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485 results on '"Ferrara, James L.M."'

1. A Day 14 Endpoint for Acute GVHD Clinical Trials

Author

Spyrou, Nikolaos, Akahoshi, Yu, Kowalyk, Steven, Morales, George, Beheshti, Rahnuma, Aguayo-Hiraldo, Paibel, Al Malki, Monzr M., Ayuk, Francis, Bader, Peter, Baez, Janna, Capellini, Alexandra, Choe, Hannah, DeFilipp, Zachariah, Eder, Matthias, Eng, Gilbert, Etra, Aaron, Gleich, Sigrun, Grupp, Stephan A., Hexner, Elizabeth, Hoepting, Matthias, Hogan, William J., Kasikis, Stelios, Katsivelos, Nikolaos, Khan, Alina, Kitko, Carrie L., Kraus, Sabrina, Kwon, Deukwoo, Merli, Pietro, Portelli, Joseph, Qayed, Muna, Reshef, Ran, Schechter, Tal, Vasova, Ingrid, Wölfl, Matthias, Wudhikarn, Kitsada, Young, Rachel, Holler, Ernst, Chen, Yi-Bin, Nakamura, Ryotaro, Levine, John E., and Ferrara, James L.M.

Published
2024
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3. A Validated Risk Stratification That Incorporates MAGIC Biomarkers Predicts Long-Term Outcomes in Pediatric Patients with Acute GVHD

Author

Qayed, Muna, Kapoor, Urvi, Gillespie, Scott, Westbrook, Adrianna, Aguayo-Hiraldo, Paibel, Ayuk, Francis A., Aziz, Mina, Baez, Janna, Choe, Hannah, DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan A., Hexner, Elizabeth, Holler, Ernst, Hogan, William J., Kowalyk, Steven, Merli, Pietro, Morales, George, Nakamura, Ryotaro, Pulsipher, Michael A., Schechter, Tal, Shah, Jay, Spyrou, Nikolaos, Srinagesh, Hrishikesh K., Wölfl, Matthias, Yanik, Gregory, Young, Rachel, Kitko, Carrie L., Ferrara, James L.M., and Levine, John E.

Published
2024
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4. Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification

Author

Etra, Aaron, Gergoudis, Stephanie, Morales, George, Spyrou, Nikolaos, Shah, Jay, Kowalyk, Steven, Ayuk, Francis, Baez, Janna, Chanswangphuwana, Chantiya, Chen, Yi-Bin, Choe, Hannah, DeFilipp, Zachariah, Gandhi, Isha, Hexner, Elizabeth, Hogan, William J., Holler, Ernst, Kapoor, Urvi, Kitko, Carrie L., Kraus, Sabrina, Lin, Jung-Yi, Al Malki, Monzr, Merli, Pietro, Pawarode, Attaphol, Pulsipher, Michael A., Qayed, Muna, Reshef, Ran, Rösler, Wolf, Schechter, Tal, Van Hyfte, Grace, Weber, Daniela, Wölfl, Matthias, Young, Rachel, Özbek, Umut, Ferrara, James L.M., and Levine, John E.

Published
2022
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5. Flares of Acute Graft-Versus-Host Disease (GVHD): A Mount Sinai Acute GVHD International Consortium (MAGIC) Analysis

Author

Akahoshi, Yu, primary, Spyrou, Nikolaos, additional, Hoepting, Matthias, additional, Aguayo-Hiraldo, Paibel, additional, Ayuk, Francis Ayuketang, additional, Chanswangphuwana, Chantiya, additional, Choe, Hannah K, additional, Eder, Matthias, additional, Etra, Aaron M., additional, Grupp, Stephan A., additional, Hexner, Elizabeth O., additional, Hogan, William J, additional, Kitko, Carrie L., additional, Kraus, Sabrina, additional, Al Malki, Monzr M, additional, Merli, Pietro, additional, Qayed, Muna, additional, Reshef, Ran, additional, Schechter-Finkelstein, Tal, additional, Ullrich, Evelyn, additional, Vasova, Ingrid, additional, Wölfl, Matthias, additional, Zeiser, Robert, additional, Baez, Janna, additional, Beheshti, Rahnuma, additional, Eng, Gilbert W, additional, Gleich, Sigrun, additional, Kasikis, Stelios, additional, Katsivelos, Nikolaos, additional, Kowalyk, Steven, additional, Morales, George, additional, Young, Rachel, additional, DeFilipp, Zachariah, additional, Ferrara, James L.M., additional, Levine, John E, additional, and Nakamura, Ryotaro, additional

Published
2024
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6. Biomarker-guided preemption of steroid-refractory graft-versus-host disease with α-1-antitrypsin

Author

Gergoudis, Stephanie C., DeFilipp, Zachariah, Özbek, Umut, Sandhu, Karamjeet S., Etra, Aaron M., Choe, Hannah K., Kitko, Carrie L., Ayuk, Francis, Aziz, Mina, Baez, Janna, Ben-David, Kaitlyn, Bunworasate, Udomsak, Gandhi, Isha, Hexner, Elizabeth O., Hogan, William J., Holler, Ernst, Kasikis, Stelios, Kowalyk, Steven M., Lin, Jung-Yi, Merli, Pietro, Morales, George, Nakamura, Ryotaro, Reshef, Ran, Rösler, Wolf, Srinagesh, Hrishikesh, Young, Rachel, Chen, Yi-Bin, Ferrara, James L.M., and Levine, John E.

Published
2020
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7. The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease

Author

Srinagesh, Hrishikesh K., Özbek, Umut, Kapoor, Urvi, Ayuk, Francis, Aziz, Mina, Ben-David, Kaitlyn, Choe, Hannah K., DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan A., Hartwell, Matthew J., Hexner, Elizabeth O., Hogan, William J., Karol, Alexander B., Kasikis, Stelios, Kitko, Carrie L., Kowalyk, Steven, Lin, Jung-Yi, Major-Monfried, Hannah, Mielke, Stephan, Merli, Pietro, Morales, George, Ordemann, Rainer, Pulsipher, Michael A., Qayed, Muna, Reddy, Pavan, Reshef, Ran, Rösler, Wolf, Sandhu, Karamjeet S., Schechter, Tal, Shah, Jay, Sigel, Keith, Weber, Daniela, Wölfl, Matthias, Wudhikarn, Kitsada, Young, Rachel, Levine, John E., and Ferrara, James L.M.

Published
2019
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10. MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

Author

Major-Monfried, Hannah, Renteria, Anne S., Pawarode, Attaphol, Reddy, Pavan, Ayuk, Francis, Holler, Ernst, Efebera, Yvonne A., Hogan, William J., Wölfl, Matthias, Qayed, Muna, Hexner, Elizabeth O., Wudhikarn, Kitsada, Ordemann, Rainer, Young, Rachel, Shah, Jay, Hartwell, Matthew J., Chaudhry, Mohammed S., Aziz, Mina, Etra, Aaron, Yanik, Gregory A., Kröger, Nicolaus, Weber, Daniela, Chen, Yi-Bin, Nakamura, Ryotaro, Rösler, Wolf, Kitko, Carrie L., Harris, Andrew C., Pulsipher, Michael, Reshef, Ran, Kowalyk, Steven, Morales, George, Torres, Ivan, Özbek, Umut, Ferrara, James L.M., and Levine, John E.

Published
2018
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12. Evaluation of Elafin as a Prognostic Biomarker in Acute Graft-versus-Host Disease

Author

Zewde, Makda Getachew, Morales, George, Gandhi, Isha, Özbek, Umut, Aguayo-Hiraldo, Paibel, Ayuk, Francis, Baez, Janna, Chanswangphuwana, Chantiya, Choe, Hannah, DeFilipp, Zachariah, Etra, Aaron, Grupp, Stephan, Hexner, Elizabeth O., Hogan, William, Javorniczky, Nora Rebeka, Kasikis, Stelios, Kitko, Carrie L., Kowalyk, Steven, Meedt, Elisabeth, Merli, Pietro, Nakamura, Ryotaro, Qayed, Muna, Reshef, Ran, Rösler, Wolf, Schechter, Tal, Weber, Daniela, Wölfl, Matthias, Yanik, Gregory, Young, Rachel, Levine, John E., Ferrara, James L.M., and Chen, Yi-Bin

Published
2021
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13. Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors

Author

Holtan, Shernan G., Khera, Nandita, Levine, John E., Chai, Xiaoyu, Storer, Barry, Liu, Hien D., Inamoto, Yoshihiro, Chen, George L., Mayer, Sebastian, Arora, Mukta, Palmer, Jeanne, Flowers, Mary E.D., Cutler, Corey S., Lukez, Alexander, Arai, Sally, Lazaryan, Aleksandr, Newell, Laura F., Krupski, Christa, Jagasia, Madan H., Pusic, Iskra, Wood, William, Renteria, Anne S., Yanik, Gregory, Hogan, William J., Hexner, Elizabeth, Ayuk, Francis, Holler, Ernst, Watanaboonyongcharoen, Phandee, Efebera, Yvonne A., Ferrara, James L.M., Panoskaltsis-Mortari, Angela, Weisdorf, Daniel, Lee, Stephanie J., and Pidala, Joseph

Published
2016
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14. International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium

Author

Harris, Andrew C., Young, Rachel, Devine, Steven, Hogan, William J., Ayuk, Francis, Bunworasate, Udomsak, Chanswangphuwana, Chantiya, Efebera, Yvonne A., Holler, Ernst, Litzow, Mark, Ordemann, Rainer, Qayed, Muna, Renteria, Anne S., Reshef, Ran, Wölfl, Matthias, Chen, Yi-Bin, Goldstein, Steven, Jagasia, Madan, Locatelli, Franco, Mielke, Stephan, Porter, David, Schechter, Tal, Shekhovtsova, Zhanna, Ferrara, James L.M., and Levine, John E.

Published
2016
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15. Contributors

Author

Abdel-Wahab, Omar, primary, Abrahm, Janet L., additional, Adams, Sharon, additional, Adewoye, Adeboye H., additional, Allen, Carl, additional, Ambinder, Richard F., additional, Anasetti, Claudio, additional, Anastasi, John, additional, Anderson, Julia A., additional, Antin, Joseph H., additional, Antony, Aśok C., additional, Araten, David J., additional, Armand, Philippe, additional, Armstrong, Gillian, additional, Armstrong, Scott A., additional, Arnold, Donald M., additional, Artz, Andrew S., additional, Awan, Farrukh T., additional, Baglin, Trevor P., additional, Benson, Don M., additional, Benz, Edward J., additional, Berliner, Nancy, additional, Bhagat, Govind, additional, Bhardwaj, Nina, additional, Bhatia, Ravi, additional, Bhatia, Smita, additional, Bhatt, Mihir D., additional, Bhatt, Vijaya Raj, additional, Bitan, Menachem, additional, Blinderman, Craig D., additional, Bollard, Catherine M., additional, Braun, Benjamin S., additional, Brenner, Malcolm K., additional, Brittenham, Gary M., additional, Brodsky, Robert A., additional, Brown, Myles, additional, Broxmeyer, Hal E., additional, Brummel-Ziedins, Kathleen, additional, Brunner, Andrew M., additional, Buadi, Francis K., additional, Burkhardt, Birgit, additional, Burns, Melissa, additional, Byrd, John C., additional, Caimi, Paolo F., additional, Caligiuri, Michael A., additional, Canavan, Michelle, additional, Cantor, Alan B., additional, Carcao, Manuel, additional, Carroll, Michael C., additional, Carty, Shannon A., additional, Castillo, Jorge J., additional, Chan, Anthony K.C., additional, Chapin, John, additional, Chiu, April, additional, Chute, John P., additional, Clark, David B., additional, Coates, Thomas D., additional, Cogle, Christopher R., additional, Connell, Nathan T., additional, Cooke, Elizabeth, additional, Cooley, Sarah, additional, Corradini, Paolo, additional, Creager, Mark A., additional, Creger, Richard J., additional, Cromwell, Caroline, additional, Crowther, Mark A., additional, Cushing, Melissa M., additional, Cutler, Corey, additional, Dang, Chi V., additional, Danial, Nika N., additional, Dave, Sandeep S., additional, DeCaprio, James A., additional, Dinauer, Mary C., additional, Dinner, Shira, additional, Diz-Küçükkaya, Reyhan, additional, Dodd, Roger Y., additional, Donato, Michele L., additional, Dorshkind, Kenneth, additional, Dotti, Gianpietro, additional, Dror, Yigal, additional, Dunleavy, Kieron, additional, Dvorak, Christopher C., additional, Ebert, Benjamin L., additional, Eck, Michael J., additional, Eikelboom, John W., additional, Epperla, Narendranath, additional, Ershler, William B., additional, Evans, William E., additional, Faderl, Stefan, additional, Ferrara, James L.M., additional, Filipovich, Alexandra Hult, additional, Fischer, Martin, additional, Fredenburgh, James C., additional, Friedman, Kenneth D., additional, Fuchs, Ephraim, additional, Fuller, Stephen J., additional, Gailani, David, additional, Galipeau, Jacques, additional, Gallagher, Patrick G., additional, Ganapathi, Karthik A., additional, Gardner, Lawrence B., additional, Gee, Adrian P., additional, Gerson, Stanton L., additional, Gertz, Morie A., additional, Giardina, Patricia J., additional, Gibson, Christopher J., additional, Golan, Karin, additional, Golub, Todd R., additional, Gonzales, Matthew J., additional, Gotlib, Jason, additional, Gottschalk, Stephen, additional, Grant, Marianne A., additional, Graubert, Timothy A., additional, Gregg, Xylina T., additional, Gribben, John G., additional, Gross, Dawn M., additional, Gruber, Tanja A., additional, Guitart, Joan, additional, Gurbuxani, Sandeep, additional, Gur-Cohen, Shiri, additional, Gutierrez, Alejandro, additional, Hamadani, Mehdi, additional, Hari, Parameswaran N., additional, Hartwig, John H., additional, Hayman, Suzanne R., additional, Hayward, Catherine P.M., additional, Hebbel, Robert P., additional, Heslop, Helen E., additional, Hillis, Christopher, additional, Hillyer, Christopher D., additional, Ho, Karin, additional, Hockenbery, David M., additional, Hoffman, Ronald, additional, Hogg, Kerstin E., additional, Holtan, Shernan G., additional, Horny, Hans-Peter, additional, Hsu, Yen-Michael S., additional, Hunter, Zachary R., additional, Huntington, James A., additional, Iancu-Rubin, Camelia, additional, Iqbal, Ali, additional, Isenman, David E., additional, Israels, Sara J., additional, Italiano, Joseph E., additional, Jaffe, Elaine S., additional, Jaffer, Iqbal H., additional, Jagannath, Sundar, additional, Jäger, Ulrich, additional, Jain, Nitin, additional, James, Paula, additional, Jeha, Sima, additional, Jordan, Michael B., additional, Josephson, Cassandra D., additional, Jung, Moonjung, additional, Kager, Leo, additional, Kambayashi, Taku, additional, Kanakry, Jennifer A., additional, Kantarjian, Hagop M., additional, Kaplan, Jason, additional, Karafin, Matthew S., additional, Karsan, Aly, additional, Kaufman, Randal J., additional, Kaufman, Richard M., additional, Keller, Frank G., additional, Kelly, Kara M., additional, Kessler, Craig M., additional, Key, Nigel S., additional, Keyzner, Alla, additional, Khandoga, Alexander G., additional, Khanna-Gupta, Arati, additional, Khatib-Massalha, Eman, additional, Klein, Harvey G., additional, Knoechel, Birgit, additional, Kollet, Orit, additional, Konkle, Barbara A., additional, Kontoyiannis, Dimitrios P., additional, Koreth, John, additional, Koretzky, Gary A., additional, Kotecha, Dipak, additional, Kremyanskaya, Marina, additional, Kumari, Anju, additional, Kuzel, Timothy M., additional, Küppers, Ralf, additional, Lacy, Martha Q., additional, Ladas, Elana, additional, Landier, Wendy, additional, Lapid, Kfir, additional, Lapidot, Tsvee, additional, Larson, Peter J., additional, Levi, Marcel, additional, Lewis, Russell E., additional, Liebman, Howard A., additional, Lillicrap, David, additional, Lim, Wendy, additional, Lin, Judith C., additional, Lindblad, Robert, additional, Lip, Gregory Y.H., additional, Little, Jane A., additional, Lohr, Jens G., additional, López, José A., additional, Luscinskas, Francis W., additional, Maciejewski, Jaroslaw P., additional, Majhail, Navneet S., additional, Manches, Olivier, additional, Mandle, Robert J., additional, Mann, Kenneth G., additional, Manno, Catherine S., additional, Marcogliese, Andrea N., additional, Mariani, Guglielmo, additional, Marincola, Francesco M., additional, Mascarenhas, John, additional, Massberg, Steffen, additional, McEver, Rodger P., additional, McGrath, Emer, additional, McKinney, Matthew S., additional, Mehta, Rohtesh S., additional, Mentzer, William C., additional, Merlini, Giampaolo, additional, Merryman, Reid, additional, Michel, Marc, additional, Migliaccio, Anna Rita, additional, Miller, Jeffrey S., additional, Mims, Martha P., additional, Mondoro, Traci Heath, additional, Moorehead, Paul, additional, Muniz, Luciana R., additional, Munshi, Nikhil C., additional, Najfeld, Vesna, additional, Nayak, Lalitha, additional, Nazy, Ishac, additional, Neff, Anne T., additional, Ness, Paul M., additional, Notarangelo, Luigi D., additional, O'Brien, Sarah H., additional, O'Connor, Owen A., additional, O'Donnell, Martin, additional, Olson, Amanda, additional, Orkin, Stuart H., additional, Pai, Menaka, additional, Pai, Sung-Yun, additional, Paidas, Michael, additional, Panch, Sandhya R., additional, Pande, Reena L., additional, Papayannopoulou, Thalia, additional, Parikh, Rahul, additional, Petersdorf, Effie W., additional, Peterson, Shane E., additional, Pittaluga, Stefania, additional, Ponce, Doris M., additional, Popolo, Laura, additional, Prchal, Josef T., additional, Pui, Ching-Hon, additional, Puigserver, Pere, additional, Rak, Janusz, additional, Ramos, Carlos A., additional, Rand, Jacob H., additional, Rand, Margaret L., additional, Rao, Dinesh S., additional, Ravandi, Farhad, additional, Rawlings, David J., additional, Reddy, Pavan, additional, Reding, Mark T., additional, Reiter, Andreas, additional, Rice, Lawrence, additional, Riese, Matthew J., additional, Ritchey, Arthur Kim, additional, Roberts, David J., additional, Roman, Elizabeth, additional, Rooney, Cliona M., additional, Rosen, Steven T., additional, Rosenthal, David S., additional, Rossmann, Marlies P., additional, Rot, Antal, additional, Rowley, Scott D., additional, Rubnitz, Jeffrey E., additional, Rydz, Natalia, additional, Salama, Mohamed E., additional, Sauk, Steven, additional, Saunthararajah, Yogen, additional, Savage, William, additional, Scadden, David, additional, Schaefer, Kristen G., additional, Schiffman, Fred, additional, Schneidewend, Robert, additional, Schrier, Stanley L., additional, Schuchman, Edward H., additional, Scullion, Bridget Fowler, additional, Selvaggi, Kathy J., additional, Senoo, Keitaro, additional, Shaheen, Montaser, additional, Shaz, Beth H., additional, Shelburne, Samuel A., additional, Shpall, Elizabeth J., additional, Shurin, Susan B., additional, Siegal, Deborah, additional, Silberstein, Leslie E., additional, Silberstein, Lev, additional, Silverstein, Roy L., additional, Sloan, Steven R., additional, Smith, Franklin O., additional, Smith, James W., additional, Smith, Katy, additional, Steensma, David P., additional, Steinberg, Martin H., additional, Stock, Wendy, additional, Storry, Jill R., additional, Stramer, Susan L., additional, Strauss, Ronald G., additional, Stroncek, David F., additional, Taylor, Justin, additional, Thota, Swapna, additional, Treon, Steven P., additional, Tulpule, Anil, additional, Valdes, Roberto Ferro, additional, Valent, Peter, additional, Vedantham, Suresh, additional, Vercellotti, Gregory M., additional, Verneris, Michael R., additional, Vichinsky, Elliott P., additional, von Andrian, Ulrich H., additional, Vose, Julie M., additional, Wagner, Andrew J., additional, Wang, Ena, additional, Wang, Jia-huai, additional, Warkentin, Theodore E., additional, Wasserstein, Melissa P., additional, Webster, Ann, additional, Weisdorf, Daniel J., additional, Weitz, Jeffrey I., additional, Westhoff, Connie M., additional, Wheeler, Allison P., additional, Widick, Page, additional, Wiley, James S., additional, William, Basem M., additional, Williams, David A., additional, Wilson, Wyndham H., additional, Wolfe, Joanne, additional, Wolgast, Lucia R., additional, Wood, Deborah, additional, Wu, Jennifer, additional, Yahalom, Joachim, additional, Yee, Donald L., additional, Younes, Anas, additional, Young, Neal S., additional, and Zeller, Michelle P., additional

Published
2018
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17. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Author

Reichenbach, Dawn K., Schwarze, Vincent, Matta, Benjamin M., Tkachev, Victor, Lieberknecht, Elisabeth, Liu, Quan, Koehn, Brent H., Pfeifer, Dietmar, Taylor, Patricia A., Prinz, Gabriele, Dierbach, Heide, Stickel, Natalie, Beck, Yvonne, Warncke, Max, Junt, Tobias, Schmitt-Graeff, Annette, Nakae, Susumu, Follo, Marie, Wertheimer, Tobias, Schwab, Lukas, Devlin, Jason, Watkins, Simon C., Duyster, Justus, Ferrara, James L.M., Turnquist, Heth R., Zeiser, Robert, and Blazar, Bruce R.

Published
2015
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18. A Refined Risk Score for Acute Graft-versus-Host Disease that Predicts Response to Initial Therapy, Survival, and Transplant-Related Mortality

Author

MacMillan, Margaret L., Robin, Marie, Harris, Andrew C., DeFor, Todd E., Martin, Paul J., Alousi, Amin, Ho, Vincent T., Bolaños-Meade, Javier, Ferrara, James L.M., Jones, Richard, Arora, Mukta, Blazar, Bruce R., Holtan, Shernan G., Jacobsohn, David, Pasquini, Marcelo, Socie, Gerard, Antin, Joseph H., Levine, John E., and Weisdorf, Daniel J.

Published
2015
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20. Effective Treatment of Low Risk Acute Gvhd with Itacitinib Monotherapy

Author

Capellini, Alexandra, primary, Etra, Aaron, additional, Alousi, Amin M, additional, Al Malki, Monzr M., additional, Choe, Hannah, additional, Defilipp, Zachariah, additional, Hogan, William J., additional, Kitko, Carrie Lynn, additional, Ayuk, Francis A., additional, Baez, Janna, additional, Gandhi, Isha, additional, Kasikis, Stelios, additional, Gleich, Sigrun, additional, Hexner, Elizabeth O., additional, Hoepting, Matthias, additional, Kapoor, Urvi, additional, Kowalyk, Steven, additional, Kwon, Deukwoo, additional, Langston, Amelia, additional, Mielcarek, Marco, additional, Morales, George, additional, Ozbek, Umut, additional, Qayed, Muna, additional, Reshef, Ran, additional, Roesler, Wolf, additional, Spyrou, Nikolaos, additional, Young, Rachel, additional, Chen, Yi-Bin, additional, Ferrara, James L.M., additional, and Levine, John E., additional

Published
2022
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21. Altered homeostatic regulation of innate and adaptive immunity in lower gastrointestinal tract GVHD pathogenesis

Author

Ferrara, James L.M., Smith, Christopher M., Sheets, Julia, Reddy, Pavan, and Serody, Jonathan S.

Subjects
Graft vs. host disease -- Development and progression -- Care and treatment, Gastrointestinal diseases -- Development and progression -- Care and treatment, Stem cell transplantation -- Complications and side effects, Health care industry
Abstract

Lower gastrointestinal (GI) tract graft-versus-host disease (GVHD) is the predominant cause of morbidity and mortality from GVHD after allogeneic stem cell transplantation. Recent data indicate that lower GI tract GVHD is a complicated process mediated by donor/host antigenic disparities. This process is exacerbated by significant changes to the microbiome, and innate and adaptive immune responses that are critical to the induction of disease, persistence of inflammation, and a lack of response to therapy. Here, we discuss new insights into the biology of lower GI tract GVHD and focus on intrinsic pathways and regulatory mechanisms crucial to normal intestinal function. We then describe multiple instances in which these homeostatic mechanisms are altered by donor T cells or conditioning therapy, resulting in exacerbation of GVHD. We also discuss data suggesting that some of these mechanisms produce biomarkers that could be informative as to the severity of GVHD and its response to therapy. Finally, novel therapies that might restore homeostasis in the GI tract during GVHD are highlighted., Lower gastrointestinal tract graft-versus-host disease: where we were Acute graft-versus-host disease (aGVHD) was noted as a complication of allogeneic bone marrow (BM) transplantation in animal models more than six decades [...]

Published
2017
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23. Etanercept plus Topical Corticosteroids as Initial Therapy for Grade One Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Author

Gatza, Erin, Braun, Thomas, Levine, John E., Ferrara, James L.M., Zhao, Shuang, Wang, Tianyi, Chang, Lawrence, Harris, Andrew, Pawarode, Attaphol, Kitko, Carrie, Magenau, John M., Yanik, Gregory A., Couriel, Daniel R., Goldstein, Steven, Connelly, James, Reddy, Pavan, Paczesny, Sophie, and Choi, Sung Won

Published
2014
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25. Plasma CXCL9 elevations correlate with chronic GVHD diagnosis

Author

Kitko, Carrie L., Levine, John E., Storer, Barry E., Chai, Xiaoyu, Fox, David A., Braun, Thomas M., Couriel, Daniel R., Martin, Paul J., Flowers, Mary E., Hansen, John A., Chang, Lawrence, Conlon, Megan, Fiema, Bryan J., Morgan, Rachel, Pongtornpipat, Prae, Lamiman, Kelly, Ferrara, James L.M., Lee, Stephanie J., and Paczesny, Sophie

Published
2014
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34. Pathogenic mechanisms of Acute Graft versus Host Disease

Author

Ferrara James L.M.

Subjects
Bone marrow transplant, cytokine, T lymphocyte, gastrointestinal tract, antigen presenting cells, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Graft-versus-host-disease (GVHD) is the major complication of allogeneic Bone Marrow Transplant (BMT). Older BMT recipients are a greater risk for acute GVHD after allogeneic BMT, but the causes of this association are poorly understood. Using well-characterized murine BMT models we have explored the mechanisms of increased GVHD in older mice. GVHD mortality and morbidity, and pathologic and biochemical indices were all worse in old recipients. Donor T cell responses were significantly increased in old recipients both in vivo and in vitro when stimulated by antigen-presenting cells (APCs) from old mice. In a haploidential GVHD model, CD4+ donor T cells mediated more severe GVHD in old mice. We confirmed the role of aged APCs in GVHD using bone marrow chimera recipient created with either old or young bone marrow. APCs from these mice also stimulated greater responses from allogeneic cells in vitro. In a separate set of experiments we evaluated whether alloantigen expression on host target epithelium is essential for tissue damage induced by GVHD. Using bone marrow chimeras recipients in which either MHC II or MHC I alloantigen was expressed only on APCs, we found that acute GVHD does not require alloantigen expression on host target epithelium and that neutralization of tumor necrosis factor-alpha and interleukin-1 prevents acute GVHD. These results pertain to CD4-mediated GVHD and to a lesser extent in CD8-mediated GVHD, and confirm the central role of most APCs as well as inflammatory cytokines.

Published
2002

35. Tumor vaccine strategies after allogeneic T-cell depleted bone marrow transplantation

Author

Ferrara James L.M.

Subjects
Granulocyte-macrophage colony-stimulating factor, bone marrow transplantation, graft-versus-host disease, graft-versus-tumor, cancer vaccination, T cell-depletion, donor leukocyte infusions, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Allogeneic bone marrow transplantation is currently restricted to hematological malignancies because of a lack of anti-tumor activity against solid cancers. We have tested a novel treatment strategy to stimulate specific anti-tumor activity against a solid tumor after transplantation by vaccination with irradiated tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor. Using the B16 melanoma model, we found that vaccination elicited potent anti-tumor activity in recipients of syngeneic bone marrow transplantation in a time dependent fashion, and that immune reconstitution was critical for the development of anti-tumor activity. Vaccination did not stimulate anti-tumor immunity after allogeneic bone marrow transplantation because of the post-transplantation immunodeficiency associated with graft-versus-host disease. Remarkably, vaccination was effective in stimulating potent and long-lasting anti-tumor activity in recipients of T cell-depleted allogeneic bone marrow. Thus T cells derived from donor stem cells were able to recognize tumor antigens even though they remained tolerant to host histocompatibility antigens. Donor leukocyte infusion from a donor immunized with the recipient-derived B16 vaccines enhanced clinical activity of tumor vaccines without exacerbating graft-versus-host disease and CD4+ T cells are essential for this enhancement. These results demonstrate that vaccination of both donors and recipients can stimulate potent anti-tumor effects without the induction of graft-versus-host disease, and this strategy has important implications for the treatment of patients with solid malignancies.

Published
2002

36. A biomarker panel for acute graft-versus-host disease

Author

Paczesny, Sophie, Krijanovski, Oleg I., Braun, Thomas M., Choi, Sung W., Clouthier, Shawn G., Kuick, Rork, Misek, David E., Cooke, Kenneth R., Kitko, Carrie L., Weyand, Angela, Bickley, Daniel, Jones, Dawn, Whitfield, Joel, Reddy, Pavan, Levine, John E., Hanash, Samir M., and Ferrara, James L.M.

Published
2009
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46. Contributors

Author

Alatrash, Gheath, primary, Alvarez, Maite, additional, Anasetti, Claudio, additional, Blazar, Bruce R., additional, Byersdorfer, Craig A., additional, Charron, Dominique, additional, Chen, Xiao, additional, Coghill, James M., additional, Cooke, Kenneth R., additional, Drobyski, William R., additional, Dudakov, Jarrod A., additional, Edinger, Matthias, additional, Ferrara, James L.M., additional, Foley, Bree, additional, Fowler, Daniel H., additional, Goulmy, Els, additional, Hanash, Alan M., additional, Hildebrandt, Gerhard C., additional, Hill, Geoffrey R., additional, Hoffmann, Petra, additional, Holler, E., additional, Jacobson, Caron A., additional, Leveson-Gower, Dennis B., additional, Levy, Robert B., additional, MacDonald, Kelli, additional, Markey, Kate A., additional, Martin, Paul J., additional, Miller, Jeffrey S., additional, Molldrem, Jeffrey J., additional, Murphy, William, additional, Mutis, Tuna, additional, Negrin, Robert S., additional, Paczesny, Sophie, additional, Penack, Olaf, additional, Perales, Miguel-Angel, additional, Petersdorf, Effie, additional, Reddy, Pavan, additional, Ritz, Jerome, additional, Serody, Jonathan S., additional, Shlomchik, Warren D., additional, Socié, Gérard, additional, Storb, R., additional, Sun, Yaping, additional, van den Brink, Marcel, additional, Wysocki, Christian A., additional, and Yu, Xue-Zhong, additional

Published
2013
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50. Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Author

Reddy, Pavan, Maeda, Yoshinobu, Hotary, Kevin, Liu, Chen, Reznikov, Leonid L., Dinarello, Charles A., and Ferrara, James L.M.

Subjects
Leukemia -- Research, Science and technology
Abstract

Acute graft-versus-host disease (GVHD) and leukemic relapse are the two major obstacles to successful outcomes after allogeneic bone marrow transplantation (BMT), an effective therapy for hematological malignancies. Several studies have demonstrated that the dysregulation of proinflammatory cytokines and the loss of gastrointestinal tract integrity contribute to GVHD, whereas the donor cytotoxic responses are critical for graft-versus-leukemia (GVL) preservation. Suberoylanilide hydroxamic acid (SAHA) is currently in clinical trials as an antitumor agent; it inhibits the activity of histone deacetylases and at low doses exhibits antiinflammatory effects by reducing the production of proinflammatory cytokines. Using two well characterized mouse models of BMT, we have studied the effects of SAHA on GVHD severity and GVL activity. Administration of SAHA from day +3 to day +7 after BMT reduced serum levels of the proinflammatory cytokines and decreased intestinal histopathology, clinical severity, and mortality from acute GVHD compared with vehicle-treated animals. However, SAHA had no effect on donor T cell proliferative and cytotoxic responses to host antigens in vivo or in vitro. When mice received lethal doses of tumor cells at the time of BMT, administration of SAHA did not impair GVL activity and resulted in significantly improved leukemia-free survival by using two different tumor and donor/recipient combinations. These findings reveal a critical role for histone deacetylase inhibition in the proinflammatory events contributing to GVHD and suggest that this class of pharmacologic agents may provide a strategy to reduce GVHD while preserving cytotoxic T cell responses to host antigens and maintaining beneficial GVL effects.

Published
2004

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