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31 results on '"Fernandez-Real, Jose M."'

1. A novel long non-coding RNA connects obesity to impaired adipocyte function

Author

Lluch, Aina, Latorre, Jèssica, Oliveras-Cañellas, Núria, Fernández-Sánchez, Ana, Moreno-Navarrete, José M., Castells-Nobau, Anna, Comas, Ferran, Buxò, Maria, Rodríguez-Hermosa, José I., Ballester, María, Espadas, Isabel, Martín-Montalvo, Alejandro, Zhang, Birong, Zhou, You, Burkhardt, Ralph, Höring, Marcus, Liebisch, Gerhard, Castellanos-Rubio, Ainara, Santin, Izortze, Kar, Asha, Laakso, Markku, Pajukanta, Päivi, Olkkonen, Vesa M., Fernández-Real, José M., and Ortega, Francisco J.

Published
2024
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3. Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Author

Latorre, Jèssica, Ortega, Francisco J., Liñares-Pose, Laura, Moreno-Navarrete, José M., Lluch, Aina, Comas, Ferran, Oliveras-Cañellas, Núria, Ricart, Wifredo, Höring, Marcus, Zhou, You, Liebisch, Gerhard, Nidhina Haridas, P.A., Olkkonen, Vesa M., López, Miguel, and Fernández-Real, José M.

Published
2020
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5. Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity

Author

Izquierdo, Andrea G., Carreira, Marcos C., Rodriguez-Carnero, Gemma, Fernandez-Quintela, Alfredo, Sueiro, Aurelio M., Martinez-Olmos, Miguel A., Guzman, German, De Luis, Daniel, Pinhel, Marcela A. S., Nicoletti, Carolina F., Nonino, Carla B., Ortega, Francisco J., Portillo, Maria P., Fernandez-Real, Jose M., Casanueva, Felipe F., and Crujeiras, Ana B.

Published
2021
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6. Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making

Author

Paslakis, Georgios, Agüera, Zaida, Granero, Roser, Sánchez, Isabel, Riesco, Nadine, Jiménez-Murcia, Susana, Fernández-García, Jose C., Garrido-Sánchez, Lourdes, Tinahones, Francisco J., Casanueva, Felipe F., Baños, Rosa M., Botella, Cristina, Crujeiras, Ana B., Torre, Rafael de la, Fernández-Real, Jose M., Frühbeck, Gema, Ortega, Francisco J., Rodríguez, Amaia, Serra-Majem, Luís, Fitó, Montserrat, Menchón, José M., and Fernández-Aranda, Fernando

Published
2019
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8. Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome

Author

Sauchelli, Sarah, Jiménez-Murcia, Susana, Sánchez, Isabel, Riesco, Nadine, Custal, Nuria, Fernández-García, Jose C., Garrido-Sánchez, Lourdes, Tinahones, Francisco J., Steiger, Howard, Israel, Mimi, Baños, Rosa M., Botella, Cristina, de la Torre, Rafael, Fernández-Real, Jose M., Ortega, Francisco J., Frühbeck, Gema, Granero, Roser, Tárrega, Salome, Crujeiras, Ana B., Rodríguez, Amaia, Estivill, Xavier, Beckmann, Jacques S., Casanueva, Felipe F., Menchón, Jose M., and Fernández-Aranda, Fernando

Published
2016
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12. Relationship between eating styles and temperament in an Anorexia Nervosa, Healthy Control, and Morbid Obesity female sample

Author

Baños, Rosa M., Cebolla, Ausias, Moragrega, Ines, Van Strien, Tatjana, Fernández-Aranda, Fernando, Agüera, Zaida, de la Torre, Rafael, Casanueva, Felipe F., Fernández-Real, Jose M., Fernández-García, Jose C., Frühbeck, Gema, Gómez-Ambrosi, Javier, Jiménez-Murcia, Susana, Rodríguez, Roser, Tinahones, Francisco J., and Botella, Cristina

Published
2014
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13. Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss

Author

Izquierdo, Andrea G., primary, Carreira, Marcos C., additional, Boughanem, Hatim, additional, Moreno‐Navarrete, Jose M., additional, Nicoletti, Carolina F., additional, Oliver, Paula, additional, Luis, Daniel, additional, Nonino, Carla B., additional, Portillo, Maria P., additional, Martinez‐Olmos, Miguel A., additional, Fernandez‐Real, Jose M., additional, Tinahones, Francisco J., additional, Martinez, J. Alfredo, additional, Macias‐González, Manuel, additional, Casanueva, Felipe F., additional, and Crujeiras, Ana B., additional

Published
2021
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14. ITCH Deficiency Protects From Diet-Induced Obesity

Author

Marino, Arianna, Menghini, Rossella, Fabrizi, Marta, Casagrande, Viviana, Mavilio, Maria, Stoehr, Robert, Candi, Eleonora, Mauriello, Alessandro, Moreno-Navarrete, Jose M., Gómez-Serrano, María, Peral, Belén, Melino, Gerry, Lauro, Renato, Fernandez Real, Jose M., and Federici, Massimo

Published
2014
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15. Weight loss normalizes enhanced expression of the oncogene survivin in visceral adipose tissue and blood leukocytes from individuals with obesity

Author

Izquierdo, Andrea G., primary, Carreira, Marcos C., additional, Rodriguez-Carnero, Gemma, additional, Fernandez-Quintela, Alfredo, additional, Sueiro, Aurelio M., additional, Martinez-Olmos, Miguel A., additional, Guzman, German, additional, De Luis, Daniel, additional, Pinhel, Marcela A. S., additional, Nicoletti, Carolina F., additional, Nonino, Carla B., additional, Ortega, Francisco J., additional, Portillo, Maria P., additional, Fernandez-Real, Jose M., additional, Casanueva, Felipe F., additional, and Crujeiras, Ana B., additional

Published
2020
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16. Adipose tissue and blood leukocytes ACE2 DNA methylation in obesity and after weight loss.

Author

Izquierdo, Andrea G., Carreira, Marcos C., Boughanem, Hatim, Moreno‐Navarrete, Jose M., Nicoletti, Carolina F., Oliver, Paula, de Luis, Daniel, Nonino, Carla B., Portillo, Maria P., Martinez‐Olmos, Miguel A., Fernandez‐Real, Jose M., Tinahones, Francisco J., Martinez, J. Alfredo, Macias‐González, Manuel, Casanueva, Felipe F., and Crujeiras, Ana B.

Subjects
WEIGHT loss, DNA methylation, ANGIOTENSIN converting enzyme, ADIPOSE tissues, OBESITY, MORBID obesity, PHANTOM limbs
Abstract

Background: Obesity was consistently associated with a poor prognosis in patients with COVID‐19. Epigenetic mechanisms were proposed as the link between obesity and comorbidities risk. Aim: To evaluate the methylation levels of angiotensin‐converting enzyme 2 (ACE2) gene, the main entry receptor of SARS‐CoV‐2, in different depots of adipose tissue (AT) and leukocytes (PBMCs) in obesity and after weight loss therapy based on a very‐low‐calorie ketogenic diet (VLCKD), a balanced hypocaloric diet (HCD) or bariatric surgery (BS). Materials and Methods: DNA methylation levels of ACE2 were extracted from our data sets generated by the hybridization of subcutaneous (SAT) (n = 32) or visceral (VAT; n = 32) adipose tissue, and PBMCs (n = 34) samples in Infinium HumanMethylation450 BeadChips. Data were compared based on the degree of obesity and after 4–6 months of weight loss either by following a nutritional or surgical treatment and correlated with ACE2 transcript levels. Results: As compared with normal weight, VAT from patients with obesity showed higher ACE2 methylation levels. These differences were mirrored in PBMCs but not in SAT. The observed obesity‐associated methylation of ACE2 was reversed after VLCKD and HCD but not after BS. Among the studied CpG sites, cg16734967 and cg21598868, located at the promoter, were the most affected and correlated with BMI. The observed DNA methylation pattern was inversely correlated with ACE2 expression. Conclusion: Obesity‐related VAT shows hypermethylation and downregulation of the ACE2 gene that is mirrored in PBMCs and is restored after nutritional weight reduction therapy. The results warrant the necessity to further evaluate its implication for COVID‐19 pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon?

Author

Manco, Melania, Fernandez-Real, Jose M., Valera-Mora, Maria E., Dechaud, Henri, Nanni, Giuseppe, Tondolo, Vincenzo, Calvani, Menotti, Castagneto, Marco, Pugeat, Michel, and Mingrone, Geltrude

Subjects
Overweight persons -- Health aspects -- Research, Hydrocortisone -- Health aspects -- Research, Weight loss -- Health aspects -- Research, Health, Research, Health aspects
Abstract

OBJECTIVE--Obesity, insulin resistance, and weight loss have been associated with changes in hypothalamic-pituitary-adrenal (HPA) axis. So far, no conclusive data relating to this association are available. In this study, we [...]

Published
2007

19. Correction: An increase in visceral fat is associated with a decrease in the taste and olfactory capacity

Author

Fernandez-Garcia, Jose Carlos, primary, Alcaide, Juan, additional, Santiago-Fernandez, Concepcion, additional, Roca-Rodriguez, MM., additional, Aguera, Zaida, additional, Baños, Rosa, additional, Botella, Cristina, additional, de la Torre, Rafael, additional, Fernandez-Real, Jose M., additional, Fruhbeck, Gema, additional, Gomez-Ambrosi, Javier, additional, Jimenez-Murcia, Susana, additional, Menchon, Jose M., additional, Casanueva, Felipe F., additional, Fernandez-Aranda, Fernando, additional, Tinahones, Francisco J., additional, and Garrido-Sanchez, Lourdes, additional

Published
2017
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20. An increase in visceral fat is associated with a decrease in the taste and olfactory capacity

Author

Fernandez-Garcia, Jose Carlos, primary, Alcaide, Juan, additional, Santiago-Fernandez, Concepcion, additional, Roca-Rodriguez, MM., additional, Aguera, Zaida, additional, Baños, Rosa, additional, Botella, Cristina, additional, de la Torre, Rafael, additional, Fernandez-Real, Jose M., additional, Fruhbeck, Gema, additional, Gomez-Ambrosi, Javier, additional, Jimenez-Murcia, Susana, additional, Menchon, Jose M., additional, Casanueva, Felipe F., additional, Fernandez-Aranda, Fernando, additional, Tinahones, Francisco J., additional, and Garrido-Sanchez, Lourdes, additional

Published
2017
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23. Glucose Homeostasis Abnormalities in Subjects with Impaired Fasting Glucose

Author

YBARRA, JUAN, COSTA, ANGELS, FERNANDEZ-REAL, JOSE M., MORINIGO, ROSA, CASAMITJANA, ROSER, RICART, WIFRED, GOMIS, RAMON, and CONGET, IGNACIO

Subjects
Diabetes -- Research, Health
Abstract

Impaired Fasting Glucose (IFG) is a new diagnostic cathegory implemented by the ADA in 1997 concerning those individuals with fasting blood glucose values between 110 and 125 mg/dl. Different degrees [...]

Published
2000

24. Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament

Author

Universitat Rovira i Virgili, Fernandez-Aranda, Fernando; Sauchelli, Sarah; Pastor, Antoni; Gonzalez, Marcela L.; de la Torre, Rafael; Granero, Roser; Jimenez-Murcia, Susana; Banos, Rosa; Botella, Cristina; Fernandez-Real, Jose M.; Fernandez-Garcia, Jose C.; Fruehbeck, Gema; Gomez-Ambrosi, Javier; Rodriguez, Roser; Tinahones, Francisco J.; Arcelus, Jon; Fagundo, Ana B.; Agueera, Zaida; Miro, Jordi; Casanueva, Felipe F., Universitat Rovira i Virgili, and Fernandez-Aranda, Fernando; Sauchelli, Sarah; Pastor, Antoni; Gonzalez, Marcela L.; de la Torre, Rafael; Granero, Roser; Jimenez-Murcia, Susana; Banos, Rosa; Botella, Cristina; Fernandez-Real, Jose M.; Fernandez-Garcia, Jose C.; Fruehbeck, Gema; Gomez-Ambrosi, Javier; Rodriguez, Roser; Tinahones, Francisco J.; Arcelus, Jon; Fagundo, Ana B.; Agueera, Zaida; Miro, Jordi; Casanueva, Felipe F.

Abstract

Endocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional study were to 1) examine differences among distinct BMI groups on daytime physical activity and time spent in moderate-vigorous physical activity (MVPA), temperament traits and plasma endocannabinoid concentrations; and 2) explore the association and interaction between MVPA, temperament, endocannabinoids and BMI.Physical activity was measured with the wrist-worn accelerometer Actiwatch AW7, in a sample of 189 female participants (43 morbid obese, 30 obese, and 116 healthy-weight controls). The Temperament and Character Inventory-Revised questionnaire was used to assess personality traits. BMI was calculated by bioelectrical impedance analysis via the TANITA digital scale. Blood analyses were conducted to measure levels of endocannabinoids and endocannabinoid-related compounds. Path-analysis was performed to examine the association between predictive variables and MVPA.Obese groups showed lower MVPA and dysfunctional temperament traits compared to healthy-weight controls. Plasma concentrations of 2-arachidonoylglyceryl (2-AG) were greater in obese groups. Path-analysis identified a direct effect between greater MVPA and low BMI (b?=?-0.13, p?=?.039) and high MVPA levels were associated with elevated anandamide (AEA) levels (b?=?0.16, p?=?.049) and N-oleylethanolamide (OEA) levels (b?=?0.22, p?=?.004), as well as high Novelty seeking (b?=?0.18, p<.001) and low Harm avoidance (b?=?-0.16, p<.001).Obese individuals showed a distinct temperament profile and circulating endocannabinoids compared to controls. Temperament and endocannabinoids may act as moderators of the

Published
2014

29. Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes.

Author

Fernandez-Real, Jose M., Catalan, Victoria, Moreno-Navarrete, Jose M., Gomez-Ambrosi, Javier, Ortega, Francisco J., Rodriguez-Hermosa, Jose I., Ricart, Wifredo, and Fruhbeck, Gema

Subjects
*GENE expression, *ADIPOSE tissues, *CONNECTIVE tissues, *FAT cells, *CONNECTIVE tissue cells
Abstract

Context: Caveolins are 21-24 kDa integral membrane proteins that serve as scaffolds to recruit numerous signaling molecules. Specific subclasses of caveolae carry out specific functions in cell metabolism. In particular, triglycerides are synthesized at the site of fatty acid entry in one of these caveolae classes. Objective and Methods: We studied the expression of caveolin-1 (CAV-1) gene in association with metabolic variables in 90 visceral and 55 subcutaneous adipose tissue samples from subjects with a wide range of fat mass, in the stromovascular fraction (SVC) and isolated adipocytes, and during differentiation of human adipocytes. Results: CAV-1 gene expression was significantly decreased in visceral adipose tissue (v-CAV-1) of obese subjects. v- CAV-1 was positively associated with several lipogenic genes such as acetyl-coA carboxylase (ACACA, r = 0.34, p = 0.004) and spot-14 (r = 0.33, p = 0.004). In non-obese subjects v-CAV-1 also correlated with fatty acid synthase (FAS, r = 0.60, p < 0.0001). Subcutaneous (sc) adipose tissue (sc-CAV-1) gene expression was not associated with these lipogenic factors when obese and non-obese subjects were studied together. In obese subjects, however, sc-CAV-1 was associated with fatty acid synthase (FAS, r = 0.36, p = 0.02), sterol regulatory element binding protein-1c (SREBP-1c (r = 0.58, p < 0.0001), ACACA (r = 0.33, p = 0.03), spot-14 (r = 0.36, p = 0.02), PPAR-γ co-activator-1 (PGC-1, r = 0.88, n = 19). In these obese subjects, sc-CAV-1 was also associated with fasting triglycerides (r = -0.50, p < 0.0001). CAV-1 expression in mature adipocytes was significantly higher than in stromal vascular cells. CAV-1 gene expression in adipocytes from subcutaneous adipose tissue (but not in adipocytes from visceral adipose tissue) was significatively associated with fasting triglycerides. CAV-1 gene expression did not change significantly during differentiation of human preadipocytes from lean or obese subjects despite significant increase of FAS gene expression. Conclusion: Decreased CAV-1 gene expression was simultaneously linked to increased triglycerides and decreased lipogenic gene expression among obese subjects, paralleling the observations of hypertriglyceridemia in CAV-1 knockout mice. However, the regulation of CAV-1 gene expression seems independent of the adipogenic program. [ABSTRACT FROM AUTHOR]

Published
2010
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30. Decision Making Impairment: A Shared Vulnerability in Obesity, Gambling Disorder and Substance Use Disorders?

Author

José Manuel Fernández-Real, Rosa M. Baños, Núria Mallorquí-Bagué, Fernando Fernández-Aranda, Cristina Botella, Gema Frühbeck, Ana B. Crujeiras, Susana Jiménez-Murcia, Amaia Rodríguez, Francisco J. Ortega, José Carlos Fernández-García, Iris Tolosa-Sola, Francisco J. Tinahones, Felipe F. Casanueva, Cristian Ochoa, Rafael de la Torre, Eva Álvarez-Moya, Roser Granero, José M. Menchón, Ana B. Fagundo, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Universitat de Barcelona, [Mallorqui-Bague, Nuria] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Fagundo, Ana B.] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Jimenez-Murcia, Susana] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Tolosa-Sola, Iris] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Alvarez-Moya, Eva] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Ochoa, Cristian] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Menchon, Jose M.] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Mallorqui-Bague, Nuria] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Fagundo, Ana B.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Jimenez-Murcia, Susana] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [de la Torre, Rafael] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Banos, Rosa M.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Botella, Cristina] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Casanueva, Felipe F.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Crujeiras, Ana B.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Fernandez-Garcia, Jose C.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Fernandez-Real, Jose M.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Fruhbeck, Gema] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Granero, Roser] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Rodriguez, Amaia] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Ortega, Francisco J.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Tinahones, Francisco J.] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Fernandez-Aranda, Fernando] Inst Salud Carlos III, GIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain, [Jimenez-Murcia, Susana] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [Menchon, Jose M.] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [de la Torre, Rafael] Hosp del Mar, Med Res Inst, Integrated Pharmacol & Syst Neurosci Res Grp, Neurosci Res Program,IMIM, Barcelona, Spain, [de la Torre, Rafael] Pompeu Fabra Univ, CEXS UPF, Barcelona, Spain, [Banos, Rosa M.] Univ Valencia, Dept Psychol Personal Evaluat & Treatment, Valencia, Spain, [Botella, Cristina] Univ Jaume 1, Dept Basic Psychol Clin & Psychobiol, Castellon de La Plana, Spain, [Casanueva, Felipe F.] Univ Santiago de Compostela, Complejo Hosp Univ Santiago, Div Endocrine, Santiago De Compostela, Spain, [Crujeiras, Ana B.] Univ Santiago de Compostela, Complejo Hosp Univ Santiago, Div Endocrine, Santiago De Compostela, Spain, [Fernandez-Garcia, Jose C.] Hosp Clin Univ Virgen de Victoria, Dept Endocrinol & Nutr, Malaga, Spain, [Tinahones, Francisco J.] Hosp Clin Univ Virgen de Victoria, Dept Endocrinol & Nutr, Malaga, Spain, [Fernandez-Real, Jose M.] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, Inst Invest Biomed Girona IdIBGi, Girona, Spain, [Ortega, Francisco J.] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, Inst Invest Biomed Girona IdIBGi, Girona, Spain, [Fruhbeck, Gema] Univ Navarra, Univ Navarra Clin, Dept Endocrinol & Nutr, Pamplona, Spain, [Rodriguez, Amaia] Univ Navarra, Univ Navarra Clin, Dept Endocrinol & Nutr, Pamplona, Spain, [Granero, Roser] Univ Autonoma Barcelona, Dept Psicobiol & Metodol, Barcelona, Spain, [Menchon, Jose M.] Inst Salud Carlos III, CIBER Salud Mental CIBERsam, Madrid, Spain, Instituto Salud Carlos III (ISCIII), Fondos Europeos de Desarrollo Regional (FEDER) funds, AGAUR, Ministerio de Economia y Competitividad, and Servicio Andaluz de Salud (SAS)

Subjects
Physiology, Vulnerability, Deficits, Social Sciences, lcsh:Medicine, Food addiction, Task (project management), Pathological psychology, Cognition, Learning and Memory, 0302 clinical medicine, Abusers, Decisió, Presa de, Task, Medicine and Health Sciences, Psychology, lcsh:Science, Healthy controls, media_common, Cognitive Impairment, Multidisciplinary, Cognitive Neurology, Neuropsychological testing, Presa de decisions, Joc compulsiu, Addicts, Substance abuse, Cognitive impairment, Neurology, Physiological Parameters, Obesitat, Sex, medicine.symptom, Alcohol, Compulsive gambling, Research Article, Behavioral addiction, medicine.medical_specialty, Cognitive Neuroscience, media_common.quotation_subject, Decision Making, Iowa Gambling Task, Addiction, Gambling disorder, Substance use disorder, behavioral disciplines and activities, 03 medical and health sciences, Neuropsychology, medicine, Addictes, Learning, Nutrition disorders, Jocs d'atzar, Obesity, Psychiatry, Set (psychology), Neuropsychological Testing, Body Weight, lcsh:R, Cognitive Psychology, Biology and Life Sciences, Addictions, Physical fitness, medicine.disease, Iowa gambling task, 030227 psychiatry, Abús de substàncies, Psicopatologia, Behavioral Addiction, Trastorns de la nutrició, Gambling, Cognitive Science, lcsh:Q, Neuropsicologia, Ventromedial prefrontal cortex, Decision making, 030217 neurology & neurosurgery, Neuroscience, Condició física
Abstract

Introduction Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling Task (IGT) and compares them with healthy con- trols (HC). Methods For the aims of this study, 591 participants (194 HC, 178 GD, 113 OB, 106 SUD) were assessed according to DSM criteria, completed a sociodemographi c interview and con- ducted the IGT. Results SUD, GD and OB present impaired decision making when compared to the HC in the over- all task and task learning, however no differences are found for the overall performanc e inthe IGT among the clinical groups. Results also reveal some specific learning across the task patterns within the clinical groups: OB maintains negative scores until the third set where learning starts but with a less extend to HC, SUD presents an early learning followed by a progressive although slow improvement and GD presents more random choices with no learning. Conclusions Decision making impairments are present in the studied clinical samples and they display individual differences in the task learning. Results can help understanding the underlying mechanisms of OB and addiction behaviors as well as improve current clinical treatment s. This manuscript was supported by grants from Instituto Salud Carlos III (ISCIII; FIS PI14/ 00290 and CIBERobn) and co-funded by Fondos Europeos de Desarrollo Regional (FEDER) funds - a way to build Europe, and AGAUR (2014 SGR 1672). This manuscript was co-funded by Ministerio de Economía y Competitividad (PSI2015-68701-R). CIBERobn and CIBERSAM are both initiativesof ISCIII. José C. Fernández-García is recipient of a research contract from Servicio Andaluz de Salud (SAS) (B-0033-2014).

Published
2016

31. An increase in visceral fat is associated with a decrease in the taste and olfactory capacity

Author

María del Mar Roca-Rodríguez, Felipe F. Casanueva, Concepcion Santiago-Fernandez, Rosa M. Baños, Rafael de la Torre, Gema Frühbeck, Juan Alcaide, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Susana Jiménez-Murcia, José Carlos Fernández-García, Zaida Agüera, Fernando Fernández-Aranda, Javier Gómez-Ambrosi, Cristina Botella, José Manuel Fernández-Real, José M. Menchón, Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina, Abe, Keiko, Universitat de Barcelona, [Carlos Fernandez-Garcia, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Aguera, Zaida] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Banos, Rosa] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Botella, Cristina] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [de la Torre, Rafael] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Fernandez-Real, Jose M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Fruhbeck, Gema] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Gomez-Ambrosi, Javier] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Jimenez-Murcia, Susana] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Casanueva, Felipe F.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Fernandez-Aranda, Fernando] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Garrido-Sanchez, Lourdes] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain, [Carlos Fernandez-Garcia, Jose] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Alcaide, Juan] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Santiago-Fernandez, Concepcion] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Roca-Rodriguez, M. M.] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Tinahones, Francisco J.] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Garrido-Sanchez, Lourdes] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga, Spain, [Aguera, Zaida] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Menchon, Jose M.] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain, [Banos, Rosa] Univ Valencia, Dept Psychol Personal Evaluat & Treatment, Valencia, Spain, [Botella, Cristina] Univ Jaume 1, Dept Basic Psychol, Clin & Psychobiol, Castellon de La Plana, Spain, [de la Torre, Rafael] Hosp del Mar Med Res Inst IMIM, Human Pharmacol & Clin Neurosci Res Grp, Neurosci Res Program, Barcelona, Spain, [de la Torre, Rafael] Univ Pompeu Fabra Barcelona, Dept Expt & Hlth Sci, Barcelona, Spain, [Fernandez-Real, Jose M.] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, Inst Invest Biomed Girona IdIBGi, Girona, Spain, [Fruhbeck, Gema] Univ Navarra, IdiSNA, Clin Univ Navarra, Metab Res Lab, Pamplona, Spain, [Gomez-Ambrosi, Javier] Univ Navarra, IdiSNA, Clin Univ Navarra, Metab Res Lab, Pamplona, Spain, [Jimenez-Murcia, Susana] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [Menchon, Jose M.] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain, [Menchon, Jose M.] Inst Salud Carlos III, CIBER Salud Mental CIBERSAM, Barcelona, Spain, [Casanueva, Felipe F.] Univ Santiago de Compostela, Complejo Hosp Univ Santiago, Div Endocrine, Santiago De Compostela, Spain, Institute Salud Carlos III, CIBERObn of ISCIII, Spain, CIBERSAM of ISCIII, Spain, Fondos Europeos de Desarrollo Regional (FEDER) Ministerio de Economia y Competitividad, Servicio Andaluz de Salud (SAS), and Fondo de Investigacion Sanitaria (FIS)

Subjects
0301 basic medicine, Leptin, Taste, Physiology, Peptide Hormones, Sensory Physiology, Olfacte, lcsh:Medicine, Social Sciences, Biochemistry, Body Mass Index, Fats, Morbid obesity, Sensitivity, 0302 clinical medicine, Odor, Discrimination, Morbidly obese, Medicine and Health Sciences, Medicine, Psychology, lcsh:Science, Children, Body mass index, media_common, education.field_of_study, Multidisciplinary, Lipids, Sensory Systems, Smell, Physiological Parameters, Obesitat, Sensory Perception, Bioelectrical impedance analysis, Research Article, medicine.medical_specialty, media_common.quotation_subject, Population, Adipokine, 030209 endocrinology & metabolism, Sweet taste, Gust, Body-weight, 03 medical and health sciences, Internal medicine, Obesity, education, 030109 nutrition & dietetics, Gustatory system, business.industry, lcsh:R, Body Weight, Correction, Biology and Life Sciences, Appetite, Insulin-resistance, medicine.disease, Hormones, Morbid Obesity, Gustatory System, Endocrinology, Taste function, lcsh:Q, Perception, business, Neuroscience
Abstract

Introduction Sensory factors may play an important role in the determination of appetite and food choices. Also, some adipokines may alter or predict the perception and pleasantness of specific odors. We aimed to analyze differences in smell–taste capacity between females with different weights and relate them with fat and fat-free mass, visceral fat, and several adipokines. Materials and methods 179 females with different weights (from low weight to morbid obesity) were studied. We analyzed the relation between fat, fat-free mass, visceral fat (indirectly estimated by bioelectrical impedance analysis with visceral fat rating (VFR)), leptin, adiponectin and visfatin. The smell and taste assessments were performed through the "Sniffin’ Sticks" and "Taste Strips" respectively. Results We found a lower score in the measurement of smell (TDI-score (Threshold, Discrimination and Identification)) in obese subjects. All the olfactory functions measured, such as threshold, discrimination, identification and the TDI-score, correlated negatively with age, body mass index (BMI), leptin, fat mass, fat-free mass and VFR. In a multiple linear regression model, VFR mainly predicted the TDI-score. With regard to the taste function measurements, the normal weight subjects showed a higher score of taste functions. However a tendency to decrease was observed in the groups with greater or lesser BMI. In a multiple linear regression model VFR and age mainly predicted the total taste scores. Discussion We show for the first time that a reverse relationship exists between visceral fat and sensory signals, such as smell and taste, across a population with different body weight conditions. Instituto Salud Carlos III (FIS PI14/ 00290) CIBERObn and CIBERSAM are both initiatives of ISCIII, Spain. Fondos Europeos de Desarrollo Regional (FEDER) Ministerio de Economı´a y Competitividad (PSI2015-68701-R) Jose C. Ferna´ndez-Garc´ıa is recipient of a research contract from Servicio Andaluz de Salud (SAS) (B- 0033-2014). L. Garrido-Sa´nchez is supported by a fellowship from the Fondo de Investigacio´n Sanitaria (FIS) “Miguel Servet I” MS13/00188-CP13/00188. The funders had no role in study design, data collection and analysis, decision topublish, or preparation of the manuscript

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