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2. Referral of Patients to Dermatology and Teledermatology Consultations in Spain. DIADERM Study

Author

Buendía, Agustín, Fernández-Crehuet, Pablo, Husein-ElAhmed, Husein, Vega, Jesús, Viera, Agustín, Manuel Carrascosa, José, Ferrán, Marta, Gómez, Enrique, Ascanio, Lucia, García Doval, Ignacio, Arias, Salvador, Gilaberte, Yolanda, Sánchez, Juan A., Serrano, Amalia, Castillo, Rosa, Fernandez, Ramón, Armario, José, Lluc Cantalejo, Carolina, Albarrán, Cristina, Cruz Martín, María, Martín, Juan Antonio, Barabash, Román, Pérez, Lara, Salamanca, Manuel, Hernández, Carlos, Millán, José Francisco, Ruiz, Inmaculada, Armesto, Susana, González, Marta, Beteta, Valia, Cuadrado de Valles, Concepción, Cristóbal, Pilar, Roth, María Magdalena, Garcias, Juan, Fernandez de Misa, Ricardo, García, Estela, Rivero, María del Pino, Suárez, José, Farthmann, Birgit, Álvarez, Alba, García, Irene, Morales, Caridad Elena, Zemba, María Cristina, Repiso, Trinidad, Sastre, Carmen, Ubals, María, Fernández, Alejandro, González, Urbà, Grimalt, Ramón, Gómez, Sara, López, Ingrid, Gemigniani, Franco Antonio, Izquierdo, María José, Alfageme, Fernando, Barrientos, Nuria, Pericet, Laura María, Vidal, Santiago, Camarero, Celia, Lázaro, Pablo, García, Cristina, de Pablo, María Pilar, Herranz, Pedro, del Olmo, Natalia, Castellanos, María, Jiménez, Natalia, Aboín, Sonsoles, Aldanondo, Isabel, Juanes, Adriana, Arranz, Dulce María, González, Olga, Casas, Luis, Vázquez, Juan José, Peña, Carmen, Cubero, José Luis, Feal, Carlos, Mayo, María Eugenia, Iglesias, Nicolás, Rojo, Rafael, Aniz, Elfidia, Kindem, Sabrina, Barrado, Nerea, Tirado, Marisa, Quecedo, Ester, Hernández, Isabel, Sahuquillo, Antonio, Bella, Rebeca, García, Ramón, Calle, Anaid, Messeguer, Francesc, Alfaro, Alberto, Casanova, Luisa, Aspe, Libe, Moreno, María Pilar, Trébol, Izaskun, Serrano, Gonzalo, Alcalde, Víctor Manuel, García, Patricia, Coscojuela, Carmen, González-López, G., Descalzo-Gallego, M.Á., Arias-Santiago, S., Molina-Leyva, A., Gilaberte, Y., Fernández-Crehuet, P., Husein-El Ahmed, H., Viera-Ramírez, A., Fernández-Peñas, P., Taberner, R., García-Doval, I., and Buendía-Eisman, A.

Published
2019
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3. Derivación de pacientes en consulta de dermatología y de teledermatología en España. Estudio DIADERM

Author

Buendía, Agustín, Fernández-Crehuet, Pablo, Husein-ElAhmed, Husein, Vega, Jesús, Viera, Agustín, Manuel Carrascosa, José, Ferrán, Marta, Gómez, Enrique, Ascanio, Lucia, García Doval, Ignacio, Arias, Salvador, Gilaberte, Yolanda, Sánchez, Juan A., Serrano, Amalia, Castillo, Rosa, Fernandez, Ramón, Armario, José, Lluc Cantalejo, Carolina, Albarrán, Cristina, Cruz Martín, María, Martín, Juan Antonio, Barabash, Román, Pérez, Lara, Salamanca, Manuel, Hernández, Carlos, Millán, José Francisco, Ruiz, Inmaculada, Armesto, Susana, González, Marta, Beteta, Valia, Cuadrado de Valles, Concepción, Cristóbal, Pilar, Roth, María Magdalena, Garcias, Juan, Fernandez de Misa, Ricardo, García, Estela, Rivero, María del Pino, Suárez, José, Farthmann, Birgit, Álvarez, Alba, García, Irene, Morales, Caridad Elena, Zemba, María Cristina, Repiso, Trinidad, Sastre, Carmen, Ubals, María, Fernández, Alejandro, González, Urbà, Grimalt, Ramón, Gómez, Sara, López, Ingrid, Gemigniani, Franco Antonio, Izquierdo, María José, Alfageme, Fernando, Barrientos, Nuria, Pericet, Laura María, Vidal, Santiago, Camarero, Celia, Lázaro, Pablo, García, Cristina, de Pablo, María Pilar, Herranz, Pedro, del Olmo, Natalia, Castellanos, María, Jiménez, Natalia, Aboín, Sonsoles, Aldanondo, Isabel, Juanes, Adriana, Arranz, Dulce María, González, Olga, Casas, Luis, Vázquez, Juan José, Peña, Carmen, Cubero, José Luis, Feal, Carlos, Mayo, María Eugenia, Iglesias, Nicolás, Rojo, Rafael, Aniz, Elfidia, Kindem, Sabrina, Barrado, Nerea, Tirado, Marisa, Quecedo, Ester, Hernández, Isabel, Sahuquillo, Antonio, Bella, Rebeca, García, Ramón, Calle, Anaid, Messeguer, Francesc, Alfaro, Alberto, Casanova, Luisa, Aspe, Libe, Moreno, María Pilar, Trébol, Izaskun, Serrano, Gonzalo, Alcalde, Víctor Manuel, García, Patricia, Coscojuela, Carmen, González-López, G., Descalzo-Gallego, M.Á., Arias-Santiago, S., Molina-Leyva, A., Gilaberte, Y., Fernández-Crehuet, P., Husein-El Ahmed, H., Viera-Ramírez, A., Fernández-Peñas, P., Taberner, R., García-Doval, I., and Buendía-Eisman, A.

Published
2019
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4. Safety of biologic therapy in combination with methotrexate in moderate to severe psoriasis: a cohort study from the BIOBADADERM registry

Author

Lluch-Galcerá, Juan José, primary, Carrascosa, Jose Manuel, additional, González-Quesada, Alicia, additional, Rivera-Díaz, Raquel, additional, Sahuquillo-Torralba, Antonio, additional, Llamas-Velasco, Mar, additional, Gómez-García, Francisco José, additional, Herrera-Acosta, Enrique, additional, de la Cueva, Pablo, additional, Baniandrés-Rodríguez, Ofelia, additional, Lopez-Estebaranz, Jose Luis, additional, Belinchón, Isabel, additional, Ferrán, Marta, additional, Mateu, Almudena, additional, Rodríguez, Lourdes, additional, Riera-Monroig, Josep, additional, Abalde-Pintos, M Teresa, additional, Carretero, Gregorio, additional, García-Donoso, Carmen, additional, Pujol-Marco, Conrad, additional, Del Alcázar, Elena, additional, Santamaría-Domínguez, Cristina, additional, Suárez-Pérez, Jorge Alonso, additional, Nieto-Benito, Lula María, additional, Ruiz-Genao, Diana Patricia, additional, Salgado-Boquete, Laura, additional, Descalzo, Miguel Ángel, additional, and García-Doval, Ignacio, additional

Published
2023
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6. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry

Author

Pérez Zafrilla, Beatriz, Muñoz-Santos, Carlos, Mendiola-Fernández, Victoria, Sánchez Roldán, Cristina, Ruiz-Genao, Diana, Echeverría, Begoña, Galiano Mejías, Sagrario, Dávila-Seijo, Paula, Dauden, Esteban, Descalzo, M.A., Carretero, Gregorio, Carrascosa, José-Manuel, Vanaclocha, Francisco, Gómez-García, Francisco-José, De la Cueva-Dobao, Pablo, Herrera-Ceballos, Enrique, Belinchón, Isabel, López-Estebaranz, José-Luis, Alsina, Merce, Sánchez-Carazo, José-Luis, Ferrán, Marta, Torrado, Rosa, Ferrandiz, Carlos, Rivera, Raquel, Llamas, Mar, Jiménez-Puya, Rafael, and García-Doval, Ignacio

Published
2017
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7. Safety of biologic therapy in combination with methotrexate in moderate to severe psoriasis: a cohort study from the BIOBADADERM registry.

Author

Lluch-Galcerá, Juan José, Carrascosa, Jose Manuel, González-Quesada, Alicia, Rivera-Díaz, Raquel, Sahuquillo-Torralba, Antonio, Llamas-Velasco, Mar, Gómez-García, Francisco José, Herrera-Acosta, Enrique, de la Cueva, Pablo, Baniandrés-Rodríguez, Ofelia, Lopez-Estebaranz, Jose Luis, Belinchón, Isabel, Ferrán, Marta, Mateu, Almudena, Rodríguez, Lourdes, Riera-Monroig, Josep, Abalde-Pintos, M Teresa, Carretero, Gregorio, García-Donoso, Carmen, and Pujol-Marco, Conrad

Subjects
BIOTHERAPY, METHOTREXATE, PSORIASIS, POISSON regression, COHORT analysis
Abstract

Background Safety is an important consideration in decisions on treatment for patients with moderate-to-severe psoriasis and the study of drug safety is the main purpose of the BIOBADADERM registry. The combination of a biologic agent and a conventional systemic drug [generally methotrexate (MTX)] is a common treatment in clinical practice. However, there is a paucity of evidence from real-world practice on the safety of such combination regimens in the treatment of psoriasis. Objectives The primary objective of this study was to ascertain whether the use of regimens combining biologic drugs with MTX in the management of moderate-to-severe psoriasis increases the risk of adverse events (AEs) or serious AEs (SAEs). We compared monotherapy using tumour necrosis factor (TNF), interleukin (IL)-17 and IL-23 inhibitors with the use of the same drugs in combination with MTX. Methods Using data from the BIOBADADERM registry, we compared biologic monotherapies with therapies that were combined with MTX. We estimated adjusted incidence rate ratios (aIRR) using a random effects Poisson regression with 95% confidence intervals for all AEs, SAEs, infections and serious infections and other AEs by system organ class. Results We analysed data from 2829 patients and 5441 treatment cycles, a total of 12 853 patient-years. The combination of a biologic with MTX was not associated with statistically significant increases in overall risk of AEs or SAEs in any treatment group. No increase in the total number of infections or serious infections in patients receiving combined therapy was observed for any group. However, treatment with a TNF inhibitor combined with MTX was associated with an increase in the incidence of gastrointestinal AEs (aIRR 2.50, 95% CI 1.57–3.98; P < 0.002). Conclusions The risk of AEs and SAEs was not significantly increased in patients with moderate-to-severe psoriasis receiving different classes of biologic drugs combined with MTX compared with those on biologic monotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The Exonuclease Trex2 Shapes Psoriatic Phenotype

Author

Manils, Joan, Casas, Eduard, Viña-Vilaseca, Arnau, López-Cano, Marc, Díez-Villanueva, Anna, Gómez, Diana, Marruecos, Laura, Ferran, Marta, Benito, Carmen, Perrino, Fred W., Vavouri, Tanya, de Anta, Josep Maria, Ciruela, Francisco, and Soler, Concepció

Published
2016
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14. The risk of urinary tract infections in patients with psoriasis on systemic medications in Biobadaderm Registry: A prospective cohort study

Author

Sahuquillo-Torralba, Antonio, Carretero, Gregorio, Rivera, Raquel, Ferrándiz, Carlos, Daudén-Tello, Esteban, de la Cueva, Pablo, Gómez-García, Francisco José, Belinchón, Isabel, Herrera-Acosta, Enrique, Ruiz-Genao, Diana, Ferrán, Marta, Alsina, Mercé, Sánchez-Carazo, Jose Luís, Baniandrés, Ofelia, Fernández-Freire, Lourdes Rodríguez, Vilar, Jaime, García-Donoso, Carmen, Carrascosa, Jose Manuel, Llamas-Velasco, Mar, Herrera-Ceballos, Enrique, López-Estebaranz, José Luis, Pujol-Marco, Conrad, Descalzo, Miguel Ángel, and García-Doval, Ignacio

Published
2020
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15. Risk of Serious Adverse Events Associated With Biologic and Nonbiologic Psoriasis Systemic Therapy: Patients Ineligible vs Eligible for Randomized Controlled Trials

Author

Garcia-Doval, Ignacio, Carretero, Gregorio, Vanaclocha, Francisco, Ferrandiz, Carlos, Daudén, Esteban, Sánchez-Carazo, Jose-Luis, Alsina, Mercé, Herrera-Ceballos, Enrique, Gómez-García, Francisco-José, Ferrán, Marta, López-Estebaranz, Jose-Luis, Hernanz, Jose-Manuel, Belinchón-Romero, Isabel, Vilar-Alejo, Jaime, Rivera, Raquel, Carrascosa, Jose-Manuel, and Carazo, Cristina

Published
2012
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16. The effectiveness and safety of ixekizumab in psoriasis patients under clinical practice conditions: A Spanish multicentre retrospective study

Author

Rivera, Raquel, primary, Velasco, Manuel, additional, Vidal, David, additional, Carrascosa, J. Manuel, additional, Daudén, Esteban, additional, Vilarrasa, E, additional, Notario, Jaime, additional, Ruíz‐Villaverde, Ricardo, additional, Yanguas, Ignacio, additional, García‐Latasa, Francisco Javier, additional, Ferrán, Marta, additional, Lázaro‐Simó, Anna, additional, Cueva, Pablo, additional, Salgado‐Boquete, Laura, additional, and Belinchón, Isabel, additional

Published
2020
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17. Change over time in the rates of adverse events in patients receiving systemic therapy for psoriasis: A cohort study

Author

Descalzo, Miguel Angel, Carretero, Gregorio, Ferrándiz, Carlos, Rivera, Raquel, Daudén, Esteban, Gómez-García, Fran J., de la Cueva, Pablo, Herrera-Ceballos, Enrique, Belinchón, Isabel, López-Estebaranz, José Luis, Alsina, Mercè, Sánchez-Carazo, José Luis, Ferrán, Marta, Baniandrés, Ofelia, Carrascosa, José Manuel, Llamas-Velasco, Mar, Ruiz-Genao, Diana, Herrera-Acosta, Enrique, Muñoz-Santos, Carlos, and García-Doval, Ignacio

Published
2018
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18. Referral of Patients to Dermatology and Teledermatology Consultations in Spain. DIADERM Study

Author

González-López, G., primary, Descalzo-Gallego, M.Á., additional, Arias-Santiago, S., additional, Molina-Leyva, A., additional, Gilaberte, Y., additional, Fernández-Crehuet, P., additional, Husein-El Ahmed, H., additional, Viera-Ramírez, A., additional, Fernández-Peñas, P., additional, Taberner, R., additional, García-Doval, I., additional, Buendía-Eisman, A., additional, Buendía, Agustín, additional, Fernández-Crehuet, Pablo, additional, Husein-ElAhmed, Husein, additional, Vega, Jesús, additional, Viera, Agustín, additional, Manuel Carrascosa, José, additional, Ferrán, Marta, additional, Gómez, Enrique, additional, Ascanio, Lucia, additional, García Doval, Ignacio, additional, Arias, Salvador, additional, Gilaberte, Yolanda, additional, Sánchez, Juan A., additional, Serrano, Amalia, additional, Castillo, Rosa, additional, Fernandez, Ramón, additional, Armario, José, additional, Lluc Cantalejo, Carolina, additional, Albarrán, Cristina, additional, Cruz Martín, María, additional, Martín, Juan Antonio, additional, Barabash, Román, additional, Pérez, Lara, additional, Salamanca, Manuel, additional, Hernández, Carlos, additional, Millán, José Francisco, additional, Ruiz, Inmaculada, additional, Armesto, Susana, additional, González, Marta, additional, Beteta, Valia, additional, Cuadrado de Valles, Concepción, additional, Cristóbal, Pilar, additional, Roth, María Magdalena, additional, Garcias, Juan, additional, Fernandez de Misa, Ricardo, additional, García, Estela, additional, Rivero, María del Pino, additional, Suárez, José, additional, Farthmann, Birgit, additional, Álvarez, Alba, additional, García, Irene, additional, Morales, Caridad Elena, additional, Zemba, María Cristina, additional, Repiso, Trinidad, additional, Sastre, Carmen, additional, Ubals, María, additional, Fernández, Alejandro, additional, González, Urbà, additional, Grimalt, Ramón, additional, Gómez, Sara, additional, López, Ingrid, additional, Gemigniani, Franco Antonio, additional, Izquierdo, María José, additional, Alfageme, Fernando, additional, Barrientos, Nuria, additional, Pericet, Laura María, additional, Vidal, Santiago, additional, Camarero, Celia, additional, Lázaro, Pablo, additional, García, Cristina, additional, de Pablo, María Pilar, additional, Herranz, Pedro, additional, del Olmo, Natalia, additional, Castellanos, María, additional, Jiménez, Natalia, additional, Aboín, Sonsoles, additional, Aldanondo, Isabel, additional, Juanes, Adriana, additional, Arranz, Dulce María, additional, González, Olga, additional, Casas, Luis, additional, Vázquez, Juan José, additional, Peña, Carmen, additional, Cubero, José Luis, additional, Feal, Carlos, additional, Mayo, María Eugenia, additional, Iglesias, Nicolás, additional, Rojo, Rafael, additional, Aniz, Elfidia, additional, Kindem, Sabrina, additional, Barrado, Nerea, additional, Tirado, Marisa, additional, Quecedo, Ester, additional, Hernández, Isabel, additional, Sahuquillo, Antonio, additional, Bella, Rebeca, additional, García, Ramón, additional, Calle, Anaid, additional, Messeguer, Francesc, additional, Alfaro, Alberto, additional, Casanova, Luisa, additional, Aspe, Libe, additional, Moreno, María Pilar, additional, Trébol, Izaskun, additional, Serrano, Gonzalo, additional, Alcalde, Víctor Manuel, additional, García, Patricia, additional, and Coscojuela, Carmen, additional

Published
2019
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19. Derivación de pacientes en consulta de dermatología y de teledermatología en España. Estudio DIADERM

Author

González-López, G., primary, Descalzo-Gallego, M.Á., additional, Arias-Santiago, S., additional, Molina-Leyva, A., additional, Gilaberte, Y., additional, Fernández-Crehuet, P., additional, Husein-El Ahmed, H., additional, Viera-Ramírez, A., additional, Fernández-Peñas, P., additional, Taberner, R., additional, García-Doval, I., additional, Buendía-Eisman, A., additional, Buendía, Agustín, additional, Fernández-Crehuet, Pablo, additional, Husein-ElAhmed, Husein, additional, Vega, Jesús, additional, Viera, Agustín, additional, Manuel Carrascosa, José, additional, Ferrán, Marta, additional, Gómez, Enrique, additional, Ascanio, Lucia, additional, García Doval, Ignacio, additional, Arias, Salvador, additional, Gilaberte, Yolanda, additional, Sánchez, Juan A., additional, Serrano, Amalia, additional, Castillo, Rosa, additional, Fernandez, Ramón, additional, Armario, José, additional, Lluc Cantalejo, Carolina, additional, Albarrán, Cristina, additional, Cruz Martín, María, additional, Martín, Juan Antonio, additional, Barabash, Román, additional, Pérez, Lara, additional, Salamanca, Manuel, additional, Hernández, Carlos, additional, Millán, José Francisco, additional, Ruiz, Inmaculada, additional, Armesto, Susana, additional, González, Marta, additional, Beteta, Valia, additional, Cuadrado de Valles, Concepción, additional, Cristóbal, Pilar, additional, Roth, María Magdalena, additional, Garcias, Juan, additional, Fernandez de Misa, Ricardo, additional, García, Estela, additional, Rivero, María del Pino, additional, Suárez, José, additional, Farthmann, Birgit, additional, Álvarez, Alba, additional, García, Irene, additional, Morales, Caridad Elena, additional, Zemba, María Cristina, additional, Repiso, Trinidad, additional, Sastre, Carmen, additional, Ubals, María, additional, Fernández, Alejandro, additional, González, Urbà, additional, Grimalt, Ramón, additional, Gómez, Sara, additional, López, Ingrid, additional, Gemigniani, Franco Antonio, additional, Izquierdo, María José, additional, Alfageme, Fernando, additional, Barrientos, Nuria, additional, Pericet, Laura María, additional, Vidal, Santiago, additional, Camarero, Celia, additional, Lázaro, Pablo, additional, García, Cristina, additional, de Pablo, María Pilar, additional, Herranz, Pedro, additional, del Olmo, Natalia, additional, Castellanos, María, additional, Jiménez, Natalia, additional, Aboín, Sonsoles, additional, Aldanondo, Isabel, additional, Juanes, Adriana, additional, Arranz, Dulce María, additional, González, Olga, additional, Casas, Luis, additional, Vázquez, Juan José, additional, Peña, Carmen, additional, Cubero, José Luis, additional, Feal, Carlos, additional, Mayo, María Eugenia, additional, Iglesias, Nicolás, additional, Rojo, Rafael, additional, Aniz, Elfidia, additional, Kindem, Sabrina, additional, Barrado, Nerea, additional, Tirado, Marisa, additional, Quecedo, Ester, additional, Hernández, Isabel, additional, Sahuquillo, Antonio, additional, Bella, Rebeca, additional, García, Ramón, additional, Calle, Anaid, additional, Messeguer, Francesc, additional, Alfaro, Alberto, additional, Casanova, Luisa, additional, Aspe, Libe, additional, Moreno, María Pilar, additional, Trébol, Izaskun, additional, Serrano, Gonzalo, additional, Alcalde, Víctor Manuel, additional, García, Patricia, additional, and Coscojuela, Carmen, additional

Published
2019
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20. Effect of Sex in Systemic Psoriasis Therapy: Differences in Prescription, Effectiveness and Safety in the BIOBADADERM Prospective Cohort.

Author

HERNÁNDEZ-FERNÁNDEZ, Carlos Pelayo, CARRETERO, Gregorio, RIVERA, Raquel, FERRÁNDIZ, Carlos, DAUDÉN, Esteban, DE LA CUEVA, Pablo, BELINCHÓN, Isabel, GÓMEZ-GARCÍA, Francisco Javier, HERRERA-ACOSTA, Enrique, RUIZ-GENAO, Diana P., FERRÁN, MARTA, ALSINA, Mercé, BANIANDRÉS-RODRÍGUEZ, Ofelia, SÁNCHEZ-CARAZO, Jose Luis, BOTELLA-ESTRADA, Rafael, SAHUQUILLO-TORRALBA, Antonio, RODRIGUEZ, Lourdes, VILAR-ALEJO, Jaime, GARCÍA-DONOSO, Carmen, and CARRASCOSA, Jose M.

Subjects
PSORIASIS treatment, GENDER, PSORIASIS, TREATMENT effectiveness, DRUG prescribing
Abstract

The effect of sex on systemic therapy for psoriasis has not been well studied. The aim of this study was to analyse a large multicentre Spanish cohort of 2,881 patients with psoriasis (58.3% males), followed from January 2008 to November 2018, to determine whether sex influences prescription, effectiveness of therapy, and the risk of adverse events. The results show that women are more likely than men to be prescribed biologics. There were no differences between men and women in effectiveness of therapy, measured in terms of drug survival. Women were more likely to develop adverse events, but the difference in risk was small and does not justify different management. Study limitations include residual confounding and the use of drug survival as a proxy for effectiveness. [ABSTRACT FROM AUTHOR]

Published
2021
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21. Change over time in the rates of adverse events in patients receiving systemic therapy for psoriasis: A cohort study

Author

Descalzo, Miguel Angel, Carretero, Gregorio, Ferrándiz, Carlos, Rivera, Raquel, Daudén, Esteban, Gómez-García, Fran J, de la Cueva, Pablo, Herrera-Ceballos, Enrique, Belinchón, Isabel, López-Estebaranz, José Luis, Alsina, Mercè, Sánchez-Carazo, José Luis, Ferrán, Marta, Baniandrés, Ofelia, Carrascosa, José Manuel, Llamas-Velasco, Mar, Ruiz-Genao, Diana, Herrera-Acosta, Enrique, Muñoz-Santos, Carlos, García-Doval, Ignacio, and Biobadaderm Study Group

Subjects
0301 basic medicine, Change over time, Male, medicine.medical_specialty, Time Factors, Drug-Related Side Effects and Adverse Reactions, Dermatology, Systemic therapy, Cohort Studies, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Psoriasis, medicine, Humans, In patient, Adverse effect, Time trends, business.industry, Diagnostic test, Middle Aged, medicine.disease, Surgery, 030104 developmental biology, Female, business, Psoriasi -- Tractament, Cohort study
Published
2017

22. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry

Author

Dávila-Seijo, Paula, primary, Dauden, Esteban, additional, Descalzo, M.A., additional, Carretero, Gregorio, additional, Carrascosa, José-Manuel, additional, Vanaclocha, Francisco, additional, Gómez-García, Francisco-José, additional, De la Cueva-Dobao, Pablo, additional, Herrera-Ceballos, Enrique, additional, Belinchón, Isabel, additional, López-Estebaranz, José-Luis, additional, Alsina, Merce, additional, Sánchez-Carazo, José-Luis, additional, Ferrán, Marta, additional, Torrado, Rosa, additional, Ferrandiz, Carlos, additional, Rivera, Raquel, additional, Llamas, Mar, additional, Jiménez-Puya, Rafael, additional, García-Doval, Ignacio, additional, Pérez Zafrilla, Beatriz, additional, Muñoz-Santos, Carlos, additional, Mendiola-Fernández, Victoria, additional, Sánchez Roldán, Cristina, additional, Ruiz-Genao, Diana, additional, Echeverría, Begoña, additional, and Galiano Mejías, Sagrario, additional

Published
2017
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23. Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study.

Author

Montes-Torres, Andrea, Aparicio, Gloria, Rivera, Raquel, Vilarrasa, Eva, Marcellán, María, Notario, Jaume, Soria, Caridad, Belinchón, Isabel, de la Cueva, Pablo, Ferrán, Marta, Carrascosa, Jose Manuel, Gómez, Francisco J., Salgado, Laura, Velasco, Manuel, Descalzo, Miguel Ángel, García-Doval, Ignacio, and Daudén, Esteban

Subjects
HIV infections, BIOTHERAPY, DRUG therapy, VIRAL load, CD4 lymphocyte count
Abstract

Background: The management of HIV-positive patients with psoriasis is controversial and limited to individual cases or short series of patients. Objectives: To evaluate the safety and effectiveness of conventional and biologic immunosuppressive drugs in the treatment of patients with psoriasis and concomitant HIV infection. Methods: A retrospective multicenter study was conducted. The study included data from 2008 to 2016. Inclusion criteria were: HIV adult patients with moderate-to-severe psoriasis, HIV viral load determinations at baseline and at least after 6 months of treatment, and systemic immunosuppressive treatment for at least 6 months. A descriptive analysis was performed. Results: Twenty-three patients with plaque-type psoriasis and HIV infection (five with AIDS) were included. Median follow-up time was 3.2 years. The main drugs used were etanercept, methotrexate, and ustekinumab. In most cases, viral load and CD4 cell count not only remained stable but also improved throughout the follow-up. Six patients presented severe adverse events during the follow-up, four of them in the AIDS stage. At the end of the follow-up period, 76.5% of the patients had achieved a PASI 75. Conclusion: Biologic drugs, both anti-TNF alpha agents and ustekinumab, seem to have an acceptable safety profile and high effectiveness in HIV-positive patients. [ABSTRACT FROM AUTHOR]

Published
2019
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24. Pityriasis rubra pilaris: a multicenter case series of 65 Spanish patients

Author

Menárguez, Julia Montero, Samaranch, Victoria Amat, Sanz, L Puig, Villaverde, R Ruiz, Santiago, S Arias, García, M Larrea, Genao, D Ruiz, Ferrán, Marta, Pavelescu, L Schneller, Ferreiro, C Romero, and Díaz, R Rivera

Abstract

Introduction: PRP is a rare entity of unknown etiopathogenesis. Lack of clinical practice guidelines makes management challenging for clinicians.

Published
2024
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27. Development of clinical prediction models for good or bad response to classic systemic drugs, anti-TNFs, and ustekinumab in psoriasis, based on the BIOBADADERM cohort.

Author

García-Doval, Ignacio, Pérez-Zafrilla, Beatriz, Ferrandiz, Carlos, Carretero, Gregorio, Daudén, Esteban, de la Cueva, Pablo, Gómez-García, Francisco J, Herrera-Ceballos, Enrique, Belinchón-Romero, Isabel, Sánchez-Carazo, Jose Luis, López-Estebaranz, Jose-Luis, Alsina, Merce, Ferrán, Marta, Torrado, Rosa, Carrascosa, Jose-Manuel, Rivera, Raquel, and Vanaclocha, Francisco

Subjects
PSORIASIS treatment, THERAPEUTIC use of monoclonal antibodies, TUMOR necrosis factors, HEALTH outcome assessment, FOLLOW-up studies (Medicine)
Abstract

Background: Identifying patients likely to have very good or bad results from systemic psoriasis therapy could improve efficiency of therapy.Objective: To develop prognostic models for good or bad response to classic systemic drugs, anti-TNFs, and ustekinumab in psoriasis.Methods: Multivariable logistic regression of a prospective multicenter cohort of psoriatic patients in clinical practice (6449 person-years of follow-up). We used as possible predictors demographic characteristics, comorbidities, characteristics of the psoriasis (type, PASI, arthritis), history of past therapy at entry in the cohort, and history of response to previous cycles while in the cohort. We defined good response to a treatment cycle as either cycle end due to disease remission or a cycle longer than 2 years that does not end later due to inefficacy in the follow-up period. Bad response to a treatment cycle was defined as a cycle that is finished due to inefficacy, based on the physician judgment, after more than 3 months of treatment.Results: Patients with fewer previous therapies, lower body mass index, older at start of therapy, and with previous history of good responses to therapy are more likely to have positive results of therapy. However, the predictive characteristics of models are poor.Conclusion: Predictive models of clinical response to systemic drugs in psoriasis with the studied variables do not seem to outperform drug selection by a dermatologist. [ABSTRACT FROM AUTHOR]

Published
2016
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30. Use of off-label doses is frequent in biologic therapy for moderate to severe psoriasis: A cross-sectional study in clinical practice.

Author

Carrascosa, Jose-Manuel, Garcia-Doval, Ignacio, Pérez-Zafrilla, Beatriz, Carretero, Gregorio, Vanaclocha, Francisco, Daudén, Esteban, De la Cueva-Dobao, Pablo, Belinchón, Isabel, Alsina, Merce, López-Estebaranz, Jose-Luis, Ferrán, Marta, Torrado, Rosa, Rivera, Raquel, Carazo, Cristina, Barboza, Lorena, and Ferrándiz, Carlos

Subjects
PSORIASIS treatment, BIOTHERAPY, DRUG efficacy, REDUCTION of drug dosage, DRUG dosage
Abstract

Introduction: Biologic medications increase dramatically the burden of a chronic and high prevalent disease like psoriasis. The objective of the study was to quantify the use of dose reduction or dose escalation strategies, not reflected in the drug summary of product characteristics, in clinical practice.Methods: An observational, cross-sectional study of a subset of patients from the Spanish Registry for Systemic Treatments in Psoriasis (BIOBADADERM) treated for over six consecutive months with the same biologic agent.Results: The study included 637 patients. At the cut-off date, the initial dose had been reduced in 223 patients (35%; 95% CI: 31.3–38.9%) and escalated in 46 (7.2%; 95% CI: 5.3–9.5%). When compared with the patients treated with standard doses, the patients on reduced doses had a lower PASI score at the cut-off date (a mean 2.6 versus 1; −1.6 points) and exhibited greater improvement in PASI since the start of biologic therapy (mean reduction over baseline 75% versus 87%). By contrast, the patients receiving an escalated dose had higher PASI scores (2.6 versus 8.0) and showed less improvement in PASI (75% versus 46.8%).Conclusion: Off-label doses of biologic agents for psoriasis are frequent in clinical practice. This information is especially relevant for pharmacoeconomic models. [ABSTRACT FROM PUBLISHER]

Published
2015
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