alessandro Travaglini, Mario Plebani, Maria Carmen Verga, Mauro Calvani, Paolo Giordani, Paolo Maria Matricardi, Noe Ontiveros, Francisco Cabrera-Chavez, Julie Galand, Etienne Beaudouin, The Anaphylaxis Working Group of the French Allergology SocietyThe Anaphylaxis Working Group of the French Allergology Society, Florence Pineau, Shinobu Sakai, Kayoko Matsunaga, Reiko Teshima, Colette Larré, Sandra Denery, Sebastian Tschirner, Valérie Trendelenburg, Gabriele Schulz, Bodo Niggemann, Kirsten Beyer, Youcef Bouferkas, Younes Belabbas, Djamel Saidi, Omar Kheroua, Kamel Eddine El Mecherfi, Malika Guendouz, Abir Haddi, Hanane Kaddouri, Luis Amaral, Ana Pereira, Susana Rodrigues, Mareen Datema, Laurian Jongejan, Michael Clausen, Andre Knulst, Nikolaos Papadopoulos, Marek Kowalski, Frédéric de Blay, Aeilko Zwinderman, Karin Hoffman-Sommergruber, Barbara Ballmer-Weber, Montserrat Fernandez-Rivas, Shan Deng, Jia Yin, Charlotte Eisenmann, Maria Nassiri, Rabea Reinert, Johanna P. M. van der Valk, Roy Gerth van Wijk, Yvonne Vergouwe, Ewout W. Steyerberg, Marit Reitsma, Harry J. Wichers, Huub F. J. Savelkoul, Berber Vlieg-Boerstra, Anthony E. J. Dubois, Fabrícia Carolino, Ana Rodolfo, Josefina Cernadas, Dasha Roa-Medellín, Ana Rodriguez-Fernandez, Joaquín Navarro, Vicente Albendiz, María Luisa Baeza, Sonsoles Intente-Herrero, Andrea Mikkelsen, Kirsten Mehlig, Lauren Lissner, Linda Verrill, Stefano Luccioli, Jolanda van Bilsen, Frieke Kuper, André Wolterbeek, Tanja Rouhani Rankouhi, Lars Verschuren, Hilde Cnossen, Prescilla Jeurink, Johan Garssen, Léon Knippels, Jossie Garthoff, Geert Houben, Winfried Leeman, M. Eleonore Pettersson, Afke M. M. Schins, Gerard H. Koppelman, Boudewjin J. Kollen, Svitlana Zubchenko, Sarah Kuntz, Pablo Mérida, Montserrat Álvaro, Monica Piquer, Carmen Riggioni, Juan Heber Castellanos, Rosa Jimenez, Melanie Cap, Elodie Drumez, Stéphanie Lejeune, Caroline Thumerelle, Clémence Mordacq, Véronique Nève, Sonia Ricò, Margherita Varini, Rita Nocerino, Linda Cosenza, Antonio Amoroso, Margherita Di Costanzo, Carmen Di Scala, Giorgio Bedogni, Roberto Berni Canani, Paul J. Turner, Paloma Poza-Guedes, Ruperto González-Pérez, Inmaculada Sánchez-Machín, Victor Matheu-Delgado, Erik Wambre, Anne-Sofie Ballegaard, Charlotte Madsen, Juliane Gregersen, Katrine Lindholm Bøgh, Philippe Aubert, Michel Neunlist, Antoine Magnan, Daniel Lozano-Ojalvo, Alba Pablos-Tanarro, Leticia Pérez-Rodríguez, Elena Molina, Rosina López-Fandiño, Akila Rekima, Patricia Macchiaverni, Mathilde Turfkruyer, Sebastien Holvoet, Lénaïck Dupuis, Nour Baiz, Isabella Annesi-Maesano, Annick Mercenier, Sophie Nutten, Valérie Verhasselt, Ines Mrakovcic-Sutic, Srdan Banac, Ivana Sutic, Zdenka Baricev-Novakovic, Ingrid Sutic, Valentino Pavisic, Rosa Muñoz-Cano, Teodoríkez Jiménez-Rodríguez, Daniel Corbacho, Jordi Roca-Ferrer, Joan Bartra, Aleksandar Bulog, Vladimir Micovic, Lidia Markiewicz, Agata Szymkiewicz, Anna Szyc, Barbara Wróblewska, Bryan M. Harvey, Lucien F. Harthoorn, A. Wesley Burks, Georgios Rentzos, Anna-Lena Bramstång Björk, Ulf Bengtsson, Colin Barber, Chrystyna Kalicinsky, Christine Breynaert, Lieve Coorevits, Cornelia Jansen, Erna Van Hoeyveld, Kristin Verbeke, Anne-Marie Kochuyt, Rik Schrijvers, Diana Deleanu, Adriana Muntean, Maria Konstantakopoulou, Maria Pasioti, Anastasia Papadopoulou, Anna Iliopoulou, Nikolaos Mikos, Evangelia Kompoti, Eunice Dias de Castro, Borja Bartalomé, Kok Loong Ue, Elizabeth Griffiths, Stephen Till, Kate Grimshaw, Graham Roberts, Anna Selby, Indre Butiene, Jose Ignacio Larco, Ruta Dubakiene, Ana Fiandor, Alessandro Fiocchi, Nikos Papadopoulos, Sigurveig Sigurdardottir, Aline Sprikkelman, Anne-Fleur Schoemaker, Paraskevi Xepapadaki, Thomas Keil, Zizi Cojocariu, Beatriz Secades Barbado, Vasti Iancu, Esozia Arroabarren, Marta Goñi Esarte, Miren Arteaga, Mayra Coutinho Andrade, Denise Borges, Jorge Kalil, Pedro Giavina Bianchi, Rosana Camara Agondi, Rinkesh Kumar Gupta, Akanksha Sharma, Kriti Gupta, Mukul Das, Premendra Dwivedi, Rusudan Karseladze, Liana Jorjoliani, Lali Saginadze, Mariam Tskhakaia, Katia Basello, Gabriele Piuri, Attilio Francesco Speciani, Michela Carola Speciani, Carla Camerotto, Francesco Zinno, Olga Pakholchuk, Svitlana Nedelska, Stefano Pattini, Maria Teresa Costantino, Silvia Peveri, Danilo Villalta, Eleonora Savi, Andrea Costanzi, Vera A. Revyakina, Marina A. Kiseleva, Elena D. Kuvshinova, Inna A. Larkova, Anton A. Shekhetov, Diana Silva, André Moreira, José Plácido, Hanneke van der Kleij, Esther van Twuijver, Robbert Sutorius, Pieter-Jan de Kam, Jenny van Odijk, Helen Lindqvist, Elin Lustig, Amyra Ali Azamar Jácome, Karla Leversia Borjas Aguilar, Miguel García Domínguez, David Alejandro Mendoza Hernández, Cristiano Caruso, Cono Casale, Gian Lodovico Rapaccini, Antonino Romano, Italo De Vitis, Renata R. Cocco, Carolina Aranda, Marcia C. Mallozi, Jackeline F. Motta, Lilian Moraes, Antonio Pastorino, Nelson Rosario, Ekaterini Goudouris, Arnaldo Porto, Neusa F. Wandalsen, Emanuel Sarinho, Flavio Sano, Dirceu Solé, Constantinos Pitsios, Maria Petrodimopoulou, Ekaterini Papadopoulou, Maria Passioti, Meropi Kontogianni, Nino Adamia, Ekaterina Khaleva, Ana Prieto del Prado, George Du Toit, Edyta Krzych, Urszula Samolinska-Zawisza, Konrad Furmanczyk, Aneta Tomaszewska, Filip Raciborski, Agnieszka Lipiec, Piotr Samel-Kowalik, Artur Walkiewicz, Jacek Borowicz, Boleslaw Samolinski, Aimee Lou Nano, Marysia Recto, Maria Luisa Somoza, Natalia Blanca López, Diana Pérez Alzate, Francisco Javier Ruano, Maria Isabel Garcimartín, Elisa Haroun, Maria Vázquez de la Torre, Antonia Rojas, Montserrat López Onieva, Gabriela Canto, Alexandra Rodrigues, Andreia Forno, António Jorge Cabral, Rute Gonçalves, Ilya Vorozhko, Tatyana Sentsova, Olga Chernyak, Svetlana Denisova, Lidia Ilènko, Valery Muhortnich, Caroline Zimmermann, Alexander Rohrbach, Faisal R. Bakhsh, Kollen Boudewijn, Anne-Marie Oomkes-Pilon, Dorien Van Ginkle, Mira Šilar, Anja Jeverica, Tina Vesel, Tadej Avčin, Peter Korošec, Johanna van der Valk, Irene Berends, Nicolette Arends, Maurits van Maaren, Harry Wichers, Joyce Emons, Anthony Dubois, Nicolette de Jong, Oksana Matsyura, Lesya Besh, Chung-Hsiung Huang, Tong-Rong Jan, Gary Stiefel, Jean Tratt, Kerrie Kirk, Fabricia Carolino, Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Chiara Fiamingo, Jlenia Fresta, Giovanni Pajno, Ben Remington, Astrid Kruizinga, W. Marty Blom, Joost Westerhout, Sabina Bijlsma, Joe Baumert, Mark Blankestijn, Henny Otten, Rob Klemans, Anouska D. Michelsen-Huisman, Harmieke van Os-Medendorp, Astrid G. Kruizinga, Astrid Versluis, Gert van Duijn, H. Mary-Lene de Zeeuw-Brouwer, Jacqueline J. M. Castenmiller, Hub P. J. M. Noteborn, Geert F. Houben, Kristian Bravin, David Luyt, Bushra Javed, Phil Couch, Christopher Munro, Phil Padfield, Matt Sperrin, Aideen Byrne, Lizalet Oosthuizen, Carina Kelleher, Fiona Ward, Niamh Brosnan, Graham King, Eva Corbet, Josué Alejandro Huertas Guzmán, Montserrat Bosque García, Oscar Asensio, Laura Valdesoiro Navarrete, Helena Larramona, Xavier Domingo Miró, Katarzyna Pyrz, Moira Austin, Yanne Boloh, Philip Couch, Deirdre Galloway, Pilar Hernandez, Jonathan O’B. Hourihane, Fiona Kenna, Barbara Majkowska-Wojciechowska, Lynne Regent, Marina Themisb, Sabine Schnadt, Aida Semic-Jusufagic, Audrey Dunn Galvin, Tiina Kauppila, Mikael Kuitunen, Nikolaos A. Kitsioulis, Nikolaos Douladiris, Sofia Kostoudi, Ioanna Manolaraki, Dimitris Mitsias, Emmanouil Manousakis, Nikolaos G. Papadopoulos, Rebecca Knibb, Jennifer Hammond, Richard Cooke, Jaakko Yrjänä, Anna-Maija Hanni, Päivi Vähäsarja, Oona Mustonen, Teija Dunder, Petri Kulmala, Eva Lasa, Carmen D’Amelio, Sara Martínez, Alejandro Joral, Gabriel Gastaminza, Maria Jose Goikoetxea, David C. A. Candy, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Adam T. Fox, Jan Knol, Louise J. Michaelis, Ines Padua, Patricia Padrao, Pedro Moreira, Renata Barros, Hanan Sharif, Manzoor Ahmed, Nehad Gomaa, Joris Mens, Koen Smit, Frans Timmermans, Tomaž Poredoš, Anja Koren Jeverica, Marjeta Sedmak, Evgen Benedik, Meta Accetto, Mirjana Zupančič, Glauce Yonamine, Gustavo Soldateli, Bruna Aquilante, Antonio Carlos Pastorino, Cleonir Lui de Moraes Beck, Andrea Keiko Gushken, Mayra de Barros Dorna, Cristiane Nunes dos Santos, Ana Paula Moschione Castro, Abdulhadi Al-Qahtani, Rand Arnaout, Agha Rehan Khaliq, Rashid Amin, Farrukh Sheikh, Jorge Alvarez, Marta Anda, Miriam Palacios, Montserrat De Prada, Carmen Ponce, Bianca Balbino, Riccardo Sibilano, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L. Reber, Stephen J. Galli, Ana Reis Ferreira, Josefina R. Cernadas, Aida del Campo García, Sara Pereiro Fernández, Nerea Sarmiento Carrera, Fernando Bandrés Sánchez-Cruz, José Ramón Fernández Lorenzo, Stephanie Claus, Claudia Pföhler, Franziska Ruëff, Regina Treudler, Mercedes Escarrer Jaume, Agustin Madroñero, Maria Teresa Guerra Perez, Juan Carlos Julia, Charlotte Hands Plovdiv, Lee Gethings, Jim Langridge, Karine Adel-Patient, Hervé Bernard, Ivona Barcievic-Jones, Raditsa Sokolova, Rumyana Yankova, Mariya Ivanovska, Marianna Murdjeva, Tatyana Popova, Svetlan Dermendzhiev, Martin Karjalainen, Ulrike Lehnigk, Duncan Brown, Julie C. Locklear, Julie Locklear, Ioana Maris, Jonathan Hourihane, Cristina Ornelas, Joana Caiado, Manuel Branco Ferreira, Manuel Pereira-Barbosa, Yolanda Puente, Juan Carlos Daza, Francisco Javier Monteseirin, Natalia Ukleja-Sokolowska, Ewa Gawronska-Ukleja, Magdalena Zbikowska-Gotz, Zbigniew Bartuzi, Lukasz Sokolowski, Aine Adams, Bernard Mahon, Karen English, Nelly Gourdon-Dubois, Laetitia Sellam, Bruno Pereira, Elodie Michaud, Khaled Messaoudi, Bertrand Evrard, Jean-Luc Fauquert, Francisca Palomares, Gador Gomez, Maria Jose Rodriguez, Luisa Galindo, Ana Molina, Lorella Paparo, Maurizio Mennini, Rosita Aitoro, Adam Wawrzeńczyk, Michał Przybyszewski, Anna Wawrzeńczyk, Hulya Ercan Sarıcoban, Meltem Ugras, Zerrin Yalvac, Bertine M. J. Flokstra-de Blok, J. L. van der Velde, Andrea Vereda, Clara Ippolito, Amaranta Traversa, Daniela Adriano, Daniela Manila Bianchi, Silvia Gallina, Lucia Decastelli, Melina Makatsori, Anne Miles, Sonja Posega Devetak, Iztok Devetak, Soraya Ainad Tabet, Jeanette Fisker Trandbohus, Pernille Winther, Hans-Jørgen Malling, Kirsten Skamstrup Hansen, Lene Heise Garvey, Chia-Chi Wang, Yin-Hua Cheng, Chun-Wei Tung, Mariola Dietrich, Ingo Marenholz, Birgit Kalb, Sarah Grosche, Katharina Blümchen, Rupert Schlags, Mareike Price, Sylke Rietz, Jorge Esparza-Gordillo, Susanne Lau, Young-Ae Lee, Ali Almontasheri, Mohammad Al Bahkali, Sahar Elshorbagi, Abdullah Alfhaid, Mashary Altamimi, Eman Madbouly, Hassan Al-Dhekri, Rand K. Arnaout, Maria Basagaña, Sira Miquel, Borja Bartolomé, Bettina Brix, Stefanie Rohwer, Sandra Brandhoff, Alena Berger, Waltraud Suer, Alf Weimann, Cristina Bueno, Laura Martín-Pedraza, Sara Abián, Pablo San Segundo-Acosta, Juan Carlos López-Rodríguez, Rodrigo Barderas, Eva Batanero, Javier Cuesta-Herranz, María Teresa Villalba, Magna Correia, Filipe Benito-Garcia, Cristina Arêde, Susana Piedade, Mário Morais-Almeida, James Hindley, Ross Yarham, Anna Kuklinska-Pijanka, David Gillick, Karine Patient, Martin D. Chapman, Katrine L. Bøgh, Ana Miranda, Eugénia Matos, Anna Sokolova, Huan Rao, Ivona Baricevic-Jones, Frances Smith, Wentong Xue, Helga Magnusdottir, Anna G. Vidarsdottir, Sigrun Lund, Anders Blom Jensen, Bjorn R. Ludviksson, Reyna Simon, Robert Elfont, Sean Bennett, Robert Voyksner, Maria de Lurdes Torre, Songül Yürek, Margaretha A. Faber, Annick Bastiaensen, Evelyne Mangodt, Athina van Gasse, Ine Decuyper, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Didier Ebo, Susanne Schwarz, Mandy Ziegert, Saskia Albroscheit, Christian Schwager, Skadi Kull, Jochen Behrends, Niels Röckendorf, Frauke Schocker, Andreas Frey, Arne Homann, Wolf-Meinhard Becker, Uta Jappe, Nesrine Zaabat, Sylvia Osscini, Chantal Agabriel, Benoît Sterling, Ania Carsin, Valérie Liabeuf, Monica Maćków, Alina Zbróg, Monica Bronkowska, Justine Courtois, Romy Gadisseur, Catherine Bertholet, Pierre Lukas, Etienne Cavalier, Philippe Delahaut, Birgit Quinting, Margareta Brandt Gertmo, Ewa Ternesten Hasseus, Vladyslava Barzylovych, Júlio Oliveira, Luis F. Ensina, Carolina S. Aranda, Leire Dopazo, Rebeca Lopez, Raquel Perez, Laura Santos-Diez, Agurtzane Bilbao, Juan Miguel Garcia, Ignacio García Núñez, María Ángeles Algaba Mármol, María José Barasona Villarejo, José Antonio Bácter Martos, Marina Suárez Vergara, José María Ignacio García, Agata Michalska, Grzegorz Sergiejko, Robert Zacniewski, Ileana-Maria Ghiordanescu, Cristina Deaconu, Mihaela Popescu, Roxana Silvia Bumbacea, Alkerta Ibranji, Elida Nikolla, Gjustina Loloci, Nanna Juel-Berg, Lau Fabricius Larsen, Lars Kjaergaard Poulsen, João Marcelino, Ricardo Prata, Ana Célia Costa, Fátima Duarte, Marta Neto, Jennifer Santos, Luís Câmara Pestana, Daniel Sampaio, Paola Minale, Paola Dignetti, Donatella Bignardi, Irena Nedelea, Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu, Carmen Saviana Ganea, Miguel Vieira, José Pedro Moreira Silva, Timothy Watts, Sophia Watts, Marta Lomikovska, Marina Peredelskaya, Natalia Nenasheva, Ivana Filipovic, Zorica Zivkovic, Djordje Filipovic, Jennette Higgs, Amena Warner, and Carla Jones
Subjects: Immunologic diseases. Allergy, RC581-607
Published: 2017
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40. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author: CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
Published: 2023

41. EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Author: Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, et al, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, and et al
Abstract: This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy‐focused clinical history followed by tests to determine IgE sensitization, such as serum allergen‐specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen‐sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
Published: 2023

42. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author: Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
Abstract: This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen-sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
Published: 2023

43. Anaphylaxis in Elderly Patients—Data From the European Anaphylaxis Registry

Author: Stefanie Aurich, Sabine Dölle-Bierke, Wojciech Francuzik, Maria Beatrice Bilo, George Christoff, Montserrat Fernandez-Rivas, Thomas Hawranek, Claudia Pföhler, Iwona Poziomkowska-Gȩsicka, Jean-Marie Renaudin, Eva Oppel, Kathrin Scherer, Regina Treudler, and Margitta Worm
Subjects: anaphylaxis, elderly, insect venom, drug hypersensitivity, adrenaline, hospitalization, Immunologic diseases. Allergy, RC581-607
Abstract: Background: Elicitors and symptoms of anaphylaxis are age dependent. However, little is known about typical features of anaphylaxis in patients aged 65 years or more.Methods: The data from the Network for Online Registration of Anaphylaxis (NORA) considering patients aged ≥65 (elderly) in comparison to data from adults (18–64 years) regarding elicitors, symptoms, comorbidities, and treatment measures were analyzed.Results: We identified 1,123 elderly anaphylactic patients. Insect venoms were the most frequent elicitor in this group (p < 0.001), followed by drugs like analgesics and antibiotics. Food allergens elicited less frequently anaphylaxis (p < 0.001). Skin symptoms occurred less frequently in elderly patients (77%, p < 0.001). The clinical symptoms were more severe in the elderly (51% experiencing grade III/IV reactions), in particular when skin symptoms (p < 0.001) were absent. Most strikingly, a loss of consciousness (33%, p < 0.001) and preexisting cardiovascular comorbidity (59%, p < 0.001) were more prevalent in the elderly. Finally, adrenaline was used in 30% of the elderly (vs. 26% in the comparator group, p < 0.001) and hospitalization was more often required (60 vs. 50%, p < 0.001).Discussion and Conclusion: Anaphylaxis in the elderly is often caused by insect venoms and drugs. These patients suffer more often from cardiovascular symptoms, receive more frequently adrenaline and require more often hospitalization. The data indicate that anaphylaxis in the elderly tends to be more frequently life threatening and patients require intensified medical intervention. The data support the need to recognize anaphylaxis in this patient group, which is prone to be at a higher risk for a fatal outcome.
Published: 2019
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44. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry

Author: Grabenhenrich, Linus B., Dölle, Sabine, Moneret-Vautrin, Anne, Köhli, Alice, Lange, Lars, Spindler, Thomas, Ruëff, Franziska, Nemat, Katja, Maris, Ioana, Roumpedaki, Eirini, Scherer, Kathrin, Ott, Hagen, Reese, Thomas, Mustakov, Tihomir, Lang, Roland, Fernandez-Rivas, Montserrat, Kowalski, Marek L., Bilò, Maria B., Hourihane, Jonathan O'B., Papadopoulos, Nikolaos G., Beyer, Kirsten, Muraro, Antonella, and Worm, Margitta
Published: 2016
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45. Insoluble and soluble roasted walnut proteins retain antibody reactivity

Author: Downs, Melanie L., Simpson, Angela, Custovic, Adnan, Semic-Jusufagic, Aida, Bartra, Joan, Fernandez-Rivas, Montserrat, Taylor, Steve L., Baumert, Joseph L., and Mills, E.N. Clare
Published: 2016
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46. Development and validation of the Food Allergy Severity Score

Author: Fernández‐Rivas, Montserrat, Gómez García, Ismael, Gonzalo‐Fernández, Alejandro, Fuentes Ferrer, Manuel, Dölle‐Bierke, Sabine, Marco‐Martín, Guadalupe, Ballmer-Weber, Barbara K, et al, University of Zurich, and Fernández‐Rivas, Montserrat
Subjects: 2403 Immunology, Immunology, 2723 Immunology and Allergy, 10177 Dermatology Clinic, Immunology and Allergy, 610 Medicine & health
Published: 2022

47. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author: Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, André C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Náyade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald
Published: 2015
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48. How much is too much? Threshold dose distributions for 5 food allergens

Author: Ballmer-Weber, Barbara K., Fernandez-Rivas, Montserrat, Beyer, Kirsten, Defernez, Marianne, Sperrin, Matthew, Mackie, Alan R., Salt, Louise J., Hourihane, Jonathan O'B., Asero, Riccardo, Belohlavkova, Simona, Kowalski, Marek, de Blay, Frédéric, Papadopoulos, Nikolaos G., Clausen, Michael, Knulst, André C., Roberts, Graham, Popov, Ted, Sprikkelman, Aline B., Dubakiene, Ruta, Vieths, Stefan, van Ree, Ronald, Crevel, René, and Mills, E.N. Clare
Published: 2015
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49. Participant characteristics and safety outcomes of peanut oral immunotherapy in the RAMSES and ARC011 trials

Author: Ciaccio, Christina, primary, Goldsobel, Alan B., additional, Anagnostou, Aikaterini, additional, Beyer, Kirsten, additional, Casale, Thomas B., additional, Deschildre, Antoine, additional, Fernández-Rivas, Montserrat, additional, Hourihane, Jonathan O'B., additional, Krawiec, Marta, additional, Lieberman, Jay, additional, Scurlock, Amy M., additional, Vickery, Brian P., additional, Smith, Alex, additional, Tilles, Stephen A., additional, Adelman, Daniel C., additional, Brown, Kari R., additional, Assa'ad, Amal H., additional, Bernstein, David I., additional, Bird, J. Andrew, additional, Carr, Tara F., additional, Carr, Warner W., additional, Cheema, Amarjit S., additional, Corren, Jonathan, additional, Darter, Amy Liebl, additional, Dorsey, Morna J., additional, Fineman, Stanley M., additional, Fleischer, David M., additional, Fritz, Stephen B., additional, Gogate, Shaila U., additional, Greiner, Alexander N., additional, Hampel, Frank C., additional, Jacobs, Joshua S., additional, Jain, Sanjeev, additional, Jarvinen-Seppo, Kirsi, additional, Jeong, David K., additional, Johnston, Douglas T., additional, Kachru, Rita, additional, Kim, Edwin H., additional, Koleilat, Majed, additional, Lanser, Bruce J., additional, Leonard, Stephanie A., additional, Maier, Mary C., additional, Manning, Michael E., additional, Mansfield, Lyndon E., additional, Matz, Jonathan, additional, Nadeau, Kari, additional, Ohayon, Jason A., additional, Perez, Elena, additional, Petroni, Daniel H., additional, Pollard, Stephen J., additional, Ponda, Punita, additional, Portnoy, Jay M., additional, Rachid, Rima, additional, Ratner, Paul H., additional, Robison, Rachel, additional, Rupp, Ned T., additional, Sanders, Georgiana M., additional, Sharma, Hemant P., additional, Sher, Ellen R., additional, Sher, Lawrence D., additional, Sher, Mandel, additional, Shreffler, Wayne G., additional, Siri, Dareen D., additional, Skolnick, Helen S., additional, Soong, Weily, additional, Soteres, Daniel F., additional, Spergel, Jonathan M., additional, Stillerman, Allan, additional, Sussman, Gordon L., additional, Tam, Jonathan, additional, Varshney, Pooja, additional, Waserman, Susan, additional, Windom, Hugh H., additional, Wood, Robert, additional, and Yang, William H., additional
Published: 2022
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50. Improving the reporting of allergic adverse events during immunotherapy for food allergy

Author: Turner, Paul J., primary, Patel, Nandinee, additional, Mäkelä, Mika J., additional, Kukkonen, Kaarina, additional, Deschildre, Antoine, additional, Blumchen, Katharina, additional, Rodríguez del Río, Pablo, additional, Fernández-Rivas, Montserrat, additional, Alvaro-Lozano, Montserrat, additional, and Beyer, Kirsten, additional
Published: 2022
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