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185 results on '"Ferrè, F"'

5. Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study

Author

Bedague, D., Blanié, A., Casez, M., Chanques, G., Chaize, C., Dessertaine, G., Ferré, F., Gaide Chevronnay, L., Hébrard, A., Hespel, A., Jaber, S., de Jong, A., Lahjaouzi, A., Marino, M.R., Moury, P.H., Neau, A.C., Protar, D., Rhem, D., Rineau, E., Robin, S., Rossignol, E., Soucemarianadin, M., Veaceslav, S., Beloeil, H., Albaladejo, P., Sion, A., Durand, M., Martinez, V., Lasocki, S., Futier, E., Verzili, D., Minville, V., Fessenmeyer, C., Belbachir, A., Aubrun, F., Renault, A., and Bellissant, E.

Published
2019
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7. A multicentre observational study on management of general anaesthesia in elderly patients at high-risk of postoperative adverse outcomes

Author

Bruder, N., Vaisse, C., Bechis, C., Bernard, L., Leone, M., Poirier, M., Vincent, A., Abdelkrim, N., Paugam, C., Lion, F., Montravers, P., Langeron, O., Raux, M., Baussier, M., Xu, K., Bart, F., Dagois, S., Plaud, B., Rabuel, C., Roland, E., Biais, M., Nouette-Gaulain, K., Cabart, A., Hanouz, J.L., Lambert, C., Godet, T., Thibault, S., Bouhemad, B., Chambade, E., Bouzat, P., Garot, M., Lebuffe, G., Lallemant, F., Lemery, C., Tavernier, B., de Jong, A., Jaber, S., Verzilli, D., Delannoy, M., Meistelman, C., Carles, M., Tran, L., Bertran, S., Cuvillon, P., Ripart, J., Simon-Pene, S., Boisson, M., Debaene, B., Beloeil, H., Godet, G., Collange, O., Mertes, P.M., Diemunsch, P., Joganah, D., Oehlkern, L., Baulieu, M., Beauchesne, B., Beraud, A.M., Berthier-Berrada, S., Bien, J.Y., Dupont, G., Gavory, J., Lambert, P., Lanoiselée, J., Zufferey, P., Ferré, F., Martin, C., Minville, V., Planté, B., Baffeleuf, B., Ben Abdelkarim, M., David, J.S., Incagnoli, P., Khaled, M., Laplace, M.C., Lefevre, M., Piriou, V., Aubrun, F., Cero, V., Delsuc, C., Faulcon, C., Meuret, P., Rimmelé, T., Truc, C., Molliex, Serge, Passot, Sylvie, Morel, Jerome, Futier, Emmanuel, Lefrant, Jean Yves, Constantin, Jean Michel, Le Manach, Yannick, and Pereira, Bruno

Published
2019
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14. Quantitative PCR: An Overview

Author

Ferré, F., Marchese, A., Pezzoli, P., Griffin, S., Buxton, E., Boyer, V., Mullis, Kary B., editor, Ferré, François, editor, and Gibbs, Richard A., editor

Published
1994
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20. PROMs in post-mastectomy care: Patient self-reports (BREAST-Q™) as a powerful instrument to personalize medical services

Author

Ghilli, M., primary, Mariniello, M.D., additional, Camilleri, V., additional, Murante, A.M., additional, Ferrè, F., additional, Colizzi, L., additional, Gennaro, M., additional, Caligo, M.A., additional, Scatena, C., additional, Del Re, M., additional, Nuti, S., additional, Caramella, D., additional, and Roncella, M., additional

Published
2020
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21. Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation

Author

Mongiardi MP 1, Radice G 1, Piras M 1, Stagni V 2, 3, Pacioni S 1, 4, Re A 1, Putti S 1, Ferrè F 5, Farsetti A 1, Pallini R4, Barilà D2, Levi A1, Falchetti ML., Mongiardi M.P., Radice G., Piras M., Stagni V., Pacioni S., Re A., Putti S., Ferre F., Farsetti A., Pallini R., Barila D., Levi A., and Falchetti M.L.

Subjects
0301 basic medicine, Senescence, Cancer Research, Axitinib, Cell, Angiogenesis Inhibitors, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Biology, angiogenesis inhibitors, antineoplastic agents, antioxidants, ataxia telangiectasia mutated proteins, axitinib, cellular senescence, endothelial cells, enzyme activation, human umbilical vein endothelial cells, humans, neovascularization, pathologic, protein kinase inhibitors, reactive oxygen species, Antioxidants, 03 medical and health sciences, Enzyme activator, chemistry.chemical_compound, 0302 clinical medicine, pathologic, Genetics, medicine, Human Umbilical Vein Endothelial Cells, Humans, Doxorubicin, Molecular Biology, Protein Kinase Inhibitors, Cellular Senescence, Neovascularization, Pathologic, Kinase, Endothelial Cells, Vascular endothelial growth factor, Enzyme Activation, No keywords provided, Settore BIO/18 - Genetica, 030104 developmental biology, medicine.anatomical_structure, chemistry, ATM, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, neovascularization, Reactive Oxygen Species, medicine.drug
Abstract

Inhibitors of Vascular Endothelial Growth Factor target both tumor vasculature and cancer cells that have hijacked VEGF Receptors (VEGFRs) signaling for tumor growth-promoting activities. It is important to get precise insight in the specificity of cell responses to these antiangiogenic drugs to maximize their efficiency and minimize off-target systemic toxicity. Here we report that Axitinib, an inhibitor of VEGFRs currently in use as a second line treatment for advanced renal cell carcinoma, promotes senescence of human endothelial cells in vitro. A one-hour pulse of Axitinib is sufficient for triggering cell senescence. Mechanistically, this requires oxidative stress-dependent activation of the Ataxia Telangiectasia Mutated (ATM) kinase. Axitinib-mediated senescence promoting action is prevented by short-term treatment with antioxidants or ATM inhibitors, which conversely fail to prevent senescence induced by the DNA-damaging drug doxorubicin. Coherently, induction of oxidative stress-related genes distinguishes the response of endothelial cells to Axitinib from that to doxorubicin. Importantly, an Axitinib pulse causes cell senescence in glioblastoma cells. However, neither antioxidants nor ATM inhibitors can reverse this phenotype. Thus, antioxidants may selectively protect endothelial cells from Axitinib by decreasing systemic toxicity and maintaining a functional vascularization necessary for efficient delivery of chemotherapeutic drugs within the tumor mass.

Published
2019
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25. Fondamenti di bioinformatica

Author

Helmer Citterich, M, Ferrè, F, Pavesi, G, Pesole, G, and Romualdi, C

Subjects
Settore BIO/11
Published
2018

35. Sequencing of the water buffalo genome: results and prospectives

Author

Iamartino D., Williams J. L., Ajmone Marsan P., Valentini A., Moioli B., Chillemi G., Strozzi F., Ferrè F., Biagini T., Mancini G., Pasquariello R., Coletta A., Castiglioni B., Macciotta N., Matassino D., Pilla F., D’andrea M., Corrado F., RAMUNNO, LUIGI, COSENZA, GIANFRANCO, ZICARELLI, LUIGI, IANNUZZI, LEOPOLDO, PERETTI, VINCENZO, Italian Journal of Animal Science, Iamartino, D., Williams, J. L., Ramunno, Luigi, Ajmone Marsan, P., Valentini, A., Moioli, B., Chillemi, G., Strozzi, F., Ferrè, F., Biagini, T., Mancini, G., Pasquariello, R., Cosenza, Gianfranco, Coletta, A., Castiglioni, B., Zicarelli, Luigi, Iannuzzi, Leopoldo, Macciotta, N., Matassino, D., Pilla, F., D’Andrea, M., Corrado, F., and Peretti, Vincenzo

Published
2013

36. Web-Beagle: a web server for the alignment of RNA secondary structures

Author

Mattei, E, Pietrosanto, M, Ferrè, F, HELMER CITTERICH, M, Mattei, Eugenio, Pietrosanto, Marco, Ferrè, Fabrizio, and Helmer-Citterich, Manuela

Subjects
Algorithm, Internet, Settore BIO/11, Sequence Analysis, RNA, Web Server issue, Nucleic Acid Conformation, RNA, Sequence Alignment, Algorithms, Software
Abstract

Web-Beagle (http://beagle.bio.uniroma2.it) is a web server for the pairwise global or local alignment of RNA secondary structures. The server exploits a new encoding for RNA secondary structure and a substitution matrix of RNA structural elements to perform RNA structural alignments. The web server allows the user to compute up to 10 000 alignments in a single run, taking as input sets of RNA sequences and structures or primary sequences alone. In the latter case, the server computes the secondary structure prediction for the RNAs on-the-fly using RNAfold (free energy minimization). The user can also compare a set of input RNAs to one of five pre-compiled RNA datasets including lncRNAs and 3' UTRs. All types of comparison produce in output the pairwise alignments along with structural similarity and statistical significance measures for each resulting alignment. A graphical color-coded representation of the alignments allows the user to easily identify structural similarities between RNAs. Web-Beagle can be used for finding structurally related regions in two or more RNAs, for the identification of homologous regions or for functional annotation. Benchmark tests show that Web-Beagle has lower computational complexity, running time and better performances than other available methods.

Published
2015

42. The financial crisis in Italy: Implications for the healthcare sector

Author

De Belvis, Antonio, Ferrè, F, Specchia, Maria Lucia, Valerio, L, Fattore, G, Ricciardi, Gualtiero, De Belvis, Antonio (ORCID:0000-0003-4456-1937), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), De Belvis, Antonio, Ferrè, F, Specchia, Maria Lucia, Valerio, L, Fattore, G, Ricciardi, Gualtiero, De Belvis, Antonio (ORCID:0000-0003-4456-1937), Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

The global economic and financial crisis is having and impact on the Italian healthcare system which is undergoing a devolution process from the central government to regions and where about one third of the regional governments (mainly in the central and southern part of the country) are facing large financial deficits. The paper briefly describes the current macro scenario and the main responses taken to face the crisis and highlights the downside risks of introducing " linear" cuts in the allocation of resources. While justified by the risk of a national debt default, present fiscal policies might increase inequalities in access to care, deteriorate overall health indicators and population wellbeing, and sharpen existing difference in the quality of care between regions. Preliminary evidence shows that the crisis is affecting the quality of nutrition and the incidence of psychiatric disorders. During this difficult financial situation Italy is also facing the risk of a major reduction in investments for preventive medicine, Evidence Based Medicine infrastructures, health information systems and physical capital renewal. This cost-cutting strategy may have negative long term consequences Also, important achievement in terms of limiting waiting lists, improving continuity of care and patients' centeredness, and promoting integration between social and health care may be negatively affected by unprecedented resources' cuts. It is essential that in such a period of public funding constraints health authorities monitor incidence of diseases and access to care of the most vulnerable groups and specifically target interventions to those who may be disproportionally hit by the crisis. © 2012 Elsevier Ireland Ltd.

Published
2012

43. The financial crisis in Italy: implications for the healthcare sector

Author

Ferrè, F, Specchia, Maria Lucia, Valerio, Luca, Fattore, G, Ricciardi, Walter, De Belvis, Antonio Giulio, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X), Ferrè, F, Specchia, Maria Lucia, Valerio, Luca, Fattore, G, Ricciardi, Walter, De Belvis, Antonio Giulio, Specchia, Maria Lucia (ORCID:0000-0002-3859-4591), and Ricciardi, Gualtiero (ORCID:0000-0002-5655-688X)

Abstract

The global economic and financial crisis is having and impact on the Italian healthcare system which is undergoing a devolution process from the central government to regions and where about one third of the regional governments (mainly in the central and southern part of the country) are facing large financial deficits. The paper briefly describes the current macro scenario and the main responses taken to face the crisis and highlights the downside risks of introducing "linear" cuts in the allocation of resources. While justified by the risk of a national debt default, present fiscal policies might increase inequalities in access to care, deteriorate overall health indicators and population wellbeing, and sharpen existing difference in the quality of care between regions. Preliminary evidence shows that the crisis is affecting the quality of nutrition and the incidence of psychiatric disorders. During this difficult financial situation Italy is also facing the risk of a major reduction in investments for preventive medicine, Evidence Based Medicine infrastructures, health information systems and physical capital renewal. This cost-cutting strategy may have negative long term consequences Also, important achievement in terms of limiting waiting lists, improving continuity of care and patients' centeredness, and promoting integration between social and health care may be negatively affected by unprecedented resources' cuts. It is essential that in such a period of public funding constraints health authorities monitor incidence of diseases and access to care of the most vulnerable groups and specifically target interventions to those who may be disproportionally hit by the crisis.

Published
2012

44. Three-dimensional view of the surface motif associated with the P-loop structure: cis and trans cases of convergent evolution

Author

Via, A, Ferrè, F, Brannetti, B, Valencia, A, and HELMER CITTERICH, M

Subjects
Protein Structure, Binding Sites, Alanine, Evolution, Settore BIO/11, Amino Acid Motifs, Static Electricity, Molecular Sequence Data, Molecular, Arginine, Substrate Specificity, Protein Structure, Tertiary, Evolution, Molecular, Nucleoside-Phosphate Kinase, Conserved Sequence, Adenosine Triphosphate, Ribonucleases, Animals, Humans, Models, Molecular, Guanosine Triphosphate, GTP-Binding Proteins, Sequence Alignment, Asparagine, Amino Acid Sequence, Models, Tertiary
Published
2000

45. Choice-option evaluation is preserved in early Huntington and Parkinson's disease

Author

Minati, L, Piacentini, Sylvie, Ferrè, F, Nanetti, L, Romito, Luigi Michele Antonio, Mariotti, Caterina, Grisoli, M, Medford, N, Critchley, Hd, Albanese, Alberto, Albanese, Alberto (ORCID:0000-0002-5864-0006), Minati, L, Piacentini, Sylvie, Ferrè, F, Nanetti, L, Romito, Luigi Michele Antonio, Mariotti, Caterina, Grisoli, M, Medford, N, Critchley, Hd, Albanese, Alberto, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

The ability to choose effectively when faced with potential risks and rewards is fundamental for adaptive survival. The striatum has a well-established role supporting learning from the outcomes of decisions, but it remains unclear whether this structure is also necessary for computing expected value (i.e., advantageousness of potential decisions) when all information is explicitly given. We addressed this question presenting simple monetary gambles, where all decisional parameters were given and outcome feedback was absent, to patients with early Huntington's and Parkinson's disease, taken as complementary models of striatal dysfunction. Behavioural responses and associated times were found to be unaltered. This negative finding suggests that striatal activity may not be essential for decision-making in situations where all information is provided and learning from outcomes is unnecessary.

Published
2011

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